Endothelial-specific RIPK1 K376 mutation triggers kinase hyperactivation and embryonic lethality
February 2027
Deciphering the role of DOT1L germline pathogenic variants in familial serrated polyposis syndrome
February 2027
Different regulatory mechanisms of hepatitis B- and C-positive hepatocellular carcinoma by single-cell RNA sequencing
February 2027
Multi-omics studies identified the molecular network of mitochondrial dysfunction in the pathogenesis of breast cancer
February 2027
Region-specific functions of S100A9-derived peptides in inflammation and intracellular delivery
February 2027
Highly restricted specificity of aberrant exons in a saturated background of differentially expressed exons
February 2027
Host diets drive microbiome evolution and functional divergence
February 2027
Substantial variation in gut microbiome function across individuals underscores the pivotal role of the host in shaping microbial diversity. Increasing evidence indicates that diet is a major selective...
Genetic kidney diseases: Decoding molecular taxonomies to drive precision nephrology and therapeutic innovation
February 2027
Genomic advances have transformed the landscape of genetic kidney diseases, enabling a shift from traditional phenotype-based diagnostics to molecularly precise classification. Large-scale genetic testing...
Molecular mechanisms and targeted therapeutic strategies for glycolytic reprogramming in osteosarcoma
February 2027
Osteosarcoma, a highly invasive and metastatic malignant bone tumor, has a poor prognosis primarily because of early pulmonary metastasis and resistance to conventional treatments. The malignant progression...
Disulfidptosis-based cancer therapy: Opportunity and challenge
February 2027
Cancer represents a significant global health threat, with traditional treatment modalities often facing substantial limitations. Consequently, novel therapeutic strategies have garnered considerable...
Not only as a Cullin3 ligase adaptor, SPOP may also act as a molecular bridge
February 2027
Speckle-type POZ protein (SPOP), a substrate-binding adaptor of the Cullin3/RING-box1 E3 ubiquitin ligase complex, induces degradative or non-degradative ubiquitination of substrates, playing a vital...
In vivo CAR-T for the treatment of autoimmune diseases: Current progress and future directions
February 2027
Autoimmune diseases are a clinical challenge because current immunosuppressive therapies fail to eliminate pathogenic immunocytes, such as autoreactive B cells, plasma cells, and antigen-presenting...
A panoramic study of circulating tumor DNA in diffuse large B-cell lymphoma
February 2027
Diffuse large B-cell lymphoma (DLBCL) is a frequently encountered aggressive form of non-Hodgkin's lymphoma, characterized by significant clinical and molecular heterogeneity. Owing to inherent limitations...