Special issue on synthetic gene and cell therapy

Published 28 October, 2022


Synthetic biology is a multidisciplinary field that rationally designs and reconstructs biological components and systems with the aim of delivering novel functions. In this special issue, we will explore the interface of synthetic circuits for precisely-controlled gene- and cell-based therapies. We will highlight original research papers, reviews and articles that integrate expertise from diverse areas, ranging from genetic engineering to the control of gene expression, genome engineering, and fine-tuning of cellular metabolic pathways for gene- and cell-based precision therapies. 

Topics covered:

These will include, but not be limited to:

  • Synthetic genetic circuits or biosensors for biomedical applications, tissue engineering and the programming of therapeutic cells
  • Controllable genetic circuits for gene therapy
  • Advanced gene delivery or expression control
  • Synthetic circuits for design cell therapy
  • Synthetic immunology: genetic circuits/switches/gates for controllable CAR-T/CAR-NK/CAR-M therapy
  • Engineering microbes for therapeutic purposes
  • Multi-cellular circuitry engineering for therapeutics
  • AI-aided design of biological systems
  • Next generation immune cell therapy

Important deadlines: 

  • Submission deadline (for full papers):31 December 2023
  • Publication date: upon acceptance

Submission instructions:

 Please read the Guide for Authors before submitting. All articles should be submitted online; please select the special issue “Synthetic gene and cell therapy”.

Manuscripts will be reviewed and published on a first-come, first-served basis. Once all accepted manuscripts are published, they will be gathered together in this special issue.

Guest editors:

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