Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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Green polyurethanes from bio-based building blocks: recent advances and applications
Available online 22 August 2024
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers thanks to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable...
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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
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Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
Available online 17 April 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
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1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
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Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
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Enantioselective synthesis of chiral N-arylpyrroles through photoinduced desymmetrization
Available online 11 March 2025
The C–N axial chirality is widely present in natural products, bioactive molecules, and chiral ligands. Catalytic asymmetric construction of C–N axially chiral compounds is a challenging task due to...
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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Copper-catalyzed aerobic photodecarboxylation of carboxylic acids to aldehydes and ketones
Available online 12 March 2025
Base-metal-catalyzed decarboxylative transformations provide an economic pathway to the efficient functionalization of carboxylic acids. Herein, a copper-catalyzed aerobic photodecarboxylation of carboxylic...
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Truce-smiles rearrangement mediated by ligand-to-iron charge transfer
Available online 6 March 2025
In this study, we utilized earth-abundant, inexpensive iron as a catalyst and inexpensive, abundant, readily available polyfluoroalkyl carboxylic acids as substrates for sulfone-group-retaining Truce-Smiles...
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Advances of Ugi reaction in natural product synthesis
Available online 28 August 2024
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
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Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
Available online 19 December 2024
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
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Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
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Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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Mechanochemical syntheses of N-acyl sulfinamidines via iron-nitrenoids and their conversions to sulfur(VI) derivatives
Available online 7 April 2025
Herein, we present an iron-catalyzed mechanochemical synthesis of N-acyl sulfinamidines via nitrenoids generated from dioxazolones. Various substituents on both sulfenamides and thiols are well tolerated,...
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Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
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Engineering glucose dehydrogenase from Sulfolobus sulfataricus toward utilizing diverse nicotinamide cofactor biomimetics
Available online 15 March 2025
Oxidoreductases are crucial for the production of widely utilized chiral building blocks, giving rise to a demand for costly NAD(P)/H. As potential substitutes for natural cofactors, nicotinamide cofactor...
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Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
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CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
Available online 7 April 2025
The catalytic conversion of carbon dioxide toward methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
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Ate complexes in organic synthesis: From ate reagents to ate catalysts
August 2024
The realm of application of organometallic catalysis to organic synthesis has witnessed a transformative shift in recent years, owing much to the evolution of ate complexes from mere reagents to versatile...
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Recent progress in selective liquid-phase hydrogenation of furfural on heterogeneous Ni-containing catalysts
Available online 9 April 2025
Lignocellulose biomass, without any doubts, is one of the most promising, and, therefore, one of the most studied sources for the production of biofuels, valuable chemicals and “green” solvents. Furfural...
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Visible light induced synthesis of the Benzoyl bioisosteres: bicyclo[1.1.1]pentane-ketone group
Available online 8 March 2025
Benzoyl groups are commonly found in the structures of various pharmaceuticals, including non-steroidal anti-inflammatory drugs (NSAIDs), central nervous system stimulants, antihyperlipidemic agents,...
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Radical azidation as a means of constructing C(sp3)-N3 bonds
November 2020
The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...
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Palladium-catalyzed intramolecular C–H arylation of ferrocenyl-sulfides, sulfoxide and its application in metal ion recognition
February 2025
An intramolecular C–H arylation of ferrocenyl ortho-bromophenyl sulfide and sulfoxide has been developed with a palladium/non-chiral monophosphine ligand. Under mild reaction conditions, a wide range...
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