Perioperative sodium overload is associated with the occurrence of pulmonary complications related to clazosentan in patients with subarachnoid hemorrhage followed by obliterative management for ruptured aneurysm: A retrospective observational study
Available online 17 March 2025
•Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage are influenced by elevated endothelin-1 levels.•Clazosentan, a selective ETA receptor antagonist is associated with a higher...
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mGluR1 characteristic in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage
Available online 17 March 2025
Glutamate receptor-mediated excitotoxicity plays crucial role in aneurysmal subarachnoid hemorrhage (aSAH). Truncation of metabotropic glutamate receptor 1 (mGluR1) is a key step in excitotoxicity,...
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Current state of endovascular treatment for cavernous and petrous internal carotid artery aneurysms
Available online 16 March 2025
Cavernous and petrous internal carotid artery (ICA) aneurysms have similar clinical characteristics, making it feasible to discuss these two types of aneurysms together. Currently, endovascular treatment...
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A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage
Available online 2 March 2025
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability. Cuproptosis is a regulatory cell death modality dependent on intracellular copper ion concentration, the...
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Mixed-reality head-mounted display in cranial neurosurgery: A proof-of-concept study
February 2025
Mixed-reality (MR) head-mounted displays (HMD) offer virtual augmentations registered with real objects, allowing for direct patient-centered lesion visualization. In contrast to other surgical subspecialties,...
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Immune System Perspective in Intracerebral Hemorrhage Research: A Focus on Monocytes and Macrophages
February 2025
Monocytes and macrophages are crucial elements of the immune system, having various roles in tissue balance, inflammation, and conditions like stroke. They exhibit significant functional diversity,...
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Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage
February 2025
Spontaneous (non-traumatic) intracerebral hemorrhage (ICH) is one of the major causes of global death. The purpose of our bioinformatics analysis was to detect viable pathophysiological targets and...
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Leakage sign based on contrast-enhanced CT is a predictive marker for hematoma expansion and poor prognosis in primary brainstem hemorrhage
February 2025
Although hematoma expansion is a poor prognostic factor in patients with intracerebral hemorrhage (ICH), its effect on primary brainstem hemorrhage (PBSH) remains unclear. Since we previously observed...
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The evolution of brain surgery: Exploring the impact of continuum robotics
February 2025
Brain surgery requires at most accuracy and precision, yet current neurosurgical robots are limited in their ability to reach intracranial regions due to their rigid and inflexible nature. However,...
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A case of bilateral vertebral artery dissecting aneurysms presenting with subarachnoid hemorrhage evaluated using computational fluid dynamics: Which is the rupture side?
February 2025
Background: Saccular aneurysms (SAs) have been long studied in hemodynamics using computational fluid dynamics (CFD), while dissecting aneurysms (DAs) remain unclear. To estimate which side of the aneurysm...
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Relationships between NT-pro-BNP and other serological indicators and the prognosis of spontaneous intracerebral hemorrhage
February 2025
Acute spontaneous intracerebral hemorrhage (ICH) is a life-threatening condition, and certain serological indicators may be associated with the prognosis after ICH. This study investigated the relationship...
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The role of blood lipid and triglyceride‑glucose index in intracranial aneurysms: A retrospective study
Available online 17 February 2025
The association between blood lipids and aneurysmal subarachnoid hemorrhage (aSAH) remains uncertain, with current research yielding conflicting results. Limited studies have explored the link between...
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Rupture of cerebral cavernous malformations due to cerebral venous sinus compression
Available online 17 February 2025
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Mid-term outcomes in stent-assisted coil embolization for ruptured cerebral aneurysms in the acute period: A single institution retrospective review
December 2024
The purposes of this study were to retrospectively review mid-term outcomes of stent-assisted coil embolization for acutely ruptured cerebral aneurysms, and to identify risk factors....
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Effects of glibenclamide/glyburide on stroke: Systematic review
December 2024
Glibenclamide (GBC), although traditionally used to treat type 2 diabetes mellitus, has demonstrated efficacy in preventing cerebral edema in the setting of stroke, including preserving the integrity...
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Brain Hemorrhages has specially appointed Professor Wang Yongjun from Beijing Tiantan Hospital as Honorary Editor-in-Chief
December 2024
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Assessment of causal relationships between white matter brain imaging-derived phenotypes and CSVD-mediated Stroke: Genetic correlation and Mendelian randomization
December 2024
Cerebral small vessel disease (CSVD) and its associated stroke are significant contributors to mortality and long-term disability globally. Despite this, there remains a lack of established predictors...
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Activation of PARP in secondary brain injury following intracerebral haemorrhage
December 2024
Intracerebral hemorrhage (ICH) represents a significant health challenge due to its high mortality and severe outcomes. Poly (ADP-ribose) polymerase (PARP) is a chromatin-associated nuclear protease,...
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Cerebrovascular disorders in patients with malignant tumors
December 2024
Patients with malignant tumors face an elevated risk of cerebrovascular complications, such as intratumoral hemorrhage, tumor invasion into arterial and venous sinuses, leptomeningeal infiltration,...
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Quadriparesis with bilateral anterior cerebral artery infarction following subarachnoid haemorrhage due to rupture of an anterior communicating artery aneurysm: A case report with literature review
December 2024
Anterior cerebral artery (ACA) territory infarctions are relatively rare, accounting for 0.3 % to 4.4 % of stroke cases, with bilateral occurrences being even rarer. These infarctions can lead to quadriplegia/paresis....
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Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME
Available online 16 November 2024
Hypertension is a major cause of cerebral hemorrhage. Although they are widely used in preclinical studies on cerebral hemorrhage, traditional in vivo cerebrovascular imaging techniques, such as positron...
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Peak perihematomal edema expansion predicts poor outcome in patients with intracerebral hemorrhage
Available online 1 November 2024
Intracerebral hemorrhage (ICH) is a highly fatal and incapacitating form of stroke. Perihematomal edema (PHE) serves as a measurable radiological indicator in the progression of secondary injury and...
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Brain hemorrhages in traumatic brain injury and the excess burden conferred by anticoagulants and antiplatelets
October 2024
The objective of this study was to compare the severity of head injury in patients on an anticoagulant or antiplatelet agent and to look at the burden of these medications in patients 55 + years vs....
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Hemorrhage of the hypothalamic cavernous malformation. Clinical case of surgical treatment
October 2024
To study the clinical and neurologic symptoms and to determine the indications for surgical treatment of hypothalamic cavernous malformations....
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VASP, HCLS1, MSN, and EZR: Key molecular beacons in the pathophysiology of perihematomal edema Post-Intracerebral hemorrhage
October 2024
•The study pinpoints VASP, HCLS1, MSN, and EZR as critical genes linked to tight junction integrity, playing significant roles in perihematomal edema following intracerebral hemorrhage.•Enhanced leukocyte...
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