Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Skeletal editing of pyridine for ring transformations
Available online 28 October 2025
The pyridine ring, functioning as a vital framework in numerous bioactive molecules, has recently witnessed significant advancements in precise skeletal editing, which has brought about a revolutionary...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
TBADT/nickel co-catalyzed three-component radical acylarylation of alkenes with aldehydes and aryl iodides
Available online 17 October 2025
Here we report a photo/nickel co-catalyzed three-component acylarylation of alkenes using aldehydes and aryl iodides. Tetrabutylammonium decatungstate (TBADT) serves as a hydrogen-atom-transfer (HAT)...
Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
Recent advances in C–B bond formation by borylation with NHC–boranes
Available online 25 September 2025
Organoboron compounds play a pivotal role in synthetic, pharmaceutical, and material chemistry due to their distinctive properties. Developing efficient, regioselective methods for C–B bond construction...
Advances of Ugi reaction in natural product synthesis
August 2025
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
Recent advances in transition-metal-free conversion of aldehydes to ketones
August 2025
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
Recent advances in electrochemically driven deoxygenation/deoxygenative coupling of C−O and C=O bonds
Available online 30 September 2025
Alcohols, aldehydes and ketones, which contain oxygen-containing functional groups such as C−O and C=O, are widely present in drugs, fine chemicals, and biomass. These compounds provide diverse carbon...
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
November 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
Azide-based difunctionalization of alkenes
Available online 5 August 2025
As an important class of nitrogen-containing functional molecules, azides have attracted considerable attention in synthetic chemistry and functional materials due to their reaction diversity and derivatization...
Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients
Available online 27 May 2025
The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...
Nickel-catalyzed construction of C(sp3)-C(sp3) bonds with alkyl halides and diazo compounds for accessing all-carbon quaternary centers
Available online 14 November 2025
Transition-metal catalyzed formation of C–C bonds has emerged as an effective strategy for constructing all-carbon quaternary centers, which represent a persistent synthetic challenge in organic synthesis....
Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
Available online 16 May 2025
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
Available online 9 December 2025
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Practical access to axially chiral triazole phosphine oxides via enantioselective CuAAC reaction
Available online 30 September 2025
The construction and application of axially biaryl N,P-ligands is of great importance in asymmetric catalysis. Herein, an enantioselective copper-catalyzed azide-alkyne cycloaddition (CuAAC) of prochiral...
Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
Available online 7 August 2025
Organic compounds bearing fluorine atoms have received widespread attention in recent years owing to their specific bioactivity and good biocompatibility compared to their nonfluorinated counterparts....
Visible-light-driven multicomponent reactions: Concurrent pyridylation and alkylation of styrenes
Available online 28 November 2025
Given the prevalence of pyridines in pharmaceuticals, methods for regioselectively introducing functional groups to the pyridine ring offer a categorical yet sustainable challenge strategy for expanding...
Transition metal-catalyzed branch-selective hydroformylation of olefins in organic synthesis
August 2021
Hydroformylation of olefins can generate linear and branched aldehydes, and the branched aldehydes are attractive precursors for the synthesis of fine chemicals and pharmaceuticals. Hydroformylation...
Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...