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ISSN: 2707-3688
e-ISSN: 2950-175X

Phytochemical profiles, biological activities and medicinal importance of Aloe vera L.: A review

Aloe vera (Av) is revered in Ayurveda as the "wand of heaven" or "heaven's blessing" and precisely the "silent healer". This herbaceous plant belongs to Asphodelaceae family, previously classified as...

Integrative network pharmacology and transcriptomics suggest the mechanism of Buyang Huanwu Decoction in attenuating vascular aging via AMPK signaling pathway

Vascular aging is a critical factor in cardiovascular diseases. Buyang Huanwu Decoction (BYHWD), a traditional Chinese medicine, shows potential in delaying vascular aging, yet its mechanisms remain...

Holistic insights of 6D printing in healthcare

Additive manufacturing has recently demonstrated significant progress in healthcare. Six-dimensional (6D) printing is an emerging field that holds great promise through the rapid, layer-by-layer creation...

Mendelian randomization analysis establishes a causal relationship between COVID-19 and cardiometabolic diseases

The causal impacts of COVID-19 on cardiometabolic diseases remained uncertain. This study utilized the two-sample Mendelian randomization (MR) method to evaluate causal relationships between COVID-19...

An integrative framework for precision medication in hypertension: Applying a dialectical perspective to traditional Chinese and Western medicine

Hypertension is the most common cardiovascular disease. In terms of diagnosis and treatment, Traditional Chinese Medicine (TCM) and Western medicine each have their own strengths, but also have certain...

Review on clinical diagnosis, pathogenesis and therapeutic strategies of drug-induced liver injury

Drug-induced liver injury (DILI) is a severe adverse reaction caused by various drugs and their metabolites, with complex clinical manifestations, and severe cases may progress to acute liver failure...

Potential small-molecule compounds and targets for Alzheimer's disease: Integrating bioinformatics analysis and in vitro verification

Alzheimer's disease (AD) is a common neurodegenerative disorder characterized by progressive memory decline and cognitive dysfunction. The specific pathogenesis of AD remains unclear. This study aimed...

Optimization, characterization, hypoglycemic and antioxidant activity studies of ultrasonic-assisted deep eutectic solvent extraction of polysaccharides from Perilla frutescens

In order to further develop and utilise Perilla frutescens polysaccharides, the aim of this study was to optimize process conditions for the extraction of Perilla frutescens polysaccharides with deep...

An assessment of antidepressant like potentiality of Phyllanthus emblica on experimental rodent model of depressive disorder under the light of numerous behavioural test batteries

The unfavorable costs and effects of currently accessible antidepressant agents necessitate the development of more potent and safe alternatives, that will obviate the potential problems associated...

The transformative power of artificial intelligence in pharmaceutical manufacturing: Enhancing efficiency, product quality, and safety

The pharmaceutical manufacturing industry transforms through artificial intelligence (AI) by implementing process improvements along with productivity enhancements and product quality improvements....

Therapeutic effects of raw rhubarb on gastrointestinal complications in ischemic stroke: An integrated analysis of gut microbiota, metabolomics, and network pharmacology

Gastrointestinal complications (GITC) are a major cause of increased morbidity and mortality in stroke patients, significantly impairing recovery by triggering systemic inflammation and hindering brain...

Baicalin induces apoptosis and autophagy in resistant human hepatocellular carcinoma cell line Bel-7402/5-FU cells via PI3K/AKT pathway

Multidrug resistance (MDR) is one main cause of chemotherapy failure. Baicalin is an important active ingredient with anticancer potential in many Chinese herbal medicines. In order to understand the...

Mitochondrial function maintenance and mitochondrial training in ageing and related diseases

Cellular senescence driven by mitochondrial dysfunction is a key contributor to ageing and related diseases. The decline in the quality and quantity of healthy mitochondria with ageing disrupts energy...

Development and ex vivo / in vitro evaluation of sodium alginate/ hydroxypropyl methylcellulose films for dermal and/or transdermal delivery of p-hydroxycinnamic acid

Skin diseases and chronic wounds are health problems that require solutions for health systems due to their high costs and difficulties in effective and rapid treatment. Hydroxycinnamic acid and its...

Research advances in the role of selenium in reversing tumor multidrug resistance

Multidrug resistance (MDR) is a significant challenge in the cancer therapy, with mechanisms primarily involving increased drug efflux mediated by ABC transporters, leading to reduced intracellular...

The ameliorative effects of honeysuckle extract and its major component luteolin on autism-like behaviors in the NDE1 deficiency model

To evaluate the effects of honeysuckle extract and its active component, luteolin, on the autistic-like behaviors and neuroinflammatory responses in NDE1-deficient autism spectrum disorder (ASD) zebrafish...

Patient-derived organoids: Advancing research on bioactive natural compounds in lung cancer

Lung cancer, the leading cause of cancer-related deaths, demands innovative models for therapy development. Bioactive natural compounds, with their structural diversity and historical therapeutic significance,...

A scoping review of five selected underutilized medicinal plants of Sri Lanka: Focusing on ethnobotany, phytochemistry and bioactivities, and evaluation of their potential for novel herbal product development

Ageratum conyzoides L., Artocarpus gomezianus Wall. ex Trécul, Euphorbia hirta L., Plectranthus zeylanicus Benth., and Piper sarmentosum Roxb. have long been utilized in traditional medical practices,...

Screening of potential markers for vitiligo based on bioinformatics and LASSO regression and prediction of Chinese medicine

This study aimed to use bioinformatics techniques to screen biomarkers related to vitiligo....

Integrating metabolism gene clusters and tumor immune microenvironment in head and neck squamous cell carcinoma

To investigate the relationship between tumor metabolism and immune cell infiltration in Head and Neck Squamous Cell Carcinoma (HNSCC), aiming to identify novel biomarkers and potential therapeutic...

Global Initiative for Glycolipid Metabolic Health

Glycolipid metabolic disorders, linked to cardiovascular diseases and cancer, are a major global health challenge. Current single-disease treatments remain ​unsatisfied in reducing long-term risks....

Development of ginger oleoresin-enriched marshmallow candy as a nutraceutical for managing pediatric chemotherapy-induced nausea and vomiting

Chemotherapy-induced nausea and vomiting (CINV) significantly impact pediatric cancer patients, affecting treatment adherence and quality of life. This study aimed to develop gingerol-enriched marshmallow...

The repair effect of α-ketoglutarate combined with mesenchymal stem cells on osteoarthritis via the hedgehog protein pathway

Mesenchymal stem cell (MSC) therapy represents a promising treatment strategy for osteoarthritis (OA). Nevertheless, the therapeutic efficacy of MSCs may be attenuated under conditions of cellular senescence...

Unravelling the gut-liver axis: The role of gut microbiota-mitochondria interactions in the pathogenesis and management of metabolic-associated fatty liver disease (MAFLD)

Metabolic-associated fatty liver disease (MAFLD) has emerged as a prevalent chronic liver disease. Our review of the existing literature reveals that the interplay between gut microbiota, mitochondria,...

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