A narrative review for antibacterials design and modification targeting outer membrane against Gram-negative bacteria
June 2026
With the increasing prevalence of refractory multidrug-resistant Gram-negative bacterial infections, the development of novel antibacterials targeting Gram-negative pathogens has become an urgent priority....
Bacillus subtilis and Bacillus megaterium alleviate colitis induced by DSS and depression-like behavior through the modulation of intestinal flora
June 2026
Inflammatory bowel disease (IBD) induces chronic intestinal inflammation and, in severe cases, may promote the development of colon cancer. IBD is frequently accompanied by psychiatric comorbidities...
A review of the mechanisms by which immune cells, cytokines, and gut microbiota regulate intestinal IgA synthesis
June 2026
Intestinal immunoglobulin A (IgA) is the predominant antibody observed within the intestinal mucosal immune system. It is essential for preserving intestinal homeostasis, protecting against infections,...
Emerging challenges and advances in porcine viral pathogenesis: A decade in review
June 2026
The past decade has witnessed unprecedented challenges posed by porcine viruses, driven by globalization and intensive livestock practices. This review consolidates critical findings from recent literature,...
Giardia duodenalis kinase-STE7 requires ROS- associated AKT/JNK signaling pathway to induce apoptosis in Caco-2 cells
June 2026
Giardia duodenalis is an opportunistic pathogenic parasite that causes giardiasis, characterized by abdominal pain, diarrhea, and indigestion as the primary symptoms. The apoptosis of host epithelial...
Host protein eEF1A1 affected the infection of Cryptosporidium parvum through interacting with CpHSP90
June 2026
Cryptosporidium parvum (C. parvum) is a common protozoan pathogen that causes severe diarrhea in humans and animals. HSP90 plays a key role in eukaryotic growth and development. Previous studies have...
Negative energy balance in transition dairy cows: Mechanisms, systemic impacts, and integrated prevention strategies
Available online 19 June 2026
Negative energy balance (NEB) is the central metabolic challenge of transition dairy cows and a major driver of impaired health, productivity, and reproductive performance during the periparturient...
A One Health perspective on chikungunya: From epidemiological insights to integrated control strategies
Available online 18 June 2026
In recent decades, factors such as climate change, accelerated urbanization, and increased human mobility have intensified the global burden of mosquito-borne infectious diseases. Among these, chikungunya...
CRISPR-Cas systems in protozoan parasites: A biological-fit decision framework for Cas9/Cas12a editing and dCas-based regulation
Available online 8 June 2026
CRISPR-Cas systems have transformed functional genomics in protozoan parasites; however, their genome engineering outcomes are strongly influenced by parasite-specific biological and genetic contexts....
Chronic antigenic stimulation induced by an inactivated vaccine drives hepatic AA amyloidosis and liver rupture syndrome in laying hens
Available online 8 June 2026
Recent epidemiological observations suggest a potential link between layer hemorrhagic liver rupture syndrome (LHLRS) and intensive vaccination protocols. However, the causal relationships and underlying...
Paramyxovirus reverse genetics system optimization strategies and emerging artificial intelligence applications
Available online 2 June 2026
Reverse genetics, a cornerstone of virology, enables the de novo generation of viruses from cloned cDNA, allowing precise functional interrogation of viral biology. It is particularly vital for the...
Immunization with the Neospora caninum TKL1-deficient strain protects C57BL/6 mice against neosporosis
Available online 15 May 2026
Neospora caninum is an apicomplexan protozoan that causes reproductive disorders in cattle and sheep, resulting in serious economic losses worldwide. However, there is still a lack of effective drugs...
Dynamic surface exposure of the fungal-affiliated putative amino acid transporter CpAAT9 in Cryptosporidium parvum
Available online 10 May 2026
Cryptosporidium parvum is an obligate intracellular parasite with highly reduced metabolic capacity and strong dependence on host-derived nutrients. Membrane transporters therefore play essential roles...
Screening and establishment of herbal-derived feed additives against Actinobacillus pleuropneumoniae infection in pigs
Available online 28 April 2026
Porcine contagious pleuropneumonia (PCP) caused by Actinobacillus pleuropneumoniae (APP) is an acute and highly contagious respiratory disease that poses a significant threat to the global swine industry....
A capsule-deficient Klebsiella pneumoniae strain reveals its O-polysaccharide as a potent immunomodulatory and protective vaccine antigen
Available online 22 April 2026
Klebsiella pneumoniae (KP), particularly hypervirulent (hvKP) and multidrug-resistant strains (e.g., Carbapenem-resistant KP, CRKP), poses a severe threat to human and animal health, underscoring the...
Integration-recognition triggered RPA-PfAgo fluorescence biosensor for one-pot detection assemblage A and B of Giardia duodenalis
March 2026
Giardia duodenalis is a common intestinal protozoan that causes diarrhea, vomiting in humans and mammals. Consequently, early diagnosis plays a crucial role in the control giardiasis. Here we combined...
CARS2 modulates cell malignant transformation induced by IFN-γ through manipulation of arginine metabolism in bovine mammary epithelial cells
March 2026
Malignant transformation induced by IFN-γ in bovine mammary epithelial cells (BMECs) is a pathological process that affects multiple cellular functions, including impaired milk fat synthesis. But the...
Confronting bacterial mastitis: From pathogen diversity to sustainable control in the post-antibiotic era
March 2026
Bacterial mastitis (BM) is a purulent inflammatory disease caused by a variety of pathogenic microorganisms, which is common in dairy cows, posing a major threat to animal husbandry. This article reviews...
Flagellin: A crucial virulence factor coordinating bacterial pathogenesis and host immune responses
March 2026
Flagella serve as the motility organs of bacteria, possessing not only the capability to facilitate movement through mechanisms such as rotation and swinging but also playing a crucial role in the establishment...
Structural and functional characterization of reovirus S1 gene-encoded proteins: Implications for viral pathogenesis and rational vaccine design
March 2026
Avian reovirus (ARV) represents a significant avian pathogen that imposes substantial economic burdens on the global poultry industry. Although it is primarily associated with arthritis and tenosynovitis,...
Recent progress on rapid diagnostic methods for viral diseases
March 2026
Viral diseases pose a persistent and evolving threat to global public health, with far-reaching impacts on clinical practice, epidemiology, and socioeconomic stability. Over the past decade, frequent...
Zoonotic diseases (zoonoses): Definitions, classifications, hazards, and prevention strategies
March 2026
Zoonotic diseases, also known as zoonoses, are infectious diseases that can be transmitted between humans and animals, including livestock, wildlife, and companion animals. These diseases have become...