Deciphering the role of liver metabolic enzymes in dementia pathogenesis
September 2025
The relationship between liver metabolic enzymes and the risk of dementia, as well as whether genetic factors can explain these potential associations, remains unclear. Based on data from 347,605 dementia-free...
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Activation of the NRF2 signaling pathway mitigates arthrofibrosis by suppressing myofibroblast ferroptosis through oxidative stress regulation
September 2025
Arthrofibrosis, a debilitating chronic disorder marked by restricted joint mobility and functional impairment, is driven by pathological fibroblast activation involving dysregulated proliferation and...
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Dual roles of LMO2 in promoting tumor angiogenesis and progression
September 2025
LIM domain only 2 (LMO2) is a critical transcription factor involved in developmental and adult angiogenesis; however, the specific mechanisms through which LMO2 regulates tumor angiogenesis remain...
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Identification of WDR62 variants as a genetic contributor for human infertility
September 2025
WDR62 is crucial for the initiation of germ cell meiosis in mice. In Wdr62-deficient male mice, germ cells are arrested at the metaphase I stage of meiosis due to asymmetric centrosome distribution...
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S-palmitoylation: A novel player in cancer and its emerging therapeutic implications
September 2025
S-palmitoylation is a reversible post-translational lipid modification involving the covalent attachment of palmitic acid to cysteine residues, thereby regulating protein localization, stability, trafficking,...
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Antioxidant dipeptide, cyclo (Phe-Phe), protects against bone dysplasia by suppression of phospholipid peroxidation
June 2025
Prenatal exposure to dexamethasone (Dex) has been identified as a significant factor that impairs longitudinal skeletal growth in fetuses, resulting in notable deficiencies in bone development. However,...
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ZDHHC9 mediates SMURF2 palmitoylation to promote lipid synthesis
June 2025
SMURF2 plays a crucial role in the regulation of protein stability through interacting with TGF-β signaling and promoting the ubiquitin-dependent proteasomal degradation in various biological and cellular...
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Clarifying AI’s role in academic writing
June 2025
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Targeting USP10–FAK pathway sensitizes BCR-ABL+ leukemia cells to tyrosine kinase inhibitors
June 2025
BCR-ABL+ leukemia is driven by constitutive tyrosine kinase activity, and tyrosine kinase inhibitors (TKIs) are the standard therapy. However, resistance to TKIs remains a significant clinical challenge....
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Endogenous double-stranded RNA: Bridging immune activation and cancer therapeutics
June 2025
Although it was previously believed that double-stranded RNAs (dsRNAs) were exclusively associated with viral infections, accumulating evidence indicates that dsRNAs can also arise from endogenous sources....
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The function and mechanisms of action of non-coding RNAs in prostatic diseases
June 2025
Non-coding RNAs (ncRNAs) are RNA molecules that lack protein-coding capacity. In recent years, research interest has surged in the roles of long non-coding RNAs (lncRNAs), circular RNAs (circRNAs),...
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RNA m6A modification: a key regulator in normal and malignant processes
June 2025
The dedicated control of gene abundance is essential for both biological and pathological processes in mammals. Multiple layers of gene expression regulation, including transcriptional, post-transcriptional,...
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Oncolytic virotherapy offers hope for high-grade glioma treatment
June 2025
High-grade glioma continues to rank among the most lethal human cancers. Due to their high invasiveness, pronounced heterogeneity and complex carcinogenic mechanism, therapeutic options remain limited....
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RNA-binding protein Roq modulates the Drosophila STING antiviral immune response
March 2025
The STING (stimulator of interferon genes) signaling pathway plays a pivotal role in the immune defense against viral infections in a wide range of vertebrates and invertebrates. However, the regulatory...
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Increased co-expression of CTLA4/LAG3 predicted adverse clinical outcomes in patients with T-cell malignancies
March 2025
The application of immune checkpoint blockers (ICBs) in immunotherapy has markedly improved the prognosis for patients with solid tumors and B-cell lymphomas, and it holds promise as a novel therapeutic...
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The molecular and immune microenvironmental landscape of brain metastases: Implications for novel treatment options
March 2025
Brain metastases (BM), in which cells from a primary malignant tumor spread through the circulatory system into the microvasculature of the brain, eventually progress despite multiple therapeutic programmes...
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Multi-omics advances for molecular characterization, precision medicine, and prognostic implications in leukemia
March 2025
Leukemia encompasses a heterogeneous group of hematologic malignancies driven by complex molecular alterations. Recent advancements in genomics, transcriptomics and proteomics have uncovered pivotal...
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The role of YTHDF2 in anti-tumor immunity
March 2025
RNA N6-methyladenosine (m6A) modification has been identified as the most abundant RNA modification and plays crucial roles in both physiological and pathological processes. YTHDF2 was the first identified...
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