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ISSN: 2589-238X

Atrous-based CBAM-Unet framework for intracranial hemorrhage segmentation and volume calculation with grading using CT images

Intracranial hemorrhage (ICH) has been recognized as a leading reason for death following trauma, can result from traumatic brain injury (TBI) if it is not appropriately evaluated and treated during...

A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability. Cuproptosis is a regulatory cell death modality dependent on intracellular copper ion concentration, the...

The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns

Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures...

Identification of non-invasive biomarkers associated with glioma hemorrhage

Gliomas are among the most prevalent primary intracranial malignancies, and their management remains complex due to high rates of morbidity and mortality. Hemorrhage within gliomas, although relatively...

Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME

Hypertension is a major cause of cerebral hemorrhage. Although they are widely used in preclinical studies on cerebral hemorrhage, traditional in vivo cerebrovascular imaging techniques, such as positron...

Non-coding RNAs in intracerebral hemorrhage: Roles, mechanisms, and therapeutic implications

Intracerebral hemorrhage (ICH), which is a form of stroke triggered by the rupture of blood vessels within the brain tissue, is a leading cause of morbidity and mortality worldwide. Although significant...

Prophylactic barbiturate step-down infusion therapy has similar and favorable effects in elderly and non-elderly patients with severe traumatic brain injuries

Objective: With the aging population, the number of elderly patients with severe traumatic brain injury (sTBI) inevitably increases. The high mortality rate for sTBI in the elderly necessitates effective...

Peak perihematomal edema expansion predicts poor outcome in patients with intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is a highly fatal and incapacitating form of stroke. Perihematomal edema (PHE) serves as a measurable radiological indicator in the progression of secondary injury and...

Effectiveness of 3D printed and mixed reality models in neurosurgical patient education: A systematic review

Neurosurgical patients often face psychological distress due to difficulty understanding their medical condition and treatment plan. Traditional educational tools like MRI or CT scans may not effectively...

The role of D-dimer in intracerebral haemorrhage outcomes

Activation of the coagulation and fibrinolysis system is a significant factor in secondary brain injury following spontaneous intracerebral haemorrhage (ICH). However, the relationships between plasma...

Robot-guided catheter drainage with urokinase versus craniotomy hematoma evacuation for spontaneous intracerebral hemorrhage: A retrospective study

The management of spontaneous intracerebral hemorrhage(ICH) is a topic of debate. While craniotomy has been the traditional treatment, minimally invasive techniques like robot-guided stereotactic catheter...

Novel middle meningeal artery-targeted mini-craniotomy incision and technique for treatment of chronic subdural hematoma with membranes/septations – technical note and case series

Subdural hematomas (SDH) requiring surgery are associated with significant morbidity in elderly patients. We describe a novel technique/incision for minimizing invasiveness and duration, minimizing...

CORM-2 attenuates red blood cell-mediated inflammation by upregulating phagocytic capacity of cerebral microglial cells of the neonatal rat in vitro

•Effectively inhibiting inflammatory response in peri-hematoma area may reduce ICH-mediated secondary ischemic brain injury.•We established microglia and RBCs co-culture in vitro, to investigate the...

Transformer-based weakly supervised intracerebral hemorrhage segmentation using image-level labels

The segmentation of intracerebral hemorrhage (ICH) lesions in brain CT scans is of paramount importance for the diagnosis and treatment of stroke. Given the tremendous challenge of pixel-wise annotation...

Fatal complication unveiled: analyzing intracerebral hemorrhage risk after CAR-T therapy in hematologic malignancies

Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated significant efficacy in the treatment of hematologic malignancies, yet it can lead to severe complications. Intracranial hemorrhage...

The role of PGC-1α in brain injury: mechanisms and therapeutic potential

Brain injury remains a significant contributor to mortality and long-term neurological disability worldwide, despite ongoing research efforts to develop effective therapies that can mitigate secondary...

Link between heart failure and stroke: a comprehensive review

Heart failure and stroke are two major cardiovascular conditions that significantly contribute to morbidity and mortality worldwide.1 While the link between heart failure and ischemic stroke is well...

Perioperative management of brain hemorrhage: Advances in anesthetic strategies and translational medicine

•Brain hemorrhage presents perioperative challenges, requiring optimized anesthetic strategies.•Anesthesia choice and agent selection significantly influence perioperative outcomes.•Advanced neuromonitoring...

Advancing deep learning for automated stroke detection: a review

Stroke remains a leading cause of death and disability worldwide, necessitating improved diagnostic tools for early detection and classification. Machine learning (ML) techniques have shown promise...

Grading of acute spontaneous cerebral hemorrhage combined with gut dysfunction assessment as a novel and improved prognostic score

•The GD-ICH model demonstrated greater accuracy and predictive value than conventional models.•Gut dysfunction is as a reliable prognostic factor in ICH.•Gut dysfunction >7.5 days predicts poor prognosis,...

The impact of body-mass-index on functional outcomes and bleeding volumes in patients suffering spontaneous intracerebral haemorrhage

The association between obesity and clinical as well as radiological outcomes in patients suffering spontaneous intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective...

Ultra-early hematoma growth predicts gastrointestinal bleeding after spontaneous intracerebral hemorrhage

Ultra-early hematoma growth (uHG) has been shown to predict hematoma expansion (HE) and poor outcomes in intracerebral hemorrhage (ICH) patients. Gastrointestinal bleeding, a severe ICH complication,...

Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage

Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality...

Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential

Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the...

Premorbid long-term statin use can reduce the risk of hemorrhagic transformation after ischemic stroke

Hemorrhagic transformation (HT) of cerebral infarction is considered as one of the most serious complications. Increasing evidence show that statin use might reduce the neuroinflammation and even improve...

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