Development of an electrochemical biosensor based on rGO/Ag₂S-Au nanocomposites and L-CHA dual signal amplification for miR-155 detection
December 2025
MicroRNA-155 (miR-155) is a critical biomarker implicated in various pathological processes, including cancer progression, immune response, and cardiovascular diseases. Consequently, accurate detection...
The health protection potential of total flavonoids of Rhizoma Drynariae in an aging society
December 2025
With the global population aging, degenerative musculoskeletal diseases (DMDs) such as osteoporosis (OP), osteoarthritis (OA), and sarcopenia (SP) have placed a substantial burden on society. Consequently,...
Machine learning empowered smartphone nanozyme sensing enables precise quantitative prediction of urinary uric acid
December 2025
The increasing incidence of gout necessitates monitoring of uric acid (UA) levels for early risk assessment and clinical management. Although nanomaterials with oxidoreductase-mimicking properties demonstrate...
Lab-on-a-chip technologies: The future of precision medicine and high-throughput biomolecular analysis
December 2025
Over the past few decades, advancements in microfabrication and biomaterials have driven the innovation of microfluidic technologies, significantly advancing the development of lab-on-a-chip (LOC) systems....
A dual-mode paper-based microfluidic chip for protamine detection
Available online 4 November 2025
Timely and accessible fertility screening remains a challenge for male reproductive health, where privacy and convenience are often critical. Here, we present a dual-mode paper-based microfluidic device...
Mechanistic insights into the anti-osteoporotic effects of Tripterygium wilfordii via network pharmacology, molecular docking, and experimental validation
September 2025
Tripterygium wilfordii (Lei Gong Teng), a traditional Chinese medicinal herb, has shown potential in promoting bone health, yet its anti-osteoporotic mechanisms remain poorly defined. This study explored...
Unsupervised classification based on m7G-related lncRNAs reveals molecular subtypes of patients with hepatocellular carcinoma
September 2025
The m7G methylation has been demonstrated to play a crucial role in the progression of various tumors. Therefore, we performed molecular subtyping of hepatocellular carcinoma (HCC) patients based on...
A review of extraction, synthesis, and pharmacological activities of naringenin and its derivatives
September 2025
Naringenin, a polyphenolic flavanone, exhibits diverse pharmacological and biological activities, including anti-inflammatory, antioxidant, anti-obesity, anticancer, antidiabetic, and antimicrobial...
One-pot synthesis of magnetic adsorbents with integrated pH regulation for convenient and rapid determination of non-steroidal anti-inflammatory drugs in plasma
September 2025
This work introduces a magnetic nanocomposite created via a one-pot method to produce a magnetic adsorbent with built-in pH regulation capabilities, optimizing the extraction and analysis of non-steroidal...
Loofah-Inspired CuS/Fe3O4@BC nanozyme: A multifunctional platform for mercury(II) detection, visual biosensing, and dye degradation
June 2025
The accumulation of toxic heavy metal ions and organic pollutants in biological systems presents critical challenges for clinical diagnostics and therapeutic safety, demanding innovative solutions for...
Molecular docking, molecular dynamics simulation and MM-PB/GBSA analysis for the inhibition of Klebsiella pneumoniae SHV-1 β-lactamase using antimicrobial peptides defensin VvK1 and snakin-1
June 2025
This computational study aims to explore the inhibition property of two plant-derived AMPs (antimicrobial peptides), defensin VvK1 and snakin-1, against SHV-1 β-lactamase from Klebsiella pneumoniae...
Multi-omics analysis reveals synergistic interplay of metabolic dysregulation, oxidative stress, and inflammation in polycystic ovary syndrome
June 2025
Polycystic ovary syndrome (PCOS) is a multifactorial endocrine and metabolic disorder characterized by hormonal imbalances, metabolic dysfunction, and chronic inflammation. To elucidate the molecular...
A label-free fluorescence sensor for bleomycin detection based on a cavity hairpin thioflavin T-light nucleic acid switch
June 2025
Accurate monitoring of bleomycin (BLM) levels in clinical samples is essential for enhancing therapeutic outcomes while minimizing potential toxicity. In this study, we present a label-free fluorescent...
3D-Printed microneedle assays for point-of-care applications
June 2025
Microneedle arrays (MNAs) offer a minimally invasive approach for point-of-care (POC) diagnostics, enabling biomarker detection in interstitial fluid (ISF) with reduced discomfort. 3D-printing technology...
Establishment of a triplex real-time quantitative fluorescence PCR method for detecting drug resistance genes mcr-1, blaNDM-1, and vanA
March 2025
This study establishes a triplex real-time quantitative fluorescence polymerase chain reaction (PCR) method for simultaneous and rapid MCR-1, vanA, and blaNDM-1 detection. Different primer-probe combinations...
Effective alternative curing/clearance of biofilm associated and antibiotic resistant bacterial infections: A relevant probiotics model
March 2025
Diverse bio-inhibitory agents have been applied as control model for microbial proliferation with specific relevance/capability in effectively balancing various nexus microbiome. However, with recent...
Assessment of oxytocin and Bacillus velezensis lipopeptide on mammalian cell lines
March 2025
This study aimed to describe the effect of Bacillus velezensis lipopeptide (BVLP), and a potential but less studied nonapeptide (love and labor hormone) oxytocin (OT) as an anti-cancer and anti-obesity...
Recent progress in the rational design and applications of nanozymes
March 2025
In order to overcome the limitations of natural enzymes, nanomaterials with enzyme-like activity, commonly named as nanozymes, have been widely studied in the past few decades. Due to their distinctive...
Gold nanoclusters-incorporated nanogels as hybrid nanozymes for sensitive chemiluminescence immunoassays
December 2024
Nanomaterials with excellent biocompatibility hold significant potential in chemiluminescence (CL) immunoassays. However, achieving green synthesis and maintaining the structural stability of such nanomaterials...
Advances in the molecular diagnostic methods for circular RNA
December 2024
Circular RNA (circRNA) is a unique type of non-coding RNA, which is produced by back splicing of mRNA to form the covalent junction without 3′-5′ polarity and poly(A) tail. With the development of detection...
An aptamer-based point-of-care diagnostic test strip for rapid diagnosis of surface spike proteins of SARS-CoV2 virus
September 2024
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) has been identified as the causative agent for the COVID-19 pandemic. Herein, we report the development of a point-of-care diagnostic (POC)...
A comprehensive study on epigenetic signatures to monitor disease progression and the response to therapy in breast cancer
September 2024
Breast cancer is the single most complex cancer type, affecting thousands around the globe annually. With the recent studies highlighting epigenetic signatures in breast cancer detection, this landscape...
Optical pickup unit-based fluorescence microscope with autofocus and deep learning capabilities
September 2024
An autofocus, cost-effective fluorescence microscope instrument is made using a commercially available Blu-ray disc optical pickup head (OPU). This ABFM consists of the optical path, system control...
An ensemble machine learning-based approach to predict thyroid disease using hybrid feature selection
September 2024
Thyroid issues are becoming more and more common, and early detection is critical for therapy that reduces mortality and complications. Because of these factors, detecting thyroid problems has become...
Halogenated 2,4-diphenyl indeno[1,2-B]pyridinol derivatives as potential inhibitors of the androgen receptor (PDB ID: 58TE): A study of QSAR modeling, molecular docking, and pharmacokinetics for prostate cancer treatment
September 2024
The present research was centered on the development of a predictive model aimed at assessing the responses of prostate tumors to a range of compounds within the scope of the pIC50 project. Our approach...