Fluid balance management with loop diuretics in patients with aneurysmal subarachnoid hemorrhage treated with clazosentan: A case series
April 2024
Pulmonary edema is a common complication in patients receiving clazonsentan. Here, we report our experience in managing fluid balance with loop diuretics in patients with aneurysmal subarachnoid hemorrhage...
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Could clazosentan, first approved in Japan, improve neurological prognosis after subarachnoid hemorrhage in combination with modified water-electrolyte management?
April 2024
An aneurysmal subarachnoid hemorrhage (aSAH) is a devastating event associated with a high mortality and morbidity rate. Though numerous medications are used to prevent cerebral vasospasm and vasospasm-related...
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Beneficial effects of clazosentan add-on treatment on delayed cerebral microcirculatory disturbances after aneurysmal subarachnoid hemorrhage
April 2024
This retrospective study aimed to analyze the prospectively collected data of computed tomography (CT) perfusion imaging and to examine if clazosentan add-on administration prevented post-subarachnoid...
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Evolving approaches in the management of patients with subarachnoid hemorrhage from 2002 to 2022: The impact of clazosentan and treatment modalities on outcomes
April 2024
This study aimed to assess the changes in patient demographics, aneurysm characteristics, and treatment modalities for subarachnoid hemorrhage (SAH) over the past two decades....
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A high cardiothoracic ratio increases the risk of severe pulmonary complications after early initiation of clazosentan in patients with aneurysmal subarachnoid hemorrhage
April 2024
Pulmonary complications, which are occasionally severe, are common adverse events following the administration of clazosentan. This study aimed to identify factors associated with severe pulmonary adverse...
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Impact of strict fluid management on the treatment outcome of clazosentan for cerebral vasospasm
April 2024
Clazosentan (CLA) reduces cerebral vasospasm after aneurysmal subarachnoid hemorrhage (aSAH). However, adverse events including pulmonary edema were reported. We examined whether the strict management...
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Initial results of clazosentan with multiple-drug management for the prevention of cerebral vasospasm after aneurysmal subarachnoid hemorrhage
April 2024
Cerebral vasospasm is an unelucidated complication of subarachnoid hemorrhage. Various treatments exist against cerebral vasospasms however, consensus on the optimal treatment is lacking. We use clazosentan,...
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Effect of mesenchymal stem cell-derived exosomes on the inflammatory response after stroke
Available online 20 April 2024
Stroke, characterized by sudden onset and significant mortality rates, represents a critical challenge in effectively treating neuroinflammation to improve treatment efficacy. In this context, mesenchymal...
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Inspiration for the treatment of intracerebral hemorrhage from the duality of glial scar: The right time point for reactive astrocytes reprogramming
Available online 18 April 2024
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VASP, HCLS1, MSN, and EZR: Key molecular beacons in the pathophysiology of perihematomal edema Post-Intracerebral hemorrhage
Available online 17 April 2024
•The study pinpoints VASP, HCLS1, MSN, and EZR as critical genes linked to tight junction integrity, playing significant roles in perihematomal edema following intracerebral hemorrhage.•Enhanced leukocyte...
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Quadriparesis with bilateral anterior cerebral artery infarction following subarachnoid haemorrhage due to rupture of an anterior communicating artery aneurysm: A case report with literature review
Available online 3 April 2024
Anterior cerebral artery (ACA) territory infarctions are relatively rare, accounting for 0.3 % to 4.4 % of stroke cases, with bilateral occurrences being even rarer. These infarctions can lead to quadriplegia/paresis....
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Recent trends of treatment strategies and outcomes of basal ganglia hemorrhages at a single institution
Available online 21 March 2024
The Early Minimally Invasive Removal of Intracerebral Hemorrhage (ENRICH) Trial was designed to evaluate the minimally invasive trans-sulcal parafascicular surgery (MIPS) approach, a technique advertised...
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Cerebral venous impairment and cerebral venous sinus thrombosis
Available online 11 March 2024
Cerebral veins are responsible for the outflow drainage of brain interstitial fluid (ISF). The importance of cerebral venous drainage has been emphasized in various neurological diseases. Impaired venous...
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The function of astrocytes in cerebral infarction and potential therapeutic approaches
Available online 11 March 2024
Astrocytes, the most prevalent cells in the central nervous system, significantly contribute to the normal physiological functions of the brain. Following cerebral infarction, these astrocytes undergo...
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An extensive basal ganglia hemorrhage in a preexisting neonatal asphyxiated lesion after mRNA-based SARS-CoV-2 vaccination: A fatal adult case of cerebral palsy
February 2024
Neurological adverse reactions to SARS-CoV-2 vaccines include a wide variety of central nervous system (CNS) disorders; however, the cause-and-effect relationship is unclear. Herein, we present a fatal...
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Admission triglyceride-glucose index predicts long-term mortality patients with subarachnoid hemorrhage a retrospective analysis of the MIMIC-IV database
February 2024
Objective：The triglyceride-glucose (TyG) index is an indicator for insulin resistance (IR). Several studies have validated the impact of the TyG index on cerebrovascular disease. However, the value...
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Impact of SARS-CoV-2 Omicron variant infection on the outcomes of patients with spontaneous intracerebral hemorrhage: A prospective cohort study
February 2024
This study aims to investigate the impact of the infection with the novel coronavirus Omicron variant on the outcomes of patients with severe spontaneous intracerebral hemorrhage....
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Increased plasma periostin concentration predicts angiographic vasospasm development in non-severe aneurysmal subarachnoid hemorrhage
February 2024
It is unknown whether plasma concentrations of a matricellular protein periostin change in association with the development of angiographic vasospasm after aneurysmal subarachnoid hemorrhage (SAH)....
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Outcomes of endovascular treatment alone or with intravenous alteplase in acute ischemic stroke Patients: A retrospective cohort study
February 2024
The aim of this study is to compare the clinical outcomes, safety, and workflow of patients who underwent endovascular treatment (EVT) alone or in combination with intravenous thrombolysis (IVT), against...
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Managing Mental Disorders in Intracranial Hemorrhage (ICH) Patients: A Case Study on The Importance of Early Recognition and Intervention
February 2024
Intracranial Hemorrhage (ICH) can lead to various clinical manifestations and complications. These include mental disorders that range from impaired cognitive function to disturbances in the sensorium,...
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Outcomes of Microsurgical Resection of Low-Grade Cerebral Arteriovenous Malformations: A Prospective Observational Multicenter Study from a Low-Middle-Income Country
February 2024
To appraise the overall outcomes of microsurgical resection of low-grade arteriovenous malformations (AVMs) in a low-middle-income country....
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Falx interhemispheric subdural hematoma in a hypertensive patient with urticaria: A case report
February 2024
Falx interhemispheric subdural hematoma (FISH) is a rare subtype of subdural hematoma that occurs between the cerebral hemispheres along with falx cerebri. It represents less than 0.5% of all subdural...
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Special considerations and pitfalls for intracerebral bleeding followed COVID-19 case treated by ECMO
February 2024
COVID-19, or coronavirus infection, is an acute respiratory illness caused by the corona virus that can develop into a life-threatening form of ARDS. Extracorporeal membrane oxygenation (ECMO) is a...
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The role of crosstalk between cerebral immune cells and peripheral immune cells in the damage and protection of blood–brain barrier after intracerebral hemorrhage
Available online 15 February 2024
•We first introduce the role of CICs and PICs in BBB damage and protection after ICH, focusing on inflammatory response.•Next, we specifically discuss the crosstalk between CICs and PICs, such as brain-spleen...
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