Perioperative management of brain hemorrhage: Advances in anesthetic strategies and translational medicine
Available online 16 July 2025
•Brain hemorrhage presents perioperative challenges, requiring optimized anesthetic strategies.•Anesthesia choice and agent selection significantly influence perioperative outcomes.•Advanced neuromonitoring...
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Advancing deep learning for automated stroke detection: a review
Available online 13 July 2025
Stroke remains a leading cause of death and disability worldwide, necessitating improved diagnostic tools for early detection and classification. Machine learning (ML) techniques have shown promise...
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Grading of acute spontaneous cerebral hemorrhage combined with gut dysfunction assessment as a novel and improved prognostic score
Available online 13 July 2025
•The GD-ICH model demonstrated greater accuracy and predictive value than conventional models.•Gut dysfunction is as a reliable prognostic factor in ICH.•Gut dysfunction >7.5 days predicts poor prognosis,...
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The impact of body-mass-index on functional outcomes and bleeding volumes in patients suffering spontaneous intracerebral haemorrhage
Available online 7 July 2025
The association between obesity and clinical as well as radiological outcomes in patients suffering spontaneous intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective...
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Ultra-early hematoma growth predicts gastrointestinal bleeding after spontaneous intracerebral hemorrhage
Available online 3 July 2025
Ultra-early hematoma growth (uHG) has been shown to predict hematoma expansion (HE) and poor outcomes in intracerebral hemorrhage (ICH) patients. Gastrointestinal bleeding, a severe ICH complication,...
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Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage
June 2025
Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality...
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Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential
June 2025
Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the...
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Premorbid long-term statin use can reduce the risk of hemorrhagic transformation after ischemic stroke
June 2025
Hemorrhagic transformation (HT) of cerebral infarction is considered as one of the most serious complications. Increasing evidence show that statin use might reduce the neuroinflammation and even improve...
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Coexistence of ruptured basilar artery perforator aneurysm undetected on initial angiogram and unruptured anterior cerebral artery saccular aneurysm: Case report and literature review
June 2025
Ruptured basilar artery perforator aneurysm (BAPA) is a rare cause of subarachnoid hemorrhage (SAH) and is difficult to diagnose....
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The Progressive Frontier of Aneurysmal subarachnoid Hemorrhage: Diagnosis and treatment Advances
June 2025
Aneurysmal subarachnoid hemorrhage affects 6 to 9 out of every 100,000 people annually, with a mortality rate of 35%. Many people suffer from long-term disabilities, often associated with cognitive...
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Effectiveness of 3D printing technology-assisted neuroendoscopic surgery for hypertensive intracerebral hemorrhage in primary hospitals
June 2025
We aimed to investigate the clinical effectiveness of integrating 3D-printing technology with neuroendoscopy for treating hypertensive intracerebral hemorrhage (HICH)....
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Simultaneous bilateral basal ganglia hemorrhage: case report and literature review
Available online 16 June 2025
To present a rare case of symmetric hemorrhages in the bilateral basal ganglia with unique imaging findings and discuss potential pathophysiological mechanisms....
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Integrated network pharmacology reveals the mechanisms of punicalagin in cardiovascular and cerebrovascular diseases treatment
Available online 10 June 2025
Cardiovascular and cerebrovascular diseases, including coronary artery disease (CAD), myocardial infarction (MI), carotid atherosclerosis (CAS), and cerebral ischemic stroke (CIS), continue to impose...
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Identification of non-invasive biomarkers associated with glioma hemorrhage
Available online 9 June 2025
Gliomas are among the most prevalent primary intracranial malignancies, and their management remains complex due to high rates of morbidity and mortality. Hemorrhage within gliomas, although relatively...
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Immune cells in intracerebral hemorrhage
April 2025
Intracerebral hemorrhage (ICH), the deadliest form of stroke, is characterized by bleeding into brain parenchyma and formation of hematoma. Currently, there is no treatment available for ICH. Inflammatory...
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Intracranial pressure monitoring and minimally invasive surgery for intracerebral hemorrhage: Current status, challenges, and future
April 2025
With the continuous advancement of medical technology, the treatment for intracerebral hemorrhage (ICH) has shifted from traditional open surgery to more precise minimally invasive surgery (MIS). This...
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Utilizing neuroimaging visualization technology to enhance standardized neurosurgical training for Traditional Chinese Medicine residents: A neuroanatomical education study
April 2025
This study aims to address the difficulties encountered by Traditional Chinese Medicine (TCM) students in learning neuroanatomy during clinical training by utilizing neuroimaging visualization tech...
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Step-down infusion of barbiturate improves neurofunction in a new rat model of rebleeding subarachnoid hemorrhage
April 2025
Rebleeding from a ruptured aneurysm is a risk factor for fatal prognosis in subarachnoid hemorrhage (SAH). A novel barbiturate treatment, step-down infusion of barbiturate (sd-B), was previously developed;...
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No association of brain CT blend sign with functional outcomes in patients with spontaneous supratentorial intracerebral hemorrhage after craniotomy
April 2025
•We found the sub-high-density region of blend sign remained in a liquid state even after a period of placement and was easily drained during the operation.•We arise a conjecture that patients with...
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Prognosis of recovery and death within 1–6 months of spontaneous cerebellar hemorrhage undergoing suboccipital craniotomy
April 2025
Suboccipital craniotomy is a considerable surgical approach for large spontaneous cerebellar hemorrhage, but its prognostic has not been comprehensively addressed. This study aims to report the surgical...
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Clazosentan for aneurysmal subarachnoid hemorrhage: Update from Japan
Available online 24 April 2025
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Ngn2 failed to induce astrocyte-to-neuron reprogramming after intracerebral hemorrhage
Available online 23 April 2025
Intracerebral hemorrhage (ICH) is a severe neurological disorder with high mortality due to neuronal loss, and current therapies face significant challenges. Cell reprogramming offers a potential solution....
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Atorvastatin and glucocorticoid therapy for retroclival epidural hematoma: Case report and literature review
Available online 3 April 2025
Retroclival epidural hematomas (REDH) are particularly rare conditions. We report for the first time the effect of conservative treatment of this rare condition with atorvastatin and glucocorticoids...
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The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns
Available online 19 March 2025
Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures...
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Development and validation of an improved ICH score: Integrating clinical and radiographic parameters for enhanced prediction of 30-day mortality in spontaneous intracerebral hemorrhage
Available online 17 March 2025
•Adding pupil status and warfarin use improves ICH score mortality prediction.•The new score achieved an AUROC of 0.91, better than the original score of 0.87.•Enhanced accuracy benefits both nonoperative...
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