Advanced green synthesis: Solvent-free and catalyst-free reaction
February 2025
The solvent-free and catalyst-free (SFCF) reaction has garnered significant interest among chemists due to its alignment with many of the 12 principles of green chemistry. In recent years, numerous...
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Transaminase catalyzed asymmetric synthesis of active pharmaceutical ingredients
Available online 16 March 2024
Chiral amine molecules constitute vital components of pharmaceutical ingredients. Recent years have witnessed a growing focus on the efficient synthesis of chiral amines. Transaminases, as catalysts,...
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Flow chemistry in the multi-step synthesis of natural products
August 2022
The total synthesis of natural products is constantly facing many challenges derived from the complexed chemical structures, the lengthy synthetic routes, the time-consuming workup procedures and the...
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Green polyurethanes from bio-based building blocks: Recent advances and applications
Available online 22 August 2024
Polyurethanes (PUs) are among the most studied, manufactured, and employed polymers due to their versatility and wide range of applications. However, their synthesis generally relies on toxic, non-renewable,...
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1,3-Indanedione: An versatile building block
May 2023
Indanone-containing compounds are very important components of various natural products, chemical drugs, agrochemicals and functionalized material fields. 1,3-Indanedione is a typical cyclic 1,3-dicarbonyl...
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Recent advances in the syntheses of pyrroles
February 2023
The pyrrole moiety is an important structural motif in functional materials, natural products, and pharmaceuticals. More and more synthetic strategies toward pyrroles have emerged, where various efficient...
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Sustainable synthetic routes to deuterium-labelled organic compounds using immobilized and recyclable (bio)catalysts
February 2025
Deuterium(D)-labelled organic compounds are used in many applications e.g., as therapeutic agents, internal standards in drug discovery and development, and new functional materials including dyes,...
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Applications of cytochrome P450 monooxygenases in the biosynthesis of active pharmaceutical ingredients
Available online 27 May 2025
The synthesis of active pharmaceutical ingredients (APIs) constitutes a pivotal juncture within the pharmaceutical industry, prompting researchers to relentlessly pursue novel methodologies that enhance...
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Advances of Ugi reaction in natural product synthesis
Available online 28 August 2024
The Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot...
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Biotechnological synthesis of nucleoside analogs: Recent progress and perspectives
Available online 16 May 2025
Nucleoside analogs play an indispensable role in antiviral and anticancer therapies, and improving their synthesis methods has become a focal area of research. In recent years, technological breakthroughs...
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Transition-metal-catalyzed transformations of C–N single bonds: Advances in the last five years, challenges and prospects
May 2021
Nitrogen atom widely exists in many organic molecules and biomacromolecules. Therefore, the formation and transformation of C–N bonds are one of the most attractive topics in organic synthetic chemistry....
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Recent advances in transition-metal-free C–H functionalization of imidazo[1,2-a]pyridines
August 2022
Imidazo[1,2-a]pyridines are unique nitrogen-containing organic compounds with wide applications in pharmaceuticals, natural products, material science and organometallics. Due to their significant biological...
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Radical dehydroxylative C-glycosylation of 1-hydroxycarbohydrates enabled by photoredox catalysis
Available online 17 April 2025
C-Glycosides, known for their superior in vivo stability compared to their O- and N-glycoside counterparts, have been widely explored as drug candidates and utilized in biological research. Traditional...
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Electrochemical generation of nitrogen-centered radicals for organic synthesis
May 2021
There is a resurgence of interests in organic electrochemistry, which is generally accepted as a green synthetic tool. In this context, many electrochemical methods have been developed in the past decade...
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CO2 hydrogenation to methanol on the incapsulated Cu-Zn catalyst: Effect of the MCM-41 and SBA-15 supports and the method of preparation on catalytic activity
Available online 7 April 2025
The catalytic conversion of carbon dioxide toward methanol is of great practical and scientific importance in the concept of reducing CO2 emissions. Moreover, it can partially solve the problem of human...
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Synthesis of tetraarylmethanes: 1897–2022
November 2023
Tetraarylmethanes (TAMs) contain a carbon atom bound to four aryl groups. They have found diverse applications in chemistry, materials science, chemical biology and medicinal chemistry because of their...
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Solvent-polarity-controlled stereoselective synthesis of cis-acyclic indoline via photocatalytic dearomatization of indole
Available online 14 June 2025
Indolines, a privileged scaffold in natural products and bioactive molecules, hold immense potential in drug discovery and organic synthesis. Herein, we report a photocatalytic dearomatization strategy...
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Radical azidation as a means of constructing C(sp3)-N3 bonds
November 2020
The azido group is found in large numbers of natural products, drugs, biochemicals and materials and to date, many elegant and useful methods for the synthesis of organic azides and their transformations...
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Spirooxindoles: Recent report of green synthesis approach
February 2024
Spirooxindole is a compound with a unique framework and broad bioactivities in medicine. In this study, we have reviewed various approaches or methods in synthesizing spirooxindole derivatives focused...
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Methodology-driven efficient synthesis of cytotoxic (±)-piperarborenine B
November 2022
The evolution of synthetic design toward the efficient synthesis of cyclobutane natural product (±)-piperarborenine B is demonstrated. Taking the advantages of good functional group compatibility of...
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Recent advances in transition-metal-free conversion of aldehydes to ketones
Available online 3 May 2024
The preparation of functionalized ketones occupies an important position in synthetic organic chemistry because ketones are ubiquitous structural motifs in a broad range of compounds with various applications....
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Visible-light-induced cascade radical cyclization of aryl alkynoates with fluoroalkyl carboxylic anhydrides to construct fluoroalkylated coumarins
Available online 27 May 2025
We herein described an efficient and practical protocol for radical cyclization of aryl alkynoates to access 3-fluoroalkyl-substituted coumarins using readily available, easy-to-handle and low-cost...
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Recent advances in the catalytic asymmetric synthesis of spirocyclic tetrahydroquinolines, tetrahydroisoquinolines and their derivatives
Available online 6 June 2025
Spirocyclic tetrahydroquinolines (spiro-THQs) and tetrahydroisoquinolines (spiro-iTHQs), along with their derivatives constitute a prominent class of natural products, which exhibit a broad spectrum...
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The cascade annulation approach to quinoxalines by radical NHC catalysis
Available online 7 May 2025
A wide range of functionalized quinoxalines were rapidly constructed by novel NHC-catalyzed cascade annulation of acyl oximes and isonitriles. The developed protocol characterized good functional group...
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Benzaldehyde lyase-catalyzed enantioselective C–C bond formation and cleavage: A review
November 2022
Benzaldehyde lyase (BAL) is an enzyme which was originally found from Pseudomonas fluorescens biovar I. It has long been used in the formation of a C–C bond. BAL can exclusively yield (R)-enantioselective...
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