#AI reads Urine#Urinary Biomarkers as Early Alarms for AAA Rupture

This study explores urinary biomarkers for abdominal aortic aneurysm (AAA) rupture, which has a mortality rate of nearly 90%. Traditional risk assessment based on aneurysm diameter is unreliable. The research collected urine samples from 5 patients with ruptured AAA and 5 with unruptured AAA, using multiplexed kinase inhibitor beads combined with quantitative mass spectrometry for analysis. It identified six tyrosine kinases, predominantly Ephrin receptors (such as EPHB6 and AXL), that were significantly downregulated in the urine of ruptured AAA patients, with partial results validated by Western blot. These findings suggest that these kinases may serve as early warning biomarkers for high-risk AAA rupture, though further validation in larger cohort studies is needed.

J Clin Med. 2025 May 29;14(11):3845. doi: 10.3390/jcm14113845.

Cracking the Kinase Code: Urinary Biomarkers as Early Alarms for AAA Rupture-A Pilot Study

Emma Maria Östling 1, Tomas Baltrunas 2 3, Nathalie Grootenboer 1, Sigitas Urbonavicius 1 4

Youhe Gao

Statement: During the preparation of this work the author(s) used Doubao / AI reading for summarizing the content. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the published article.

For earlier AI Reads Urine articles：

https://www.keaipublishing.com/en/journals/advances-in-biomarker-sciences-and-technology/ai-reads-urine/