DualNeuro: A Dual-Model Framework for Selectivity Between Neurotoxic Insecticides and CNS Drugs
Available online 2 September 2026
The insect nervous system represents a primary target for insecticide development. However, the evolutionary conservation of neural targets between insects and mammals, the off-target safety of neurotoxic...
Novel dual-effect isobavachalcone synergistic formulations for integrated management of Fusarium diseases and mycotoxin contamination in maize
Available online 29 August 2026
Fusarium spp. are critical pathogenic fungi threatening the safe production of maize (Zea mays). Their infections not only cause substantial yield losses, but also drive the accumulation of carcinogenic...
Transcending production limits: A rational platform–barrier co-design framework for next-generation dsRNA biopesticides
Available online 29 August 2026
Scalable dsRNA production is essential for RNAi-based pest control, yet production yield alone does not determine field efficacy. Environmental degradation, insufficient pest exposure, and pest-specific...
Sensitive screen-printed photoelectrochemical immunoassay based on flower-shaped ZnIn2S4 nanomaterials
Available online 29 August 2026
Cucumber mosaic virus (CMV) has seriously affected the yield of crops and caused huge economic losses. By exploring the detection methods of CMV, CMV can be detected more accurately and rapidly. The...
Balancing efficacy and safety: An optimized difenoconazole nano-formulation for managing sheath blight and minimizing residue risks in rice
Available online 26 August 2026
The development of nanoscale pesticide delivery systems has significantly enhanced pesticide bioactivity while reducing the associated toxicological risks. However, the variability in efficacy across...
Comparative mechanisms of mercury and cadmium phytotoxicity: From uptake and intracellular targets to stress signaling and remediation
Available online 25 August 2026
Mercury (Hg) and cadmium (Cd) contamination in agricultural soils severely compromises plant growth, food safety, and ecosystem stability. Although both metals inhibit plant growth and induce oxidative...
Balancing efficacy and safety: Particle size-dependent trade-off of suspension concentrate for pest control and non-target ecotoxicity
Available online 20 August 2026
The application of nanotechnology in agriculture has offered promising opportunities for nanopesticides, yet the particle size effects that govern their performance remain poorly understood, especially...
Discovery of Novel Potent GABA Receptor Insecticides against Spodoptera frugiperda and Other Lepidopteran Pests via Scaffold Simplification
Available online 20 August 2026
Spodoptera frugiperda is a major global migratory pest that severely impacts agricultural production. To discover new effective agents against S. frugiperda, we designed and synthesized a series of...
Design, synthesis, antifungal activity and mechanism of novel thiourea glycosides based on N-acetyl-glucosamine
Available online 13 August 2026
To explore the potential of utilizing renewable bioresources as sustainable alternatives to fossil-derived chemicals in green pesticide development, N-acetylglucosamine (NAG), the monomer of chitin,...
Design, synthesis, and evaluation of eugenol derivative Eug-32 as a novel acaricide targeting complex I to disrupt mitochondrial quality control
Available online 13 August 2026
Eugenol displays intrinsic acaricidal activity against both plant mites and parasitic mites, yet its further development as a commercial agrochemical acaricide is restricted by suboptimal bioactivity...
Engineering a strigolactone receptor to evade viral hijacking in rice
Available online 13 August 2026
This highlight discusses the study by Yang et al. (Cell, 2026), which reveals an unexpected function of strigolactone (SL) signaling in rice antiviral immunity. This work shows that SL signaling promotes...
E93 and its kinase-mediated S530 phosphorylation regulate ovarian development and oogenesis in Nilaparvata lugens via Egfr and Cpr83
Available online 12 August 2026
Insect reproduction serves as a primary target for insecticide development and resistance management in insects. Ovarian development, a key determinant of insect reproduction, is tightly regulated through...
HLDP nanocarrier potentiates emamectin benzoate against destructive fall armyworm: Reduced dosage with enhanced efficacy and improved biosafety
Available online 10 August 2026
The fall armyworm (Spodoptera frugiperda), a highly migratory and polyphagous invasive pest, poses a severe threat to global food security and has rapidly emerged as one of the most destructive agricultural...
