Interdisciplinary integration and development trends of intelligent diagnosis in traditional Chinese medicine: a topic evolution analysis
March 2026
To systematically characterize the developmental trajectory and interdisciplinary integration of intelligent diagnosis in traditional Chinese medicine (TCM) through quantitative topic evolution analysis,...
Multi-label fundus disease classification using dual-branch deep learning: an intelligent diagnosis framework inspired by traditional Chinese medicine Five Wheels theory
March 2026
To develop a dual-branch deep learning framework for accurate multi-label classification of fundus diseases, addressing the key limitations of insufficient complementary feature extraction and inadequate...
Integrated network pharmacology and experimental validation for identification of mechanism of icariin targeting PLK1 in inhibiting hepatocellular carcinoma
March 2026
To systematically elucidate the molecular mechanisms and core targets underlying the anti-hepatocellular carcinoma (HCC) effects of icariin through integrated network pharmacology and experimental ...
Exploring the mechanism of myofascial trigger points deactivation by Tuina via the TGF-β1/Smad3 signaling pathway
March 2026
To investigate whether Tuina alleviates fibrotic symptoms in myofascial trigger points (MTrPs) by regulating transforming growth factor (TGF)-β1/Smad3 signaling pathway, thereby deactivating these ...
Attenuation of esophageal precancerous lesions in mice by Banxia Xiexin Decoction through gut microbiota modulation
March 2026
To investigate the microbial mechanisms of Banxia Xiexin Decoction (半夏泻心汤, BXXXD) in the treatment of esophageal precancerous lesions....
Ameliorative effects of Ayurvedic Latakaranja vati on dehydroepiandrosterone-induced polycystic ovarian syndrome in rats via inhibition of pro-inflammatory cytokines and oxidative stress
March 2026
To evaluate the therapeutic potential and underlying mechanism of Latakaranja vati (LV) in dehydroepiandrosterone (DHEA)-induced polycystic ovarian syndrome (PCOS) in female Wistar rats through integrated...
Fine-Med-Mental-T&P: a dual-track approach for high-quality instructional datasets of mental disorders in traditional Chinese medicine
March 2026
To investigate methods for constructing a high-quality instructional dataset for traditional Chinese medicine (TCM) mental disorders and to validate its efficacy....
Knowledge graph-enhanced long-tail learning approach for traditional Chinese medicine syndrome differentiation
March 2026
To address the dual challenges of long-tail distribution and feature sparsity in traditional Chinese medicine (TCM) syndrome differentiation within real clinical settings, we propose a data-efficient...
A machine learning-based depression recognition model integrating spirit-expression features from traditional Chinese medicine
March 2026
To develop a depression recognition model by integrating the spirit-expression diagnostic framework of traditional Chinese medicine (TCM) with machine learning algorithms. The proposed model seeks to...
Association of traditional Chinese medicine syndromes with blood lipid profiles and cardiovascular prognosis in post-percutaneous coronary intervention atherosclerotic cardiovascular disease patients: a prospective cohort study
March 2026
Patients with atherosclerotic cardiovascular disease (ASCVD) following percutaneous coronary intervention (PCI) are classified as very-high-risk individuals in cardiovascular disease (CVD) risk stratification....
QingNangTCM: a parameter-efficient fine-tuning large language model for traditional Chinese medicine
March 2026
To develop QingNangTCM, a specialized large language model (LLM) tailored for expert-level traditional Chinese medicine (TCM) question-answering and clinical reasoning, addressing the scarcity of domain-specific...
Clinical decision and prescription generation for diarrhea in traditional Chinese medicine based on large language model
March 2026
To develop a clinical decision and prescription generation system (CDPGS) specifically for diarrhea in traditional Chinese medicine (TCM), utilizing a specialized large language model (LLM), Qwen-TCM-Dia,...
Protection of morusin against lipopolysaccharide-induced acute liver injury through gut microbiota modulation and anti-inflammatory effects in mice
December 2025
To investigate the protective effects of morusin on lipopolysaccharide (LPS)-induced acute liver injury in mice and its underlying mechanisms....
Mechanisms of Chinese herbal medicine in modulating gut microbiota on primary open-angle glaucoma: a study based on data mining, network pharmacology, and Mendelian randomization
December 2025
To elucidate the potential mechanisms by which Chinese herbal medicine (CHM) regulates gut microbiota (GM) to influence the development of primary open-angle glaucoma (POAG)....
Mechanism prediction and experimental verification of Maxing Shigan Decoction against influenza A virus infection based on UPLC-MS/MS and network pharmacology
December 2025
To investigate the chemical compositions of Maxing Shigan Decoction (麻杏石甘汤, MXSGD) and elucidate its anti-influenza A virus (IAV) mechanism from prediction to validation....
Traditional Chinese medicine-based phytotherapeutics for junk food-induced obesity and metabolic dysfunction
December 2025
Obesity driven by high-sugar and high-fat dietary patterns has become a major global health challenge and is closely associated with metabolic syndrome, diabetes, and cardiovascular disorders. Growing...
The study of traditional Chinese medicine five-element music therapy for depression: a bibliometric analysis
December 2025
To systematically analyze the research status, highlights, and advancements of five-element music therapy (FEMT) in intervening depression with bibliometric methods....
Quantitative research on tongue diagnosis in traditional Chinese medicine for obstructive coronary artery disease: a computational analysis based on multimodal feature fusion
December 2025
To investigate morphological differences between obstructive and non-obstructive coronary artery disease (CAD) patients using computer-aided image analysis, and identify color and texture features for...
Unveiling core acupoints in acupuncture treatment for primary depressive disorder: integrating data mining and network acupuncture-based analysis
December 2025
To identify core acupoint patterns and elucidate the molecular mechanisms of acupuncture for primary depressive disorder (PDD) through data mining and network analysis....
Mitigation of inflammation and oxidative stress by sarsasapogenin in complete Freund’s adjuvant-induced arthritis: evidence from in silico and in vivo studies
December 2025
To evaluate the anti-arthritic efficacy of sarsasapogenin (SG) alone and in combination with the corticosteroid fluticasone (FC) in a rat model of rheumatoid arthritis (RA), which was induced by complete...
Facial color-preserving generative adversarial network-based privacy protection of facial diagnostic images in traditional Chinese medicine
December 2025
To develop a facial image generation method based on a facial color-preserving generative adversarial network (FCP-GAN) that effectively decouples identity features from diagnostic facial complexion...
Configuration of complex traditional Chinese medicine prescriptions using digit topology circles
December 2025
To configure the complex traditional Chinese medicine (TCM) prescription using digit topology circle and to derive digit topology circle....
Phenomics of traditional Chinese medicine 2.0: the integration with digital medicine
September 2025
Modern western medicine typically focuses on treating specific symptoms or diseases, and traditional Chinese medicine (TCM) emphasizes the interconnections of the body’s various systems under external...
Bone protective potential of Nelumbo nucifera Gaertn. seed hydroalcoholic extract on ovariectomy-induced osteoporosis in Wistar rats via ER/OPG/RANKL signaling pathway
September 2025
To investigate the bone-protective potential of Nelumbo nucifera Gaertn. seed hydroalcoholic extract (NNHE) in an ovariectomized (OVX) rat model by modulating the estrogen receptor/osteoprotegerin/receptor...
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