Development of a certified reference material for Angiotensin Ⅱ with the mass balance method and isotope dilution mass spectrometry method
September 2026
Angiotensin Ⅱ, the primary effector of the renin-angiotensin-aldosterone system, plays a significant role in blood pressure regulation and fluid-electrolyte homeostasis. It also serves as a crucial...
Preparation and evaluation of bovine serum albumin-protected copper sulfide nanoparticles
September 2026
This study aimed to prepare bovine serum albumin (BSA)-protected copper sulfide nanoparticles (CuS@BSA), systematically characterize their physicochemical properties, and preliminarily evaluate their...
Microfluidic flow cytometry toward point-of-care testing: advances in fluid driving, cell focusing, signal detection, and data analysis
September 2026
Microfluidic technologies, with advantages in low sample consumption, controllable fluid manipulation, structural integration, and system miniaturization, provide a promising route for adapting flow...
Label-free enrichment and identification of circulating tumor cells integrating inertial microfluidics and deep learning
September 2026
Circulating tumor cells (CTCs) hold great promise as liquid biopsy biomarkers for cancer diagnosis and treatment monitoring. However, their efficient enrichment and accurate identification from blood...
Portable detection of vitamin B12 using fluorescence quenching method of boron and nitrogen co-doped carbon dots
September 2026
A portable sensing method for vitamin B12 (VB12) was constructed based on B and N co-doped carbon dots (B, N-CDs). B, N-CDs were synthesized by a one-step hydrothermal method with 3-aminophenylboronic...
Preparation and evaluation of iRGD-modified PLGA-PEG nanoparticles encapsulating TPEN
June 2026
This study developed an iRGD-modified PLGA-PEG nanoparticle for targeted delivery of the metal chelator N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN). Different from conventional nanoplatforms...
Direct mass spectrometry for traditional Chinese medicine analysis: Analytical strategies, applications, and future perspectives
June 2026
Direct mass spectrometry has become an important analytical approach in traditional Chinese medicine (TCM) because it enables rapid, direct, and minimally destructive characterization with little or...
Machine learning driven multi omics and probiotic integration for precision colorectal cancer management
June 2026
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, driven by tumor heterogeneity, late-stage detection, and variable therapeutic response. The integration of machine...
Ameliorative effects of silver nanoparticles on hyperglycemia-induced cellular stress in gangrene
June 2026
Diabetes-induced hyperglycemia leads to oxidative stress, inflammation, and impaired wound healing, particularly in gangrene. In this study, silver nanoparticles (AgNPs) were synthesized using flower...
Progress in non-endocytic dependent transmembrane delivery of biological macromolecules
June 2026
Biomacromolecules—including proteins, nucleic acids, and gene-editing tools—have demonstrated immense potential for therapeutic applications. However, their intracellular bioavailability is severely...
Publisher Note
June 2026
Preparation and characterization of phenylboronic acid cross-linked hydrogel
March 2026
Hydrogels demonstrate significant value in the biomedical field, particularly in wound management and tissue engineering, owing to their unique three-dimensional network structure, excellent biocompatibility,...
The application advances of highly efficient signal amplification methods in the detection of active DNA demethylation products
March 2026
DNA methylation and active demethylation are key epigenetic mechanisms that dynamically regulate gene expression in multicellular organisms. Intermediates of active DNA demethylation—5-hydroxymethylcytosine...
Development of nanogold immunochromatographic assay strip based on novel nanobody for rapid detection of imazalil in food and environmental water samples
March 2026
The misuse of the broad-spectrum fungicide imazalil (IMZ) poses significant challenges to food safety and environmental safety, which requires rapid and accurate methods for detecting IMZ in complex...
pH-responsive antibacterial biomedical platform based on SH@ZIF-8/AgNPs promotes healing of infected wounds
March 2026
Infected wounds feature an acidic microenvironment, providing an endogenous stimulus for targeted therapy. Taking advantage of the acid-triggered decomposition of zeolitic imidazolate framework-8 (ZIF-8),...
A dual-mode paper-based microfluidic chip for protamine detection
December 2025
Timely and accessible fertility screening remains a challenge for male reproductive health, where privacy and convenience are often critical. Here, we present a dual-mode paper-based microfluidic device...
Development of an electrochemical biosensor based on rGO/Ag₂S-Au nanocomposites and L-CHA dual signal amplification for miR-155 detection
December 2025
MicroRNA-155 (miR-155) is a critical biomarker implicated in various pathological processes, including cancer progression, immune response, and cardiovascular diseases. Consequently, accurate detection...
The health protection potential of total flavonoids of Rhizoma Drynariae in an aging society
December 2025
With the global population aging, degenerative musculoskeletal diseases (DMDs) such as osteoporosis (OP), osteoarthritis (OA), and sarcopenia (SP) have placed a substantial burden on society. Consequently,...
Machine learning empowered smartphone nanozyme sensing enables precise quantitative prediction of urinary uric acid
December 2025
The increasing incidence of gout necessitates monitoring of uric acid (UA) levels for early risk assessment and clinical management. Although nanomaterials with oxidoreductase-mimicking properties demonstrate...
Lab-on-a-chip technologies: The future of precision medicine and high-throughput biomolecular analysis
December 2025
Over the past few decades, advancements in microfabrication and biomaterials have driven the innovation of microfluidic technologies, significantly advancing the development of lab-on-a-chip (LOC) systems....
A fusion-mediated FRET approach for rapid analysis of extracellular vesicle miRNA as a diagnostic biomarker in ischemic stroke
December 2025
Ischemic stroke is an acute neurological emergency caused by cerebral blood flow obstruction, with current diagnosis heavily dependent on time-consuming neuroimaging techniques that often delay critical...
Graphene-enabled glucose biosensors: Toward flexible, non-invasive, and wearable technologies
December 2025
The global diabetes epidemic necessitates precise, affordable, and continuous glucose monitoring technologies. Graphene and its derivatives, with their high conductivity, tunable chemistry, and mechanical...
Healthcare monitoring with earables: A paradigm shift towards digital health
December 2025
The convergence of consumer electronics and digital health has spurred the rise of earables—advanced in-ear wearable devices that exploit their unique anatomical position to monitor a wide range of...
Radio conjugated nanoparticles for cancer theranostics: Advances in targeted imaging and radiotherapy
December 2025
Cancer remains one of the most challenging diseases worldwide due to limitations in conventional diagnostic and therapeutic approaches, including non-specific targeting, multidrug resistance, and systemic...
Mechanistic insights into the anti-osteoporotic effects of Tripterygium wilfordii via network pharmacology, molecular docking, and experimental validation
September 2025
Tripterygium wilfordii (Lei Gong Teng), a traditional Chinese medicinal herb, has shown potential in promoting bone health, yet its anti-osteoporotic mechanisms remain poorly defined. This study explored...