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ISSN: 2667-2405

Exploring the role of British dementia protein-2 (Bri2) and its BRICHOS domain in neurodegenerative disorders

Protein functionality hinges on precise three-dimensional structures, while molecular chaperones orchestrate folding, proteome maintenance, and proteostasis. Recent attention has focused on BRICHOS...

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The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain

Cells contain numerous membrane-less (MLOs) and multiple membrane-bound organelles. Most of the MLOs have a spherical shape except for a few organelles (that have a filamentous appearance, e.g. FXR1...

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Mechanically Interlocked Biomacromolecules

Mechanical interlocking is a prominent phenomenon both in macroscopic objects and in microscopic molecules. Not only is it aesthetically appealing, it also leads to unique properties such as extraordinary...

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Exploring water−macromolecule interactions at the single-molecule level: A comprehensive review

Water is ubiquitous and indispensable on the Earth. Its importance has long been recognized on a macroscopic scale. However, it took a long time to comprehend the impact of water molecules on the microscopic...

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Fabrication of the polyetherketoneketone-reinforced nano-hydroxyapatite composites as inspired by the cortical bone

•The cortical bone-inspired composites were produced successfully by 20 vol% poly-dopamine (pDA)-nano hydroxyapatite (nHA) and 2 wt% PVA/PEKK.•pDA modified nano hydroxyapatite (nHA) slurries can fabricate...

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Supramolecular co-assembled hybrid hydrogels for antibacterial therapy

Bacterial infections arising from antibiotic-resistant strains represent a formidable global health threat. In the realm of antibacterial therapies, supramolecular hydrogels stand out with unique advantages...

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Supramolecular fluorescence biosensing based on macrocycles

Fluorescence sensing converts chemical events into measurable readings by utilizing fluorescence signals for the qualitative or quantitative detection of specific analytes. Supramolecular chemistry,...

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A visualizable strategy to real-time monitor chiral block copolypeptide assembly by AIE fluorescent probes

Aggregation-induced emission (AIE) luminogens show great potential in many applications. In this study, we have synthesized diblock copolymers poly (ethylene glycol) -b-poly (9-anthrylmethyl-L-lysine)...

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A self-cascade terpolymer platform for amplified chemo-chemodynamic therapy with synergistic immunogenic cell death enhancement

Chemodynamic therapy, which relies on the generation of cytotoxic radicals, can be amplified by a nanoplatform that produces hydroxyl radicals while also compromising natural radical scavenging mechanisms....

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Temperature-Responsive Self-Assembly Nanochaperone Protects Green Fluorescent Proteins from Thermal Denaturation

Protein products perform important roles in the biochemistry field, but the thermal inactivation of proteins will increase the difficulty of their transport, storage and application. Therefore, improving...

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Hydrogen-bonding induced assembly of polymer-grafted nanoparticles towards photothermal antibacterial activities

•Hydrogen-bonding interactions induce the self-assembly of polymer-grafted nanoparticles (PGNPs) in a good solvent.•The PGNP assemblies with controllable size can be obtained by regulating the concentration...

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Dynamic covalent bond-based materials: From construction to biomedical applications

Dynamic covalent bonds (DCBs) have received significant interest due to their unique reversibility and stimuli-responsiveness. The introduction of DCBs provides materials with self-healing and controllable...

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Stretchable and self-healable lithium-ion batteries with all-in-one configuration

•The LIB exhibits both stretchability and self-healability.•The electrolyte and electrodes form fused interfaces by the exchange of imine bond.•The LIB can supply power upon stretch or after being cut...

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Phosphatidylserine-targeting bis(zinc-dipicolylamine) farnesol inhibits ATP production in cancer cells to overcome multidrug resistance

Multidrug resistance significantly impedes the efficacy of cancer chemotherapy. Resistance often arises from the reduced cellular uptake of chemotherapeutic drugs, a process crucial for their cytotoxic...

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Versatile preparation of jellyfish-inspired color transition hydrogels via polymerization induced supramolecular geletion (PISG)

Supramolecular hydrogels based on host–guest interactions constitute a class of intriguing soft matter and have attracted great attention due to their unique properties, etc. In this study, we successfully...

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Exploring chemical space and structural diversity of supramolecular peptide materials

Searching chemical space and expanding the structural diversity of supramolecular self-assembly based on the development of combinatorial libraries is significant to the guided design of bio-inspired...

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Perylene diimide supramolecular aggregates: Constructions and sensing applications

Perylene diimides (PDIs) with high fluorescence quantum yield and well π-conjugated plane have been widely studied to construct supramolecular aggregates via noncovalent interactions and to further...

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Hydrogen-bonded supramolecular adhesives: Synthesis, responsiveness, and application

Adhesive bonding to diverse substances is vital to a great number of the established, cutting-edge and emerging applications. We have witnessed, in the last few years, the transformative progress in...

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In situ supramolecular self-assembly for alleviating multidrug resistance in cancer

Drug resistance is one of the major causes of cancer treatment failures. In recent years, to combat the issue of drug resistance, a large volume of strategies has been established along the development...

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Block copolymer particles with tunable and robust internal nanostructures by combining hydrogen-bonding and crosslinking

Nanostructured block copolymer (BCP) particles are attractive due to their ordered internal structures, unique shape and surface patterns; however, their structural integrity can be easily lost because...

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Hydrazide–pillar[5]arene-mediated silver nanoparticles for highly efficient reductive degradation of organic dyes

•Supramolecular method for organic dyes degradation.•Synthetic macrocycles assist in the preparation of AgNPs.•Hybrid material for efficient catalysis....

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Self-powered assemblies for tissue engineering applications

•It systematically summarizes the basic physical rules underlining electric field generations and provide a practical guide for the designing of electrically active supramolecular assemblies.•The general...

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An injectable macroporous hydrogel templated by gasification reaction for enhanced tissue regeneration

Owing to excellent biocompatibility, tunable modulus to match biological tissues, full of water environment, and wide range of constituents, injectable hydrogels have always been preferred as superior...

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Exploring computational tools for improved structural design and stability of helical AApeptides

Peptidomimetics have garnered increased attention due to their unique structural properties and self-assembly, as well as their promising applications in material sciences and peptidomimetic drug design....

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Investigation of differences in the protein transport capability of homochiral nanochannels

•DP modified membrane has a higher affinity for BSA than LP modified membrane.•Chiral nanochannel separates proteins based on H-bond differences.•Nanochannel membrane can be served as a nanoscaled chiral...

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