Theranostic applications of PSMA-targeted radiopharmaceuticals: From molecular design to clinical translation and emerging paradigms
July 2026
Theranostics is an innovative concept in nuclear medicine that combines molecular imaging with targeted radionuclide therapy. PSMA is the best-studied and most clinically utilized oncological theranostic...
Open problems for the preparation and quality control of Ac-225 radiopharmaceuticals
January 2026
The aim of this brief review is to analyze the persistent chemical and radiochemical hurdles that still hinder the development of clinically useful actinium-225 (225Ac) radiopharmaceuticals for alpha-targeted...
Next‑generation theranostic radiopharmaceuticals: Integrating alpha emitters and nanocarriers for precision oncology
July 2026
Alpha-emitting radionuclides, characterized by high-linear energy transfer (LET) and short path length, are emerging as potent tools in targeted cancer therapy. When combined with advanced nanocarrier...
The role of 131I in the treatment and management of thyroid cancer
January 2026
For individuals with thyroid cancer, the most common cause of mortality worldwide is recurrent, metastatic disease. Radioactive iodine (RAI) remains the cornerstone of treatment for these patients....
Optimization of reaction conditions and process automation for [99mTc]Tc-PSMA-I&S preparation on a GAIA® synthesizer
July 2026
Radioguided surgery (RGS) using PSMA radioligands emerged as a valuable approach for the detection of metastatic lymph nodes in prostate cancer. [99mTc]Tc-PSMA-I&S is specifically designed for combined...
MPI SPECT and GSPECT in type 2 diabetes mellitus patient: Combined perfusion and functional imaging for cardiovascular risk stratification
July 2026
Cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes mellitus (T2DM). Early detection of subclinical coronary and myocardial injury is therefore essential...
Synergistic role of multi-omics analysis combined with multimodal imaging in precision diagnosis and treatment of thoracic and abdominal tumors
May 2026
Thoracic and abdominal tumors, such as lung, breast, liver, and colorectal cancers, are characterized by high incidence and mortality rates, posing a significant threat to global health. Traditional...
Radiopharmaceuticals for microbiome imaging: A narrative review of emerging approaches to mapping host–microbe interactions
January 2026
The human microbiome has immense effects on immunity, metabolism, and therapeutic response, but non-invasive in vivo visualization is underdeveloped. Radiopharmaceuticals, traditionally applied in oncology...
Convergence methodologies for PSMA-targeted radiotheranostics: A transformative blueprint for precision prostate cancer management
July 2026
PSMA-targeted radiotheranostics has become an important component of precision prostate cancer management, supported by recent clinical trials of ^177Lu-PSMA-617 and ^225Ac-PSMA ligands. Concurrently,...
The PSMA paradox: How biology, androgen signaling, and therapy sequencing shape Lu-177 efficacy
July 2026
Prostate-specific membrane antigen (PSMA)-directed radioligand therapy improves outcomes in advanced prostate cancer, yet appears less effective when moved earlier in the disease course....
EAVS-TF: A bio-inspired spiking neural network for energy-efficient multimodal emotion recognition
May 2026
Accurate recognition of emotional states is critical for monitoring neuropsychiatric disorders, however, deploying such systems on battery-powered wearable devices necessitates exceptional energy efficiency....
Accuracy study of deep learning-based synthetic CT images for adaptive radiotherapy of pelvic tumors
January 2026
To evaluate the accuracy of deep learning conversion of cone-beam computed tomography (CBCT) into synthetic CT (sCT) for adaptive pelvic radiotherapy and to inform clinical application....
Research on image segmentation of lightweight thyroid nodules
May 2026
This study aims to address the challenges inherent in thyroid nodule ultrasound image segmentation, such as excessive computational complexity, limited data availability, and the suboptimal segmentation...
Myrtus communis ameliorates ionizing radiation-induced cardiopulmonary injury in rats: TROD-GROG-003 study
January 2026
Ionizing radiation (IR), widely used in diagnostic and therapeutic procedures, can damage vital organs such as the heart and lungs through oxidative stress. This study aims to assess the potential radioprotective...
Activity-normalized survey-meter assessment around patients undergoing ⁹⁹ᵐTc-pertechnetate thyroid scintigraphy: Implications for radiation protection
July 2026
Patients undergoing diagnostic nuclear medicine procedures temporarily become sources of external radiation, potentially contributing to exposure of staff, accompanying persons, and other patients....
Real-time motion compensation in cyberknife radiosurgery: Advances in fiducial marker tracking and clinical outcomes
January 2026
CyberKnife, a stereotactic radiosurgery (SRS) technique, delivers highly precise radiation beams to tumors. However, the patient motion, such as respiration and positional changes, can lead to tumor...
GATA3 contributes to radiation-induced lung injury by regulating ESM1-mediated NF-κB signaling and inflammatory responses
May 2026
Radiation-induced lung injury (RILI) is damage to normal lung tissue caused by thoracic tumor radiotherapy (RT), but effective interventions are lacking and its molecular mechanisms remain unclear....
Proteomics- and bioinformatics-based identification of regulators of radiosensitivity in lung cancer
July 2026
Radiotherapy resistance is a major challenge in lung cancer (LC) treatment, affecting patient outcomes. The protein networks underlying radiotherapy response remain incompletely understood....
Structural MRI reveals brain differences in asthmatic patients with and without atopic dermatitis
May 2026
Building on accumulating evidence that atopic inflammation and neuroimmune/neurocognitive processes may influence the central nervous system, we aimed to compare structural brain imaging features between...
Association of mean cardiac dose with model-predicted risk of radiation-induced pericarditis in breast cancer patients
January 2026
This study aimed to investigate the association between mean cardiac dose (MCD) and the model-predicted risk of radiation-induced pericarditis in breast cancer patients undergoing radiotherapy....
Dose prediction of intensity-modulated radio therapy for brain tumors based on an improved deep learning framework
May 2026
Accurate calculation of dose distribution is a critical component in intensity-modulated radiation therapy (IMRT). The dose distribution exhibits significant variability across patients. To address...
Case report of systemic inflammatory response syndrome in refractory gout mimicking infective endocarditis: Diagnosis via PET–CT and successful treatment with firsekibart
July 2026
Severe gout can manifest as systemic inflammatory response syndrome (SIRS), closely mimicking infective endocarditis (IE) and presenting a diagnostic challenge, particularly in patients with complex...
Radiation dosimetry of [124I]-metaiodobenzylguanidine (mIBG) dynamic PET/CT in pediatric neuroblastoma through animal-to-human extrapolation with MCNPX code and OLINDA/EXM software
January 2026
Iodine-124 metaiodobenzylguanidine (mIBG) positron emission tomography (PET)/computed tomography (CT) is well-established for imaging and pre-therapeutic dosimetry in pediatric neuroblastoma. However,...
Exploring radiation pneumonitis associated with immune checkpoint inhibitors: Insights from the FAERS pharmacovigilance database
January 2026
The combination of immunotherapy and radiotherapy has become an important strategy for treating thoracic tumors. However, both treatment modalities can cause adverse effects to lung tissue. Research...
Analysis of set-up errors in daily kilovolt fan beam CT for rectal cancer treated with volumetric modulated arc therapy
January 2026
To analyze inter-fractional set-up errors in rectal cancer patients undergoing volumetric modulated arc therapy (VMAT) guided by daily kilovolt fan beam CT (kV-FBCT)....