Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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Green polyurethanes from bio-based building blocks: recent advances and applications
Available online 22 August 2024
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers thanks to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable...
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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
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Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Advances of Ugi reaction in natural product synthesis
Available online 28 August 2024
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
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Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
Available online 19 December 2024
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
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Enantioselective synthesis of chiral N-arylpyrroles through photoinduced desymmetrization
Available online 11 March 2025
The C–N axial chirality is widely present in natural products, bioactive molecules, and chiral ligands. Catalytic asymmetric construction of C–N axially chiral compounds is a challenging task due to...
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Copper-catalyzed aerobic photodecarboxylation of carboxylic acids to aldehydes and ketones
Available online 12 March 2025
Base-metal-catalyzed decarboxylative transformations provide an economic pathway to the efficient functionalization of carboxylic acids. Herein, a copper-catalyzed aerobic photodecarboxylation of carboxylic...
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Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
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Truce-smiles rearrangement mediated by ligand-to-iron charge transfer
Available online 6 March 2025
In this study, we utilized earth-abundant, inexpensive iron as a catalyst and inexpensive, abundant, readily available polyfluoroalkyl carboxylic acids as substrates for sulfone-group-retaining Truce-Smiles...
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Organophosphorus catalytic reaction based on reduction of phosphine oxide
May 2023
The special electronic configuration of phosphorus atoms endows organophosphorus reagents with unique chemical properties, which enable them to be used to catalyze various organic reactions, such as...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
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Ate complexes in organic synthesis: From ate reagents to ate catalysts
August 2024
The realm of application of organometallic catalysis to organic synthesis has witnessed a transformative shift in recent years, owing much to the evolution of ate complexes from mere reagents to versatile...
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Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
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Asymmetric catalytic hydrogenation of imines and enamines in natural product synthesis
June 2020
Asymmetric catalytic hydrogenations of imines and enamines with chiral transition-metal complexes bearing chiral ligands are among the most green and powerful approaches for the elaboration of chiral...
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Carbonylative transformation of aryl halides and strong bonds via cheap metal catalysts and sustainable technologies
November 2024
The development of catalytic carbonylation reactions has increased considerably. Although many reviews/chapters/books on carbonylation reactions have been published, summaries on cheap metal-catalyzed...
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Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
Available online 17 April 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
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Radical azidation as a means of constructing C(sp3)-N3 bonds
November 2020
The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...
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Copper-catalyzed deuterodehalogenation of aryl halides
Available online 4 January 2025
There is growing potential and interest in the development of precise and practical deuterium labelling methodologies using an easy-handling deuterated source for alkylarenes and methylarenes. Here...
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Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
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Enantioselective epimerizations of meso-diols via asymmetric hydrogen atom abstraction catalysis
Available online 29 January 2025
A new type of asymmetric hydrogen atom abstraction catalysts, originated from the cinchona alkaloid family of natural products, has been successfully developed to access enantioselective epimerizations...
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Accelerated flow synthesis of aripiprazole and brexpiprazole in environmentally benign solvents
Available online 22 February 2025
Aripiprazole and Brexpiprazole are both second-generation atypical antipsychotic medications to treat a wide range of psychiatric disorders, the retail sales of which reached $1.35 billion and $2.07...
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Engineering glucose dehydrogenase from Sulfolobus sulfataricus toward utilizing diverse nicotinamide cofactor biomimetics
Available online 15 March 2025
Oxidoreductases are crucial for the production of widely utilized chiral building blocks, giving rise to a demand for costly NAD(P)/H. As potential substitutes for natural cofactors, nicotinamide cofactor...
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