Recent Articles

A candidate PTPN5 frameshift variant in a family with a neurodevelopmental disorder supported by a zebrafish loss-of-function model

March 2027

Yunlong Meng | Yu Chen | Xingkun Tang | Kangyu Liu | YanLi Ma | Yuanhai Xie | Zilin Zhong | Jianjun Chen

Integrating single-cell transcriptomics and machine learning to reveal prognostic and immune significance of lactylation in breast cancer

March 2027

Da Qian | Haotian Liu | Jianchen Mou | Zhuotao Yang | Liquan Zhu | Chaoqi He | Bo Wang | Xuli Meng

Genetic engineering of primary human mesenchymal stromal cells using the CRISPR/Cas9 synergistic activation mediator

March 2027

M.C. Killer | X. Zhang | T. Adhikary | C. Kasper | A. Neubauer | M. Frech | C. Brendel

Expanding the phenotypic spectrum of familial digital arthropathy-brachydactyly due to a novel monoallelic variant in TRPV4: A report of the fourth family

March 2027

Xingzhu Geng | Yunyun Zhang | Chunhai Gao | Kai Liu | Yuda Wei | Xiaxia Liu | Hongyan Xu | Xiangyu Zhao

Patient-specific iPSCs-derived neuronal models of spinocerebellar ataxia type 1 as a platform for studying calcium mishandling

March 2027

Dmitriy Grekhnev | Egor Volovikov | Olga Lebedeva | Anton Skopin | Konstantin Gusev | Sergey Klyushnikov | Alexandra Bogomazova | Guanghui Wang | Elena Zerkalenkova | Sergey Illarioshkin | Maria Lagarkova | Elena Kaznacheyeva | Vladimir Vigont

Overexpression of LINC01605 promotes early tumorigenic phenotypes in primary human colon epithelial organoids

March 2027

Tracy Kongai | Erin E. Johnson | András K. Ponti | Maryssa Shanteau-Jackson | Gail A. West | Tatiana Dombrovski | Christine McDonald | Thomas LaFramboise

Phase separation of Snail1 modulates transcription and cancer progression

March 2027

Yi-Ping Huang | Peng-Wei Zhang | Ke He | Zhong-Bao Shao | Wei-Jing Liu | You-Qing Zhu | Shi-Jie Zeng | Zhi Shi

Single-cell transcriptome analysis highlights conserved transcriptional responses across multiple models of Retinitis Pigmentosa

March 2027

Santiago Negueruela | Martina Di Guida | Paola Brandi | Sandro Banfi

Thymidylate synthase expression identifies hepatocellular carcinoma vulnerable to fluoropyrimidine-based therapy

March 2027

Hyunji Choi | Yeeun Lee | Juyoung Lee | Jang-Yu Lee | Sangwon Byun | Kyunghee Noh | Kyung Chan Park | Wonbeak Yoo

Impact of MTHFR C677T polymorphism on recurrent spontaneous abortion: Bridging hyperhomocysteinemia, bile acid metabolism, and the epigenetic–immune axis

March 2027

Na Yu | Yuxian Wu | Ting Sun | Yang Liu | Yaoyang Liu | Shihua Bao

Identification of novel therapeutic targets for heart failure and its subtypes: Insights from proteomic and transcriptomic Mendelian randomization

March 2027

Haozhang Huang | Huangtao Ruan | Jin Liu | Yong Liu

Exploring the transcriptional and post-transcriptional regulatory networks of methionine sulfoxide reductase B1 in breast cancer

March 2027

Jingsong Cheng | Diyuan Zhang | Xue Chen | Xinyi Zhu | Siqi Luo | Nanting Chen | Ziheng Zheng | Qingyao Yin | Liming Yi | Na Sun

Characterization of cerebrospinal fluid and peripheral blood immune niche in a patient with primary neurolymphomatosis

March 2027

Xinyang Li | Qiguo Zhang | Jing Guo | Jingjing Wang | Ying Xie | Huanhuan Liu | Wenjing Li | Hang Chen | Yuzhen Cui | Mingru Jiang | Christina He | Zhiqiang Liu | Wenrong Huang

Circular RNAs as promising biomarkers for human diseases: An update for 2018–2025

March 2027

Yiqing Chen | Shuting Guo | Dongchao Lu | Michail Spanos | Xuan Ye | Huihua Chen | Junjie Xiao

Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs characterized by their unique covalently closed-loop structure. These molecules are key regulators of gene expression and are closely...

Novel post-translational modifications in fibrosis: The mechanisms and implications

March 2027

Qianshi Wu | Li Luo | Yanqun Li | Jidi Wu | Junle Li | Wanhong He | Yulin Mou | Shiying Qu | Yanqi Lei | Wei Huang | Ling Cao

Fibrosis constitutes a pathological phenomenon characterized by excessive deposition of fibrous connective tissue and concomitant reduction of parenchymal cells in tissues and organs. Post-translational...

Critical roles of phosphorylation in multiple signaling pathways during the progression of osteoarthritis

March 2027

Jingwen Li | Muhammad Umar | Xin Dai | Yu-Ching Hsu | Hongxun Sang | Di Chen | Ke Lu

Osteoarthritis (OA) is a progressive degenerative joint disease characterized by synovial inflammation, cartilage degradation and alterations of subchondral bone remodeling. The complex pathogenesis...

Epigenetic insights into cancer metastasis via lineage trans-differentiation

February 2027

Cong Zou | Caixia Xia | Hongwei Peng | Shenjuan Li | Jia Shang | Wan Xiang | Haoli Ma | Fangjin Chen | Xinyue Cao | Gang Wang

Endothelial-specific RIPK1 K376 mutation triggers kinase hyperactivation and embryonic lethality

February 2027

Zhuyang Wu | Lingxia Wang | Xiaoxia Wu | Ming Li | Haibing Zhang

An antibiotic-free plasmid vector platform for non-viral DNA delivery

February 2027

Dan Zhao | Zakary D. Carden | Yifei Wang | Cole S. Hudson | Perry A. Maza | Dana Cyril-Ramirez | Yong Li

Differential contribution of elastin and fibrillin-1 to the cardiovascular phenotype of a double heterozygous Marfan and Williams-Beuren syndrome mouse model

February 2027

Isaac Rodríguez-Rovira | Lize Sels | Jana Ruíz-Castro | Alba Aizpuru-Gómez | Ana Paula Dantas | Victoria Campuzano | Gustavo Egea

C1orf127 deficiency causes cardiac abnormalities by disrupting the regulation of transcription initiation and interactions with RNA-binding proteins

February 2027

Yan Chen | Cancan Yao | Kun Yu | Bangguo Wu | Yuan Zhang | Xiangyu Zhou

Deciphering the role of DOT1L germline pathogenic variants in familial serrated polyposis syndrome

February 2027

Gemma Llargués-Sistac | Yasaman Sadat Keshmiri | Irene Boluda-Luis | Jenifer Muñoz | Teresa Ocaña | Stefan Aretz | Daniel Rodríguez-Alcalde | Leticia Moreira | Sergi Castellví-Bel

A novel adenoma–carcinoma sequence- and disulfidptosis-associated gene signature for prognostic prediction and mechanistic insights in colorectal cancer

February 2027

Zhen Wang | Yirong Li | Runlin Gui | Yang Li | Yuanyuan Ren | Jie Liu | Wenzhen Shi | Yuyan Xiong