#AI Reads Urine# Elastokines are Associated with a Poor Prognosis in Idiopathic Pulmonary Fibrosis
Published 20 June, 2025
The study analyzed urine and partial serum samples from 81 patients with idiopathic pulmonary fibrosis and 24 healthy volunteers, detecting the concentrations of desmosine and isodesmosine, two elastin degradation products, via ELISA. It found that concentrations of elastokines in both urine and serum of patients with idiopathic pulmonary fibrosis were significantly higher than those in healthy individuals, and there was no statistical difference in elastokine concentrations between urine and serum. Meanwhile, urinary elastokine concentrations were negatively correlated with the pulmonary function index forced vital capacity in patients, and those with higher concentrations had lower 3-year transplant-free survival rates. The research indicates that circulating and urinary elastokines can serve as biomarkers for matrix turnover in patients with idiopathic pulmonary fibrosis, being associated with clinical outcomes. Moreover, urine testing may be a practical specimen due to its advantages of low invasiveness and easy accessibility.
medRxiv [Preprint]. 2025 Jun 7:2025.06.06.25327886. doi: 10.1101/2025.06.06.25327886.
Elastokines are Associated with a Poor Prognosis in Idiopathic Pulmonary Fibrosis
D J Nagel, Takuma Okutani, Samia Lopa, T J Mariani, P J Sime, R M Kottmann, Denise Hocking
Youhe Gao
With Doubao
Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.
For earlier AI Reads Urine articles：