Real-world adverse event signals of immunotherapeutic agents in lung cancer: A pharmacovigilance data mining approach
October 2026
Real-world safety data for immune checkpoint inhibitors nivolumab, pembrolizumab, and durvalumab are essential to guide their clinical use for the treatment of lung cancer. This study analyzed their...
Smilax glabra Roxb. alleviates gout through targeting FOS and CD40LG: Insights from multi-omics integration
October 2026
Smilax glabra Roxb. (SGB) is traditionally used for gout treatment, but the underlying mechanisms remain unclear. We aimed to explore the effect of SGB on Gout....
Association of bevacizumab added to chemotherapy and whole-brain radiotherapy with peritumoral edema and prognosis in patients with brain metastases from non-squamous non-small cell lung cancer
October 2026
Peritumoral edema is common in patients with brain metastases from non-squamous non-small cell lung cancer (NSCLC). This study evaluated the association of adding bevacizumab to chemotherapy and whole-brain...
A novel stability indicating LC method for simultaneous determination of Vildagliptin and Pioglitazone hydrochloride in API and marketed formulations
October 2026
The purpose of this study was to develop and validate a simple, rapid, precise, accurate, stability-indicating, and environmentally sustainable RP-HPLC method for the simultaneous determination of Vildagliptin...
Quercetin suppresses the malignant phenotypes and epithelial-mesenchymal transition in head and neck squamous cell carcinoma cells by regulating the PI3K/AKT signaling pathway
October 2026
Quercetin (Que) has demonstrated anticancer potential against head and neck squamous cell carcinoma (HNSCC), but its role in regulating epithelial-mesenchymal transition (EMT) through the PI3K/AKT signaling...
Sustainable synthetic strategies for active pharmaceutical ingredients using renewable resources: A systematic review
October 2026
The manufacture of active pharmaceutical ingredients (APIs) is shifting towards sustainable feedstocks rather than petrochemicals, but the industrial viability and environmental attributes of renewable...
Schisandra lignans in hepatocellular carcinoma: multi-mechanistic insights and translational horizons
October 2026
Network pharmacology and molecular docking reveal the active compounds and key targets of JiaWei SiNi San in hepatocellular carcinoma
October 2026
This study aims to investigate the potential anti-tumor efficacy and mechanisms of JiaWei SiNi San (JWSNS) against hepatocellular carcinoma via network pharmacology....
Bioinformatics and artificial intelligence for the discovery of food-derived bioactive compounds with health applications: Current advances and future perspectives
October 2026
Food-derived bioactive compounds have attracted considerable attention because of their ability to modulate biological pathways involved in chronic disease prevention and management. However, the remarkable...
Design and in silico optimization of pyrazolopyridine-based pantothenate synthetase (PanC) inhibitors as novel anti-tuberculosis leads
September 2026
Tuberculosis (TB), caused by Mycobacterium tuberculosis, remains a major global health challenge, particularly due to the rising prevalence of multidrug-resistant strains. Pantothenate synthetase (PanC),...
Quality markers of GFDH pills based on multi-component qualitative and quantitative analysis combined with network pharmacology and chemometric analysis
September 2026
Guifu Dihuang (GFDH) Pills is a classic traditional Chinese medicine prescription for kidney yang deficiency. At present, its quality control only takes Paeonol as the single marker, which is difficult...
HPLC determination of two oxidative degradation impurities in exemestane active pharmaceutical ingredient
September 2026
Exemestane is prone to oxidative degradation, forming structurally similar isomeric impurities. This study established an high-performance liquid chromatography (HPLC) method for the determination of...
Exploring the mechanism of dandelion in treating helicobacter pylori-induced chronic gastritis based on network pharmacology
September 2026
Helicobacter pylori-induced chronic gastritis (HAG) is a significant healthcare burden in China due to its prevalence and carcinogenic potential. Current clinical management relies on antimicrobial...
Clinical utility of FEV1/FVC in asthma management: A data-driven model
September 2026
This study aimed to compare the real-world efficacy of budesonide/glycopyrronium/formoterol (BGF) and budesonide/formoterol (BF), and to develop and internally validate a FEV₁/FVC-based machine learning...
Therapeutic potential of Tanshinone ⅡA in periodontitis: An in vitro study revealing its anti-inflammatory effect through activation of autophagy in lipopolysaccharide-induced human periodontal ligament fibroblasts
September 2026
This study was designed to investigate the underlying mechanisms of Tanshinone ⅡA using an in vitro model of lipopolysaccharide (LPS)-induced human periodontal ligament fibroblasts (HPDLFs)....
Development and formulation of anti-diabetic capsules containing extract of E. denticulatum: Physicochemical study, encapsulation, and release kinetics
September 2026
Eucheuma denticulatum has been widely used to treat diabetes mellitus due to its several antidiabetic components. The current study aimed to formulate capsules containing the crude extract of E. de...
Progress in anti-IgE monoclonal antibody targeting therapy for allergic bronchial asthma: A review
September 2026
Allergic bronchial asthma is a prevalent chronic airway disease characterized by immunoglobulin E (IgE)-mediated inflammation. For patients with moderate-to-severe diseases that remain inadequately...
In silico discovery of novel benzenesulfonamide-tetrahydropyrimidine hybrids as dual target inhibitors of EGFR and thymidylate synthase
September 2026
Breast cancer remains a major global health challenge, characterized by high heterogeneity and frequent resistance to single-target therapies. Multi-target drug design offers a promising strategy to...
From chemometrics to foundation models in pharmaceutical analysis: Current evidence, limitations, and future directions
September 2026
Pharmaceutical analysis has always been shaped by a careful dialogue between measurement and meaning. Early chemometric approaches brought structure to this dialogue, allowing scientists to uncover...
Exploitation of Ziziphus lotus fruit as a functional culture medium: Impact of yeast fermentation on bioactive composition, antioxidant activity, and In Silico evaluation
September 2026
The fermentation of Ziziphus lotus fruit medium by Saccharomyces cerevisiae was investigated to elucidate the biotransformation of phenolic constituents and their potential molecular mechanisms of ...
A Comparative Bibliometric Analysis of Natural Product-Based Combination Therapies in Lung Cancer: Insights into Analytical Strategies and Translational Challenges
Available online 24 September 2026
Natural products have attracted increasing attention in lung cancer because of their direct antitumor activity and their potential roles as sensitizers or synergistic agents in combination therapy....
Metabolic Reprogramming in Periodontitis: Evidence Stratification, Pharmacological Modulators, and Translational Challenges
Available online 24 September 2026
Periodontitis is a biofilm-associated inflammatory disease in which dysregulated host responses drive progressive destruction of the tooth-supporting tissues. Although recent reviews have emphasized...
Paeoniflorin alleviates sepsis-induced liver injury: insights from integrative transcriptomic and metabolomic analysis
Available online 23 September 2026
Sepsis-induced liver injury (SILI) is a critical complication of sepsis and contributes substantially to mortality. Paeoniflorin (PF), a bioactive compound derived from traditional Chinese medicine,...
Novel Dichloroacetamide Derivatives: Synthesis, Cytotoxicity Evaluation, Molecular Docking Study, MD Simulations, and ADME study
Available online 23 September 2026
The development of novel anticancer agents with improved biological activity remains an important research objective. The present study aimed to synthesize and evaluate a series of novel dichloroacetamide...