Metabolic Fuel, Molecular Code: How Cancer Rewires Metabolite-Driven Post-Translational Modifications to Shape Tumor Fate
Available online 17 June 2026
Metabolic reprogramming is a cardinal hallmark of cancer that, beyond fulfilling bioenergetic demands, generates a diverse array of intermediate metabolites—including acetyl-CoA, lactate, palmitoyl-CoA,...
Natural Products Targeting the Tumor Microenvironment: A Comprehensive Overview of Colorectal Cancer Therapeutics
Available online 17 June 2026
Colorectal cancer poses a significant clinical challenge, with an alarming annual incidence of nearly 1.88 million new cases and limited therapeutic strategies, especially for advanced stages. The tumor...
Artemisinin and Its Derivatives in Cancer: A Mechanistic Review
Available online 16 May 2026
Artemisinin and its derivatives (ARTs) have attracted increasing interest in oncology as candidates for drug repurposing, supported primarily by broad antitumor activity in preclinical models and only...
Reprogramming Cancer-associated Fibroblast: the Emerging Role of Traditional Chinese Medicine
Available online 15 May 2026
Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal components in tumor microenvironment (TME), which participate in key processes such as extracellular matrix remodeling, immune...
Reverse activity-based protein profiling identifies a class of METTL16 covalent inhibitors
Available online 28 April 2026
Covalent inhibition of disease-associated proteins offers a rapid and robust strategy for drug discovery. METTL16, an RNA N6-methyladenosine (m6A) methyltransferase, plays oncogenic roles in multiple...