Open problems for the preparation and quality control of Ac-225 radiopharmaceuticals
January 2026
The aim of this brief review is to analyze the persistent chemical and radiochemical hurdles that still hinder the development of clinically useful actinium-225 (225Ac) radiopharmaceuticals for alpha-targeted...
Critical perspectives on nanoparticle-enabled radiopharmaceuticals: Integrating molecular imaging, targeted therapy, and theranostic translation
March 2026
Radiopharmaceuticals based on nanoparticles are transforming the landscape of molecular imaging, targeted therapy and theranostics. Nevertheless, despite the accelerating innovation, translation is...
Integration of conventional MRI and diffusion-weighted imaging for differential diagnosis of high-grade gliomas and metastatic brain tumors
March 2026
Brain tumors, particularly high-grade gliomas (HGG) and solitary brain metastases (SBM), often present with overlapping clinical and imaging features, complicating accurate diagnosis and management....
The role of 131I in the treatment and management of thyroid cancer
January 2026
For individuals with thyroid cancer, the most common cause of mortality worldwide is recurrent, metastatic disease. Radioactive iodine (RAI) remains the cornerstone of treatment for these patients....
Dosimetric comparison and clinical evaluation of hybrid three-dimensional conformal radiotherapy and intensity modulated radiotherapy in simultaneous integrated boost radiotherapy for breast cancer
March 2026
Hybrid radiotherapy plans combining three-dimensional conformal radiation therapy (3D-CRT) and intensity-modulated radiation therapy (IMRT) aim to optimize dose distribution in simultaneous integrated...
Radiopharmaceuticals for microbiome imaging: A narrative review of emerging approaches to mapping host–microbe interactions
January 2026
The human microbiome has immense effects on immunity, metabolism, and therapeutic response, but non-invasive in vivo visualization is underdeveloped. Radiopharmaceuticals, traditionally applied in oncology...
Preclinical evaluation of [68Ga]Ga-DFO for molecular imaging of Vibrio cholerae infection
March 2026
In this study, a novel diagnostic radiopharmaceutical, [68Ga]Ga-DFO, was developed for positron emission tomography (PET) imaging of the pandemic infection of Vibrio cholerae....
Accuracy study of deep learning-based synthetic CT images for adaptive radiotherapy of pelvic tumors
January 2026
To evaluate the accuracy of deep learning conversion of cone-beam computed tomography (CBCT) into synthetic CT (sCT) for adaptive pelvic radiotherapy and to inform clinical application....
Feasibility of deep learning-based high-quality CBCT images for adaptive radiotherapy in rectal cancer
March 2026
Cone-beam computed tomography (CBCT) presents challenges for adaptive radiotherapy (ART) due to scatter artifacts and inaccurate CT numbers. While, deep learning-based synthetic CT (sCT) offers a potential...
The correlation between bone alteration and intestinal fibrosis of Crohn's disease: A preclinical μCT-based study on the bone-gut axis
March 2026
The relationship between osteoporosis and intestinal fibrosis, a prominent manifestation of Crohn's disease (CD), has not been fully investigated. Focusing on this correlation may offer new insights...
Anatomy as a guide: Using learned priors for precise organ segmentation
March 2026
Accurate segmentation of abdominal organs from Computed Tomography (CT) is essential for clinical tasks such as radiotherapy planning but is hindered by ambiguity at organ boundaries. Standard deep...
Real-time motion compensation in cyberknife radiosurgery: Advances in fiducial marker tracking and clinical outcomes
January 2026
CyberKnife, a stereotactic radiosurgery (SRS) technique, delivers highly precise radiation beams to tumors. However, the patient motion, such as respiration and positional changes, can lead to tumor...
Synergistic role of multi-omics analysis combined with multimodal imaging in precision diagnosis and treatment of thoracic and abdominal tumors
May 2026
Thoracic and abdominal tumors, such as lung, breast, liver, and colorectal cancers, are characterized by high incidence and mortality rates, posing a significant threat to global health. Traditional...
m6A RNA methylation: A key regulator in renal cell carcinoma development and tumor radioresistance
March 2026
Renal cell carcinoma (RCC) is a highly prevalent malignancy within the urinary system. While surgery combined with adjuvant therapy has significantly improved survival rates for early-stage patients,...
Proteomics combined with ultrasound radiomics predicts central lymph node metastasis in papillary thyroid carcinoma
March 2026
Accurate preoperative prediction of central lymph node metastasis (CLNM) in papillary thyroid carcinoma (PTC) remains challenging. This study sought to develop and validate a combined model that combines...
METTL3-activated CCNE2 promotes hepatocellular carcinoma cell growth, metastasis, stemness and radioresistance
March 2026
Methyltransferase-like 3 (METTL3) has been confirmed to participate in regulating hepatocellular carcinoma (HCC) progression. However, more roles and mechanisms of METTL3 in HCC progression still need...
Structural MRI reveals brain differences in asthmatic patients with and without atopic dermatitis
May 2026
Building on accumulating evidence that atopic inflammation and neuroimmune/neurocognitive processes may influence the central nervous system, we aimed to compare structural brain imaging features between...
Radiation dosimetry of [124I]-metaiodobenzylguanidine (mIBG) dynamic PET/CT in pediatric neuroblastoma through animal-to-human extrapolation with MCNPX code and OLINDA/EXM software
January 2026
Iodine-124 metaiodobenzylguanidine (mIBG) positron emission tomography (PET)/computed tomography (CT) is well-established for imaging and pre-therapeutic dosimetry in pediatric neuroblastoma. However,...
Dose prediction of intensity-modulated radio therapy for brain tumors based on an improved deep learning framework
May 2026
Accurate calculation of dose distribution is a critical component in intensity-modulated radiation therapy (IMRT). The dose distribution exhibits significant variability across patients. To address...
Design semi-automated radio-synthesis strategy and synthesis of benzimidazole-based radiotracer 2-(4-(2-(fluoro-18F) ethyl) piperidin-1-yl) benzo imidazo[1,2-a] pyrimidine for Tau as a PET imaging agent
March 2026
Several studies have reported that benzimidazole-based structures are used in the diagnosis of Alzheimer's disease. Various modified benzimidazole-based structures serve as radiotracers. Among them,...
Association of mean cardiac dose with model-predicted risk of radiation-induced pericarditis in breast cancer patients
January 2026
This study aimed to investigate the association between mean cardiac dose (MCD) and the model-predicted risk of radiation-induced pericarditis in breast cancer patients undergoing radiotherapy....
Myrtus communis ameliorates ionizing radiation-induced cardiopulmonary injury in rats: TROD-GROG-003 study
January 2026
Ionizing radiation (IR), widely used in diagnostic and therapeutic procedures, can damage vital organs such as the heart and lungs through oxidative stress. This study aims to assess the potential radioprotective...
Exploring radiation pneumonitis associated with immune checkpoint inhibitors: Insights from the FAERS pharmacovigilance database
January 2026
The combination of immunotherapy and radiotherapy has become an important strategy for treating thoracic tumors. However, both treatment modalities can cause adverse effects to lung tissue. Research...
EAVS-TF: A bio-inspired spiking neural network for energy-efficient multimodal emotion recognition
May 2026
Accurate recognition of emotional states is critical for monitoring neuropsychiatric disorders, however, deploying such systems on battery-powered wearable devices necessitates exceptional energy efficiency....