Therapeutic approaches to dyslipidaemia in Unani medicine: a narrative review
March 2026
Dyslipidaemia is one of the most common metabolic disorders, strongly linked with cardiovascular disease, obesity, and other components of metabolic syndrome. In Unani medicine, this condition is understood...
From traditional herb to modern therapeutics: phytochemistry, pharmacology, toxicology, and clinical translation challenges of Cyperus rotundus L
March 2026
Cyperus rotundus L. (C. rotundus.), widely distributed in tropical and temperate regions, is a perennial herb with a long history of application in traditional medical systems for treating emotional...
Nimbolide as a multi-targeted phytochemical against prostate cancer therapy: Current evidence and future directions
March 2026
Prostate cancer remains one of the leading causes of cancer-related morbidity and mortality among men worldwide. Despite considerable progress in early detection and androgen receptor-targeted therapies,...
Mechanistic insights into the preventive efficacy of 21-day prefeeding with β-galactosidase hydrolyzed milk in DSS-induced ulcerative colitis mice
March 2026
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited preventive strategies. Here, we investigated the 21-day preventive effects of β-galactosidase hydrolyzed milk (Milk β-gal)...
Design and optimization of polyherbal tablets for anti-inflammatory therapy: A design of experiment approach with in vitro and in vivo evaluation
March 2026
To develop and optimize polyherbal tablets containing Terminalia chebula, Moringa oleifera, and Ocimum sanctum as a multi-targeted therapeutic approach for the management of chronic inflammatory di...
Study on the potential medical beauty efficacy screening of acetyl hexapeptide-8 and the mechanism of regulating collagen regeneration
March 2026
Acetyl hexapeptide-8 (AH-8) is a synthetic polypeptide that can promote collagen regeneration; however, the underlying mechanism of this promoting effect and other potential medical beauty efficacy...
Shugan Paidu Decoction promotes cuproptosis of hepatoma cells by downregulating STAT3 levels
March 2026
Shugan Paidu Decoction (SGPDT) is a traditional Chinese medicine (TCM) formula clinically used to treat Wilson's disease. Through network pharmacology analysis, we predicted that SGPDT might also be...
Gut–brain axis in neurological disorders: mechanistic links and regulatory role of Chinese herbal medicines
March 2026
The gut–brain axis (GBA) is a bidirectional communication network integrating neural, immune, endocrine, and metabolic pathways that link the gastrointestinal tract and the central nervous system. Increasing...
Exploring synergistic effects of bioactive compounds and pharmaceuticals in therapeutic applications
March 2026
Synergy arises when the combined effect of multiple agents exceeds the sum of their individual activities. Pharmacological and bioactive chemical synergy offers a promising approach to enhance therapeutic...
Autophagy in neuropathic pain: Cell specificity, molecular mechanisms, and therapeutic prospects
March 2026
Neuropathic pain (NP) is a chronic pain caused by damage or disease of the somatosensory system, with a global prevalence of 6.9%–10%. Due to the limited efficacy of current clinical treatments, there...
Traditional uses, chemical composition and pharmacological properties of genus Crotalaria
March 2026
The plants of genus Crotalaria are widely employed in traditional folk medicine to address various ailments. Extracts from these plants have been reported to exhibit diverse pharmacological properties,...
Harnessing the bioactive phytocompounds and drug discovery potential of hydrophytes: A review
March 2026
Water-based ecosystems have provided an ideal condition for unique and diverse group of aquatic plants to evolve with a wide range of adaptations known as hydrophytes. Such ecological niches have made...
Antidiabetic activity of bioactive fractions from Momordica cymbalaria Fenzl ex Naudin leaves: In vitro, in silico and in vivo evaluation
March 2026
This study evaluated the antidiabetic activity of Momordica cymbalaria Fenzl ex Naudin (MC) leaf fractions, a traditionally used remedy in southern India, through comprehensive in vitro, in silico,...
