Human papillomavirus 115 infects Yili horses
June 2025
The E6 gene of human papillomavirus 115 (HPV-115) has been amplified in samples from Yili horses. This study aims to investigate the unexpected presence of HPV-115 in horses, considering whether it...
The cellular host factors for severe fever with thrombocytopenia syndrome virus infection
June 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a newly discovered life-threatening disease caused by SFTS virus (SFTSV), an emerging tick-borne bunyavirus. The severity of SFTSV infection can...
Host protein eEF1A1 affected the infection of Cryptosporidium parvum through interacting with CpHSP90
Available online 31 May 2025
Cryptosporidium parvum (C. parvum) is a common protozoan pathogen that causes severe diarrhea in humans and animals. HSP90 plays a key role in eukaryotic growth and development. Previous studies have...
Current review for biological control of six common environmental mycotoxins
Available online 15 May 2025
Aflatoxin B1 (AFB1), zearalenone (ZEN), deoxynivalenol (DON), T-2 toxin (T-2), fumonisin B1 (FB1) and ochratoxin A (OTA) are the 6 most common environmental mycotoxins that are widely present in food...
Trichomonas vaginalis inhibits autophagy in VK2/E6E7 cells via the AMPK-ULK1 pathway
Available online 7 April 2025
Trichomonas vaginalis (T. vaginalis) is an infectious protozoan parasite responsible for trichomoniasis, which is one of the world's most pervasive non-viral sexually transmitted infections globally....
The effects of serotonin (5-hydroxytryptamine) on histone acetylation in early porcine embryos
Available online 4 April 2025
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter with emerging roles in mammalian embryonic development. However, its epigenetic effects on early porcine embryos remain poorly understood....
Oral administration of antimicrobial peptide MPX ameliorates orchitis and inflammatory damage in other organs
March 2025
Bacterial orchitis has a very high percentage of reproductive diseases in males. Therefore, specific medicines are urgently needed to prevent and treat orchitis. Antimicrobial peptides (AMPs) are widely...
Emerging role of ruminal microbiota in the development of perinatal bovine diseases
March 2025
As the largest and most important digestive organ of ruminant, rumen was a natural fermentation tank of dairy cows, in which there were many kinds of microorganisms. These microorganisms constituted...
Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2
March 2025
The pandemic of coronavirus disease 2019 (COVID-19) is no longer a global health emergency, but variants of the causative agent (severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2) are still...
The NF-κB pathway negatively regulates the replication of rabies virus by triggering inflammatory responses
March 2025
Rabies, which is caused by the rabies virus (RABV), is a neurological disease of mammals, including humans. The disease is untreatable, as drugs and antibodies are prevented from entering brain tissue...
Rheumatoid arthritis animal model in mice
March 2025
Rheumatoid arthritis (RA) is an autoimmune disease that causes significant disability and has a high recurrence rate. Currently, there is no cure for this disease. Identifying the cause of RA and developing...
Probiotic potential of Bacillus isolated from horses and its therapeutic effect against DSS-induced colitis in mice
March 2025
The superior biological characteristics of probiotics and their therapeutic applicability in the treatment of specific disorders have been proved by accumulating evidence. Although horses are susceptible...
Genetic evolution, phylodynamic and phylogeographic of H5Ny AIVs in mammals
March 2025
The growing incidence of H5Ny virus infection in humans and mammals causes an increasing public health concern. To date, H5Ny virus infection in humans and mammals has been reported in 46 countries...
A dual-purpose monoclonal antibody for in vitro neutralization and diagnostic detection of the lumpy skin disease virus
March 2025
The global cattle industry faces a persistent threat from lumpy skin disease virus (LSDV), resulting in significant economic losses and creating an urgent need for effective therapeutic and preventive...
Construction and immunogenicity of recombinant Lactiplantibacillus plantarum vaccine candidate expressing SARS-CoV-2 Omicron S1 protein
March 2025
The current intramuscular SARS-CoV-2 vaccine failed to prevent variant strain outbreaks due to its inadequate stimulation of mucosal immunity. Therefore, nasal immunization is emerging as a promising...
Monkeypox immunity: A landscape of host-virus interactions, vaccination strategies, and future research horizons
March 2025
Monkeypox virus (MPXV) is the cause of monkeypox (mpox), which is a viral zoonotic disease similar to smallpox. It is currently a re-emerging and a cause of global concern for human health. The emergence...
Role of parasite extracellular vesicles/exosomes in the interaction between hosts and virus-infected flagellate protozoa: Progress and prospects
Available online 18 March 2025
Parasite extracellular vesicles/exosomes (EVs/exos) are an emerging field in parasitology, sharing many commonalities with cell-derived EVs. Parasite EVs/exos have been recognized as mediators in parasite-parasite...
Promising strategies for accelerating the eradication of avian leukosis in China
Available online 18 March 2025
The national breeding and disease eradication programs in China are crucial for the healthy and sustainable development of the poultry industry. Among them, avian leukosis virus, the causative agent...
Prevention of Clostridium perfringens induced chicken necrotic enteritis by probiotics: A review
Available online 21 February 2025
Necrotic enteritis (NE), predominantly affecting poultry with significant disorder, is mainly caused by bacterial pathogen Clostridium perfringens. The restriction of growth enhancers based on animal...
Critical role of cellular microRNAs in virus infection: Decades of progress
Available online 13 January 2025
MicroRNAs, or miRNAs, play a critical role in the complex interplay between viruses and their host organisms during viral infections. Over the past several decades, investigations into the functions...
The effect of rumen fungal flora in the susceptibility of subacute ruminal acidosis in dairy goats
Available online 28 December 2024
Subacute rumen acidosis (SARA) is a condition commonly observed in high-yielding dairy cows, typically resulting from prolonged feeding of high-concentration diets (HCD). However, differences exist...