A hybrid deep learning framework based on VGG19 and U-Net for accurate brain tumor segmentation in MRI images
November 2026
Accurate segmentation of brain tumors from magnetic resonance imaging (MRI) is a critical task in neuro-oncology, directly impacting diagnosis, treatment planning, and patient outcomes. This study presents...
The perspective of artificial intelligence for NMR
February 2027
Nuclear magnetic resonance (NMR) spectroscopy is an indispensable analytical technique in chemistry, biology, and medicine, offering molecular-level structural and dynamic insights for metabolite identification...
A designed fusion tag improves soluble expression of nanobody in E. coli
November 2026
Nanobodies are small, single-domain antibody fragments derived from camelid heavy-chain antibodies that offer high stability, strong binding affinity, and excellent potential for therapeutic and diagnostic...
Analysis of the electron transfer pathway in small laccase by EPR and UV–vis spectroscopy coupled with redox titration
August 2024
Bacterial small laccases (SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline pH. Electron...
Rapid and quantitative 1D 13C NMR analysis of polypropylene tacticity with relaxation agent and proton polarization transfer
November 2025
Polypropylene (PP) accounts for approximately 28.0% of the global polyolefin market, valued at $243.4 billion in 2022. Known for its lightweight, chemical resistance, cost-effectiveness, high strength...
Using 19F NMR to quantify enthalpy-entropy compensation in protein-protein interactions
February 2027
Protein structural, stability, and functional equilibria are sensitive to the solution environment and governed by enthalpic and entropic contributions. NMR spectroscopy of suitably labeled- or isotopically...
New pulse sequence for improving cardiac black-blood and PSIR MRI quality in cases of arrhythmia
May 2027
Most conventional cardiac MRI scans, which rely on electrocardiogram (ECG)-triggered segmented acquisition for k-space data, are highly sensitive to arrhythmia—a vulnerability that can induce severe...
Going high-throughput: Dynamic conformations and interactions in vivo
February 2027
Proteins are intrinsically dynamic molecules that continuously explore conformational ensembles to execute biological functions. Conventional structural biology methods rely on in vitro reconstitution...
Language reorganization in brain arteriovenous malformations with fiber-based regional functional connectivity
May 2027
Structure and function changes of language function processing in brain arteriovenous malformations (AVMs) have been investigated, while the alterations of brain connectivity remain unexplored. This...
Chemical exchange saturation transfer NMR: An analytical tool and its applications
August 2026
NMR spectroscopy has proven to be a powerful tool for elucidating structural information and studying dynamic processes. Among NMR techniques, chemical exchange saturation transfer (CEST) is particularly...
Applications and future development of solid-state nuclear magnetic resonance for investigating metal-organic frameworks
February 2027
Metal-organic frameworks (MOFs) are a class of porous materials that feature permanent porosity, high crystallinity, and diverse structures. The 2025 Nobel Prize in Chemistry was awarded to three pioneering...
Structural anisotropy in celery stalks by microscopic MRI and polarized light microscopy
May 2026
Structural anisotropy of celery stalks was studied using T2 anisotropy in microscopic MRI (μMRI) and supplemented by quantitative polarized light microscopy (PLM) at optical resolutions. Parenchyma,...
Predictions and cross-center validation of IDH status and 1p/19q status in adult diffuse glioma with non-invasive magnetic resonance spectroscopy
February 2027
This study developed and validated a non-invasive multi-metabolite magnetic resonance spectroscopy framework for preoperative molecular subtyping of adult diffuse gliomas. Using a cross-center, cross-vendor...
Real-time NMR analysis of glutamine metabolism for screening anti-cancer agents in living cells
February 2027
Metabolic reprogramming is a substantial obstacle for anticancer drug screening, as targeted therapeutics often lose efficiency due to the dynamic adaption of cancer cells. Glutamine metabolism in cancer...
NMR methods for investigating functionally relevant biomolecular dynamics
November 2025
The dynamics of biomolecules span across a wide range of timescales, reflecting the complexity of free energy landscapes of biomolecules. Among these, the microsecond-to-millisecond (μs–ms) timescale...
RF power design optimization in MRI system
August 2021
Magnetic resonance image quality and patient safety have been the focus of engineering and research ever since the invention of equipment in the early 1970s. In high field (or ultrahigh field) MRI systems,...
Rheo-NMR: A versatile hyphenated technique for capturing molecular dynamics and structure under flow
February 2024
The general development of Rheo-NMR during the last four decades as well as selective hyphenated apparatuses is presented. Based on different magnet types, the current review is divided into two categories,...
Probing electronic structures of transition metal complexes using electron paramagnetic resonance spectroscopy
February 2023
Electron paramagnetic resonance (EPR) or electron spin resonance (ESR) has been widely employed to characterize transition metal complexes. However, because of the high degree of complexity of transition...
A pseudo-labeling approach for automated assignment of unlabeled proteins exceeding 100 amino acid residues
May 2027
In the era of AI-driven protein structure prediction, there is an urgent demand for rapid, accessible experimental approaches to validate computationally predicted structural models or to improve the...
Dynamic nuclear polarization and chemically induced hyperpolarization: Progress, mechanisms, and opportunities
August 2025
Nuclear magnetic resonance (NMR) spectroscopy is a powerful and broadly used spectroscopic technique for characterizing molecular structures and dynamics. Yet the power of NMR is restricted by its inherently...
Progress in in-situ electrochemical nuclear magnetic resonance for battery research
May 2024
A thorough understanding of the fundamental electrochemical and chemical processes in batteries is crucial to advancing energy density and power density. However, the characterizations of such processes...
Accurate measurement of longitudinal paramagnetic relaxation enhancement through division after subtraction
February 2027
Paramagnetic relaxation enhancement (PRE) provides valuable distance constraints with respect to unpaired electron for the structural and dynamic characterization of biomolecules. While transverse PRE...
Progress in magnetic resonance imaging of the glymphatic system
November 2024
The glymphatic system (GS) is a newly discovered brain anatomy. Its discovery improves our understanding of brain fluid flow and waste removal paths and provides an anatomical basis for the flow of...
Magnetic resonance imaging techniques for lithium-ion batteries: Principles and applications
May 2024
Operando monitoring of internal and local electrochemical processes within lithium-ion batteries (LIBs) is crucial, necessitating a range of non-invasive, real-time imaging characterization techniques...
Numerical design of transverse gradient coil with transformed magnetic gradient field over an effective imaging area
February 2025
Gradient coil is an essential component of a magnetic resonance imaging (MRI) scanner. To achieve high spatial resolution and imaging speed, a high-efficiency gradient coil with high slew rate is required....