Volume 2 Issue 4 The parallel tetrameric DNA G-quadruplex formed by the two-repeat C9orf72 GGGGCC sequence in solution
06 December 2022
The G-rich hexanucleotide repeat, GGGGCC (G4C2), in C9orf72 gene can fold into two kinds of eight-layer parallel tetrameric G-quadruplexes which exchange fast in solution. The formation of high-order G-quadruplexes via 5'-5'/3'-3' π-π stacking cause the death of neuron, eventually resulting in ALS/FTD.
08 April 2022
Mycobacterium tuberculosis (Mtb), the pathogen of tuberculosis, has latently infected about one-third of the world's population and may lead to severe clinical symptoms and death. The WhiB4 protein, a transcription factor, plays a crucial role in the survival and pathology of Mtb. WhiB4 leads to the condensation of mycobacterial nucleoids and regulates the expression of genes involved in central metabolism, respiration, and maintaining redox homeostasis. Here, we report the solution structure of reduced...
Volume 1 Issue 2 Two open metal sites on the same metal sites on the same metal: Dynamics of CO2 in MOF UTSA-74
06 January 2022
13C SSNMR provides dynamic information about the 13CO2 molecules adsorbed on the two open metal sites in the same Zn metal in UTSA-74 MOF.
Volume 1 Issue 1 Solid-state NMR in the field of drug delivery: State of the art and new perspectives
30 November 2021
In the last decades, a variety of nuclear magnetic resonance (NMR) techniques have been applied with success in the field of advanced functional materials, including the important area of drug delivery. In such field, solid-state NMR (SSNMR) is an irreplaceable tool in the arsenal of characterization techniques, offering unique and comprehensive perspectives for the description of chemical structure, spatial connectivity and interfacial phenomena of solid dosage forms.