#AI reads Urine# Noninvasive Detection of Siderophores for Mixed Fungal Infections Diagnosis

This study explores the use of liquid chromatography-mass spectrometry (LC-MS) to detect Aspergillus fumigatus-specific siderophore triacetylfusarinine C (TafC) and Rhizopus microsporus-specific siderophore rhizoferrin (Rhf) in urine for noninvasive diagnosis of mixed fungal infections. Through research on a female patient with angioblastic T-cell lymphoma who developed neutropenia after allogeneic transplantation, the study found that compared with traditional diagnostic methods such as chest radiography, galactomannan (sGM), and beta-D-glucan (sBDG) serology, creatinine-normalized microbial siderophore detection can more sensitively and specifically detect A. fumigatus and R. microsporus infections at an earlier stage. Additionally, siderophore indices are sensitive to antifungal therapy and correlate with the timely recurrence of invasive disease, demonstrating the potential of this novel approach in unraveling the complexities of dual fungal infections.

ACS Omega. 2025 May 21;10(21):21908-21914. doi: 10.1021/acsomega.5c01914. Detection of Siderophores as a Superior Noninvasive Diagnostic Tool in Unraveling Mixed Fungal Infections

Radim Dobiáš 1 2, Milan Navrátil 3 4, Rutuja H Patil 5, Dominika Luptáková 5, David A Stevens 6, Vladimír Havlíček 5

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/