Immune cells in intracerebral hemorrhage
April 2025
Intracerebral hemorrhage (ICH), the deadliest form of stroke, is characterized by bleeding into brain parenchyma and formation of hematoma. Currently, there is no treatment available for ICH. Inflammatory...
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Intracranial pressure monitoring and minimally invasive surgery for intracerebral hemorrhage: Current status, challenges, and future
April 2025
With the continuous advancement of medical technology, the treatment for intracerebral hemorrhage (ICH) has shifted from traditional open surgery to more precise minimally invasive surgery (MIS). This...
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Utilizing neuroimaging visualization technology to enhance standardized neurosurgical training for Traditional Chinese Medicine residents: A neuroanatomical education study
April 2025
This study aims to address the difficulties encountered by Traditional Chinese Medicine (TCM) students in learning neuroanatomy during clinical training by utilizing neuroimaging visualization tech...
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Step-down infusion of barbiturate improves neurofunction in a new rat model of rebleeding subarachnoid hemorrhage
April 2025
Rebleeding from a ruptured aneurysm is a risk factor for fatal prognosis in subarachnoid hemorrhage (SAH). A novel barbiturate treatment, step-down infusion of barbiturate (sd-B), was previously developed;...
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No association of brain CT blend sign with functional outcomes in patients with spontaneous supratentorial intracerebral hemorrhage after craniotomy
April 2025
•We found the sub-high-density region of blend sign remained in a liquid state even after a period of placement and was easily drained during the operation.•We arise a conjecture that patients with...
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Prognosis of recovery and death within 1–6 months of spontaneous cerebellar hemorrhage undergoing suboccipital craniotomy
April 2025
Suboccipital craniotomy is a considerable surgical approach for large spontaneous cerebellar hemorrhage, but its prognostic has not been comprehensively addressed. This study aims to report the surgical...
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Clazosentan for aneurysmal subarachnoid hemorrhage: Update from Japan
Available online 24 April 2025
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Ngn2 failed to induce astrocyte-to-neuron reprogramming after intracerebral hemorrhage
Available online 23 April 2025
Intracerebral hemorrhage (ICH) is a severe neurological disorder with high mortality due to neuronal loss, and current therapies face significant challenges. Cell reprogramming offers a potential solution....
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Atorvastatin and glucocorticoid therapy for retroclival epidural hematoma: Case report and literature review
Available online 3 April 2025
Retroclival epidural hematomas (REDH) are particularly rare conditions. We report for the first time the effect of conservative treatment of this rare condition with atorvastatin and glucocorticoids...
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The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns
Available online 19 March 2025
Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures...
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Development and validation of an improved ICH score: Integrating clinical and radiographic parameters for enhanced prediction of 30-day mortality in spontaneous intracerebral hemorrhage
Available online 17 March 2025
•Adding pupil status and warfarin use improves ICH score mortality prediction.•The new score achieved an AUROC of 0.91, better than the original score of 0.87.•Enhanced accuracy benefits both nonoperative...
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Perioperative sodium overload is associated with the occurrence of pulmonary complications related to clazosentan in patients with subarachnoid hemorrhage followed by obliterative management for ruptured aneurysm: A retrospective observational study
Available online 17 March 2025
•Delayed cerebral ischemia (DCI) following aneurysmal subarachnoid hemorrhage are influenced by elevated endothelin-1 levels.•Clazosentan, a selective ETA receptor antagonist is associated with a higher...
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mGluR1 characteristic in cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage
Available online 17 March 2025
Glutamate receptor-mediated excitotoxicity plays crucial role in aneurysmal subarachnoid hemorrhage (aSAH). Truncation of metabotropic glutamate receptor 1 (mGluR1) is a key step in excitotoxicity,...
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Current state of endovascular treatment for cavernous and petrous internal carotid artery aneurysms
Available online 16 March 2025
Cavernous and petrous internal carotid artery (ICA) aneurysms have similar clinical characteristics, making it feasible to discuss these two types of aneurysms together. Currently, endovascular treatment...
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A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage
Available online 2 March 2025
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability. Cuproptosis is a regulatory cell death modality dependent on intracellular copper ion concentration, the...
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Mixed-reality head-mounted display in cranial neurosurgery: A proof-of-concept study
February 2025
Mixed-reality (MR) head-mounted displays (HMD) offer virtual augmentations registered with real objects, allowing for direct patient-centered lesion visualization. In contrast to other surgical subspecialties,...
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Immune System Perspective in Intracerebral Hemorrhage Research: A Focus on Monocytes and Macrophages
February 2025
Monocytes and macrophages are crucial elements of the immune system, having various roles in tissue balance, inflammation, and conditions like stroke. They exhibit significant functional diversity,...
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Bioinformatics analysis of potential pathogenesis and risk genes of neuroinflammation-promoted brain injury in intracerebral hemorrhage
February 2025
Spontaneous (non-traumatic) intracerebral hemorrhage (ICH) is one of the major causes of global death. The purpose of our bioinformatics analysis was to detect viable pathophysiological targets and...
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Leakage sign based on contrast-enhanced CT is a predictive marker for hematoma expansion and poor prognosis in primary brainstem hemorrhage
February 2025
Although hematoma expansion is a poor prognostic factor in patients with intracerebral hemorrhage (ICH), its effect on primary brainstem hemorrhage (PBSH) remains unclear. Since we previously observed...
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The evolution of brain surgery: Exploring the impact of continuum robotics
February 2025
Brain surgery requires at most accuracy and precision, yet current neurosurgical robots are limited in their ability to reach intracranial regions due to their rigid and inflexible nature. However,...
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A case of bilateral vertebral artery dissecting aneurysms presenting with subarachnoid hemorrhage evaluated using computational fluid dynamics: Which is the rupture side?
February 2025
Background: Saccular aneurysms (SAs) have been long studied in hemodynamics using computational fluid dynamics (CFD), while dissecting aneurysms (DAs) remain unclear. To estimate which side of the aneurysm...
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Relationships between NT-pro-BNP and other serological indicators and the prognosis of spontaneous intracerebral hemorrhage
February 2025
Acute spontaneous intracerebral hemorrhage (ICH) is a life-threatening condition, and certain serological indicators may be associated with the prognosis after ICH. This study investigated the relationship...
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Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage
Available online 19 February 2025
Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality...
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Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential
Available online 18 February 2025
Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the...
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The role of blood lipid and triglyceride‑glucose index in intracranial aneurysms: A retrospective study
Available online 17 February 2025
The association between blood lipids and aneurysmal subarachnoid hemorrhage (aSAH) remains uncertain, with current research yielding conflicting results. Limited studies have explored the link between...
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