Liquid-liquid phase separation: Fundamental physical principles, biological implications, and applications in supramolecular materials engineering
December 2023
Liquid-liquid phase separation (LLPS) is a captivating phenomenon in which a uniform mixture spontaneously divides into two liquid phases with differing component concentrations. It is prevalent in...
Anti-aging and anti-inflammatory fulfilled through the delivery of supramolecular bakuchiol in ionic liquid
December 2025
Bakuchiol, as a derivative of retinol, has attracted attention due to its strong anti-aging ability on the skin. However, how to solve its irritability and low permeability is a challenge in the field...
Zwitterionic hydrogels from material design to wound dressing applications
December 2025
Zwitterionic hydrogels, synthesized from zwitterions such as sulfobetaine, carboxybetaine, and phosphorylcholine, feature a balanced mix of positive and negative charges within the same polymer chains....
Light-triggered one-pot synthesis of covalent-supramolecular double network elastomer
December 2026
The double-network (DN) structure is an important strategy for toughening elastomers. Developing efficient preparation methods for DN elastomers remains a key challenge in this field. Herein, we developed...
Stimuli-responsive protein hydrogels: From dynamic tuning of hydrogel mechanics to shape morphing
December 2025
Protein hydrogels represent a rapidly evolving class of biomaterials with significant potential in biomedicine, soft robotics, and tissue engineering. These hydrogels are uniquely engineered from natural...
Self-healing hydrogels based on reversible noncovalent and dynamic covalent interactions: A short review
December 2023
The self-healing capability of a material refers to its ability to autonomously heal fractures or defects and restore its original structures and functionalities. Self-healing hydrogels, with enhanced...
Tyrosinase inhibitors as melanoma sensitizers: Boosting therapeutic efficacy
December 2025
Melanoma therapy faces critical challenges due to melanin-mediated resistance mechanisms. The use of tyrosinase inhibitors to suppress tyrosinase activity and reduce melanogenesis, thereby sensitizing...
Supramolecular engineering of luminescent materials: From molecular design to optoelectronic applications
December 2026
Luminescent materials often face trade-offs between efficiency, stability, and dynamic responsiveness, which limit their performance in advanced optoelectronic devices and bioimaging. Supramolecular...
Self-Assembly of Short Peptides and DNA-Based Materials in Precision Biomedical Applications
Available online 13 November 2025
The spontaneous assembly of molecular components into highly organised and functional nanostructures through non-covalent interactions constitutes a defining aspect of advanced biomaterials design....
Dynamic covalent bond-based materials: From construction to biomedical applications
December 2024
Dynamic covalent bonds (DCBs) have received significant interest due to their unique reversibility and stimuli-responsiveness. The introduction of DCBs provides materials with self-healing and controllable...
3D-Printed metal organic frameworks-based supramolecular hydrogel as biological materials
December 2025
•The gap in the review of 3D-printed MOF-based supramolecular hydrogels was presented.•An overview of 3D-Printing techniques for MOFs-based supramolecular hydrogels was highlighted.•The challenges and...
Recent advances of supramolecular systems in precise cancer theranostics
December 2025
Cancer remains a leading cause of death globally, with traditional treatments like surgery, chemotherapy, and radiotherapy often causing severe side effects and facing challenges due to tumor heterogeneity...
Piezoelectric-triboelectric hybrid nanogenerator based on tough, stretchable BaTiO3 doped antibacterial hydrogel for self-powered sensors
December 2025
•A robust and stretchable BaTiO3-doped hydrogel was obtained through arationalpreparation strategy.•The obtainedhydrogel was utilized as electrode material for constructing high-performance piezoelectric-triboelectric...
Fundamental and Application of Co-assembly of Peptides and Proteins: Experiment and Computation
December 2025
Peptides and proteins can co-assemble into various nanostructures based on complementary non-covalent interactions such as electrostatic forces, hydrogen bonding, and hydrophobic associations. These...
Polyrotaxanes in motion: recent advances in slide-ring supramolecular polymers
December 2026
Polyrotaxanes (PRs) are mechanically interlocked supramolecular systems with the ring components threading linear axle component. When two rings are connected with a covalent linker and incorporating...
Biodegradable power sources for transient bioelectronics
December 2025
The development of biodegradable power sources has opened new avenues for transient bioelectronics, offering temporary energy solutions for implantable medical devices. This review presents a systematic...
Recent advances in chirality sensing/recognition using supramolecular macrocycles
December 2025
Chiral sensing is crucial for understanding and controlling the biological activity of chiral molecule such as carbohydrates, amino acids, and proteins. It also plays a vital role in asymmetric synthesis,...
Revolutionizing supramolecular materials design with artificial intelligence
December 2025
The design and development of supramolecular materials are hindered by complex non-covalent interactions and a lack of comprehensive rational design theories. Traditional "trial-and-error" methods are...
Perylene diimide supramolecular aggregates: Constructions and sensing applications
December 2023
Perylene diimides (PDIs) with high fluorescence quantum yield and well π-conjugated plane have been widely studied to construct supramolecular aggregates via noncovalent interactions and to further...
Hydrogen-bonded supramolecular adhesives: Synthesis, responsiveness, and application
December 2023
Adhesive bonding to diverse substances is vital to a great number of the established, cutting-edge and emerging applications. We have witnessed, in the last few years, the transformative progress in...
Supramolecular self-assembly in solid-state lithium batteries: Bulk electrolyte design and interface engineering
December 2025
The development of solid-state lithium batteries (SSLBs) is pivotal to addressing the escalating global demand for advanced electrochemical energy storage systems, driven notably by electric vehicles...
Exploring water−macromolecule interactions at the single-molecule level: A comprehensive review
December 2024
Water is ubiquitous and indispensable on the Earth. Its importance has long been recognized on a macroscopic scale. However, it took a long time to comprehend the impact of water molecules on the microscopic...
Responsive to adaptive supramolecular hydrogels for diabetic wound treatment
December 2025
Wound healing is a dynamic process involving four phases such as hemostasis, inflammation, proliferation, and remodeling of tissue at the wound site. Diabetes patients are more susceptible to the development...
Advancements in active filler-contained polymer solid-state electrolytes for lithium-metal batteries: A concise review
December 2025
Lithium-metal batteries (LMBs) usually are regarded as the pinnacle of next-generation energy storage due to the high specific capacity and low redox potential of the Li-metal anode. However, their...
Mechanically Interlocked Biomacromolecules
December 2024
Mechanical interlocking is a prominent phenomenon both in macroscopic objects and in microscopic molecules. Not only is it aesthetically appealing, it also leads to unique properties such as extraordinary...
