Integration-recognition triggered RPA-PfAgo fluorescence biosensor for one-pot detection assemblage A and B of Giardia duodenalis
Available online 16 July 2025
Giardia duodenalis is a common intestinal protozoan that causes diarrhea, vomiting in humans and mammals. Consequently, early diagnosis plays a crucial role in the control giardiasis. Here we combined...
Emerging challenges and advances in porcine viral pathogenesis: A decade in review
Available online 4 July 2025
The past decade has witnessed unprecedented challenges posed by porcine viruses, driven by globalization and intensive livestock practices. This review consolidates critical findings from recent literature,...
Omega-3 polyunsaturated fatty acids, especially DHA and EPA, remold gut microbiota to suppress inflammation in rabbits with atherosclerosis
June 2025
Atherosclerosis (AS) caused by a high-fat diet becomes a critical cause of cardiovascular diseases, which has been regarded as an urgent public health problem. Omega-3 polyunsaturated fatty acids (omega-3...
Uncovering the profile of ubiquitination motif in catalytic proteins using sequence contextual features
June 2025
Ubiquitin molecules modify their target protein by conjugating the amino group of lysine side chain, thereby regulating the activity and function of most intracellular proteins. However, within multiple...
Pathogens infected or carried by exotic pets pose emerging threat to human health
June 2025
Exotic pets refer to a variety of uncommon pets that are different from traditional pets such as cats, dogs, birds and fish. Due to the convenience of international travel, the diversity and globalization...
Virulence factors in biofilm formation and therapeutic strategies for Staphylococcus aureus: A review
June 2025
Staphylococcus aureus (S. aureus) is a significant human pathogen known for its ability to form biofilms, which increase its resistance to antibiotics and immune defenses. This review delves into the...
CRISPR/Cas13a-based RNA analysis for non-enrichment Listeria monocytogenes in food
June 2025
Listeria monocytogenes (LM) is an opportunistic and invasive Gram-positive bacterium. They can grow in foods that are closely related to humans. However, the development of rapid and sensitive methods...
Prevalence of zoonotic diseases in the Northeastern region, one health perspective
June 2025
Zoonotic diseases are long known for their disease transmission from animals to human beings or from human beings to animals. These illnesses are primarily spread by the ingestion of contaminated food...
Progress in the molecular epidemiology of chikungunya virus
June 2025
In recent years, with the global climate warming up, Aedes albopictus and Aedes aegypti have gradually expanded their range of activities from the tropics to subtropical and temperate regions, which...
Host immune response to Cryptosporidium spp.: Insights and perspectives for vaccine development
June 2025
Cryptosporidium, a zoonotic protozoan parasite, poses a significant threat to both public health and the livestock sectors globally, leading to lethal diarrheal disease and associated economic losses....
Human papillomavirus 115 infects Yili horses
June 2025
The E6 gene of human papillomavirus 115 (HPV-115) has been amplified in samples from Yili horses. This study aims to investigate the unexpected presence of HPV-115 in horses, considering whether it...
The cellular host factors for severe fever with thrombocytopenia syndrome virus infection
June 2025
Severe fever with thrombocytopenia syndrome (SFTS) is a newly discovered life-threatening disease caused by SFTS virus (SFTSV), an emerging tick-borne bunyavirus. The severity of SFTSV infection can...
Host protein eEF1A1 affected the infection of Cryptosporidium parvum through interacting with CpHSP90
Available online 31 May 2025
Cryptosporidium parvum (C. parvum) is a common protozoan pathogen that causes severe diarrhea in humans and animals. HSP90 plays a key role in eukaryotic growth and development. Previous studies have...
Current review for biological control of six common environmental mycotoxins
Available online 15 May 2025
Aflatoxin B1 (AFB1), zearalenone (ZEN), deoxynivalenol (DON), T-2 toxin (T-2), fumonisin B1 (FB1) and ochratoxin A (OTA) are the 6 most common environmental mycotoxins that are widely present in food...
Trichomonas vaginalis inhibits autophagy in VK2/E6E7 cells via the AMPK-ULK1 pathway
Available online 7 April 2025
Trichomonas vaginalis (T. vaginalis) is an infectious protozoan parasite responsible for trichomoniasis, which is one of the world's most pervasive non-viral sexually transmitted infections globally....
The effects of serotonin (5-hydroxytryptamine) on histone acetylation in early porcine embryos
Available online 4 April 2025
Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter with emerging roles in mammalian embryonic development. However, its epigenetic effects on early porcine embryos remain poorly understood....
Oral administration of antimicrobial peptide MPX ameliorates orchitis and inflammatory damage in other organs
March 2025
Bacterial orchitis has a very high percentage of reproductive diseases in males. Therefore, specific medicines are urgently needed to prevent and treat orchitis. Antimicrobial peptides (AMPs) are widely...
Emerging role of ruminal microbiota in the development of perinatal bovine diseases
March 2025
As the largest and most important digestive organ of ruminant, rumen was a natural fermentation tank of dairy cows, in which there were many kinds of microorganisms. These microorganisms constituted...
Thermal shift assay (TSA)-based drug screening strategy for rapid discovery of inhibitors against the Nsp13 helicase of SARS-CoV-2
March 2025
The pandemic of coronavirus disease 2019 (COVID-19) is no longer a global health emergency, but variants of the causative agent (severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2) are still...
The NF-κB pathway negatively regulates the replication of rabies virus by triggering inflammatory responses
March 2025
Rabies, which is caused by the rabies virus (RABV), is a neurological disease of mammals, including humans. The disease is untreatable, as drugs and antibodies are prevented from entering brain tissue...
Probiotic potential of Bacillus isolated from horses and its therapeutic effect against DSS-induced colitis in mice
March 2025
The superior biological characteristics of probiotics and their therapeutic applicability in the treatment of specific disorders have been proved by accumulating evidence. Although horses are susceptible...
Monkeypox immunity: A landscape of host-virus interactions, vaccination strategies, and future research horizons
March 2025
Monkeypox virus (MPXV) is the cause of monkeypox (mpox), which is a viral zoonotic disease similar to smallpox. It is currently a re-emerging and a cause of global concern for human health. The emergence...