Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage
June 2025
Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality...
Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential
June 2025
Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the...
Premorbid long-term statin use can reduce the risk of hemorrhagic transformation after ischemic stroke
June 2025
Hemorrhagic transformation (HT) of cerebral infarction is considered as one of the most serious complications. Increasing evidence show that statin use might reduce the neuroinflammation and even improve...
Coexistence of ruptured basilar artery perforator aneurysm undetected on initial angiogram and unruptured anterior cerebral artery saccular aneurysm: Case report and literature review
June 2025
Ruptured basilar artery perforator aneurysm (BAPA) is a rare cause of subarachnoid hemorrhage (SAH) and is difficult to diagnose....
The Progressive Frontier of Aneurysmal subarachnoid Hemorrhage: Diagnosis and treatment Advances
June 2025
Aneurysmal subarachnoid hemorrhage affects 6 to 9 out of every 100,000 people annually, with a mortality rate of 35%. Many people suffer from long-term disabilities, often associated with cognitive...
Effectiveness of 3D printing technology-assisted neuroendoscopic surgery for hypertensive intracerebral hemorrhage in primary hospitals
June 2025
We aimed to investigate the clinical effectiveness of integrating 3D-printing technology with neuroendoscopy for treating hypertensive intracerebral hemorrhage (HICH)....
Simultaneous bilateral basal ganglia hemorrhage: case report and literature review
Available online 16 June 2025
To present a rare case of symmetric hemorrhages in the bilateral basal ganglia with unique imaging findings and discuss potential pathophysiological mechanisms....
Integrated network pharmacology reveals the mechanisms of punicalagin in cardiovascular and cerebrovascular diseases treatment
Available online 10 June 2025
Cardiovascular and cerebrovascular diseases, including coronary artery disease (CAD), myocardial infarction (MI), carotid atherosclerosis (CAS), and cerebral ischemic stroke (CIS), continue to impose...
Immune cells in intracerebral hemorrhage
April 2025
Intracerebral hemorrhage (ICH), the deadliest form of stroke, is characterized by bleeding into brain parenchyma and formation of hematoma. Currently, there is no treatment available for ICH. Inflammatory...
Intracranial pressure monitoring and minimally invasive surgery for intracerebral hemorrhage: Current status, challenges, and future
April 2025
With the continuous advancement of medical technology, the treatment for intracerebral hemorrhage (ICH) has shifted from traditional open surgery to more precise minimally invasive surgery (MIS). This...
Utilizing neuroimaging visualization technology to enhance standardized neurosurgical training for Traditional Chinese Medicine residents: A neuroanatomical education study
April 2025
This study aims to address the difficulties encountered by Traditional Chinese Medicine (TCM) students in learning neuroanatomy during clinical training by utilizing neuroimaging visualization tech...
Step-down infusion of barbiturate improves neurofunction in a new rat model of rebleeding subarachnoid hemorrhage
April 2025
Rebleeding from a ruptured aneurysm is a risk factor for fatal prognosis in subarachnoid hemorrhage (SAH). A novel barbiturate treatment, step-down infusion of barbiturate (sd-B), was previously developed;...
No association of brain CT blend sign with functional outcomes in patients with spontaneous supratentorial intracerebral hemorrhage after craniotomy
April 2025
•We found the sub-high-density region of blend sign remained in a liquid state even after a period of placement and was easily drained during the operation.•We arise a conjecture that patients with...
Prognosis of recovery and death within 1–6 months of spontaneous cerebellar hemorrhage undergoing suboccipital craniotomy
April 2025
Suboccipital craniotomy is a considerable surgical approach for large spontaneous cerebellar hemorrhage, but its prognostic has not been comprehensively addressed. This study aims to report the surgical...
Clazosentan for aneurysmal subarachnoid hemorrhage: Update from Japan
Available online 24 April 2025
Ngn2 failed to induce astrocyte-to-neuron reprogramming after intracerebral hemorrhage
Available online 23 April 2025
Intracerebral hemorrhage (ICH) is a severe neurological disorder with high mortality due to neuronal loss, and current therapies face significant challenges. Cell reprogramming offers a potential solution....
Atorvastatin and glucocorticoid therapy for retroclival epidural hematoma: Case report and literature review
Available online 3 April 2025
Retroclival epidural hematomas (REDH) are particularly rare conditions. We report for the first time the effect of conservative treatment of this rare condition with atorvastatin and glucocorticoids...
Development and validation of an improved ICH score: Integrating clinical and radiographic parameters for enhanced prediction of 30-day mortality in spontaneous intracerebral hemorrhage
Available online 17 March 2025
•Adding pupil status and warfarin use improves ICH score mortality prediction.•The new score achieved an AUROC of 0.91, better than the original score of 0.87.•Enhanced accuracy benefits both nonoperative...
Perioperative sodium overload is associated with the occurrence of pulmonary complications related to clazosentan in patients with subarachnoid hemorrhage followed by obliterative management for ruptured aneurysm: A retrospective observational study
Available online 17 March 2025
•Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage are influenced by elevated endothelin-1 levels.•Clazosentan, a selective ETA receptor antagonist is associated with a higher...
mGluR1 characteristic in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage
Available online 17 March 2025
Glutamate receptor-mediated excitotoxicity plays crucial role in aneurysmal subarachnoid hemorrhage (aSAH). Truncation of metabotropic glutamate receptor 1 (mGluR1) is a key step in excitotoxicity,...
Current state of endovascular treatment for cavernous and petrous internal carotid artery aneurysms
Available online 16 March 2025
Cavernous and petrous internal carotid artery (ICA) aneurysms have similar clinical characteristics, making it feasible to discuss these two types of aneurysms together. Currently, endovascular treatment...
Immune System Perspective in Intracerebral Hemorrhage Research: A Focus on Monocytes and Macrophages
February 2025
Monocytes and macrophages are crucial elements of the immune system, having various roles in tissue balance, inflammation, and conditions like stroke. They exhibit significant functional diversity,...
Leakage sign based on contrast-enhanced CT is a predictive marker for hematoma expansion and poor prognosis in primary brainstem hemorrhage
February 2025
Although hematoma expansion is a poor prognostic factor in patients with intracerebral hemorrhage (ICH), its effect on primary brainstem hemorrhage (PBSH) remains unclear. Since we previously observed...
A case of bilateral vertebral artery dissecting aneurysms presenting with subarachnoid hemorrhage evaluated using computational fluid dynamics: Which is the rupture side?
February 2025
Background: Saccular aneurysms (SAs) have been long studied in hemodynamics using computational fluid dynamics (CFD), while dissecting aneurysms (DAs) remain unclear. To estimate which side of the aneurysm...
Relationships between NT-pro-BNP and other serological indicators and the prognosis of spontaneous intracerebral hemorrhage
February 2025
Acute spontaneous intracerebral hemorrhage (ICH) is a life-threatening condition, and certain serological indicators may be associated with the prognosis after ICH. This study investigated the relationship...
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