Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
April 2026
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Skeletal editing of pyridine for ring transformations
Available online 28 October 2025
The pyridine ring, functioning as a vital framework in numerous bioactive molecules, has recently witnessed significant advancements in precise skeletal editing, which has brought about a revolutionary...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
April 2026
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
Available online 29 December 2025
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
Recent advances in C–B bond formation by borylation with NHC–boranes
Available online 25 September 2025
Organoboron compounds play a pivotal role in synthetic, pharmaceutical, and material chemistry due to their distinctive properties. Developing efficient, regioselective methods for C–B bond construction...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
Organocatalytic [4+4] annulation of indole-4-boronic acid with o-hydroxybenzyl alcohols for constructing indole-fused oxaborocanes
Available online 11 March 2026
An organocatalytic [4 + 4] annulation between indole-4-boronic acids and o-hydroxybenzyl alcohols has been developed. This method enables the synthesis of a diverse range of indole-fused oxaborocanes...
Lewis acid-catalyzed [4π+2σ] cycloaddition of bicyclo[2.1.0]pentanes with nitrones: Access to 2-oxa-3-azabicyclo[3.2.1]octanes
Available online 1 April 2026
The hetero-bicyclo[3.2.1]octane scaffold is a prevalent structural motif in bioactive natural products and pharmaceuticals, yet general synthetic methods for its construction remain limited. Herein,...
Visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate for the synthesis of carboxylated quinolinones and ester-containing phenanthridines
Available online 19 March 2026
Described here is a visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate to access various carboxylated quinolinones and ester-containing phenanthridines....
Photocatalytic radical amination/cyclization of N-allyl and N-homoallyl aldehyde hydrazones: Access to sulfonaminated pyrazoles and tetrahydropyridazines
Available online 6 March 2026
A photocatalytic strategy for the sulfonamidation/cyclization of N-allyl and N-homoallyl aldehyde hydrazones has been developed with N-aminopyridinium salts as sulfonylamino radical precursors. This...
Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications
April 2026
Benzaldehyde lyase (BAL), a thiamine diphosphate (ThDP)-dependent enzyme requiring divalent cations (e.g., Mg2+), mediates enantioselective C-C bond formation and cleavage to exclusively produce (R)-configured...
Ferrioxalate photocatalysis as a versatile system for reductive iron catalysis
Available online 25 March 2026
A novel photochemical strategy based on the ligand-to-metal charge transfer (LMCT) process of ferrioxalate complexes has been developed. This method represents the first application of ferrioxalate...
Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
February 2026
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
Metal-free electrochemical synthesis of sulfinamides via alkyl radical addition to sulfinylamines
Available online 6 February 2026
Sulfinamides are important sulfur-containing motifs with broad applications in pharmaceuticals, agrochemicals, and materials. Traditional alkyl sulfinamide synthesis often requires prefunctionalized...
Visible-light-driven Na2CO3-enabled photocatalyst- and metal-free selective thio- and selenosulfonylation of unactivated alkenes
Available online 11 March 2026
Atom transfer radical addition (ATRA) of alkenes with thiosulfonates is a powerful strategy to construct valuable thioalkylsulfones. However, these methods employ complex catalytic systems, a high loading...
Photocatalytic 1,2-difluoromethylation/aminosulfonylation of unactivated alkenes: Access to β-difluoromethylated sulfonamides
Available online 12 March 2026
While radical addition to SO2 serves as a fundamental strategy for constructing sulfone frameworks, its application in building sulfonamide skeletons, particularly for the modular installation of an...
Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
Recent advances in photocatalytic C-H amination to nitrogenous structures
February 2026
Nitrogen-containing structures represent a significant branch exhibiting remarkable biological activity, surpassing non-nitrogen architectures. Given the vast array of nitrogen-containing compounds...
Unsaturated C2 synthons in photocatalysis: Taming and directing acetylene and ethylene in radical reactions
Available online 28 January 2026
The conversion of the simplest unsaturated C2 molecular building units (C2H2 and C2H4) to high-value-added fine chemicals has been a pivotal domain in modern synthetic chemistry. Because of the inherent...
TBADT/nickel co-catalyzed three-component radical acylarylation of alkenes with aldehydes and aryl iodides
Available online 17 October 2025
Here we report a photo/nickel co-catalyzed three-component acylarylation of alkenes using aldehydes and aryl iodides. Tetrabutylammonium decatungstate (TBADT) serves as a hydrogen-atom-transfer (HAT)...
Microfluidic-enabled solid-phase biosynthesis of carbohydrates
Available online 9 March 2026
Carbohydrates serve as essential energy sources, structural components, and bioactive substances in living organisms, making the study of their synthesis methods a significant focus in chemistry and...
Recent advances in transition-metal-free conversion of aldehydes to ketones
August 2025
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
