Cocktail-style multifunctional resuscitation fluids: Where are we now in 2026?
March 2026
For over half a century, fluid resuscitation has traditionally included crystalloids for volume expansion and colloids for potential oncotic advantage. The paradigm, however, could be shifting now....
Acute cerebral infarction caused by severe anaphylactic shock: A case report
March 2026
Perioperative anaphylactic reactions, especially those induced by colloid solutions like gelatins, can lead to severe hypotension and tissue hypoperfusion, with potential serious complications....
Electroencephalographic phenotypes of postoperative delirium in the perioperative period
March 2026
Postoperative delirium (POD) is a common and severe complication among older surgical patients. Perioperative electroencephalography (EEG) monitoring provides a noninvasive, real-time window into cerebral...
Advances in biomarkers for myocardial injury after non-cardiac surgery
March 2026
Myocardial injury after non-cardiac surgery (MINS) is a common and clinically important postoperative complication associated with increased short- and long-term mortality. As most cases lack typical...
Propofol treatment correlates with changes in pain sensitivity and thalamocortical glutamate/GABA balance in sleep-deprived mice
March 2026
Sleep disorders profoundly impair patients’ daily quality of life and present substantial challenges to clinical management. Accumulating evidence has shown that propofol improves sleep architecture...
Mechanisms of the RGS12-GPX4-ACSL4 signaling axis in regulating ferroptosis during myocardial ischemia-reperfusion injury
March 2026
Acute myocardial infarction (AMI) is one of the leading causes of death worldwide. Timely reperfusion therapy following AMI can effectively salvage ischemic cardiomyocytes. However, myocardial ischemia-reperfusion...
Remote assessment of instrumental activities of daily living and cognitive impairment in older surgical patients
March 2026
We aimed to investigate the prevalence of instrumental activities of daily living (IADL) dependence in older surgical patients, its association with cognitive impairment, and risk factors associated...
TOC
March 2026
Anxiety and depression in non-cardiac surgical patients and associations with adverse outcomes: A systematic review and meta-analysis
December 2025
Mental health disorders such as anxiety and depression are associated with advanced disease at presentation, reduced treatment uptake, and worse postoperative outcomes. Despite this, preoperative screening...
Perioperative predictors of complications in open abdominal aortic surgery: A retrospective analysis under a structured perioperative goal-directed therapy protocol
December 2025
Perioperative goal-directed therapy (PGDT) optimizes hemodynamics in high-risk vascular surgery. However, data on postoperative risk factors and temporal hemodynamic and arterial blood gas (ABG) data...
Contraceptive implant removal: Case report and the role of an ultrasound-trained anesthesiologist in perioperative localization and regional anesthesia
December 2025
Contraceptive implants offer a long-term reversible option for contraception. While palpable implants can be removed under local anesthesia in an office setting, nonpalpable implants can present greater...
Association between preoperative anemia and postoperative delirium in elderly patients undergoing total hip arthroplasty with combined spinal-epidural anesthesia: A retrospective cohort study
December 2025
The effect of preoperative anemia on postoperative delirium (POD) risk in elderly patients undergoing total hip arthroplasty (THA) with spinal-epidural anesthesia remains unclear. This study aimed to...
Neuroprotective mechanisms of dexmedetomidine in perioperative neurocognitive disorders: From molecular pathways to clinical translation
December 2025
Perioperative neurocognitive disorders (PNDs) are common severe complications observed in elderly patients following surgery, primarily characterized by a decline in postoperative cognitive function...
Considerations for regional anaesthesia for the shoulder joint – Beyond the C5-C6 nerve roots
December 2025
Shoulder pain in the perioperative setting remains a significant clinical challenge, with persistent postoperative discomfort reported in up to 22 % of patients following primary shoulder arthroplasty....
Effect of intraoperative hypotension depth and duration on acute kidney injury after Type A acute aortic dissection repair: An observational cohort study based on early risk stratification models
December 2025
The impact of adjusting intraoperative mean arterial pressure (MAP) management strategies on early detection and prevention of acute kidney injury (AKI) after Type A acute aortic dissection (TA-AAD)...
Clinical practice guidelines for the prevention and management of postoperative nausea and vomiting (2025 edition)
December 2025
Postoperative nausea and vomiting (PONV) is a common postoperative complication that substantially influences patient recovery and healthcare quality. To further standardize PONV management in China,...
The incidence of postoperative sleep disturbance and its influencing factors in cancer patients
December 2025
Sleep disturbances are a risk factor for poor prognosis, which is significantly related to postoperative recovery in cancer patients. In this cross-sectional study, we investigated the incidence of...
MANF improves cognitive function and attenuates neuroinflammation in APP/PS1 transgenic mice through the TLR4/MYD88/NF-κB signaling pathway
December 2025
Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, characterized by progressive cognitive decline, as well as pathological features such as β-amyloid (Aβ) plaque deposition,...
TOC
December 2025
Future perspective on chronic kidney disease management
September 2025
Over-activation of the sympathetic nervous system is one of the major characteristics in chronic kidney disease (CKD), with renal ischemia playing a pivotal role in its development. While various pharmacologic...
Pain trajectory after total knee arthroplasty (TKA) with prolonged use of outpatient adductor canal catheters
September 2025
In this prospective observational study, we sought to evaluate whether the prolonged use of adductor canal nerve block catheters provides benefits for patients undergoing primary total knee arthrop...
Mechanism of antidepressant action of ketamine and differences between its two enantiomers
September 2025
Ketamine has been widely used since its discovery, and in addition to its anesthetic effects, in recent years it has been found to exhibit rapid and sustained antidepressant effects in rodent models...
From static to dynamic: Artificial intelligence revolution in perioperative care through multimodal data fusion and closed-loop optimization
September 2025
The integration of artificial intelligence (AI) into perioperative care represents a paradigmatic transformation from static decision frameworks to dynamic, adaptive systems. This comprehensive review...
Remimazolam in anesthesia and sedation: A narrative review
September 2025
Remimazolam, an innovative sedative, provides a rapid onset and quick recovery by being rapidly hydrolyzed into pharmacologically inactive CNS7054 via ubiquitous nonspecific esterases. Its pharmacokinetic...
Open lung ventilation with low tidal volumes, staircase recruitment maneuvers, high PEEP and decremental PEEP titration vs ARDSNet in ARDS: A systematic review and meta-analysis
September 2025
The impact of open lung ventilation (OLV) with low tidal volumes (TV), staircase recruitment maneuvers (SRMs), high positive end-expiratory pressure (PEEP), and decremental PEEP titration on acute respiratory...