Wastewater-based epidemiology for monitoring cocaine and cannabis: A review of methods and applications
April 2026
Wastewater-based epidemiology (WBE) is an effective tool for monitoring public health, drug use, chemical exposure, and lifestyle habits. This review summarises and discusses analytical protocols for...
Pharmacological basis and antifibrotic potential of Zhuang medicine huanggen in hepatic and pulmonary fibrosis
April 2026
Fibrosis is a dynamic yet a stage that poses therapeutic challenges in chronic liver diseases and other systemic disorders. Huanggen (HG), the dried root of Prismatomeris connata or Prismatomeris tetrandra,...
Jiawei Guilu Erxian Decoction enhances CD8⁺ T-cell activation and cytotoxicity via JNK/c-JUN activation to suppress non-small cell lung cancer tumor growth in vivo
April 2026
The immunological effects of Jiawei Guilu Erxian Decoction (JGED) in non-small cell lung cancer (NSCLC) have not been fully defined. This study investigated whether JGED influences CD8⁺ T-cell activity...
The pharmacological actions of berberine: From a traditional medicine to modern polypharmacology
April 2026
Screening the effective metabolites of Mosla soochowensis Matsuda on LPS-induced inflammation in RAW264.7 cells by integrated LC-triple TOF-MS/MS and network pharmacology
April 2026
Mosla soochowensis Matsuda (MSM) is a traditional Chinese herbal medicine empirically used for treating inflammatory conditions such as tonsillitis and the common cold. Previous studies focused solely...
Computational design and evaluation of novel thienopyrimidine PI3Kδ inhibitors for diffuse large b-cell lymphoma: QSAR, docking, molecular dynamics, and density functional theory studies
April 2026
Phosphoinositide 3-kinase delta (PI3Kδ) is a key regulator of B-cell receptor signalling and a validated therapeutic target in diffuse large B-cell lymphoma (DLBCL). The development of selective and...
HPLC–DAD quantitative analysis via multiomics elucidated the potential HSP90AB1-targeted mechanism of the Scutellaria–Coptis herb pair in high-risk prostate cancer
April 2026
The core mechanism and potential intervention targets of Scutellaria–Coptis in the treatment of high-risk prostate cancer were systematically explored on the basis of network pharmacology and molecular...
Advances in analytical strategies for fixed-dose gliflozin combinations: A comprehensive evaluation
April 2026
Fixed-dose combinations (FDCs) containing gliflozin derivatives have become important therapeutic options in type 2 diabetes, offering complementary mechanisms and improved treatment adherence. Their...
Effects of different doses of esketamine combined with propofol on gastrointestinal endoscopy in elderly patients
March 2026
Propofol alone for painless gastroscopy/colonoscopy in elderly patients causes frequent movement and respiratory depression due to poor analgesia. Esketamine, the only intravenous anesthetic with analgesic...
Advances in electroanalytical techniques for pharmaceuticals and biological samples: Insights from the last decade
March 2026
Over the past decade, electroanalytical techniques have emerged as powerful and sustainable alternatives to conventional spectroscopic and chromatographic methods for pharmaceutical and biological analysis....
Nigellidine from Nigella sativa Targets AKT1 and GAPDH in rectal cancer: Insights from network pharmacology and molecular dynamics simulations
March 2026
Rectal cancer continues to pose a significant therapeutic challenge, underscoring the need for novel multi-target treatment strategies. Nigella sativa is rich in bioactive phytochemicals with reported...
Stability of Ketamine-Xylazine-Butorphanol formulation to establish an evidence-based beyond-use date
March 2026
A combination injection formulation containing 8.3 % w/v ketamine (K), 0.83 % w/v xylazine (X), and 0.083 % w/v butorphanol (B) is frequently used for sedation and anesthesia in New World Camelids....
Formulation and simultaneous estimation of sustained release bilayer tablet containing polythiazide and reserpine
March 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2 mg) with sustained-release Reserpine...
Advances in traditional Chinese medicine for the treatment of acute radiation-induced oral mucositis: A review from clinical efficacy to pharmacological and analytical insights
March 2026
Acute radiation-induced oral mucositis (ROM) is a debilitating complication of radiotherapy for head and neck cancer. Despite advances in supportive care, current therapies remain suboptimal. Traditional...
Sponging innovations: A new era of porous nanocarriers in drug delivery and biomedical applications
March 2026
Nanosponges (NSs) are highly crosslinked porous, colloidal carriers that possess a unique three-dimensional, sponge-like structure. It is this special structure that enables them to entrap a broad range...
Autophagy inhibition by sevoflurane reduces neutrophil extracellular trap formation and alleviates organ injury and inflammation in sepsis
Available online 12 March 2026
Sevoflurane, a widely used anesthetic, has been reported to modulate inflammatory responses in sepsis models. However, its influence on autophagy-related neutrophil extracellular trap (NET) formation...
Analytical advances in the quantitative and qualitative determination of clonidine and methyldopa: A review
January 2026
Clonidine and methyldopa are centrally acting antihypertensive agents that lower blood pressure by stimulating α₂-adrenoceptors in the brain stem, thereby reducing sympathetic outflow. While clonidine...
Exploring the potential anti-hepatocarcinoma mechanism of Ruangan Lidan Decoction through UHPLC-Q-TOF-MS/MS analysis and network pharmacology approaches
January 2026
Hepatocellular carcinoma (HCC) remains a highly aggressive malignancy with limited therapeutic options. Although Ruangan Lidan Decoction (RGLD), a traditional Chinese medicine (TCM) formula, shows clinical...
Ferulic acid targets AKT1/STAT3/EGFR signaling to induce apoptosis and inhibit metastasis in gastric cancer cells
January 2026
Identification of potential anti-tubercular inhibitors through virtual screening, DFT, and molecular dynamics simulation studies
January 2026
Tuberculosis (TB) continues to pose a significant threat to global health, a problem intensified by the rise of strains of Mycobacterium tuberculosis that resist multiple drugs. Identifying novel inhibitors...
Immunomodulatory and skin-compatible effects of Amaranthus retroflexus volatile compounds: An in-silico network and pathway-based approach
January 2026
This study investigated the phytochemical profile, in silico skin sensitization, cosmetic toxicity, and endocrine-disrupting potential of compounds from Amaranthus retroflexus identified through GC-MS...
Identification of key molecular targets and mechanism of action in acute kidney injury by integrating network pharmacology and molecular docking
January 2026
Acute kidney injury (AKI) is a frequent renal complication in surgical settings. This study aimed to identify key molecular targets for AKI and to elucidate the mechanism of action of drugs that targeted...
A narrative literature review on revolutionizing traditional Chinese medicine: Exploring the potential of spectral imaging technology
January 2026
Spectral imaging facilitates the spatially resolved detection of chemical components within pharmaceutical compounds through established techniques including fluorescence, near-infrared chemical, mid-infrared,...
RP-HPLC method development and validation for the simultaneous estimation of Piceatannol and L-Arginine in pharmaceutical formulations
January 2026
Dental caries results from microbial dysbiosis, making microbiota balance a superior strategy to antibiotics, which can disrupt oral flora and promote resistance. The Piceatannol–L-Arginine combination...
