Structural determinants of mitochondrial STAT3 targeting and function
2024
Signal transducer and activator of transcription (STAT) 3 has been found within mitochondria in addition to its canonical role of shuttling between cytoplasm and nucleus during cytokine signaling. Mitochondrial...
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Mitochondrial calcium transport during autophagy initiation
2024
While it has been shown that Ca2+ dynamics at the ER membrane is essential for the initiation of certain types of autophagy such as starvation-induced autophagy, how mitochondrial Ca2+ transport changes...
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Photobleaching and phototoxicity of mitochondria in live cell fluorescent super-resolution microscopy
2024
Photobleaching and phototoxicity can induce detrimental effects on cell viability and compromise the integrity of collected data, particularly in studies utilizing super-resolution microscopes. Given...
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Antioxidants targeting mitochondria function in kidney diseases
2024
Kidney diseases are a growing health problem worldwide, causing millions of deaths. Acute kidney injury (AKI) commonly evolves into chronic kidney disease (CKD) and fibrosis, which is a feature of CKD...
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OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation
2023
Optic Atrophy 1 (OPA1), a mitochondrial inner protein, is involved in both mitochondrial fusion dynamic and cell apoptosis. OPA1 Exon4b (OPA1-Exon4b) was reported to be downregulated in hepatocellular...
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The metabolism and function of phospholipids in Mitochondria
2023
Mitochondria are important organelles of eukaryotic cells and involved in a variety of cellular processes including oxidative phosphorylation for generating ATP, apoptosis, steroid synthesis, and signal...
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A brief introduction to the history of mitochondrial research in Japan
2023
The Japanese Society for Mitochondrial Research and Medicine (J-mit) has a 21-year history in 2022, with its predecessor society holding its first meeting in 2001. During this time, the society, which...
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Correcting abnormal mitochondrial dynamics to facilitate tumor treatment
2023
Mitochondrial dynamics are closely related to various cellular physiological activities, including cell proliferation, homeostasis, and cell migration, and are regulated by a variety of enzymes, proteins...
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Structure-destabilizing mutations unleash an intrinsic perforation activity of antiapoptotic Bcl-2 in the mitochondrial membrane enabling apoptotic cell death
2023
Bcl-2 and Bax share a similar structural fold in solution, yet function oppositely in the mitochondrial outer membrane (MOM) during apoptosis. The proapoptotic Bax forms pores in the MOM to trigger...
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TELP theory: Elucidating the major observations of Rieger et al. 2021 in mitochondria
2023
The transmembrane-electrostatically localized protons (TELP) theory may represent a complementary development to Mitchell's chemiosmotic theory. The combination of the two together can now excellently...
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Role of TFEB and TFE3 in mediating lysosomal and mitochondrial adaptations to contractile activity in skeletal muscle myotubes
2023
Exercise is potent stimulus for mitochondrial adaptations, serving to activate mitochondrial biogenesis as well as mitochondrial turnover. Through the process of mitophagy, dysfunctional mitochondria...
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