Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
Skeletal editing of pyridine for ring transformations
Available online 28 October 2025
The pyridine ring, functioning as a vital framework in numerous bioactive molecules, has recently witnessed significant advancements in precise skeletal editing, which has brought about a revolutionary...
Intelligent enzyme design and hybrid catalytic systems: Driving innovation in biocatalysis
April 2026
Enzyme engineering has emerged as a pivotal technology driving advances in biocatalysis, environmental remediation, and green chemistry. It is undergoing a transformative shift, propelled by the synergistic...
Lewis acid-catalyzed [4π+2σ] cycloaddition of bicyclo[2.1.0]pentanes with nitrones: Access to 2-oxa-3-azabicyclo[3.2.1]octanes
Available online 1 April 2026
The hetero-bicyclo[3.2.1]octane scaffold is a prevalent structural motif in bioactive natural products and pharmaceuticals, yet general synthetic methods for its construction remain limited. Herein,...
Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
November 2025
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
April 2026
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
Recent advances in C–B bond formation by borylation with NHC–boranes
Available online 25 September 2025
Organoboron compounds play a pivotal role in synthetic, pharmaceutical, and material chemistry due to their distinctive properties. Developing efficient, regioselective methods for C–B bond construction...
Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
Recent advances in ligand-accelerated nickel-catalyzed carbonylation under CO gas
Available online 29 December 2025
Carbonyl groups are fundamental structural motifs in organic chemistry, prominently featured in drug molecules, functional materials, and as versatile synthetic intermediates. Transition metal-catalyzed...
Green polyurethanes from bio-based building blocks: Recent advances and applications
August 2025
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
Ferrioxalate photocatalysis as a versatile system for reductive iron catalysis
Available online 25 March 2026
A novel photochemical strategy based on the ligand-to-metal charge transfer (LMCT) process of ferrioxalate complexes has been developed. This method represents the first application of ferrioxalate...
Advances in benzaldehyde lyase-catalyzed biotransformations: From enzyme engineering to industrial applications
April 2026
Benzaldehyde lyase (BAL), a thiamine diphosphate (ThDP)-dependent enzyme requiring divalent cations (e.g., Mg2+), mediates enantioselective C-C bond formation and cleavage to exclusively produce (R)-configured...
Photo-free electron donor-acceptor complexes driven divergent synthesis of thioethers and thioimidate esters with aryldiazonium salts and thiols/thiophenols
Available online 1 May 2026
A catalyst- and photo-free strategy for the divergent synthesis of thioethers and thioimidate esters from thiophenols/thiols and aryldiazonium salts has been developed. The reaction pathway is precisely...
CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
June 2026
The catalytic conversion of carbon dioxide to methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
Perspectives on green synthesis and catalysis
June 2020
Despite their impressive capacity to access diverse functional groups and to synthesize structurally complex molecules, the majority of the organic reactions suffers from harsh conditions, low atom...
Recent advances in the photocatalytic applications of ethyl bromodifluoroacetate: A review
Available online 7 August 2025
Organic compounds bearing fluorine atoms have received widespread attention in recent years owing to their specific bioactivity and good biocompatibility compared to their nonfluorinated counterparts....
Recent advancements in visible-light-induced direct C(3)–H functionalization of quinoxalin-2(1H)-ones
February 2026
Quinoxalin-2(1H)-ones are unique nitrogen-containing organic compounds with wide applications in the agrochemical, pharmaceutical, and chemical industries as well as in material science. During the...
Organocatalytic [4+4] annulation of indole-4-boronic acid with o-hydroxybenzyl alcohols for constructing indole-fused oxaborocanes
Available online 11 March 2026
An organocatalytic [4 + 4] annulation between indole-4-boronic acids and o-hydroxybenzyl alcohols has been developed. This method enables the synthesis of a diverse range of indole-fused oxaborocanes...
Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
Metal-free electrochemical synthesis of sulfinamides via alkyl radical addition to sulfinylamines
Available online 6 February 2026
Sulfinamides are important sulfur-containing motifs with broad applications in pharmaceuticals, agrochemicals, and materials. Traditional alkyl sulfinamide synthesis often requires prefunctionalized...
Advances of Ugi reaction in natural product synthesis
August 2025
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
Metal- and light-free C–C coupling of aryl halides with quinoxalinones and related N-heterocycles under molecular iodine promotion
Available online 17 April 2026
A metal- and light-free strategy for C–C cross-coupling of aryl halides with quinoxalinones and related N-heterocycles has been developed using molecular iodine (I2). The NH2 (or OH) group in the aryl...
Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
Recent advances in transition-metal-free conversion of aldehydes to ketones
August 2025
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
Visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate for the synthesis of carboxylated quinolinones and ester-containing phenanthridines
Available online 19 March 2026
Described here is a visible-light-catalyzed cascade carboxylation/cyclization of o-cyano(bi)arylacrylamides with formate to access various carboxylated quinolinones and ester-containing phenanthridines....