Integration of network pharmacology and experimental validation to elucidate the mechanism of Moutan cortex against acute lung injury
September 2026
This study aims to investigate the underlying mechanisms of Moutan Cortex (MC) against acute lung injury (ALI) by integrating network pharmacology, molecular docking and experimental validation in zebrafish...
Puerarin attenuates inflammatory progression in atherosclerosis by inhibiting NLRP3 inflammasome activation via the SphK1/S1P/S1PR1 axis
September 2026
Atherosclerosis (AS) is a chronic inflammatory cardiovascular disease. The sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P) signaling axis plays a key role in inflammation regulation, but...
Sterile inflammation and cognitive decline: Dissecting the HMGB1-RAGE-NLRP3 signaling cascade in the aging brain
September 2026
Chronic, non-resolving neuroinflammation accompanies brain aging and progressively undermines the integrity of the central nervous system, contributing to cognitive decline. In this review, we evaluate...
Holistic insights of ethnopharmacology, nutritional composition, phytochemical composition, pharmacological potential, and multifaceted applications of Moringa oleifera Lam. Leaves, seed, and seed oil
September 2026
Moringa oleifera Lam., widely recognized as the "miracle tree", has garnered global attention for its exceptional nutritional composition, diverse phytochemistry, and broad pharmacological potential....
Emerging self-regulated organic nanogel against osteoarthritis: An expanding horizon towards intelligent diagnosis and therapy
September 2026
Osteoarthritis (OA) comprises joint and bone ailments aiding numerous pathological and molecular events constituting articular cartilage degeneration grievance and synovial and subchondral bone remodelling....
Nanotechnology-driven delivery of Cordycepin derived from Cordyceps species: Mainly focusing on application of inflammatory pulmonary disease and lung cancer
September 2026
Inflammatory pulmonary diseases, including acute lung injury, asthma, chronic obstructive pulmonary disease, pulmonary arterial hypertension, and viral respiratory infections, pose a major global health...
Green-synthesized nanomaterials as next-generation antimicrobials: a sustainable pharmaceutical perspective
September 2026
Antimicrobial resistance (AMR) demands sustainable technological interventions that couple efficacy with environmental responsibility. Green-synthesized nanomaterials (GSNs) integrate biogenic reduction,...
WRKY-mediated regulation of secondary metabolite production in medicinal plants
June 2026
WRKY transcription factors represent a quintessential regulatory clade involved in plant growth, stress adaptation, and secondary metabolic processes. Extensive research has elucidated that WRKY proteins...
Characterization of Alismatis Rhizoma and its salt-processed products via near-infrared spectroscopy with partial least squares regression
June 2026
Alismatis Rhizoma (AR) is the dried rhizome of Alisma orientale (Sam.) Juzep. and Alisma plantago-aquatica Linn., as recorded in the Chinese Pharmacopoeia (2025 Edition, Part I). This study aimed to...
From components to mechanisms: study on the anti-inflammatory effects and mechanisms of active compounds in Phoebezhennan
June 2026
To analyse the chemical components of Phoebe zhennan and preliminarily investigate its anti-inflammatory mechanism based on network pharmacology and cell experiments, thereby providing a scientific...
Ethnobotanical survey and evaluation of antioxidant and angiotensin-converting enzyme inhibitory activities of selected medicinal plants
June 2026
The pathophysiology of several diseases, including hypertension, is linked to oxidative stress. Natural antioxidants play a crucial role in maintaining the balance between pro- and antioxidant levels....
Rapid identification of lingnan traditional Chinese medicinal materials via headspace-gas chromatography-ion mobility spectrometry combined with deep learning
June 2026
To develop a rapid, accurate, and non-destructive authentication method for Lingnan traditional Chinese medicinal materials (TCMMs), this study integrated headspace-gas chromatography-ion mobility spectrometry...
Study of tea bran: comprehensive chemical profiling by UPLC-Q-TOF-MS/MS linked to antibacterial and antioxidant activities for potential high-value applications
June 2026
Tea bran, also referred to as tea residue or tea seed cake, is the residual by-product generated after the extraction and pressing of tea oil. As a traditional agricultural waste product, the high-value...
miR-221-3p mediates T-cell differentiation through repressing DYRK1A
June 2026
This study aims to comprehensively investigate the role and underlying molecular mechanism of hsa-miR-221-3p in regulating the differentiation and effector functions of distinct T cell subpopulations,...
Gut–brain–immune crosstalk in drug-resistant epilepsy: mechanisms and therapeutic perspectives
June 2026
Epilepsy is one of the most prevalent neurological disorders worldwide, affecting approximately 50–52 million individuals. Approximately 30% of patients develop drug-resistant epilepsy (DRE) despite...
Gut microbiota and radiotherapy: towards enhancing radiotherapy efficacy and mitigating toxicities
June 2026
Radiotherapy (RT) is a principal modality for cancer treatment; however, its clinical benefit is often limited by treatment-associated toxicities, particularly radiation enteritis (RE), which can reduce...
Cannabidiol as a modulator of NLRP3 inflammasome: Mechanistic insights and therapeutic potential
June 2026
Dysregulated activation of the NLRP3 inflammasome is a central driver of chronic inflammatory, neurodegenerative, metabolic, and autoimmune diseases, contributing significantly to the global burden...
Discovery of an undescribed pyrazine and five known alkaloids from the myxobacterium Corallococcus silvisoli sp. nov. GDMCC 1.1387
June 2026
This study aims to study the chemical compositions from Corallococcus silvisoli sp. nov. GDMCC 1.1387 and explore their antibacterial activity and ABTS radical scavenging capacity....
Isoliquiritin apioside, a natural product from Glycyrrhizae radix et rhizoma, alleviates cerebral ischemia-reperfusion injury by suppressing TXNIP/NLRP3-mediated pyroptosis
June 2026
Cerebral ischemia-reperfusion (I/R) injury contributes substantially to neuronal damage after stroke. Recent studies have demonstrated the efficacy of Glycyrrhizae radix et rhizoma in I/R injury, yet...
Study on quality grading of Scutellaria baicalensis based on correlation analysis between appearance traits and intrinsic components
June 2026
To validate the scientific basis of the traditional Chinese medicine (TCM) principle "identifying morphological characteristics for quality assessment" and establish a quality grading standard for Scutellaria...
Flavone scaffold: A polypharmacological strategy in multifactorial disease
June 2026
Flavones are a subclass of flavonoids, the plant-derived polyphenolic compounds that are biologically constructed in terms of chemical structure and are constructed around a 2-phenylchromen-4-one nucleus...
Green-synthesized CuO–ZnO nanoparticles and nanocomposites derived from Chloris virgata Swartz leaves for reducing rheumatic inflammation: Nanotherapeutic insights
June 2026
This study aimed to green-synthesize ZnO, CuO, and bimetallic CuO-ZnO nanocomposites using Chloris virgata leaf (CVL) extract and evaluate their synergistic anti-arthritic potential....
Compound Lingzhi granules alleviated atherosclerosis by reducing lipid accumulation and inflammation
June 2026
Cardiovascular disease, primarily driven by atherosclerosis, is a leading cause of global mortality. Compound Lingzhi Granules (CLG), a traditional Chinese medicine formulation, have shown potential...
ToC
June 2026
Therapeutic approaches to dyslipidaemia in Unani medicine: a narrative review
March 2026
Dyslipidaemia is one of the most common metabolic disorders, strongly linked with cardiovascular disease, obesity, and other components of metabolic syndrome. In Unani medicine, this condition is understood...