Recent Articles

Enhancing ovarian cancer immunotherapy through TAGLN2-modified CAR-T cells

January 2027

Fang Yang | Hanqi Lou | Chun Zhao | Shiwei Duan | Yongming Xia

Long-term survival following SCLC transformation after osimertinib resistance in EGFR-mutant NSCLC: Benefit from local surgical resection and osimertinib rechallenge

January 2027

Qian Zhang

Transcriptional circuits of the glioma microenvironment: FOSL2 as a master regulator of the pathological niche

January 2027

Jia'ning Zhang | Chao Guan | Zechen Wang | Lizheng Jin | Zhen Lin | Jin Wen | Guangliang Chen | Pin Guo

On-demand treatment of icatibant in a patient of hereditary angioedema with KNG1 mutation

January 2027

Wo Yao | Boyun Yang | Huiying Wang

A novel causative LMNA variant in acrogeria syndrome and literature review of genotype–phenotype correlations

January 2027

Haisheng Huang | Yingying Miao | Yumeng Wang | Rui Lei | Mo Zhang | Cheng Zhang | Xianwei Cao | Ming Li | Yunqing Ren

Splice rescue of protein-truncating variants is associated with reduced selection pressure and attenuated disease phenotypes

January 2027

Xi Cheng | Fei Liu | Yixuan Gai | Lina Zhao | Wen Wen | Xueqing Lu | Zhihong Wu | Jianguo Zhang | Sen Zhao | Nan Wu

Ginsenoside Rg1 attenuates mitochondrial dysfunction in bleomycin-induced pulmonary fibrosis by inhibiting Nrf2/Sirt3 pathways

January 2027

Qi Qi | Shihao Wen | Linchao Niu | Ru Zhang | Meili Lu | Jingliang Zhang | Hongxin Wang

Robust prediction of response to growth hormone therapy by five PBMC-based transcripts

January 2027

Valerie van Kekem | Irene Victoria Bermúdez-Pérez | Alexandra E. Kulle | Maik Welzel | Nadine Hornig | Gerhard Binder | Matthias Hübenthal | Robert Häsler | Paul-Martin Holterhus

The ATG4 isotype is a key regulator in CSE/H2S-mediated mitophagy in cardiac hypertrophy

January 2027

Yijun Xin | Zhaoji Yuan | Yong Zhang | Xiaofei Qiao | Xiangdong Wang | Siying Li

Targeting nucleolin-driven cancer stemness suppresses high-risk neuroblastoma in vivo

January 2027

Dan Qi | Ronghu Ke | Euni Wu | Yizhong Pan | S. Stephen Yi | Jason H. Huang | Erxi Wu

TfR1 deficiency beyond combined immunodeficiency. Pivotal role of mitochondrial function and iron-sulfur cluster biogenesis in disease pathogenesis

January 2027

Gerard Muñoz-Pujol | Elise J. Huisman | Juan-Francisco Mesa | Marieke Joosten | Annick Devos | Miguel Fernandez-Burriel | Olatz Ugarteburu | Eulàlia Segur-Bailach | Sabrina Gea-Sorlí | Sonia Moliner | Laia Farré-Tarrats | Mariona Guitart-Mampel | Gianluca Arauz-Garofalo | Marina Gay | Neus Villamor | Gemma Martín | María Calvo | Gloria Garrabou | María J. Macias | Laura Gort | Judit García-Villoria | Cristina Fillat | Frederic Tort | Antonia Ribes

Clinical and iPSC-based characterization of the HNF1A p.T82M variant

January 2027

Ran Liu | Aysha Bakari Murusuri | Siyi Huang | Zhe Dai | Wei Jiang | Jun Tang

ENO1 as a potential tumor prognostic marker promotes the proliferation, invasion, and metastasis of breast cancer cells

January 2027

Lifang He | Yue Xu | Lu Huang | Lijuan He | Zexiao Chen | Zhaochang Qi | Yukun Cui

Ionizing radiation induces senescence of dermal papilla cells through inhibiting the FOXM1–KIF20A pathway

January 2027

Zou Jia | Kai Tian | Yinxuan Suo | Wushuang Xu | Pingfan Wu | Wei Sun | Lijun Wu | Lei Sheng | Xiaozhong Zhou

Construction and characterization of a cardiac organoid ARVC disease model with its application in gene therapy targeting PKP2

January 2027

Yanan Zhu | Hui Zhang | Zhen Qi | Xinyue Ding | Sijie Yao | Xuan Zhao | Junqing Gao | Lina Xing | Xin Wang | Zongjun Liu

The DDIT4L-TOM40-ATP5A pathway suppresses glioblastoma oncogenesis

January 2027

Pu You | Zeng-Xin Qi | Hao Luo | Bing Cai | Xu-Ye Hu | Jing Pan | Pan-Pan Gan | Xin-Ying Zeng | Ri-Jing Liao | Qisheng Tang | Ye Yu | Zhen-Ning Zhang | Bojie Yang | Liang Chen | Xu Zhang | Kai-Cheng Li | Ying Mao

VCP at the crossroads of UPS and autophagy in cancer

January 2027

Charlie J. Hitchman | Julia I. Phillips | Hee-Won Park | Hua Lu

Proteostasis is maintained by the coordinated action of the ubiquitin–proteasome system (UPS) and autophagy–lysosome pathways. Valosin-containing protein (VCP/p97), an AAA + unfoldase, sits at its intersection...

ONC201/dordaviprone for H3 K27M-mutant tumors: Discovery, mechanisms, therapeutic potential, and future directions

January 2027

Julio M. Pimentel | Jun-Ying Zhou | Gen Sheng Wu

ONC201 (dordaviprone) has recently received accelerated approval for the treatment of recurrent H3 K27M–mutant diffuse midline glioma. Originally identified as TRAIL-inducing compound 10 (TIC10), ONC201...

Metabolic reprogramming in colorectal cancer: Mechanisms and therapeutic insights

January 2027

Wen Xiao | Dan Tan | Wen Zeng | Xiaoming Nie | Mingliang Wang

Metabolic reprogramming is an important factor contributing to tumor medication resistance and recurrence in cancer cells. There is ample proof that metabolic remodeling is vital in colorectal cancer’s...

Necroptosis-related diseases are regulated by the unfolded protein response during endoplasmic reticulum stress

January 2027

Tong Li | Tian Su | Sha Tang | Kun Cao | Pengbing Hua | Jingbiao Gao | Hongwang Cui | Tongmeng Jiang

In recent years, research has highlighted that necroptosis plays a significant role in various diseases, suggesting that studying the pathways of necroptosis may offer novel avenues for developing treatments...

Commentary on clim-TIME: A paradigm shift in spatially resolved perturbation mapping of the metastatic tumor microenvironment

November 2026

Yang Fang | Lu Bai | Lingjie Jing | Jinkai Tong | Quanjun Yang

FLCN c.1300G>A: Selective advantage in medieval France

November 2026

Agathe Hercent | Ibrahima Ba | Dimitri Tchernitchko

A novel chimeric RNA RPGR-EEF1A1 enhances autophagy by interaction with the small GTPase RAB37 in a GTP-dependent manner

November 2026

Cong Li | Anqi Zhu | Wenhui Shi | Yifei Wang | Rongjia Zhou | Yanghua Tian | Zhimin Zhai | Qiang Hong