Role of TFEB and TFE3 in mediating lysosomal and mitochondrial adaptations to contractile activity in skeletal muscle myotubes
2023
Exercise is potent stimulus for mitochondrial adaptations, serving to activate mitochondrial biogenesis as well as mitochondrial turnover. Through the process of mitophagy, dysfunctional mitochondria...
A brief introduction to the history of mitochondrial research in Japan
2023
The Japanese Society for Mitochondrial Research and Medicine (J-mit) has a 21-year history in 2022, with its predecessor society holding its first meeting in 2001. During this time, the society, which...
OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation
2023
Optic Atrophy 1 (OPA1), a mitochondrial inner protein, is involved in both mitochondrial fusion dynamic and cell apoptosis. OPA1 Exon4b (OPA1-Exon4b) was reported to be downregulated in hepatocellular...
The metabolism and function of phospholipids in Mitochondria
2023
Mitochondria are important organelles of eukaryotic cells and involved in a variety of cellular processes including oxidative phosphorylation for generating ATP, apoptosis, steroid synthesis, and signal...
Structure-destabilizing mutations unleash an intrinsic perforation activity of antiapoptotic Bcl-2 in the mitochondrial membrane enabling apoptotic cell death
2023
Bcl-2 and Bax share a similar structural fold in solution, yet function oppositely in the mitochondrial outer membrane (MOM) during apoptosis. The proapoptotic Bax forms pores in the MOM to trigger...
TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria
2023
The transmembrane-electrostatically localized protons (TELP) theory may represent a complementary development to Mitchell's chemiosmotic theory. The combination of the two together can now excellently...
Correcting abnormal mitochondrial dynamics to facilitate tumor treatment
2023
Mitochondrial dynamics are closely related to various cellular physiological activities, including cell proliferation, homeostasis, and cell migration, and are regulated by a variety of enzymes, proteins...
