Inflammatory biomarkers in patients with intracranial aneurysms
Available online 10 October 2025
Intracranial aneurysm (IA) is a serious cerebrovascular disease. This study aimed to investigate the clinical characteristics and plasma biomarkers associated with IA....
Early anticoagulation in HI-1 hemorrhagic transformation after AF-associated stroke: A randomized trial
Available online 10 October 2025
•First RCT on early DOAC use in asymptomatic hemorrhagic transformation in atrial fibrillation patients.•Early anticoagulation improved 30-day NIHSS and mRS scores without increasing severe bleeding...
Sleep Disordered Breathing in Intracerebral Hemorrhage Survivors in Japan: a Meta-analysis and Systematic Review
Available online 8 October 2025
We evaluated the prevalence and correlates of sleep-disordered breathing (SDB) in intracerebral hemorrhage (ICH) survivors in Japan....
Machine learning-based radiomics model for predicting hematoma enlargement in spontaneous intracerebral hemorrhage: A multicenter study
Available online 20 September 2025
This study aimed to establish and validate three predictive models: a clinical model (CM), a radiomics model (RM), and a combined clinical–radiomics model (CRM) for forecasting hematoma progression...
Pituitary apoplexy following heart surgery: a comprehensive review of the literature
Available online 16 September 2025
Pituitary apoplexy (PA) is a clinical syndrome characterized by abrupt infarction or hemorrhage of the hypophysis, typically within a pituitary adenoma. Heart surgery, particularly with the use of cardiopulmonary...
Reversible cerebral vasoconstriction syndrome: not just a “reversible” condition. Retrospective observational study and literature review
Available online 16 September 2025
This study aims to critically evaluate the evolving understanding of reversible cerebral vasoconstriction syndrome (RCVS) by examining its potential for long-term complications. While reversible cerebral...
Atrous-based CBAM-Unet framework for intracranial hemorrhage segmentation and volume calculation with grading using CT images
Available online 11 September 2025
Intracranial hemorrhage (ICH) has been recognized as a leading reason for death following trauma, can result from traumatic brain injury (TBI) if it is not appropriately evaluated and treated during...
A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage
August 2025
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability. Cuproptosis is a regulatory cell death modality dependent on intracellular copper ion concentration, the...
The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns
August 2025
Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures...
Identification of non-invasive biomarkers associated with glioma hemorrhage
August 2025
Gliomas are among the most prevalent primary intracranial malignancies, and their management remains complex due to high rates of morbidity and mortality. Hemorrhage within gliomas, although relatively...
Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME
August 2025
Hypertension is a major cause of cerebral hemorrhage. Although they are widely used in preclinical studies on cerebral hemorrhage, traditional in vivo cerebrovascular imaging techniques, such as positron...
Non-coding RNAs in intracerebral hemorrhage: Roles, mechanisms, and therapeutic implications
August 2025
Intracerebral hemorrhage (ICH), which is a form of stroke triggered by the rupture of blood vessels within the brain tissue, is a leading cause of morbidity and mortality worldwide. Although significant...
Prophylactic barbiturate step-down infusion therapy has similar and favorable effects in elderly and non-elderly patients with severe traumatic brain injuries
August 2025
Objective: With the aging population, the number of elderly patients with severe traumatic brain injury (sTBI) inevitably increases. The high mortality rate for sTBI in the elderly necessitates effective...
Peak perihematomal edema expansion predicts poor outcome in patients with intracerebral hemorrhage
August 2025
Intracerebral hemorrhage (ICH) is a highly fatal and incapacitating form of stroke. Perihematomal edema (PHE) serves as a measurable radiological indicator in the progression of secondary injury and...
Effectiveness of 3D printed and mixed reality models in neurosurgical patient education: A systematic review
Available online 30 August 2025
Neurosurgical patients often face psychological distress due to difficulty understanding their medical condition and treatment plan. Traditional educational tools like MRI or CT scans may not effectively...
CORM-2 attenuates red blood cell-mediated inflammation by upregulating phagocytic capacity of cerebral microglial cells of the neonatal rat in vitro
Available online 8 August 2025
•Effectively inhibiting inflammatory response in peri-hematoma area may reduce ICH-mediated secondary ischemic brain injury.•We established microglia and RBCs co-culture in vitro, to investigate the...
The role of PGC-1α in brain injury: mechanisms and therapeutic potential
Available online 26 July 2025
Brain injury remains a significant contributor to mortality and long-term neurological disability worldwide, despite ongoing research efforts to develop effective therapies that can mitigate secondary...
Perioperative management of brain hemorrhage: Advances in anesthetic strategies and translational medicine
Available online 16 July 2025
•Brain hemorrhage presents perioperative challenges, requiring optimized anesthetic strategies.•Anesthesia choice and agent selection significantly influence perioperative outcomes.•Advanced neuromonitoring...
Grading of acute spontaneous cerebral hemorrhage combined with gut dysfunction assessment as a novel and improved prognostic score
Available online 13 July 2025
•The GD-ICH model demonstrated greater accuracy and predictive value than conventional models.•Gut dysfunction is as a reliable prognostic factor in ICH.•Gut dysfunction >7.5 days predicts poor prognosis,...
Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage
June 2025
Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality...
Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential
June 2025
Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the...
Premorbid long-term statin use can reduce the risk of hemorrhagic transformation after ischemic stroke
June 2025
Hemorrhagic transformation (HT) of cerebral infarction is considered as one of the most serious complications. Increasing evidence show that statin use might reduce the neuroinflammation and even improve...
Coexistence of ruptured basilar artery perforator aneurysm undetected on initial angiogram and unruptured anterior cerebral artery saccular aneurysm: Case report and literature review
June 2025
Ruptured basilar artery perforator aneurysm (BAPA) is a rare cause of subarachnoid hemorrhage (SAH) and is difficult to diagnose....
The Progressive Frontier of Aneurysmal subarachnoid Hemorrhage: Diagnosis and treatment Advances
June 2025
Aneurysmal subarachnoid hemorrhage affects 6 to 9 out of every 100,000 people annually, with a mortality rate of 35%. Many people suffer from long-term disabilities, often associated with cognitive...
Effectiveness of 3D printing technology-assisted neuroendoscopic surgery for hypertensive intracerebral hemorrhage in primary hospitals
June 2025
We aimed to investigate the clinical effectiveness of integrating 3D-printing technology with neuroendoscopy for treating hypertensive intracerebral hemorrhage (HICH)....
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