Recent progress on rapid diagnostic methods for viral diseases
Available online 30 October 2025
Viral diseases pose a persistent and evolving threat to global public health, with far-reaching impacts on clinical practice, epidemiology, and socioeconomic stability. Over the past decade, frequent...
Structural and functional characterization of reovirus S1 gene-encoded proteins: Implications for viral pathogenesis and rational vaccine design
Available online 24 October 2025
Avian reovirus (ARV) represents a significant avian pathogen that imposes substantial economic burdens on the global poultry industry. Although it is primarily associated with arthritis and tenosynovitis,...
Advances in mammalian ovarian tissue cryopreservation
September 2025
In mammals, the ovum is one of the largest cells with a relatively small ratio of surface area to cytoplasm and unique biological characteristics. The quantity of ova in the ovary is very limited and...
Regulation of immune metabolism in Th17 and Treg cells
September 2025
Immunometabolism is the intersection between immunity and metabolism, and the effects of some important metabolic pathways on the development, differentiation, activation and function of immune cells...
Experimental animal models for urolithiasis (kidney stone): A comprehensive review
September 2025
Experimental animal models play a crucial role in scientific research in different fields such as medicine, biology and pharmacology. Animal models help to understanding human physiology and pathology...
Alveolar macrophage endosomal-lysosomal system: Potential therapeutic targets for COVID-19
September 2025
Dysfunctional immune responses contribute critically to the progression of coronavirus disease-2019 (COVID-19) induced by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Alveolar...
Combining herbal fermentation with Lactobacillus expressing recombinant PEDV-S1 protein offers protection against PEDV infection
September 2025
The porcine epidemic diarrhea virus (PEDV) causes porcine epidemic diarrhea, an acute, highly contagious infectious disease that has caused significant economic losses in the global pig industry. Due...
Epidemiological survey of cat infectious diseases in China from 2022 to 2023
September 2025
The study investigates and analyzes the positive rates of 11 cat pathogens in 14 provinces across China from 2022 to 2023. The aim is to enhance understanding of the epidemiological characteristics...
First report of a pure growth of Providencia stuartii infection in the United Kingdom isolated from a dog with suppurative otitis
September 2025
The authors report a seven-year-old dog imported from Romania with otitis caused by a pure growth of Providencia stuartii. This has rarely been isolated in the UK but never been described as the single...
Advances in endometrial receptivity and embryo implantation by multi-omics techniques
September 2025
Endometrial receptivity is a critical determinant of successful embryo implantation, yet current clinical assessments (e.g., ultrasound, hysteroscopy) primarily focus on morphological evaluation and...
A comprehensive review of tick-borne disease epidemiology, clinical manifestations, pathogenesis, and prevention
September 2025
Ticks are arthropod vectors that transmit pathogens by biting and bloodsucking, and they have been found to carry or transmit over one hundred types of pathogens. The majority of these pathogens are...
Berberine hydrochloride attenuates avian pathogenic Escherichia coli-induced macrophage inflammation via NAD⁺/NADH-SIRT1-NF-κB regulatory axis
September 2025
Avian pathogenic Escherichia coli (APEC) poses a significant threat to the poultry industry, primarily causing multisystemic infections through respiratory tract invasion, which can lead to acute mortality....
Flagellin: A crucial virulence factor coordinating bacterial pathogenesis and host immune responses
Available online 18 September 2025
Flagella serve as the motility organs of bacteria, possessing not only the capability to facilitate movement through mechanisms such as rotation and swinging but also playing a crucial role in the establishment...
Confronting bacterial mastitis: From pathogen diversity to sustainable control in the post-antibiotic era
Available online 8 August 2025
Bacterial mastitis (BM) is a purulent inflammatory disease caused by a variety of pathogenic microorganisms, which is common in dairy cows, posing a major threat to animal husbandry. This article reviews...
Giardia duodenalis kinase-STE7 requires ROS- associated AKT/JNK signaling pathway to induce apoptosis in Caco-2 cells
Available online 31 July 2025
Giardia duodenalis is an opportunistic pathogenic parasite that causes giardiasis, characterized by abdominal pain, diarrhea, and indigestion as the primary symptoms. The apoptosis of host epithelial...
CARS2 modulates cell malignant transformation induced by IFN-γ through manipulation of arginine metabolism in bovine mammary epithelial cells
Available online 21 July 2025
Malignant transformation induced by IFN-γ in bovine mammary epithelial cells (BMECs) is a pathological process that affects multiple cellular functions, including impaired milk fat synthesis. But the...
Integration-recognition triggered RPA-PfAgo fluorescence biosensor for one-pot detection assemblage A and B of Giardia duodenalis
Available online 16 July 2025
Giardia duodenalis is a common intestinal protozoan that causes diarrhea, vomiting in humans and mammals. Consequently, early diagnosis plays a crucial role in the control giardiasis. Here we combined...
Emerging challenges and advances in porcine viral pathogenesis: A decade in review
Available online 4 July 2025
The past decade has witnessed unprecedented challenges posed by porcine viruses, driven by globalization and intensive livestock practices. This review consolidates critical findings from recent literature,...
CRISPR/Cas13a-based RNA analysis for non-enrichment Listeria monocytogenes in food
June 2025
Listeria monocytogenes (LM) is an opportunistic and invasive Gram-positive bacterium. They can grow in foods that are closely related to humans. However, the development of rapid and sensitive methods...
Prevalence of zoonotic diseases in the Northeastern region, one health perspective
June 2025
Zoonotic diseases are long known for their disease transmission from animals to human beings or from human beings to animals. These illnesses are primarily spread by the ingestion of contaminated food...
Progress in the molecular epidemiology of chikungunya virus
June 2025
In recent years, with the global climate warming up, Aedes albopictus and Aedes aegypti have gradually expanded their range of activities from the tropics to subtropical and temperate regions, which...
Host immune response to Cryptosporidium spp.: Insights and perspectives for vaccine development
June 2025
Cryptosporidium, a zoonotic protozoan parasite, poses a significant threat to both public health and the livestock sectors globally, leading to lethal diarrheal disease and associated economic losses....