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OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation
2023
Optic Atrophy 1 (OPA1), a mitochondrial inner protein, is involved in both mitochondrial fusion dynamic and cell apoptosis. OPA1 Exon4b (OPA1-Exon4b) was reported to be downregulated in hepatocellular...
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The metabolism and function of phospholipids in Mitochondria
2023
Mitochondria are important organelles of eukaryotic cells and involved in a variety of cellular processes including oxidative phosphorylation for generating ATP, apoptosis, steroid synthesis, and signal...
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A brief introduction to the history of mitochondrial research in Japan
2023
The Japanese Society for Mitochondrial Research and Medicine (J-mit) has a 21-year history in 2022, with its predecessor society holding its first meeting in 2001. During this time, the society, which...
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Correcting abnormal mitochondrial dynamics to facilitate tumor treatment
2023
Mitochondrial dynamics are closely related to various cellular physiological activities, including cell proliferation, homeostasis, and cell migration, and are regulated by a variety of enzymes, proteins...
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Structure-destabilizing mutations unleash an intrinsic perforation activity of antiapoptotic Bcl-2 in the mitochondrial membrane enabling apoptotic cell death
2023
Bcl-2 and Bax share a similar structural fold in solution, yet function oppositely in the mitochondrial outer membrane (MOM) during apoptosis. The proapoptotic Bax forms pores in the MOM to trigger...
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