Anticancer flavonoids producing endophytic fungi: A review
December 2024
Plants living in different environments inhabit endophytic microbes. The relationship between plants and endophytic microbes may be symbiotic or parasitic. Transmission of endophytes varies when they...
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Pedalitin could regulate lipid metabolism and attenuate inflammatory factors in a non-alcoholic fatty liver disease cell model
December 2024
Nonalcoholic fatty liver disease (NAFLD) is an escalating global health issue, leading to liver fat accumulation, inflammation, fibrosis, and potential liver failure. In our preliminary network pharmacological...
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Exploring the mechanism of Lingbao Huxin Dan in the treatment of bradycardia based on atrioventricular node electrical signal conduction
December 2024
Prolonged bradycardia leads to inadequate pumping of the heart, causing myocardial ischemia, which in turn affects cardiac function. Depending on its clinical features, improving the AV node conduction...
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Visual analysis of drug research and development based on artificial intelligence
December 2024
The iteration of artificial intelligence (AI) technology provides new opportunities for drug research and experimental development. In recent years, AI-based drug research has continuously made new...
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Enlightenment of EU Herbal Medicinal Products regulation on the registration of Traditional Chinese Medicines in the Guangdong-Hong Kong-Macao Greater Bay Area
December 2024
This study analyzes the European Union's (EU's) regulatory practices of Herbal Medicinal Products (HMPs), aiming to provide implications for Traditional Chinese Medicines (TCMs) registration process...
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Preparation of purine functionalized biochar and analysis of nephrotoxic substances in traditional Chinese medicine
September 2024
In recent years, a growing lack of comprehension regarding the safety of traditional Chinese medicines (TCMs) has led to an escalating incidence of drug-induced organ damage, particularly kidney damage...
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Holistic integrative medicine declaration
September 2024
Holistic integrative medicine, abbreviated as HIM, has been officially proposed since 2012. Its theoretical system has been continuously improved, and its practical methods have become increasingly...
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Ferroptosis: A prospective therapeutic target for radiotherapy- and chemotherapy-induced gastrointestinal inflammation
September 2024
Ferroptosis is a unique mode of cell death driven by iron-dependent lipid peroxidation, and the process is regulated by a variety of cellular metabolic pathways, including redox homeostasis, iron processing,...
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Research progress in application of alginate gel as tumor drug delivery carrier, for tumor localization and 3D tumor cell model
September 2024
As one of the hot materials in biomedical research, alginate gel shows great potential in tumor therapy with its unique physical and chemical properties. In order to better meet the complex needs of...
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Exercise therapy: Anti-tumor and improving chemotherapy efficacy
September 2024
The extant research evidence indicates that sensible exercise has a beneficial impact on the prevention and treatment of cancer. This paper presents a comprehensive literature review of the field of...
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The research advance on the theory of Chinese medicine-exterior-interior correlation between the Lung and Large Intestine in the treatment of chronic cough
September 2024
Coughing as the main symptom of a chronic cough is a persistent respiratory disease that poses a substantial challenge to Western medicine and traditional Chinese medicine (TCM). The Large Intestine...
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Zebrafish as a rapid model system for early cardiotoxicity assessment of drugs
September 2024
There are some problems in the evaluation of drug cardiotoxicity in zebrafish, such as unsystematic indicators and weak sensitivity. This study aims to explore the advantages and disadvantages of various...
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Potential anti-colon cancer agents: Molecular modelling, docking, pharmacokinetics studies and molecular dynamic simulations
September 2024
The objective of this investigation is to create a trustworthy Quantitative Structure-Activity Relationship (QSAR) model that generates little to no side effects and is low-cost for treating colon cancer...
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Safety and risk control study of antibody preparation based on CiteSpace
September 2024
To analyze the hotspots, patterns, and distribution of research on the safety and risk of antibody preparations in the past 20 years. It also seeks to summarize the current status and trends of research...
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Puerarin alleviates LPS-induced endothelial cells injury via SIRT1-mediated mitochondrial homeostasis signaling
September 2024
Endothelial inflammation injury is a key mechanism that occurs in the pathological processes of various cardiovascular diseases. Puerarin (PUE) is an isoflavone compound with strong antioxidant properties...
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Cyclotides prediction in Leptopetalum biflorum based on de novo transcriptome assembly and annotation
June 2024
There is a scarcity of transcriptome sequencing data available for the Leptopetalum biflorum, and numerous cyclotides remain undiscovered. It is urgent to establish a workflow based on de novo transcriptome...
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Construction a six-gene prognostic model for hepatocellular carcinoma based on WGCNA co-expression network
June 2024
Currently, the incidence of hepatocellular carcinoma remains high, and the prognosis of patients is poor. Prognostic biomarkers are still worth exploring....
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Deciphering the anti-senescence immune paradigm: Kidney yin-yang equilibrium in traditional Chinese medicine
June 2024
In traditional Chinese medicine (TCM), the kidney is considered the "innate foundation", and the abundance or diminution of its essence directly affects the growth, development, physical form, and physiological...
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Liujunzi decoction attenuates cisplatin-induced anorexia in rats via inhibiting PERK/eIF2α/ATF4/CHOP pathway and GDF15/GFRAL expression
June 2024
Liujunzi Decoction (LJZD), also called Rikkunshito, is a traditional formula that has proven effective in clinical treatment against chemotherapy-induced anorexia (CIA). Previous study indicated the...
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Progress, challenges, and prospects of small extracellular vesicles isolation and characterization
June 2024
Exosomes are nanoparticles that can be secreted by almost all cells into the extracellular space and carry active substances such as nucleic acids, lipids, and proteins and can participate in intercellular...
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The functions and applications of organoids in rheumatic immune diseases
June 2024
Rheumatic immune disorders are a group of conditions that affect the immune system, leading to various clinical symptoms. These diseases can cause pain, reduce the quality of life, and increase the...
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Evolution of Salvia key enzyme genes based on metabolomic and transcriptomic insights into mitochondrial quality control
June 2024
The purpose of this study was to explore the relationship between the evolution of key Salvia enzyme genes and metabolite biological activity on mitochondrial quality control. Metabolomics and transcriptomics...
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Qingjie Fuzheng granules treat ulcerative colitis by regulating Th17/Treg balance
June 2024
To investigate the anti-inflammatory properties of Qingjie Fuzheng granules (QFG) in vivo using a dextran sulfate sodium (DSS)–induced ulcerative colitis (UC) model and elucidate the mechanism of which...
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Pharmacognostic studies on three species of Spermacoce
March 2024
To provide a scientific basis for identification of Spermacoce species, including Spermacoce remota Lamarck, Spermacoce exilis (L. O. Williams) C. D. Adams, and Spermacoce alata Aubl., the current study...
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