Recent Advances on Herpesvirus Unique Long Protein 41
Available online 11 December 2025
The Unique long protein 41 (UL41), also known as the virion host shutoff (vhs) protein, is a conserved and multifunctional component of herpesviruses, first identified in herpes simplex virus (HSV)...
Epidemiology, antimicrobial resistance, economic burden, and management approaches for staphylococcus aureus-associated bovine mastitis: a systematic review
Available online 6 December 2025
Bovine mastitis, an inflammatory condition of the mammary gland, represents a formidable challenge to the global dairy industry, causing substantial economic losses and posing significant public health...
First Detection of Parainfluenza Virus 5 in Sika Deer: Evidence for Cross-Species Transmission and Zoonotic Potential
Available online 28 November 2025
Parainfluenza virus 5 (PIV5), a member of the Paramyxoviridae family, is a widely distributed respiratory pathogen with a broad host range; however, infection in sika deer has not previously been reported....
Nature: A novel molecular mechanism of animal coronavirus infection mediated by the ACE2 receptor
Available online 26 November 2025
Genetic evolutionary dynamics and interspecies transmission risk of H9N2 subtype of avian influenza viruses
Available online 25 November 2025
Will avian influenza virus (H10N3) cause a major public health threat?
Available online 22 November 2025
Avian influenza viruses (AIVs) cause significant economic losses to the poultry industry and pose a persistent threat to public health due to their capacity for cross-species infection of mammals and...
Viola yedoensis Makiho alleviates LPS-induced oxidative stress and inflammatory injury by regulating Nrf2 and NF-κB/NLRP3 signaling pathways in broilers
Available online 20 November 2025
Viola yedoensis Makiho (VYM), a traditional Chinese herbal medicine with anti-inflammatory and antioxidative properties, was investigated for its effects on lipopolysaccharide (LPS)-induced liver damage...
Zoonotic diseases in low and middle-income countries (LMICs): Economic burden, challenges, strategies, and future directions
Available online 5 November 2025
More than 200 zoonotic diseases are known to affect humans, representing a significant share of both emerging and existing infectious diseases worldwide. These diseases pose a major global public health...
Recent progress on rapid diagnostic methods for viral diseases
Available online 30 October 2025
Viral diseases pose a persistent and evolving threat to global public health, with far-reaching impacts on clinical practice, epidemiology, and socioeconomic stability. Over the past decade, frequent...
Structural and functional characterization of reovirus S1 gene-encoded proteins: Implications for viral pathogenesis and rational vaccine design
Available online 24 October 2025
Avian reovirus (ARV) represents a significant avian pathogen that imposes substantial economic burdens on the global poultry industry. Although it is primarily associated with arthritis and tenosynovitis,...
Advances in mammalian ovarian tissue cryopreservation
September 2025
In mammals, the ovum is one of the largest cells with a relatively small ratio of surface area to cytoplasm and unique biological characteristics. The quantity of ova in the ovary is very limited and...
Regulation of immune metabolism in Th17 and Treg cells
September 2025
Immunometabolism is the intersection between immunity and metabolism, and the effects of some important metabolic pathways on the development, differentiation, activation and function of immune cells...
Experimental animal models for urolithiasis (kidney stone): A comprehensive review
September 2025
Experimental animal models play a crucial role in scientific research in different fields such as medicine, biology and pharmacology. Animal models help to understanding human physiology and pathology...
Alveolar macrophage endosomal-lysosomal system: Potential therapeutic targets for COVID-19
September 2025
Dysfunctional immune responses contribute critically to the progression of coronavirus disease-2019 (COVID-19) induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Alveolar...
Combining herbal fermentation with Lactobacillus expressing recombinant PEDV-S1 protein offers protection against PEDV infection
September 2025
The porcine epidemic diarrhea virus (PEDV) causes porcine epidemic diarrhea, an acute, highly contagious infectious disease that has caused significant economic losses in the global pig industry. Due...
Epidemiological survey of cat infectious diseases in China from 2022 to 2023
September 2025
The study investigates and analyzes the positive rates of 11 cat pathogens in 14 provinces across China from 2022 to 2023. The aim is to enhance understanding of the epidemiological characteristics...
First report of a pure growth of Providencia stuartii infection in the United Kingdom isolated from a dog with suppurative otitis
September 2025
The authors report a seven-year-old dog imported from Romania with otitis caused by a pure growth of Providencia stuartii. This has rarely been isolated in the UK but never been described as the single...
Advances in endometrial receptivity and embryo implantation by multi-omics techniques
September 2025
Endometrial receptivity is a critical determinant of successful embryo implantation, yet current clinical assessments (e.g., ultrasound, hysteroscopy) primarily focus on morphological evaluation and...
A comprehensive review of tick-borne disease epidemiology, clinical manifestations, pathogenesis, and prevention
September 2025
Ticks are arthropod vectors that transmit pathogens by biting and bloodsucking, and they have been found to carry or transmit over one hundred types of pathogens. The majority of these pathogens are...
Berberine hydrochloride attenuates avian pathogenic Escherichia coli-induced macrophage inflammation via NAD⁺/NADH-SIRT1-NF-κB regulatory axis
September 2025
Avian pathogenic Escherichia coli (APEC) poses a significant threat to the poultry industry, primarily causing multisystemic infections through respiratory tract invasion, which can lead to acute mortality....
Flagellin: A crucial virulence factor coordinating bacterial pathogenesis and host immune responses
Available online 18 September 2025
Flagella serve as the motility organs of bacteria, possessing not only the capability to facilitate movement through mechanisms such as rotation and swinging but also playing a crucial role in the establishment...
The impaired hepatic PNPLA2-PPARα/δ signaling pathway is associated with lipid accumulation and inflammation in dairy cows with fatty liver
Available online 1 September 2025
Hepatic triacylglycerol (TAG) metabolic dysregulation, characterized by concurrent enhancement of synthesis and attenuation of degradation, is fundamental to the pathogenesis of fatty liver in dairy...
Confronting bacterial mastitis: From pathogen diversity to sustainable control in the post-antibiotic era
Available online 8 August 2025
Bacterial mastitis (BM) is a purulent inflammatory disease caused by a variety of pathogenic microorganisms, which is common in dairy cows, posing a major threat to animal husbandry. This article reviews...
Giardia duodenalis kinase-STE7 requires ROS- associated AKT/JNK signaling pathway to induce apoptosis in Caco-2 cells
Available online 31 July 2025
Giardia duodenalis is an opportunistic pathogenic parasite that causes giardiasis, characterized by abdominal pain, diarrhea, and indigestion as the primary symptoms. The apoptosis of host epithelial...
CARS2 modulates cell malignant transformation induced by IFN-γ through manipulation of arginine metabolism in bovine mammary epithelial cells
Available online 21 July 2025
Malignant transformation induced by IFN-γ in bovine mammary epithelial cells (BMECs) is a pathological process that affects multiple cellular functions, including impaired milk fat synthesis. But the...