Influence of extraction techniques and solvent polarity on phytochemical yield: A comprehensive analytical study of Malvastrum coromandelianum (L.) Garcke
March 2026
Malvastrum coromandelianum (L.) Garcke, (Family: Malvaceae) is traditionally valued for its therapeutic properties. This study aimed to evaluate the phytochemical composition and bioactivities of different...
Bibliometric analysis of research on plant exosomes/extracellular vesicles: current status, hotspots, and trends
March 2026
This study performed a comprehensive bibliometric analysis on 1373 valid publications of plant exosomes/extracellular vesicles from 2010 to 2026, retrieved from CNKI, WoSCC and PubMed and screened manually....
Synthesis of a novel C46 ceramide and its skin barrier repair effect verified by molecular dynamics and cellular assays
March 2026
Ceramides play a critical role in skin barrier function. Here, we synthesized a novel long-chain ceramide, C46 EOP, via a sustainable catalyst-free route and elucidated its molecular mechanisms and...
Recent advances in artificial intelligence for melanoma: A review of history, models, datasets, applications, and ethical and legal considerations
March 2026
Melanoma is one of the most lethal and aggressive forms of skin cancer, often presenting as evolving pigmented lesions. This review aims to examine melanoma from a holistic perspective by evaluating...
Machine learning models for predicting pharmacokinetics and pharmacodynamics: A step toward personalized dosing
March 2026
Machine learning (ML) has become increasingly integrated within pharmacokinetics (PK) and pharmacodynamics (PD) modeling in recent years, and represents a new paradigm in precision medicine, enabling...
Banxia Shumi decoction targets ribosome biogenesis to alleviate insomnia
December 2025
This study aims to investigate the novel mechanism by which Banxia Shumi Decoction (BXSM) alleviates insomnia through the regulation of ribosome biogenesis (Ribosis)....
Integrating pharmacokinetics and network pharmacology to reveal mechanism of Shuangxia decoction in the treatment of insomnia
December 2025
Shuangxia Decoction is a traditional Chinese medicine classic formula used clinically to treat insomnia, consisting of Pinellia ternata (Banxia) and Prunella vulgaris (Xiakucao). The aim of this study...
Study on extraction technology and antioxidant activity of "Sibai" extracts based on orthogonal design and Caenorhabditiselegans
December 2025
This study examined the antioxidant, whitening, anti-aging, and safety properties of "Sibai" extract obtained from Bombyx Batryticatus, Ampelopsis japonica, Radix Paeoniae Alba, and Atractylodes ma...
Polysaccharides from Anemarrhena asphodeloides Bge. improve glucose and lipid metabolism in diabetic rats via the PPAR-γ/NF-κB pathway
December 2025
We aim to investigate the therapeutic effects of polysaccharides from Anemarrhena asphodeloides Bge. (DT) on glucose and lipid metabolism in type 2 diabetic (T2DM) rats and explore its underlying mechanisms,...
A review on the extraction, separation, purification, detection of flavonoids from aging Citri Reticulatae Pericarpium and its beneficial effects on spleen deficiency
December 2025
Citri Reticulatae Pericarpium (CRP) plays beneficial effects on regulating Qi and strengthening spleen, drying dampness, and resolving phlegm in traditional Chinese medicine. This review centered on...
The impact of solvent composition, concentration, and temperature on the solubility of naproxen: A review of mono-solvent, binary, and ternary systems
December 2025
Solubility is a key factor affecting drug absorption and therapeutic effectiveness. Naproxen, a common anti-inflammatory medication, has poor water solubility, which limits its bioavailability. This...
Research progress on the application of Pleuropterus multiflorus in the treatment of androgenetic alopecia
December 2025
Androgenetic alopecia (AGA) is the most common form of hair loss, affecting approximately 21.3% of men and 6% of women in China, with an increasing trend among younger individuals. Currently, finasteride...