Analytical advances in the quantitative and qualitative determination of clonidine and methyldopa: A review
January 2026
Clonidine and methyldopa are centrally acting antihypertensive agents that lower blood pressure by stimulating α₂-adrenoceptors in the brain stem, thereby reducing sympathetic outflow. While clonidine...
Exploring the potential anti-hepatocarcinoma mechanism of Ruangan Lidan Decoction through UHPLC-Q-TOF-MS/MS analysis and network pharmacology approaches
January 2026
Hepatocellular carcinoma (HCC) remains a highly aggressive malignancy with limited therapeutic options. Although Ruangan Lidan Decoction (RGLD), a traditional Chinese medicine (TCM) formula, shows clinical...
Ferulic acid targets AKT1/STAT3/EGFR signaling to induce apoptosis and inhibit metastasis in gastric cancer cells
January 2026
Identification of potential anti-tubercular inhibitors through virtual screening, DFT, and molecular dynamics simulation studies
January 2026
Tuberculosis (TB) continues to pose a significant threat to global health, a problem intensified by the rise of strains of Mycobacterium tuberculosis that resist multiple drugs. Identifying novel inhibitors...
Immunomodulatory and skin-compatible effects of Amaranthus retroflexus volatile compounds: An in-silico network and pathway-based approach
January 2026
This study investigated the phytochemical profile, in silico skin sensitization, cosmetic toxicity, and endocrine-disrupting potential of compounds from Amaranthus retroflexus identified through GC-MS...
Identification of key molecular targets and mechanism of action in acute kidney injury by integrating network pharmacology and molecular docking
January 2026
Acute kidney injury (AKI) is a frequent renal complication in surgical settings. This study aimed to identify key molecular targets for AKI and to elucidate the mechanism of action of drugs that targeted...
A narrative literature review on revolutionizing traditional Chinese medicine: Exploring the potential of spectral imaging technology
January 2026
Spectral imaging facilitates the spatially resolved detection of chemical components within pharmaceutical compounds through established techniques including fluorescence, near-infrared chemical, mid-infrared,...
RP-HPLC method development and validation for the simultaneous estimation of Piceatannol and L-Arginine in pharmaceutical formulations
January 2026
Dental caries results from microbial dysbiosis, making microbiota balance a superior strategy to antibiotics, which can disrupt oral flora and promote resistance. The Piceatannol–L-Arginine combination...
Trifluridine/tipiracil exhibits potent antitumor activity in triple-negative breast cancer by targeting SKP2 and inducing cell cycle arrest and apoptosis
January 2026
Trifluridine/Tipiracil (TFTD) is an innovative oral medication comprising trifluridine and tipiracil. While TFTD has shown efficacy in metastatic colorectal cancer, its therapeutic potential in triple-negative...
Integrating metabolomics, DPPH assay, and literature mining for quality marker prediction and the establishment of a quality control strategy for Ampelopsis grossedentata
January 2026
A member of Vitaceae, Ampelopsis grossedentata (AG) is well-studied for its rich phytochemistry and bioactivities, indicating high medicinal value; yet, a reliable method for comprehensive quality control...
FORMULATION AND SIMULTANEOUS ESTIMATION OF SUSTAINED RELEASE BILAYER TABLET CONTAINING POLYTHIAZIDE AND RESERPINE
Available online 23 January 2026
Hypertension management often requires combination therapy for optimal control. This study developed a bilayer tablet combining immediate-release Polythiazide (2mg) with sustained-release Reserpine...
Novel Therapeutic Targets and Drugs for Liver Injury and Regeneration: Recent Advances
Available online 19 January 2026
Stability of Ketamine-Xylazine-Butorphanol Formulation to Establish an Evidence-Based Beyond-Use Date
Available online 19 January 2026
A combination injection formulation containing 8.3% w/v ketamine (K), 0.83% w/v xylazine (X), and 0.083% w/v butorphanol (B) is frequently used for sedation and anesthesia in New World Camelids. In...
Advances in Electroanalytical Techniques for Pharmaceuticals and Biological Samples: Insights from the Last Decade
Available online 14 January 2026
Over the past decade, electroanalytical techniques have emerged as powerful and sustainable alternatives to conventional spectroscopic and chromatographic methods for pharmaceutical and biological analysis....
Nigellidine from Nigella sativa Targets AKT1 and GAPDH in Rectal Cancer: Insights from Network Pharmacology and Molecular Dynamics Simulations
Available online 14 January 2026
Rectal cancer remains a global clinical challenge. We applied an integrated network-pharmacology and molecular simulation pipeline to prioritize Nigella sativa phytochemicals against rectal cancer....
Preparation, in vitro dissolution, and in vivo pharmacokinetic evaluations of pazopanib tablets
Available online 25 December 2025
Pazopanib is an important agent in the era of targeted cancer therapy, particularly for the treatment of advanced renal cell carcinoma and soft tissue sarcoma. In this study, we evaluated the quality...
Wastewater-Based Epidemiology for Monitoring Cocaine and Cannabis: A Review of Methods and Applications
Available online 5 December 2025
Wastewater-based epidemiology (WBE) is an effective tool for monitoring public health, drug use, chemical exposure, and lifestyle habits. This review summarises and discusses analytical protocols for...
Implementation of QbD approach in RP-HPLC method optimization and validation for concurrent estimation of Deflazacort and Tamsulosin hydrochloride under ICH Q14 and Q2R2 framework
November 2025
The simultaneous estimation of Tamsulosin Hydrochloride (TAM) and Deflazacort (DEF) in capsule dosage form requires a reliable analytical method. Reverse-phase high-performance liquid chromatography...
Two-dimensional HPLC method for determining linezolid concentrations in plasma and its clinical application in therapeutic drug monitoring
November 2025
The trough concentration (Cmin) of linezolid (LEN) is closely associated with therapeutic efficacy and adverse reactions in patients with complex Gram-positive bacterial infections. However, substantial...
Identification and characterization of the Fd+ 16 Da fragment impurity in therapeutic CD47 monoclonal antibodies expressed in CHO-K1 cell lines
November 2025
Monoclonal antibodies (mAbs) are typically produced using mammalian expression systems—with Chinese hamster ovary (CHO) cells being the most widely employed. To guarantee the efficacy, safety, and consistency...
Single-cell RNA sequencing identifies CCR4 as a therapeutic target for sepsis with DB07845 as a potential inhibitor
November 2025
Sepsis is characterized by immune dysregulation and systemic inflammation. This study aimed to identify key genes and potential therapeutic compounds through scRNA-seq analysis....
Chemical characterization, antioxidant effect and xanthine oxidase inhibition of Micromeria fruticosa (L.) druce hexane extract
November 2025
Micromeria fruticosa (L.) Druce, a medicinal plant applied for several diseases, is recognized for its essential oils and bioactive constituents. However, there is a lack of data concerning the phytochemical...
Effects of Different Doses of Esketamine Combined with Propofol on Gastrointestinal Endoscopy in Elderly Patients
Available online 13 November 2025
Propofol alone for painless gastroscopy/colonoscopy in elderly patients causes frequent movement and respiratory depression due to poor analgesia. Esketamine, the only intravenous anesthetic with analgesic...
