Pharmacognostic studies on three species of Spermacoce
March 2024
To provide a scientific basis for identification of Spermacoce species, including Spermacoce remota Lamarck, Spermacoce exilis (L. O. Williams) C. D. Adams, and Spermacoce alata Aubl., the current study...
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Danhong injection alleviates OGD-induced blood-brain barrier injury via VEGFR2/PI3K/AKT pathway based on network pharmacology and experimental evidence
March 2024
Previous studies have shown that Danhong injection (DHI) has a protective effect on the blood-brain barrier (BBB) function after ischemic stroke. However, the role of DHI in protecting the integrity...
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Genetic diversity analysis of Cinnamomum cassia Presl and Cinnamomum cassia Presl var. macrophyllum Chu based on ISSR
March 2024
ISSR technology can provide detailed data on the genetic information of species. In this study, ISSR was used to find dominant bands at the DNA level to stably identify Cinnamomum cassia Presl and Cinnamomum...
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Identifying candidate drugs based on transcriptional landscape associated with triple-negative breast cancer
December 2023
Triple-negative breast cancer (TNBC) is a special type of breast cancer in which ER, PR and HER2 are all negative, characterized by high malignancy, strong invasiveness, and high recurrence rate. It...
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Combining single-cell RNA sequencing data and network pharmacology to explore the mechanism of action of Dayuan Yin in the treatment of acute lung injury
December 2023
This study aimed to analyze the usefulness of combined single-cell RNA sequencing data and network pharmacology in understanding the molecular regulation mechanism of Dayuan Yin (DYY) in acute lung...
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Exploring the therapeutic effects of Zingiberis Rhizoma Preparatum (Pao-Jiang) against DSS-induced ulcerative colitis in mice by metabolomics-guided analysis
December 2023
Zingiberis Rhizoma Recens (Sheng-Jiang) is a kind of edible and medicinal plant resource in China. Both Zingiberis Rhizoma Recens and its dried form, Zingiberis Rhizome (Gan-Jiang), have been widely...
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Synthesis, cytotoxicity study of novel bisacridine derivatives and their interaction with c-myc promoter G-quadruplex/i-motif
December 2023
To synthesize novel bisacridine derivatives A1-A4 and study cytotoxicity and their interaction with c-myc G-quadruplex/i-motif DNA....
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Research progress in the regulation of secondary metabolism in medicinal plants by MYB transcription factors
December 2023
MYB transcription factors (MYB TFs)are one of the largest families of transcription factors in plants, which are widely involved in various fields of plant growth and development, and play an important...
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Methodological project (SMART-PT) for transparency and methodological characteristics of randomized controlled trials of phytotherapy interventions
December 2023
Randomized controlled trials (RCTs) are the gold standard for evaluating the efficacy and safety of medical interventions. Phytotherapy, which plays a critical role in the prevention and treatment of...
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Vitamins strategies for psoriasis: An update on current scientific evidence
December 2023
Psoriasis is an aggressive chronic skin disorder that requires various therapies such as topical, oral, and occasionally, subcutaneous, or intravenous. In contrast, vitamins have more significant evidence...
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Chloroplast genome of Thesium chinense: The insight into phylogeny of Santalaceae
December 2023
Thesium chinense is an important and commonly used traditional Chinese medicine. The aim of this study is to obtain more bioinformatics from Thesium chinense and to conduct a more comprehensive and...
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Genomics-based tools for drug discovery and development: From network maps to efficacy prediction
November 2023
Computing technology plays a crucial role in the field of drug discovery and development. With the rapid development of genomics and the improvement of databases, the application of genomics-based tools...
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Research progress on Prunella vulgaris and its monomers in protecting against ulcerative colitis
November 2023
Prunella vulgaris is a traditional Chinese herbal medicine with many pharmacological effects, among which the anti-inflammatory effect is more significant. It is widely reported that Prunella vulgaris...
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Review of compounds and activities from mangrove Sonneratia genus and their endophytes
November 2023
Sonneratia is an important mangrove plant, and its fruit has been used as traditional medicine and food in southeast China. With recent research focusing on its compounds and activities, an increasing...
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Pharmacognostical study of Croton Crassifolius Geisel
November 2023
Croton Crassifolius Geisel of the genus Croton in the Euphorbia family is a widely distributed herb in South China. It has medicinal value for the treatment of a sore throat, soothing tendons, activating...
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A Ruthenium(II) complex based long lifetime phosphorescent probe for copper ions and pH detection
November 2023
Transition metal ruthenium(II) complex was used to prepare a dual-functional phosphorescent probe for the detection of Cu2+ ion and pH....
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The critical role of signal transducers and activators of transcription-3 in the proliferation of vascular smooth muscle cells
November 2023
The proliferation of vascular smooth muscle cells (VSMCs) is a key pathogenic characteristic of vascular remodeling diseases. The signal transducers and activators of transcription-3 (STAT3) signaling...
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Study on the synergistic development of TCM service trade within the GBA
November 2023
This study analyzed the synergistic development of the Traditional Chinese Medicine (TCM) service trade within the Greater Bay Area (GBA) in China, aiming to provide suggestions and references for the...
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Combination treatment of a deep diabetic toe ulcer with collagenase-santyl dressings and antibiotics: A case report
November 2023
A diabetic foot ulcer is defined as the ulceration of tissues brought on by trauma and some peripheral neurological abnormalities, primarily as a result of the bacterial infection. The infection of...
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A pan-cancer analysis of oncogenic protein tyrosine phosphatase subfamily PTP4As
October 2023
The objective of this study was to conduct a comprehensive pan-cancer analysis of Protein tyrosine phosphatase 4A (PTP4As), specifically PTP4A1, PTP4A2, and PTP4A3, to investigate their aberrant expression,...
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Optimisation study on the flavonoid extraction process from Abrus precatorius leaves and the comparison of total flavonoid content by HPLC and UV
October 2023
Abrus precatorius is a leguminous plant with high medicinal value. Its leaves are rich in flavonoids. There only are limited reports on the extraction process and quality assessment of total flavonoids...
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Near infrared spectroscopy discrimination and pattern recognition of Chinese Pogostemon cablin and Agastache rugosa
October 2023
Pogostemon cablin (Blanco) Benth. and Agastache rugosa (Fisch. et Mey.) O. Ktze. are commonly used traditional Chinese medicines. They belong to the family Lamiaceae and have very similar macroscopical...
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A new design of coculture microfluidic chip for HepG2 and LO2 cells
October 2023
In order to better screen targeted drugs, a microfluidic chip that can culture both diseased and normal cells is designed....
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Analysis of clinical drug use and construction of pharmacy service model for children with Kawasaki disease based on integration concept
October 2023
This study aimed to summarize and share the experience of clinical pharmacists in the clinical treatment of children with Kawasaki disease based on the “integration” concept....
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Tianhuang formula ameliorates non-alcoholic fatty liver diseases in type 2 diabetic mice through CRLS1-ATF3/ChREBP pathway
October 2023
Tianhuang Formula (THF) is a hospital formula summarized by Professor Jiao Guo's 30 years of clinical experience. Some studies have shown that it can alleviate dyslipidemia in the body. The purpose...
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