WRKY-mediated regulation of secondary metabolite production in medicinal plants
June 2026
WRKY transcription factors represent a quintessential regulatory clade involved in plant growth, stress adaptation, and secondary metabolic processes. Extensive research has elucidated that WRKY proteins...
Characterization of Alismatis Rhizoma and its salt-processed products via near-infrared spectroscopy with partial least squares regression
June 2026
Alismatis Rhizoma (AR) is the dried rhizome of Alisma orientale (Sam.) Juzep. and Alisma plantago-aquatica Linn., as recorded in the Chinese Pharmacopoeia (2025 Edition, Part I). This study aimed to...
From components to mechanisms: study on the anti-inflammatory effects and mechanisms of active compounds in Phoebezhennan
June 2026
To analyse the chemical components of Phoebe zhennan and preliminarily investigate its anti-inflammatory mechanism based on network pharmacology and cell experiments, thereby providing a scientific...
Ethnobotanical survey and evaluation of antioxidant and angiotensin-converting enzyme inhibitory activities of selected medicinal plants
June 2026
The pathophysiology of several diseases, including hypertension, is linked to oxidative stress. Natural antioxidants play a crucial role in maintaining the balance between pro- and antioxidant levels....
Rapid identification of lingnan traditional Chinese medicinal materials via headspace-gas chromatography-ion mobility spectrometry combined with deep learning
June 2026
To develop a rapid, accurate, and non-destructive authentication method for Lingnan traditional Chinese medicinal materials (TCMMs), this study integrated headspace-gas chromatography-ion mobility spectrometry...
Study of tea bran: comprehensive chemical profiling by UPLC-Q-TOF-MS/MS linked to antibacterial and antioxidant activities for potential high-value applications
June 2026
Tea bran, also referred to as tea residue or tea seed cake, is the residual by-product generated after the extraction and pressing of tea oil. As a traditional agricultural waste product, the high-value...
miR-221-3p mediates T-cell differentiation through repressing DYRK1A
June 2026
This study aims to comprehensively investigate the role and underlying molecular mechanism of hsa-miR-221-3p in regulating the differentiation and effector functions of distinct T cell subpopulations,...
Gut–brain–immune crosstalk in drug-resistant epilepsy: mechanisms and therapeutic perspectives
June 2026
Epilepsy is one of the most prevalent neurological disorders worldwide, affecting approximately 50–52 million individuals. Approximately 30% of patients develop drug-resistant epilepsy (DRE) despite...
Gut microbiota and radiotherapy: towards enhancing radiotherapy efficacy and mitigating toxicities
June 2026
Radiotherapy (RT) is a principal modality for cancer treatment; however, its clinical benefit is often limited by treatment-associated toxicities, particularly radiation enteritis (RE), which can reduce...
Cannabidiol as a modulator of NLRP3 inflammasome: Mechanistic insights and therapeutic potential
June 2026
Dysregulated activation of the NLRP3 inflammasome is a central driver of chronic inflammatory, neurodegenerative, metabolic, and autoimmune diseases, contributing significantly to the global burden...
Discovery of an undescribed pyrazine and five known alkaloids from the myxobacterium Corallococcus silvisoli sp. nov. GDMCC 1.1387
June 2026
This study aims to study the chemical compositions from Corallococcus silvisoli sp. nov. GDMCC 1.1387 and explore their antibacterial activity and ABTS radical scavenging capacity....
Therapeutic approaches to dyslipidaemia in Unani medicine: a narrative review
March 2026
Dyslipidaemia is one of the most common metabolic disorders, strongly linked with cardiovascular disease, obesity, and other components of metabolic syndrome. In Unani medicine, this condition is understood...
From traditional herb to modern therapeutics: phytochemistry, pharmacology, toxicology, and clinical translation challenges of Cyperus rotundus L
March 2026
Cyperus rotundus L. (C. rotundus.), widely distributed in tropical and temperate regions, is a perennial herb with a long history of application in traditional medical systems for treating emotional...
Nimbolide as a multi-targeted phytochemical against prostate cancer therapy: Current evidence and future directions
March 2026
Prostate cancer remains one of the leading causes of cancer-related morbidity and mortality among men worldwide. Despite considerable progress in early detection and androgen receptor-targeted therapies,...
Mechanistic insights into the preventive efficacy of 21-day prefeeding with β-galactosidase hydrolyzed milk in DSS-induced ulcerative colitis mice
March 2026
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited preventive strategies. Here, we investigated the 21-day preventive effects of β-galactosidase hydrolyzed milk (Milk β-gal)...
Design and optimization of polyherbal tablets for anti-inflammatory therapy: A design of experiment approach with in vitro and in vivo evaluation
March 2026
To develop and optimize polyherbal tablets containing Terminalia chebula, Moringa oleifera, and Ocimum sanctum as a multi-targeted therapeutic approach for the management of chronic inflammatory di...
Study on the potential medical beauty efficacy screening of acetyl hexapeptide-8 and the mechanism of regulating collagen regeneration
March 2026
Acetyl hexapeptide-8 (AH-8) is a synthetic polypeptide that can promote collagen regeneration; however, the underlying mechanism of this promoting effect and other potential medical beauty efficacy...
Shugan Paidu Decoction promotes cuproptosis of hepatoma cells by downregulating STAT3 levels
March 2026
Shugan Paidu Decoction (SGPDT) is a traditional Chinese medicine (TCM) formula clinically used to treat Wilson's disease. Through network pharmacology analysis, we predicted that SGPDT might also be...
Gut–brain axis in neurological disorders: mechanistic links and regulatory role of Chinese herbal medicines
March 2026
The gut–brain axis (GBA) is a bidirectional communication network integrating neural, immune, endocrine, and metabolic pathways that link the gastrointestinal tract and the central nervous system. Increasing...
Exploring synergistic effects of bioactive compounds and pharmaceuticals in therapeutic applications
March 2026
Synergy arises when the combined effect of multiple agents exceeds the sum of their individual activities. Pharmacological and bioactive chemical synergy offers a promising approach to enhance therapeutic...
Autophagy in neuropathic pain: Cell specificity, molecular mechanisms, and therapeutic prospects
March 2026
Neuropathic pain (NP) is a chronic pain caused by damage or disease of the somatosensory system, with a global prevalence of 6.9%–10%. Due to the limited efficacy of current clinical treatments, there...
Traditional uses, chemical composition and pharmacological properties of genus Crotalaria
March 2026
The plants of genus Crotalaria are widely employed in traditional folk medicine to address various ailments. Extracts from these plants have been reported to exhibit diverse pharmacological properties,...
Harnessing the bioactive phytocompounds and drug discovery potential of hydrophytes: A review
March 2026
Water-based ecosystems have provided an ideal condition for unique and diverse group of aquatic plants to evolve with a wide range of adaptations known as hydrophytes. Such ecological niches have made...
Antidiabetic activity of bioactive fractions from Momordica cymbalaria Fenzl ex Naudin leaves: In vitro, in silico and in vivo evaluation
March 2026
This study evaluated the antidiabetic activity of Momordica cymbalaria Fenzl ex Naudin (MC) leaf fractions, a traditionally used remedy in southern India, through comprehensive in vitro, in silico,...
Influence of extraction techniques and solvent polarity on phytochemical yield: A comprehensive analytical study of Malvastrum coromandelianum (L.) Garcke
March 2026
Malvastrum coromandelianum (L.) Garcke, (Family: Malvaceae) is traditionally valued for its therapeutic properties. This study aimed to evaluate the phytochemical composition and bioactivities of different...