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ISSN: 2667-2405

Exploring the role of British dementia protein-2 (Bri2) and its BRICHOS domain in neurodegenerative disorders

Protein functionality hinges on precise three-dimensional structures, while molecular chaperones orchestrate folding, proteome maintenance, and proteostasis. Recent attention has focused on BRICHOS...

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The role of filamentous membraneless organelle in 3UTR-mediated Protein-Protein interfaces and localization: TIGER Domain

Cells contain numerous membrane-less (MLOs) and multiple membrane-bound organelles. Most of the MLOs have a spherical shape except for a few organelles (that have a filamentous appearance, e.g. FXR1...

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Mechanically Interlocked Biomacromolecules

Mechanical interlocking is a prominent phenomenon both in macroscopic objects and in microscopic molecules. Not only is it aesthetically appealing, it also leads to unique properties such as extraordinary...

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Exploring water−macromolecule interactions at the single-molecule level: A comprehensive review

Water is ubiquitous and indispensable on the Earth. Its importance has long been recognized on a macroscopic scale. However, it took a long time to comprehend the impact of water molecules on the microscopic...

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Fabrication of the polyetherketoneketone-reinforced nano-hydroxyapatite composites as inspired by the cortical bone

•The cortical bone-inspired composites were produced successfully by 20 vol% poly-dopamine (pDA)-nano hydroxyapatite (nHA) and 2 wt% PVA/PEKK.•pDA modified nano hydroxyapatite (nHA) slurries can fabricate...

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Supramolecular co-assembled hybrid hydrogels for antibacterial therapy

Bacterial infections arising from antibiotic-resistant strains represent a formidable global health threat. In the realm of antibacterial therapies, supramolecular hydrogels stand out with unique advantages...

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Supramolecular fluorescence biosensing based on macrocycles

Fluorescence sensing converts chemical events into measurable readings by utilizing fluorescence signals for the qualitative or quantitative detection of specific analytes. Supramolecular chemistry,...

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A visualizable strategy to real-time monitor chiral block copolypeptide assembly by AIE fluorescent probes

Aggregation-induced emission (AIE) luminogens show great potential in many applications. In this study, we have synthesized diblock copolymers poly (ethylene glycol) -b-poly (9-anthrylmethyl-L-lysine)...

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Exploring chemical space and structural diversity of supramolecular peptide materials

Searching chemical space and expanding the structural diversity of supramolecular self-assembly based on the development of combinatorial libraries is significant to the guided design of bio-inspired...

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Perylene diimide supramolecular aggregates: Constructions and sensing applications

Perylene diimides (PDIs) with high fluorescence quantum yield and well π-conjugated plane have been widely studied to construct supramolecular aggregates via noncovalent interactions and to further...

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Hydrogen-bonded supramolecular adhesives: Synthesis, responsiveness, and application

Adhesive bonding to diverse substances is vital to a great number of the established, cutting-edge and emerging applications. We have witnessed, in the last few years, the transformative progress in...

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In situ supramolecular self-assembly for alleviating multidrug resistance in cancer

Drug resistance is one of the major causes of cancer treatment failures. In recent years, to combat the issue of drug resistance, a large volume of strategies has been established along the development...

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Block copolymer particles with tunable and robust internal nanostructures by combining hydrogen-bonding and crosslinking

Nanostructured block copolymer (BCP) particles are attractive due to their ordered internal structures, unique shape and surface patterns; however, their structural integrity can be easily lost because...

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Hydrazide–pillar[5]arene-mediated silver nanoparticles for highly efficient reductive degradation of organic dyes

•Supramolecular method for organic dyes degradation.•Synthetic macrocycles assist in the preparation of AgNPs.•Hybrid material for efficient catalysis....

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Self-powered assemblies for tissue engineering applications

•It systematically summarizes the basic physical rules underlining electric field generations and provide a practical guide for the designing of electrically active supramolecular assemblies.•The general...

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An injectable macroporous hydrogel templated by gasification reaction for enhanced tissue regeneration

Owing to excellent biocompatibility, tunable modulus to match biological tissues, full of water environment, and wide range of constituents, injectable hydrogels have always been preferred as superior...

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Exploring computational tools for improved structural design and stability of helical AApeptides

Peptidomimetics have garnered increased attention due to their unique structural properties and self-assembly, as well as their promising applications in material sciences and peptidomimetic drug design....

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Investigation of differences in the protein transport capability of homochiral nanochannels

•DP modified membrane has a higher affinity for BSA than LP modified membrane.•Chiral nanochannel separates proteins based on H-bond differences.•Nanochannel membrane can be served as a nanoscaled chiral...

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Sequence-dependent catalysis and assembly to form peptide/Au nanoenzyme for glucose and plasma GSH detecting in cancer patients

Metal ions play a pivotal role in regulating and determining the functions of proteins and peptides in nature. This study aims to investigate the regulatory role of metal ions in peptide assembly and...

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Thiol-5-methylene pyrrolones hydrogels with pH-tunable stress-relaxation and self-healing properties

Hydrogels containing dynamically crosslinked networks through covalent bonds have garnered substantial attention in both academia and technology sectors. This interest stems from their impressive mechanical...

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The dynamical signature and scaling of supramolecular assemblies

We present a brief overview of current investigations on the dynamics of supramolecular assemblies, with the focus on applying broadband dielectric spectroscopy (BDS) combined with different techniques....

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Well-Tunable, 3D-printable, and Fast Autonomous Self-Healing Elastomers

Self-healing elastomers provide extended longevity of functional materials, due to their unique adaptability and durability. However, a major scientific challenge remains in developing materials with...

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Bio-inspired nano-/micro-channels via supramolecular assembling: From fundamentals to applications

Ion channels play a vital role in regulating the flow of ions across cell membranes to maintain physiological functions. Mimicking this biological process and fabricating artificial nano-/micro-channels...

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Self-healing hydrogels based on reversible noncovalent and dynamic covalent interactions: A short review

The self-healing capability of a material refers to its ability to autonomously heal fractures or defects and restore its original structures and functionalities. Self-healing hydrogels, with enhanced...

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Supramolecular gelators enabling chiral organogels for naked-eye enantiodifferentiation with wide accessibility and applicability

Techniques to acquire chiral information from molecules are essential for deciphering important biological processes and improving the performance of industrial chiral materials. Herein, we report novel...

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