Research progress of peripheral inflammation in spontaneous cerebral hemorrhage
Available online 4 April 2026
This review systematically summarizes the research progress on peripheral inflammation in spontaneous intracerebral hemorrhage (ICH), focusing on the interaction mechanisms of the “peripheral-central...
The therapeutic potential of baicalin for stroke
Available online 4 April 2026
Despite rapid advances in modern medicine, stroke remains a life-threatening neurological emergency and a leading cause of death and disability worldwide. Stroke is broadly classified into ischemic...
Pathophysiology and treatment approaches for perihematomal edema following spontaneous intracerebral hemorrhages
Available online 3 April 2026
To summarize the involvement of perihematomal edema (PHE) in the progression of spontaneous intracerebral hemorrhage (sICH) correlated with the clinical outcome under systematic, structured review....
Digital twins for stroke prediction and management
Available online 2 April 2026
•Digital twins: dynamic computational replicas integrating multimodal patient data.•Patient-specific left atrial modelling stratifies AF-related embolic risk.•Imaging-informed cerebrovascular hemodynamics...
Association of pre-admission use of sartans and calcium channel antagonists with outcomes after spontaneous intracerebral hemorrhage: A retrospective cohort study
Available online 2 April 2026
Spontaneous intracerebral hemorrhage (ICH) is a severe stroke subtype associated with high morbidity and mortality. Preclinical studies suggest that angiotensin II-type 1 receptor blockers such as sartans...
Oxidative stress in post-stroke neurorestoration: from mechanisms to therapy
Available online 1 April 2026
The TLR4/MyD88 axis: Orchestrator of neuroinflammation from molecular initiation to systemic crosstalk
Available online 1 April 2026
Neuroinflammation is a convergent feature of neurodegenerative diseases, hemorrhagic and ischemic stroke, and spinal cord injury. Central to this process is the Toll-like receptor 4 (TLR4) and myeloid...
Dual-port robot-assistant visualized minimally invasive aspiration (RAVMIA) for evacuation of irregular basal ganglia hemorrhage: A technical note
Available online 31 March 2026
The surgical management of intracerebral hemorrhage (ICH) remains controversial. While minimally invasive endoscopic techniques have shown promise, recent trials have not demonstrated positive outcomes...
Effectiveness of clazosentan in aneurysmal subarachnoid hemorrhage: A 12-year multicenter real-world study
Available online 31 March 2026
Outcomes of aneurysmal subarachnoid hemorrhage (SAH) remain poor. This study aimed to investigate changes in outcomes before and after the introduction of an endothelin A receptor antagonist clazosentan...
Precision medicine for cerebral Haemorrhage: Integrating Neuromarkers, Therapeutics, and recovery pathways
Available online 9 March 2026
Atrous-based CBAM-Unet framework for intracranial hemorrhage segmentation and volume calculation with grading using CT images
February 2026
Intracranial hemorrhage (ICH) is a leading cause of death following trauma, often resulting from traumatic brain injury (TBI) when not promptly evaluated and treated within the first 24 hours. Quantitative...
Pituitary apoplexy following heart surgery: a comprehensive review of the literature
February 2026
Pituitary apoplexy (PA) is a clinical syndrome characterized by abrupt infarction or hemorrhage of the hypophysis, typically within a pituitary adenoma. Heart surgery, particularly with the use of cardiopulmonary...
Research progress on risk stratification warning models for early hematoma expansion and poor outcome in intracerebral hemorrhage: A narrative review
February 2026
This review explores recent advances in risk stratification systems for early hematoma expansion (HE), focusing on predictive models using CTA, NCCT, radiomics, and artificial intelligence to enhance...
mGluR1 characteristic in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage
February 2026
Glutamate receptor-mediated excitotoxicity plays crucial role in aneurysmal subarachnoid hemorrhage (aSAH). Truncation of metabotropic glutamate receptor 1 (mGluR1) is a key step in excitotoxicity,...
Integrated network pharmacology reveals the mechanisms of punicalagin in cardiovascular and cerebrovascular diseases treatment
February 2026
Cardiovascular and cerebrovascular diseases, including coronary artery disease (CAD), myocardial infarction (MI), carotid atherosclerosis (CAS), and cerebral ischemic stroke (CIS), continue to impose...
The role of PGC-1α in brain injury: mechanisms and therapeutic potential
February 2026
Brain injury remains a significant contributor to mortality and long-term neurological disability worldwide, despite ongoing research efforts to develop effective therapies that can mitigate secondary...
Simultaneous bilateral basal ganglia hemorrhage: case report and literature review
February 2026
To present a rare case of symmetric hemorrhages in the bilateral basal ganglia with unique imaging findings and discuss potential pathophysiological mechanisms....
Application of “three-in-one” technique in spontaneous supratentorial intracerebral hemorrhage with cerebral herniation
Available online 5 February 2026
Spontaneous supratentorial intracerebral hemorrhage (SSICH) with cerebral herniation has extremely high mortality rate and poor prognosis. Rapid and sufficient decompression is of great significance...
Prognostic value of TC/HDL-C ratios in ischemic stroke: a multicenter observational study
Available online 3 February 2026
This study aimed to determine the relationship between the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and adverse outcomes in patients with first-ever ischemic stroke...
Neural decoding for EEG-BCI: from conventional machine learning to deep learning models
Available online 12 January 2026
Brain–computer interfaces (BCIs) decode neural signals to support alternative communication for individuals with motor and speech impairments, including severe speech disorders. We review EEG-BCI decoding...
Comparison of single-channel EEG decoding performance in imagined speech tasks
Available online 5 January 2026
EEG-based imagined speech decoding technology offers a communication solution for patients with language impairments. However, existing research on English-language systems cannot be directly applied...
The impact of body-mass-index on functional outcomes and bleeding volumes in patients suffering spontaneous intracerebral haemorrhage
December 2025
The association between obesity and clinical as well as radiological outcomes in patients suffering spontaneous intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective...
Novel middle meningeal artery-targeted mini-craniotomy incision and technique for treatment of chronic subdural hematoma with membranes/septations – technical note and case series
December 2025
Subdural hematomas (SDH) requiring surgery are associated with significant morbidity in elderly patients. We describe a novel technique/incision for minimizing invasiveness and duration, minimizing...
The role of D-dimer in intracerebral haemorrhage outcomes
December 2025
Activation of the coagulation and fibrinolysis system is a significant factor in secondary brain injury following spontaneous intracerebral haemorrhage (ICH). However, the relationships between plasma...
Application and future directions of brain-computer interfaces in neurological disorders: Technological advances, clinical practices, and challenges
December 2025
Brain-Computer Interfaces (BCIs) represent an innovative frontier in technology, establishing a direct link between the brain and external devices. This rapidly evolving field is increasingly recognized...
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