Uptake and translocation of serine-modified and fludioxonil-encapsulated nanocarriers in Banana (Musa spp.) after foliar application
Available online 7 August 2026
Nanopesticides offer unique advantages for the targeted delivery of agrochemicals against destructive plant vascular diseases due to their superior in planta transport capability. However, a fundamental...
Chalcogen-based bioisosteric replacement for discovering new pyrido[1,2-a]pyrimidine mesoionics against lepidopteran pests
Available online 7 August 2026
Lepidopteran pests are a major driver of global maize yield losses and have evolved substantial resistance to many conventional insecticides. Current management practices lack new active ingredients...
Copper- and nickel-catalyzed coupling reactions of aryl halides in agrochemical synthesis
Available online 4 August 2026
The development of sustainable and cost-effective synthetic methodologies is centrally important in modern agrochemical research. Benefiting from the unique electronic structures of 3d transition metals,...
Microfluidic technology in agrochemical development: Advances in pesticide synthesis, nanopesticide preparation, and on-chip sensing
Available online 3 August 2026
Microfluidic technology has emerged as a powerful enabling platform in agrochemical science, offering precise manipulation of minute fluid volumes coupled with enhanced mass and heat transfer efficiency,...
A dual-responsive HACC-modified indoxacarb-loaded mesoporous silica nanoparticles with controlled release and ROS-driven toxicity against Plutella xylostella
Available online 24 July 2026
Plutella xylostella, one of the most destructive pests of cruciferous crops, causes significant economic losses worldwide. Given the limitations of conventional insecticides, including environmental...
Acclimation of soybean in saline-alkali soil by reactive oxygen species-scavenging carbon dots supplemented with calcium ions
Available online 23 July 2026
Carbon dots (CDs) possessing reactive oxygen species (ROS) scavenging activity have emerged as promising agents for enhancing plant tolerance to salt stress. However, their potential in saline-alkali...
A novel amino acid substitution S376P in FgCYP51B confers prothioconazole resistance via distinct binding mode in Fusarium graminearum
Available online 22 July 2026
Fusarium graminearum is the primary causal agent of Fusarium head blight (FHB), a devastating disease frequently managed with sterol demethylation inhibitors (DMIs). Although prothioconazole (Prot)...
Cobalt-encapsulated N-doped carbon nanotube nanozymes generate ROS to suppress Ralstonia solanacearum and prime systemic resistance in tomato
Available online 22 July 2026
Nanomaterials offer new opportunities for sustainable control of crop diseases caused by soil-borne pathogens. Here, cobalt-encapsulated nitrogen-doped carbon nanotubes (Co@N-CNTs) with tubular and...
Acrylonitrile-based oxathiapiprolin analogues: A new structural strategy for oomycete fungicide development
Available online 13 July 2026
Oomycete pathogens cause destructive crop diseases worldwide, leading to substantial economic losses and posing a continuous threat to agricultural sustainability. Oxathiapiprolin, the first piperidinyl-thiazole-isoxazoline...
Revisiting fosetyl-Al: mechanisms, systemic behavior and its role as a host-driven tool in integrated management of soil-borne oomycete diseases
Available online 10 July 2026
Soilborne oomycete diseases, represented by Phytophthora and Pythium, pose a persistent challenge to the management of crops and perennial woody plants owing to the long-term survival and recurrent...
Nanobiopesticide based on Cry3Aa@mesoporous silica: improving stability and pesticide activity via support engineering
Available online 8 July 2026
In this study, a nanobiopesticide based on mesoporous silica was prepared as a support for the Bacillus thuringiensis Cry3Aa protein. The selected support material was UVM-7 silica, which has been demonstrated...
Risk assessment and resistance mechanism analysis of phenamacril resistance in Fusarium verticillioides
Available online 8 July 2026
Phenamacril is a cyanoacrylate fungicide with a novel mode of action and strong inhibitory activity against Fusarium species. Fusarium verticillioides is a major maize pathogen that causes maize stem...