From Developmental Bias to Functional Plasticity: Reprogramming Neutrophil Fate in Cancer
Available online 21 September 2026
Neutrophils are the most abundant effector cells of the innate immune system and are indispensable for host defense and immune homeostasis. Under persistent tumor-derived pressure, however, they can...
Comparative Performance and Concordance of VIA, Cytology, and HPV Molecular Assays for Cervical Cancer Screening in Taraba State, Nigeria
Available online 8 September 2026
Cervical cancer remains the fourth most common cancer among women worldwide and a major cause of morbidity and mortality in low- and middle-income countries (LMICs), including Nigeria. Persistent infection...
Splenic Extramedullary Granulopoiesis and Neutrophil States in Cancer Immunity: Systemic Immunosuppression and Therapeutic Resistance
Available online 7 September 2026
Neutrophils undergo extensive systemic reprogramming during cancer progression. Although splenic extramedullary haematopoiesis is a long-recognised response to sustained haematopoietic stress, recent...
Artificial Intelligence: Shaping Next Generation Oncotherapy
Available online 27 August 2026
Cancer is one of the urgent global health challenges, with millions of lives lost each year. In medical technology, cancer is a multifactorial and dynamic disease and a complex process. It remains a...
Recent advances in nuclear medicine for cancer diagnosis and targeted therapy
Available online 26 August 2026
Nuclear medicine has experienced remarkable growth in the past 15 years, driven by innovations in molecular imaging and targeted radionuclide therapy that have reshaped cancer diagnosis and treatment...
Metabolic Fuel, Molecular Code: How Cancer Rewires Metabolite-Driven Post-Translational Modifications to Shape Tumor Fate
Available online 17 June 2026
Metabolic reprogramming is a cardinal hallmark of cancer that, beyond fulfilling bioenergetic demands, generates a diverse array of intermediate metabolites—including acetyl-CoA, lactate, palmitoyl-CoA,...
Natural Products Targeting the Tumor Microenvironment: A Comprehensive Overview of Colorectal Cancer Therapeutics
Available online 17 June 2026
Colorectal cancer poses a significant clinical challenge, with an alarming annual incidence of nearly 1.88 million new cases and limited therapeutic strategies, especially for advanced stages. The tumor...
Artemisinin and Its Derivatives in Cancer: A Mechanistic Review
Available online 16 May 2026
Artemisinin and its derivatives (ARTs) have attracted increasing interest in oncology as candidates for drug repurposing, supported primarily by broad antitumor activity in preclinical models and only...
Reprogramming Cancer-associated Fibroblast: the Emerging Role of Traditional Chinese Medicine
Available online 15 May 2026
Cancer-associated fibroblasts (CAFs) are one of the most abundant stromal components in tumor microenvironment (TME), which participate in key processes such as extracellular matrix remodeling, immune...
Reverse activity-based protein profiling identifies a class of METTL16 covalent inhibitors
Available online 28 April 2026
Covalent inhibition of disease-associated proteins offers a rapid and robust strategy for drug discovery. METTL16, an RNA N6-methyladenosine (m6A) methyltransferase, plays oncogenic roles in multiple...