Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
Oxocarbenium Lewis acid complex: A neutral thiol-specific bioconjugation reagent
Available online 4 July 2025
Oxocarbenium ions are pivotal intermediates in organic synthesis, driving key transformations like glycosylation, rearrangement and cyclization. However, their generation typically requires Lewis or...
Advances of Ugi reaction in natural product synthesis
August 2025
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
Transition-metal-catalyzed transformations of C–N single bonds: Advances in the last five years, challenges and prospects
May 2021
Nitrogen atom widely exists in many organic molecules and biomacromolecules. Therefore, the formation and transformation of C–N bonds are one of the most attractive topics in organic synthetic chemistry....
Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients
Available online 27 May 2025
The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...
Recent advances in transition-metal-free conversion of aldehydes to ketones
August 2025
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
Recent advances in electrochemical transformations of p-substituted phenols
Available online 9 July 2025
At present, the electrochemical transformations of p-substituted phenols have achieved plentiful applications in organic synthesis. The efficient functionalization of two key anodically generated intermediates—p-quinone...
Recent advances in the catalytic asymmetric synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their derivatives
Available online 6 June 2025
Spirocyclic tetrahydroquinolines (spiro-THQs) and tetrahydroisoquinolines (spiro-iTHQs), along with their derivatives constitute a prominent class of natural products, which exhibit a broad spectrum...
Synthesis of nucleoside drugs for the treatment of HBV infection: An updated review
Available online 7 June 2025
Hepatitis B virus (HBV) is a significant global health concern, characterized by its potential to cause acute and chronic liver diseases. Despite the availability of effective vaccines and treatments,...
Recent advances in transition-metal-free C–H functionalization of imidazo[1,2-a]pyridines
August 2022
Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharmaceuticals, natural products, material science and organometallics. Due to their significant biological...
Azide-based difunctionalization of alkenes
Available online 5 August 2025
As an important class of nitrogen-containing functional molecules, azides have attracted considerable attention in synthetic chemistry and functional materials due to their reaction diversity and derivatization...
Carbon dioxide radical anion mediated regioselective carboxy-cyclization of alkenes
Available online 29 July 2025
Cyclopropyl fatty acid linkers and their derivatives serve as high-value pharmacophores in pharmaceutical and biotechnological research. Despite significant advancements in the hydrocarboxylation and...
Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
Available online 16 May 2025
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Palladium/copper-catalyzed 1,2-arylboration of styrenes with b2pin2 and indoles
Available online 4 July 2025
Boryldifunctionalization of alkenes has emerged as a valuable synthetic tool for constructing complex organoboron compounds. While significant advances have been achieved in carboboration reactions...
CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
Available online 7 April 2025
The catalytic conversion of carbon dioxide toward methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
Aminoalkylation of alkynyl bromides for accessing propargylamines via visible-light-driven multicomponent reaction
Available online 20 August 2025
Propargylamines are an important class of organic motifs that exist in a myriad of biologically active molecules. In this paper, we present a new approach for synthesising propargylamines, which utilises...
Rapid access to diverse indoles by addition/SNAr with Grignard reagents and 2-fluorophenyl acetonitriles
May 2025
Indoles are essential heterocycles in natural products, biological chemistry, and medicinal chemistry. Efficient approaches to their synthesis, therefore, remain in demand. Herein is reported a novel...