Application and future directions of brain-computer interfaces in neurological disorders: Technological advances, clinical practices, and challenges
Available online 14 September 2025
Brain-Computer Interfaces (BCIs) represent an innovative frontier in technology, establishing a direct link between the brain and external devices. This rapidly evolving field is increasingly recognized...
Atrous-based CBAM-Unet framework for intracranial hemorrhage segmentation and volume calculation with grading using CT images
Available online 11 September 2025
Intracranial hemorrhage (ICH) has been recognized as a leading reason for death following trauma, can result from traumatic brain injury (TBI) if it is not appropriately evaluated and treated during...
A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage
August 2025
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability. Cuproptosis is a regulatory cell death modality dependent on intracellular copper ion concentration, the...
The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns
August 2025
Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures...
Identification of non-invasive biomarkers associated with glioma hemorrhage
August 2025
Gliomas are among the most prevalent primary intracranial malignancies, and their management remains complex due to high rates of morbidity and mortality. Hemorrhage within gliomas, although relatively...
Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME
August 2025
Hypertension is a major cause of cerebral hemorrhage. Although they are widely used in preclinical studies on cerebral hemorrhage, traditional in vivo cerebrovascular imaging techniques, such as positron...
Non-coding RNAs in intracerebral hemorrhage: Roles, mechanisms, and therapeutic implications
August 2025
Intracerebral hemorrhage (ICH), which is a form of stroke triggered by the rupture of blood vessels within the brain tissue, is a leading cause of morbidity and mortality worldwide. Although significant...
Prophylactic barbiturate step-down infusion therapy has similar and favorable effects in elderly and non-elderly patients with severe traumatic brain injuries
August 2025
Objective: With the aging population, the number of elderly patients with severe traumatic brain injury (sTBI) inevitably increases. The high mortality rate for sTBI in the elderly necessitates effective...
Peak perihematomal edema expansion predicts poor outcome in patients with intracerebral hemorrhage
August 2025
Intracerebral hemorrhage (ICH) is a highly fatal and incapacitating form of stroke. Perihematomal edema (PHE) serves as a measurable radiological indicator in the progression of secondary injury and...
Effectiveness of 3D printed and mixed reality models in neurosurgical patient education: A systematic review
Available online 30 August 2025
Neurosurgical patients often face psychological distress due to difficulty understanding their medical condition and treatment plan. Traditional educational tools like MRI or CT scans may not effectively...
The role of D-dimer in intracerebral haemorrhage outcomes
Available online 28 August 2025
Activation of the coagulation and fibrinolysis system is a significant factor in secondary brain injury following spontaneous intracerebral haemorrhage (ICH). However, the relationships between plasma...
Robot-guided catheter drainage with urokinase versus craniotomy hematoma evacuation for spontaneous intracerebral hemorrhage: A retrospective study
Available online 22 August 2025
The management of spontaneous intracerebral hemorrhage(ICH) is a topic of debate. While craniotomy has been the traditional treatment, minimally invasive techniques like robot-guided stereotactic catheter...
Novel middle meningeal artery-targeted mini-craniotomy incision and technique for treatment of chronic subdural hematoma with membranes/septations – technical note and case series
Available online 21 August 2025
Subdural hematomas (SDH) requiring surgery are associated with significant morbidity in elderly patients. We describe a novel technique/incision for minimizing invasiveness and duration, minimizing...
CORM-2 attenuates red blood cell-mediated inflammation by upregulating phagocytic capacity of cerebral microglial cells of the neonatal rat in vitro
Available online 8 August 2025
•Effectively inhibiting inflammatory response in peri-hematoma area may reduce ICH-mediated secondary ischemic brain injury.•We established microglia and RBCs co-culture in vitro, to investigate the...
Transformer-based weakly supervised intracerebral hemorrhage segmentation using image-level labels
Available online 29 July 2025
The segmentation of intracerebral hemorrhage (ICH) lesions in brain CT scans is of paramount importance for the diagnosis and treatment of stroke. Given the tremendous challenge of pixel-wise annotation...
Fatal complication unveiled: analyzing intracerebral hemorrhage risk after CAR-T therapy in hematologic malignancies
Available online 28 July 2025
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated significant efficacy in the treatment of hematologic malignancies, yet it can lead to severe complications. Intracranial hemorrhage...
The role of PGC-1α in brain injury: mechanisms and therapeutic potential
Available online 26 July 2025
Brain injury remains a significant contributor to mortality and long-term neurological disability worldwide, despite ongoing research efforts to develop effective therapies that can mitigate secondary...
Link between heart failure and stroke: a comprehensive review
Available online 25 July 2025
Heart failure and stroke are two major cardiovascular conditions that significantly contribute to morbidity and mortality worldwide.1 While the link between heart failure and ischemic stroke is well...
Perioperative management of brain hemorrhage: Advances in anesthetic strategies and translational medicine
Available online 16 July 2025
•Brain hemorrhage presents perioperative challenges, requiring optimized anesthetic strategies.•Anesthesia choice and agent selection significantly influence perioperative outcomes.•Advanced neuromonitoring...
Advancing deep learning for automated stroke detection: a review
Available online 13 July 2025
Stroke remains a leading cause of death and disability worldwide, necessitating improved diagnostic tools for early detection and classification. Machine learning (ML) techniques have shown promise...
Grading of acute spontaneous cerebral hemorrhage combined with gut dysfunction assessment as a novel and improved prognostic score
Available online 13 July 2025
•The GD-ICH model demonstrated greater accuracy and predictive value than conventional models.•Gut dysfunction is as a reliable prognostic factor in ICH.•Gut dysfunction >7.5 days predicts poor prognosis,...
The impact of body-mass-index on functional outcomes and bleeding volumes in patients suffering spontaneous intracerebral haemorrhage
Available online 7 July 2025
The association between obesity and clinical as well as radiological outcomes in patients suffering spontaneous intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective...
Ultra-early hematoma growth predicts gastrointestinal bleeding after spontaneous intracerebral hemorrhage
Available online 3 July 2025
Ultra-early hematoma growth (uHG) has been shown to predict hematoma expansion (HE) and poor outcomes in intracerebral hemorrhage (ICH) patients. Gastrointestinal bleeding, a severe ICH complication,...
Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage
June 2025
Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality...
Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential
June 2025
Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the...
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