The role of fusion proteins as biomarkers and therapeutic agents for Alzheimer's disease: A narrative review
June 2025
Alzheimer's disease (AD) is the most common neurodegenerative disorder characterized by the accumulation of misfolded amyloid-beta and tau proteins in the brain, which causes memory and cognitive functions...
Identification of novel biomarkers and immune characteristics of spinal cord injury based on comprehensive bioinformatic analysis: A retrospective observational study
June 2025
The exact mechanisms underlying spinal cord injury are not fully understood, and effective treatments are scarce. Therefore, there is an urgent need to identify novel biomarkers that can guide therapy...
Blood biomarkers for clinical applications in Alzheimer's disease: A narrative review
June 2025
Alzheimer's disease is a prevalent neurodegenerative disorder that imposes a significant burden on both patients and society. Currently, the primary methods for diagnosing Alzheimer’s disease include...
Role of the amygdala and possible biomarkers in psychiatric disorders
March 2025
In the early 1800s, the "cerebral amygdala" was described as an almond-shaped structure within the temporal lobe. A century later, the role of amygdala in modulating behavior became evident, specifically...
Artificial intelligence-driven radiological biomarkers: A narrative review of artificial intelligence in meningioma diagnosis
March 2025
Meningiomas, the most common primary intracranial tumors, present unique challenges in diagnosis and management due to their diverse behaviors and potential for recurrence. Recent advances in artificial...
Peroxisome proliferator-activated receptors as biomarkers in cerebrovascular diseases: A narrative review
March 2025
Cerebrovascular disease, a critical global health challenge, profoundly affects the quality and longevity of human life due to its alarmingly high incidence, disability, mortality, recurrence rate,...
The role of machine learning in discovering biomarkers and predicting treatment strategies for neurodegenerative diseases: A narrative review
March 2025
Machine learning in the field of computational intelligence continues to increase significantly and shows potential in the identification, management, treatment, and monitoring of complex diseases,...
Identifying Alzheimer's disease-associated genes related to N6-methyladenosine modification as potential biomarkers through correlation analysis: A retrospective observational study
March 2025
Alzheimer's disease is a prevalent neurodegenerative disorder characterized by cognitive deficits and abnormal neurological activity. Recent evidence suggests that the pathogenesis of Alzheimer's disease...
Glial fibrillary acidic protein as a biomarker for diagnosis of Alzheimer’s disease in cerebrospinal fluid, plasma and saliva measured with Lumipulse technology: a narrative review
March 2025
Glial fibrillary acidic protein is an intermediate filament protein released primarily by astrocytes in the central nervous system, providing structural and functional support to neurons. Glial fibrillary...
Misdiagnoses of psychiatric disorders and the utility of diagnostic microRNA biomarkers
September 2024
Due to overlapping symptoms and similarities with other illnesses, misdiagnosis and inappropriate treatment of psychiatric disorders frequently occur. Objective laboratory-based biomarkers that can...
MicroRNAs as potential biomarkers for diagnosis of major depressive disorder and influence of antidepressant treatment
September 2024
We performed a PubMed search for microRNA biomarkers in major depressive disorder (MDD) and found 25 original research articles on studies performed with human patients and published January 2019 to...
Pathophysiology and markers of very early classic Guillain-Barré syndrome
September 2024
Guillain-Barré syndrome is a rare neurological disorder characterized by the body's immune system mistakenly attacking the peripheral nerves. This condition often follows an infection and can lead to...
BCL2 interacting protein 3 as a potential biomarker for Alzheimer’s disease: an observational study
September 2024
As important organelles for energy production, mitochondria exhibit dysfunction as an early hallmark of Alzheimer’s disease, potentially leading to cell death and impaired brain function. The mitophagy...
Peering into the nervous system
September 2024