A study on the relationship between the severity of leukoaraiosis and post-thrombolytic hemorrhage in acute cerebral infarction thrombolysis patients
October 2026
This study aims to investigate the relationship between the severity of leukoaraiosis and post-thrombolytic intracerebral hemorrhage (ICH) in patients with acute cerebral infarction undergoing thrombolytic...
Microglia-neuron crosstalk in intracerebral hemorrhage: from neuroimmunomodulation to neurorepair
October 2026
Intracerebral hemorrhage (ICH) remains a devastating disease with high mortality and disability rates, yet effective therapeutic strategies are still limited. Emerging evidence has highlighted that...
Beyond recanalisation: The ATTRACTION trial shows a promising role for tirofiban after successful thrombectomy
October 2026
Despite successful thrombectomy, many patients with large-vessel occlusion stroke remain functionally dependent. The ATTRACTION trial evaluated low-dose tirofiban after successful endovascular reperfusion...
Ngn2 failed to induce astrocyte-to-neuron reprogramming after intracerebral hemorrhage
October 2026
Intracerebral hemorrhage (ICH) is a severe neurological disorder with high mortality due to neuronal loss, and current therapies face significant challenges. Cell reprogramming offers a potential solution....
Effectiveness of 3D printed and mixed reality models in neurosurgical patient education: A systematic review
October 2026
Neurosurgical patients often face psychological distress due to difficulty understanding their medical condition and treatment plan. Traditional educational tools like MRI or CT scans may not effectively...
Current state of endovascular treatment for cavernous and petrous internal carotid artery aneurysms
October 2026
Cavernous and petrous internal carotid artery (ICA) aneurysms have similar clinical characteristics, making it feasible to discuss these two types of aneurysms together. Currently, endovascular treatment...
CORM-2 attenuates red blood cell-mediated inflammation by upregulating phagocytic capacity of cerebral microglial cells of the neonatal rat in vitro
October 2026
•Effectively inhibiting inflammatory response in peri-hematoma area may reduce ICH-mediated secondary ischemic brain injury.•We established microglia and RBCs co-culture in vitro, to investigate the...
Minimally invasive surgery for supratentorial intracerebral Haemorrhage: Systematic review and network Meta-Analysis
Available online 6 October 2026
To compare conventional craniotomy (CC), endoscopic surgery (ES), and minimally invasive surgery with thrombolysis (MISTIE) versus medical management (MM) for supratentorial intracerebral hemorrhag...
Neuroprotective effects of spermidine in stroke and other neurological disorders: mechanisms and translational challenges
Available online 3 September 2026
Spermidine (SPD), an endogenous polyamine, has garnered increasing interest for its pleiotropic biological activities and potential benefits for neurological health. This review aims to evaluates the...
Hemodynamic variables in cerebral Aneurysms: integrating CFD-based computational modeling and clinical insight
Available online 1 September 2026
Hemodynamic forces play a central role in the initiation, growth, and rupture of cerebral aneurysms. Although numerous computational fluid dynamics (CFD)-derived hemodynamic variables have been proposed,...
Dual-port robot-assistant visualized minimally invasive aspiration (RAVMIA) for evacuation of irregular basal ganglia hemorrhage: A technical note
August 2026
The surgical management of intracerebral hemorrhage (ICH) remains controversial. While minimally invasive endoscopic techniques have shown promise, recent trials have not demonstrated positive outcomes...
Development and validation of an improved ICH score: Integrating clinical and radiographic parameters for enhanced prediction of 30-day mortality in spontaneous intracerebral hemorrhage
August 2026
•Adding pupil status and warfarin use improves ICH score mortality prediction.•The new score achieved an AUROC of 0.91, better than the original score of 0.87.•Enhanced accuracy benefits both nonoperative...
Machine learning-based radiomics model for predicting hematoma enlargement in spontaneous intracerebral hemorrhage: A multicenter study
August 2026
This study aimed to establish and validate three predictive models: a clinical model (CM), a radiomics model (RM), and a combined clinical–radiomics model (CRM) for forecasting hematoma progression...
Efficacy and safety of middle meningeal artery embolization in combination with burr hole craniostomy for chronic subdural hematomas: A single-center experience
August 2026
Chronic subdural hematoma (CSDH) is a prevalent neurosurgical condition. The mass effect of hematoma could lead to a series of neurological dysfunctions. Surgical intervention, such as burr hole craniostomy...
Reversible cerebral vasoconstriction syndrome: not just a “reversible” condition. Retrospective observational study and literature review
August 2026
This study aims to critically evaluate the evolving understanding of reversible cerebral vasoconstriction syndrome (RCVS) by examining its potential for long-term complications. While reversible cerebral...
Decoding the spatiotemporal pleiotropy of CCL2-CCR2 signaling to guide staged therapies in central nervous system injury
Available online 26 August 2026
Intracerebral hemorrhage (ICH) and other acute central nervous system (CNS) injuries share a devastating pathological hallmark: neuroinflammation. Within this complex immune network, the CCL2-CCR2 signaling...
Safety and efficacy of clazosentan monotherapy in aneurysmal subarachnoid hemorrhage with intracerebral hematoma: A real-world analysis
Available online 25 August 2026
Evidence for clazosentan in aneurysmal subarachnoid hemorrhage (aSAH) complicated by intracerebral hematoma (ICH) remains limited. We evaluated outcomes of clazosentan monotherapy in patients with ICH...
“ICH-CARE”: ICH-integrated care for accelerated response to intracerebral hemorrhage using a phased approach
Available online 17 August 2026
Intracerebral hemorrhage (ICH) is a deadly stroke subtype requiring ultra-early bundled interventions. The Mayo Clinic Comprehensive Stroke Center implemented a “ICH Phases” three-tiered communication...
The TLR4/MyD88 axis: Orchestrator of neuroinflammation from molecular initiation to systemic crosstalk
June 2026
Neuroinflammation is a convergent feature of neurodegenerative diseases, hemorrhagic and ischemic stroke, and spinal cord injury. Central to this process is the Toll-like receptor 4 (TLR4) and myeloid...
Digital twins for stroke prediction and management
June 2026
•Digital twins: dynamic computational replicas integrating multimodal patient data.•Patient-specific left atrial modelling stratifies AF-related embolic risk.•Imaging-informed cerebrovascular hemodynamics...
Association of pre-admission use of sartans and calcium channel antagonists with outcomes after spontaneous intracerebral hemorrhage: A retrospective cohort study
June 2026
Spontaneous intracerebral hemorrhage (ICH) is a severe stroke subtype associated with high morbidity and mortality. Preclinical studies suggest that angiotensin II-type 1 receptor blockers such as sartans...
Research progress of peripheral inflammation in spontaneous cerebral hemorrhage
June 2026
This review systematically summarizes the research progress on peripheral inflammation in spontaneous intracerebral hemorrhage (ICH), focusing on the interaction mechanisms of the “peripheral-central...
Minimally invasive puncture and drainage combined with urokinase in the treatment of spontaneous intracerebral hemorrhage in the basal ganglia (MIPDU): A multicenter randomized controlled trial protocol
June 2026
Spontaneous intracerebral hemorrhage (ICH) represents a severe subtype of stroke with a notably high incidence, particularly in China, where it constitutes 21%–48% of cerebrovascular events. This condition...
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