Collagen II hydrogel-mediated sustained delivery of lacosamide attenuates cartilage degeneration and pain in osteoarthritis
July 2026
Osteoarthritis (OA) lacks effective disease-modifying therapies. Nav1.7 has recently been identified as a regulator of both chondrocyte metabolism and pain, establishing it as a dual-acting therapeutic...
Quercetin-derived carbon dots-modified ZIF-8 and M2 macrophage-derived migrasomes-functionalized microenvironment-responsive nanocomposite hydrogel for osteoporotic bone defects regeneration
February 2027
The impaired regenerative capacity of osteoporotic individuals poses a significant challenge to the repair of bone defects. In the osteoporotic microenvironment, low pH, excessive reactive oxygen species...
Biomimetic injectable hydrogel microspheres with enhanced lubrication and controllable drug release for the treatment of osteoarthritis
October 2021
The occurrence of osteoarthritis (OA) is highly associated with the reduced lubrication property of the joint, where a progressive and irreversible damage of the articular cartilage and consecutive...
Artificial Intelligence Virtual Organoids (AIVOs)
May 2026
Organoid platforms have reshaped in vitro human biology yet remain constrained by batch variability, sparse longitudinal readouts and barriers to scale. This review introduces Artificial Intelligence...
Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration
September 2023
Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading...
Reprogramming macrophage mechanosensation via TRPV4 modulating mechano-immunotherapy controls fibrotic encapsulation of biomaterial implants
December 2026
Modulating how macrophages sense mechanical cues offers a novel strategy to control fibrosis around implanted biomaterials. We term this approach ‘mechano-immunotherapy’, which involves the desensitization...
Systematic discovery of immunomodulatory plant-derived nanoparticles reveals RNA-mediated macrophage reprogramming
December 2026
Plant-derived nanoparticles (PNPs) have emerged as a promising class of bioactive nanomaterials with intrinsic immunomodulatory properties, offering a sustainable and biocompatible alternative to synthetic...
Bone grafts and biomaterials substitutes for bone defect repair: A review
December 2017
Bone grafts have been predominated used to treat bone defects, delayed union or non-union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency of synthetic bone graft...
Nanozyme-crosslinked dual-network hydrogel enables multi-stage modulation of the dysregulated repair cascade for regenerative wound healing
December 2026
Adult mammalian wound healing typically results in fibrosis-associated repair rather than regenerative restoration, a process that can be further exacerbated by persistent inflammation, microbial infection,...
Dual-modal antioxidant and epigenetic synergy attenuates the self-perpetuating senescence cycle in osteoarthritis
January 2027
Osteoarthritis (OA) arises from chondrocyte senescence driven by intertwined oxidative stress and abnormal m6A methylation, with few treatments targeting both pathological pathways. Lycopene, an antioxidant,...
AI-powered the toughest biohydrogels
December 2026
Hydrogel soft materials hold immense promise for applications ranging from bionic soft robots to flexible human-machine interfaces, but realizing this potential critically depends on excellent mechanical...
Advances in orthodontic clear aligner materials
April 2023
Rapid technological improvements in biomaterials, computer-aided design (CAD) and manufacturing (CAM) have endorsed clear aligner therapy (CAT) as a mainstay of orthodontic treatment, and the materials...
Biodegradable Mg2+-releasing piezoelectric scaffold for segmental bone defect repair
July 2026
Critical-sized bone defects, particularly segmental injuries such as radial defects, remain one of the most formidable challenges in orthopedic regeneration, as spontaneous healing is rarely achieved...
Skin-mimetic bilayer hydrogel enhances spatiotemporal coordination of neuro-immune-vascular interactions to accelerate diabetic wound healing
July 2026
Diabetic wound healing is a complex spatiotemporal process that requires stage-specific interventions to address disrupted neuro-immune interactions and impaired angiogenesis. However, achieving such...
Bioelectric signals promote diabetic bone regeneration through Piezo1-mediated activation of the efferocytic immune microenvironment
October 2026
Defective macrophage efferocytosis sustains inflammation and compromises bone repair in diabetic defects, yet strategies that restore efferocytic immune homeostasis remain limited. Here, we engineered...
A safe and anti-inflammatory plant-derived nanovesicle platform for targeted delivery in acute lung injury
August 2026
Acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS), are life-threatening pulmonary disorders with extremely high mortality rates, for which effective and safe...
Microalgae extracellular vesicles-loaded dual antioxidative and anti-inflammatory hydrogel system for wound healing and peripheral nerve repair in diabetes
October 2026
Chronic wound healing and peripheral nerve repair in diabetes remain a major clinical challenge due to persistent oxidative stress, inflammation, and impaired tissue regeneration. Here, we developed...
AI for bioactive materials: From material design to biological applications
October 2026
Bioactive materials are engineered to actively interact with biological systems and induce favorable cellular and tissue responses. The development of bioactive materials is inherently challenging due...
Activating the cellular scavenger: A bioactive hydrogel promotes diabetic wounds via plant exosome-like nanovesicles enhanced macrophage efferocytosis
August 2026
The core pathological process of impaired diabetic wound healing is closely associated with macrophage homeostasis imbalance and defective efferocytosis. To address this clinical challenge, this study...
Defining biomaterial-driven design principles for bioabsorbable flow diverters: current state and perspectives
January 2027
Flow diverters (FDs) have revolutionized intracranial aneurysm management, but current permanent metallic devices remain constrained by their bulk and surface properties, which induce chronic inflammation,...
Real-time sensing-integrated organoid-on-a-chip platforms: Technological progress and emerging biomedical applications
December 2026
As micro-scale 3D tissues self-organized from stem cells, organoids can highly recapitulate the cellular composition and complex spatial architecture of human organs, establishing themselves as pivotal...
Antibacterial conductive self-healing hydrogel wound dressing with dual dynamic bonds promotes infected wound healing
December 2023
In clinical applications, there is a lack of wound dressings that combine efficient resistance to drug-resistant bacteria with good self-healing properties. In this study, a series of adhesive self-healing...
Innovative strategies for diabetic peripheral neuropathy: From clinical management to emerging bioengineering solutions
July 2026
Diabetic peripheral neuropathy (DPN) is a common, incurable complication of diabetes that causes sensory loss, pain, and motor problems. Conventional treatments like blood glucose management, pain relief,...
Biomedical application of materials for external auditory canal: History, challenges, and clinical prospects
September 2024
Biomaterials play an integral role in treatment of external auditory canal (EAC) diseases. Regarding the special anatomic structure and physiological characteristics of EAC, careful selection of applicable...
Intelligent responsive alloy scaffold temporally regulates the immune-osteogenic axis for the treatment of infectious bone defects
December 2026
Excessive immune activation induced by persistent bacterial infection, which further impairs osteogenic function, is a crucial factor contributing to the poor healing of infectious bone defects. Therapeutic...
Production and hosting by Elsevier on behalf of KeAi Communications Co. Ltd