PDAI: A green pesticide molecule design technology platform driven by high-performance computing and artificial intelligence
June 2025
Pesticides are integral to agricultural productivity and food security. Despite the notable advancements in Computer Aided Drug Design (CADD) and Artificial Intelligence Drug Discovery (AIDD) in pharmaceuticals,...
Science:Core regulator of rice immunity: The role of classical protein complexes on homeostasis and multipathogen resistance
June 2025
Plants have evolved complex immune networks to adapt to survival needs, and their immune mechanisms have unique regulatory patterns to cope with different environments. In rice, the maintenance of immune...
Erucamide: A special biological control agent targeting T3SS for plant bacterial diseases
June 2025
The incidence of plant bacterial diseases has been rising annually alongside the development of facility agriculture, which can seriously affect the yield and quality of crops, and cause significant...
Science: Pathogenic fungi exploit plant phosphate sensing via Nudix hydrolase effectors
June 2025
Inorganic phosphate (Pi) homeostasis in plants is regulated by inositol pyrophosphates (PP-InsPs), which mediate phosphate starvation responses. While beneficial microorganisms, such as arbuscular mycorrhizal...
Optimizing role assignment for scaling innovations through AI in agricultural frameworks: An effective approach
June 2025
In the dynamic and constantly evolving world of agriculture, promoting innovation and ensuring sustainable growth are crucial. A planned division of tasks and responsibilities within agricultural systems,...
Phytic acid-assisted amorphization of bone mineral for improved phosphorus fertilizer efficiency
Available online 19 June 2025
Phosphorus plays an indispensable role in the food chain, yet phosphorus mineral resources are finite, underscoring the urgency for developing a closed-loop phosphorus economy. Although there have been...
Synthesis and insecticidal activity evaluation of sulfonamide derivatives oriented by atom replacement strategy
Available online 10 June 2025
The single-atom replacement strategy is a typical approach which just converts elements in lead compounds into their analogues with very small chemical changes. In this research, we implemented this...
Carbonyl-bridged trifluoromethyl pyridine derivatives for pest control and mechanistic investigations
Available online 6 June 2025
Trifluoromethyl pyridine (TFMP) motif is commonly discovered in structures of active pharmaceuticals. Flonicamid, characterized by the TFMP moiety, is well known as a prodrug in the knockdown of pests....
Directed evolution of HIS1-Like proteins to enhance herbicide metabolism in crops
Available online 3 June 2025
HPPD (4-hydroxyphenylpyruvate dioxygenase) inhibitor are widely used in agriculture due to their high efficacy and environmental friendliness. However, many important crops, such as rice, wheat, and...
Antibiotics pollution in cropland and crops: A comprehensive review
Available online 18 May 2025
Production of synthetic antibiotics has rapidly expanded to meet the increasing demands in human healthcare, animal husbandry, and agriculture. Meanwhile, however, substantial quantities of untreated...
Design, synthesis, and biological evaluation of 2-(benzylsulfonyl)-5-(2-methoxypyridin-4-yl)-1,3,4-oxadiazole derivatives as novel herbicides
Available online 13 May 2025
To develop herbicides with a novel mechanism of action, a series of 1,3,4-oxadiazolpyridine derivatives were designed and synthesized based on active substructure splicing and structure optimization....
Recent developments in the synthesis of pharmacological alkyl phosphonates
March 2025
Organophosphate analogues are commonly occurring structural features that are widely present in numerous natural substances, biologically active molecules and modern pharmaceutical compounds. The development...
The isolation, identification and efficacy of Bacillus velezensis XF-8 in tomato bacterial wilt control
March 2025
Tomato bacterial wilt is an important disease caused by Ralstonia solanacearum, which is harmful to the development of tomato industry and seriously affects the yield and quality of tomato. In this...
Toxicological response and bioaccumulation of strontium in Triticum durum (Nachit) and Triticum aestivum (Ibtissam)
March 2025
The present study examines the toxicological effects and bioaccumulation of strontium (Sr2+) in two Moroccan wheat species, Triticum durum (Nachit) and Triticum aestivum (Ibtissam). Germination rates...
From tryptophan to gramine: A journey into the mysterious transformation of biocatalysis
March 2025
As a natural alkaloid found extensively in cereal crops, gramine not only plays a crucial role in protecting barley and other grasses from various pests, but also reduces palatability for ruminants....
Development of novel pyridine-based agrochemicals: A review
March 2025
Pyridine-based agrochemical products have become the most commercially successful in the 21st century. About half of the agrochemicals with pyridine scaffold were released, registered or invented only...
Migrated silicon dioxide nanoparticles activates the rice immunity for systemic resistance against two pathogens
March 2025
Rice, the world's primary staple food, is under severe threat from several devastating diseases. To sustainably management rice diseases, developing safe, environmentally friendly alternatives urgently...
Plants self-synthesize “agrochemical” to fight pests and diseases
March 2025
In this article, we present recent findings from a Nature Chemical Biology paper that elucidate the mechanism of crucial biosynthetic steps involved in the synthesis of steroidal glycoalkaloids (SGAs),...
A novel fluorescent probe for MGO detection and its application for monitoring root growth and drought stress in Arabidopsis thaliana
March 2025
Methylglyoxal (MGO) is a vital signaling molecule that related to a variety of pathologies in both animals and plants. However, high levels of MGO are associated with several diseases. Therefore, developing...
Key players in plant defense: How scaffold protein GAME15 orchestrates the biosynthesis of steroidal defense metabolite
March 2025
GAME15, a scaffold protein, orchestrates the biosynthesis of steroidal glycoalkaloids (a class of compounds with known defensive properties) and steroidal saponins (which contribute to plant defense)...
Recovery of NH4+‒N and PO43-‒P is Promoted by competitive interactions between M. aeruginosa and MgCO3
March 2025
Here we report that the presence of MgCO3 stimulates the extracellular polymeric substance (EPS) secretion of Microcystis Aeruginosa (M. Aeruginosa). This stimulation led to a significant reduction...
Cell: Dual-functional ABCH transporter lit the light for pesticide discovery
March 2025
Pesticides play a pivotal role in modern agriculture. However, the pesticide industry faces significant challenges closely linked to major global concerns such as pesticide resistance, environmental...
Aflatoxin B1 contamination level detection in almond kernels through short wave infrared hyperspectral image analysis
Available online 26 March 2025
Aflatoxin B1 (AFB1) is a toxic fungal metabolite that contaminates almonds from cultivation to harvesting. It leads to chronic health problems and significant economic loss to the producers. Therefore,...
Heuristic ab initio elucidation of low-level impurity structures in clothianidin material
Available online 18 March 2025
Clothianidin (CLO) is an insecticide with a high prevalence in environment and food samples. The identification of structural impurities is of great importance for the development of certified reference...