Phytochemical profiles, biological activities and medicinal importance of Aloe vera L.: A review
September 2025
Aloe vera (Av) is revered in Ayurveda as the "wand of heaven" or "heaven's blessing" and precisely the "silent healer". This herbaceous plant belongs to Asphodelaceae family, previously classified as...
Integrative network pharmacology and transcriptomics suggest the mechanism of Buyang Huanwu Decoction in attenuating vascular aging via AMPK signaling pathway
September 2025
Vascular aging is a critical factor in cardiovascular diseases. Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, shows potential in delaying vascular aging, yet its mechanisms remain...
Holistic insights of 6D printing in healthcare
September 2025
Additive manufacturing has recently demonstrated significant progress in healthcare. Six-dimensional (6D) printing is an emerging field that holds great promise through the rapid, layer-by-layer creation...
Mendelian randomization analysis establishes a causal relationship between COVID-19 and cardiometabolic diseases
September 2025
The causal impacts of COVID-19 on cardiometabolic diseases remained uncertain. This study utilized the two-sample Mendelian randomization (MR) method to evaluate causal relationships between COVID-19...
An integrative framework for precision medication in hypertension: Applying a dialectical perspective to traditional Chinese and Western medicine
September 2025
Hypertension is the most common cardiovascular disease. In terms of diagnosis and treatment, Traditional Chinese Medicine (TCM) and Western medicine each have their own strengths, but also have certain...
Review on clinical diagnosis, pathogenesis and therapeutic strategies of drug-induced liver injury
September 2025
Drug-induced liver injury (DILI) is a severe adverse reaction caused by various drugs and their metabolites, with complex clinical manifestations, and severe cases may progress to acute liver failure...
Unlocking artemisinin's potential in polycystic ovary syndrome treatment: A call for controlled human trials
September 2025
Potential small-molecule compounds and targets for Alzheimer's disease: Integrating bioinformatics analysis and in vitro verification
September 2025
Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by progressive memory decline and cognitive dysfunction. The specific pathogenesis of AD remains unclear. This study aimed...
Optimization, characterization, hypoglycemic and antioxidant activity studies of ultrasonic-assisted deep eutectic solvent extraction of polysaccharides from Perilla frutescens
September 2025
In order to further develop and utilise Perilla frutescens polysaccharides, the aim of this study was to optimize process conditions for the extraction of Perilla frutescens polysaccharides with deep...
An assessment of antidepressant like potentiality of Phyllanthus emblica on experimental rodent model of depressive disorder under the light of numerous behavioural test batteries
September 2025
The unfavorable costs and effects of currently accessible antidepressant agents necessitate the development of more potent and safe alternatives, that will obviate the potential problems associated...
Protective effects of fresh Dendrobium officinale against gastric ulcer by regulating Keap1-Nrf2 signaling pathway
September 2025
This study aimed to systematically investigate the gastroprotective effects and underlying mechanisms of fresh Dendrobium officinale granules (FDG), a clinically convenient formulation of fresh Dendrobium...
ToC
September 2025
The transformative power of artificial intelligence in pharmaceutical manufacturing: Enhancing efficiency, product quality, and safety
June 2025
The pharmaceutical manufacturing industry transforms through artificial intelligence (AI) by implementing process improvements along with productivity enhancements and product quality improvements....
Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology
June 2025
Gastrointestinal complications (GITC) are a major cause of increased morbidity and mortality in stroke patients, significantly impairing recovery by triggering systemic inflammation and hindering brain...
Baicalin induces apoptosis and autophagy in resistant human hepatocellular carcinoma cell line Bel-7402/5-FU cells via PI3K/AKT pathway
June 2025
Multidrug resistance (MDR) is one main cause of chemotherapy failure. Baicalin is an important active ingredient with anticancer potential in many Chinese herbal medicines. In order to understand the...
Mitochondrial function maintenance and mitochondrial training in ageing and related diseases
June 2025
Cellular senescence driven by mitochondrial dysfunction is a key contributor to ageing and related diseases. The decline in the quality and quantity of healthy mitochondria with ageing disrupts energy...
Development and ex vivo / in vitro evaluation of sodium alginate/ hydroxypropyl methylcellulose films for dermal and/or transdermal delivery of p-hydroxycinnamic acid
June 2025
Skin diseases and chronic wounds are health problems that require solutions for health systems due to their high costs and difficulties in effective and rapid treatment. Hydroxycinnamic acid and its...
Research advances in the role of selenium in reversing tumor multidrug resistance
June 2025
Multidrug resistance (MDR) is a significant challenge in the cancer therapy, with mechanisms primarily involving increased drug efflux mediated by ABC transporters, leading to reduced intracellular...
The ameliorative effects of honeysuckle extract and its major component luteolin on autism-like behaviors in the NDE1 deficiency model
June 2025
To evaluate the effects of honeysuckle extract and its active component, luteolin, on the autistic-like behaviors and neuroinflammatory responses in NDE1-deficient autism spectrum disorder (ASD) zebrafish...
Patient-derived organoids: Advancing research on bioactive natural compounds in lung cancer
June 2025
Lung cancer, the leading cause of cancer-related deaths, demands innovative models for therapy development. Bioactive natural compounds, with their structural diversity and historical therapeutic significance,...
A scoping review of five selected underutilized medicinal plants of Sri Lanka: Focusing on ethnobotany, phytochemistry and bioactivities, and evaluation of their potential for novel herbal product development
June 2025
Ageratum conyzoides L., Artocarpus gomezianus Wall. ex Trécul, Euphorbia hirta L., Plectranthus zeylanicus Benth., and Piper sarmentosum Roxb. have long been utilized in traditional medical practices,...
Screening of potential markers for vitiligo based on bioinformatics and LASSO regression and prediction of Chinese medicine
June 2025
This study aimed to use bioinformatics techniques to screen biomarkers related to vitiligo....
Integrating metabolism gene clusters and tumor immune microenvironment in head and neck squamous cell carcinoma
June 2025
To investigate the relationship between tumor metabolism and immune cell infiltration in Head and Neck Squamous Cell Carcinoma (HNSCC), aiming to identify novel biomarkers and potential therapeutic...
Global Initiative for Glycolipid Metabolic Health
June 2025
Glycolipid metabolic disorders, linked to cardiovascular diseases and cancer, are a major global health challenge. Current single-disease treatments remain unsatisfied in reducing long-term risks....
Development of ginger oleoresin-enriched marshmallow candy as a nutraceutical for managing pediatric chemotherapy-induced nausea and vomiting
March 2025
Chemotherapy-induced nausea and vomiting (CINV) significantly impact pediatric cancer patients, affecting treatment adherence and quality of life. This study aimed to develop gingerol-enriched marshmallow...