About the Cover

Open access

ISSN: 2772-5162
CN: 42-1917/O4
p-ISSN: 2097-0048

Volume 2 Issue 3 Conformational dynamics in GPCR signaling by NMR

G-protein-coupled receptors (GPCRs) mediate a wide range of cellular responses to various ligands or stimuli, and are the most important drug targets associated with human diseases. While major advances in GPCR structural biology have greatly deepened our understanding of its activation mechanism, the highly complex changes in the structural dynamics of GPCRs during activation remain underdetermined and their links to physiological functions largely unknown. Solution nuclear magnetic resonance (NMR) ...

Volume 2 Issue 2 Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy

Considerable developments have been observed in fragment-based lead/drug discovery (FBLD/FBDD) recently, with four drugs approved and many others under investigation. Nuclear magnetic resonance (NMR) has gained increasing popularity in FBLD due to its intrinsic capability in characterizing protein-ligand interactions in a large dynamic range of affinity, from weak hits to highly potent drugs. Here, we summarize NMR applications in fragment-based hit-to-lead evolution, including the construction of ...

Volume 2 Issue 1 DNA binding mechanism of WhiB4 from Mycobacterium tuberculosis

Mycobacterium tuberculosis (Mtb), the pathogen of tuberculosis, has latently infected about one-third of the world's population and may lead to severe clinical symptoms and death. The WhiB4 protein, a transcription factor, plays a crucial role in the survival and pathology of Mtb. WhiB4 leads to the condensation of mycobacterial nucleoids and regulates the expression of genes involved in central metabolism, respiration, and maintaining redox homeostasis. Here, we report the solution structure of reduced...

Volume 1 Issue 2 Two open metal sites on the same metal: Dynamics of CO2 in MOF UTSA-74: Dedicated to Professor Xiuwen Han on the occasion of her 80th birthday

Metal-organic frameworks (MOFs) are an emerging class of porous materials with many unique properties that make them promising candidates for carbon dioxide (CO2) capture and storage. A better understanding of the behavior of CO2 adsorbed inside MOF will enable researchers to develop the ability of designing new MOF based materials with high CO2 adsorption capabilities. It is well known that presence of open metal sites (OMSs) can greatly enhance the gas adsorption capability of MOFs...

Volume 1 Issue 1 Solid-state NMR in the field of drug delivery: State of the art and new perspectives

In the last decades, a variety of nuclear magnetic resonance (NMR) techniques have been applied with success in the field of advanced functional materials, including the important area of drug delivery. In such field, solid-state NMR (SSNMR) is an irreplaceable tool in the arsenal of characterization techniques, offering unique and comprehensive perspectives for the description of chemical structure, spatial connectivity and interfacial phenomena of solid dosage forms.

Stay Informed

Register your interest and receive email alerts tailored to your needs. Sign up below.