Artemisinin and Its Derivatives in Cancer: A Mechanistic Review
Available online 16 May 2026
Artemisinin and its derivatives (ARTs) have attracted increasing interest in oncology as candidates for drug repurposing, supported primarily by broad antitumor activity in preclinical models and only...
Recent advances in nuclear medicine for cancer diagnosis and targeted therapy
Available online 26 August 2026
Nuclear medicine has experienced remarkable growth in the past 15 years, driven by innovations in molecular imaging and targeted radionuclide therapy that have reshaped cancer diagnosis and treatment...
Artificial Intelligence: Shaping Next Generation Oncotherapy
Available online 27 August 2026
Cancer is one of the urgent global health challenges, with millions of lives lost each year. In medical technology, cancer is a multifactorial and dynamic disease and a complex process. It remains a...
Natural Products Targeting the Tumor Microenvironment: A Comprehensive Overview of Colorectal Cancer Therapeutics
Available online 17 June 2026
Colorectal cancer poses a significant clinical challenge, with an alarming annual incidence of nearly 1.88 million new cases and limited therapeutic strategies, especially for advanced stages. The tumor...
Reprogramming Cancer-associated Fibroblast: the Emerging Role of Traditional Chinese Medicine
Available online 15 May 2026
Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal components in tumor microenvironment (TME), which participate in key processes such as extracellular matrix remodeling, immune...
Metabolic Fuel, Molecular Code: How Cancer Rewires Metabolite-Driven Post-Translational Modifications to Shape Tumor Fate
Available online 17 June 2026
Metabolic reprogramming is a cardinal hallmark of cancer that, beyond fulfilling bioenergetic demands, generates a diverse array of intermediate metabolites—including acetyl-CoA, lactate, palmitoyl-CoA,...
From Developmental Bias to Functional Plasticity: Reprogramming Neutrophil Fate in Cancer
Available online 21 September 2026
Neutrophils are the most abundant effector cells of the innate immune system and are indispensable for host defense and immune homeostasis. Under persistent tumor-derived pressure, however, they can...
Splenic Extramedullary Granulopoiesis and Neutrophil States in Cancer Immunity: Systemic Immunosuppression and Therapeutic Resistance
Available online 7 September 2026
Neutrophils undergo extensive systemic reprogramming during cancer progression. Although splenic extramedullary haematopoiesis is a long-recognised response to sustained haematopoietic stress, recent...
Reverse activity-based protein profiling identifies a class of METTL16 covalent inhibitors
Available online 28 April 2026
Covalent inhibition of disease-associated proteins offers a rapid and robust strategy for drug discovery. METTL16, an RNA N6-methyladenosine (m6A) methyltransferase, plays oncogenic roles in multiple...
The Emerging Role of Oxaloacetate in Tumor Metabolic Reprogramming: Mechanisms and Translational Perspectives
Available online 3 October 2026
Oxaloacetate (OAA), traditionally recognized as a central intermediate of the tricarboxylic acid cycle and a key precursor in gluconeogenesis, is increasingly appreciated for functions that extend beyond...
Comparative Performance and Concordance of VIA, Cytology, and HPV Molecular Assays for Cervical Cancer Screening in Taraba State, Nigeria
Available online 8 September 2026
Cervical cancer remains the fourth most common cancer among women worldwide and a major cause of morbidity and mortality in low- and middle-income countries (LMICs), including Nigeria. Persistent infection...
Tumor neuromicrobiology: Toward an integrative framework of neural–microbial–immune crosstalk in cancer
Available online 3 October 2026
The nervous system and the gut microbiota have emerged as critical regulators of tumor biology, and accumulating evidence indicates that their roles in cancer are interconnected. In this review, we...
miRNA-Mediated Regulatory Networks in Cancer Stem Cell Stemness: From Molecular Mechanisms and Microenvironmental Communication to Artificial Intelligence-Driven Precision Intervention
Available online 4 October 2026
Cancer stem cells (CSCs) serve as the "seeds" of tumor recurrence, metastasis, and drug resistance, with their fate decisions governed by a highly sophisticated microRNA (miRNA) regulatory networks....
Food Consumption Patterns and Nutritional Impact Symptoms Among Adults Undergoing Antineoplastic Treatment: A Cross-Sectional Study
Available online 11 October 2026
Cancer treatment is frequently associated with gastrointestinal and sensory symptoms that may interfere with food consumption and compromise patients' nutritional status. This study aimed to characterize...
RNases: Critical Regulators From Cellular Guardian to Tumor Progression and Drug Resistance
Available online 5 October 2026
The escalating challenge of tumor resistance has brought dysregulation of RNA metabolic homeostasis into focus as a critical driver of malignancy. This review delineates a profound paradigm shift in...
Metabolic Stability In Hepatocellular Carcinoma Drug Design: Current Challenges And Optimization Strategies
Available online 2 October 2026
Metabolic stability is a critical determinant in the successful design and development of anticancer agents, particularly for hepatocellular carcinoma (HCC), where hepatic metabolism significantly influences...