Elucidating chain conformation in interfacial and crystalline domains of polyethylene-like polyesters by solid-state NMR
November 2026
Design of a fast broadband RF switch for multi-nuclear NMR in lithium-ion batteries
November 2026
To address the need for observing the electrolyte influenced by dissolved metal ions during the charge and discharge process of lithium-ion battery, a fast-switching broadband radio frequency (RF) switch...
Physics-embedded CycleGAN for robust metabolite mapping in short-readout deuterium metabolic imaging
November 2026
Deuterium metabolic imaging (DMI) enables noninvasive, spatially resolved mapping of in vivo metabolism by tracking deuterium-labeled substrates and downstream products, yet it is frequently signal-to-noise-ratio...
Effect of basis choice on quantitative parameter estimation in accelerated subspace reconstructions
November 2026
This work assesses the effects of different simulated and data-driven subspaces on quantitative parameter estimation in highly accelerated subspace reconstructions. Three different methods for generating...
A hybrid deep learning framework based on VGG19 and U-Net for accurate brain tumor segmentation in MRI images
November 2026
Accurate segmentation of brain tumors from magnetic resonance imaging (MRI) is a critical task in neuro-oncology, directly impacting diagnosis, treatment planning, and patient outcomes. This study presents...
In vivo targeted MRS detection of 2-hydroxyglutarate molecules in IDH-mutant gliomas via spin regulation
November 2026
2-hydroxyglutarate (2-HG) is a key metabolic biomarker for identifying IDH-mutant gliomas. Non-invasive and accurate detection of 2-HG is of great significance for the early diagnosis of diseases and...
A low-frequency pulsed EPR spectrometer for hyperfine clock transition measurement
November 2026
Low-frequency electron paramagnetic resonance (EPR) spectroscopy proves large sample space and special selectivity to hyperfine spin related transitions in molecules. For instance, the hyperfine clock...
A designed fusion tag improves soluble expression of nanobody in E. coli
November 2026
Nanobodies are small, single-domain antibody fragments derived from camelid heavy-chain antibodies that offer high stability, strong binding affinity, and excellent potential for therapeutic and diagnostic...
Production of isotope-labeled nanobody KN035 in Pichia pastoris yields native-like conformation and PD-L1 binding activity comparable to KN035 expressed in mammalian cells
August 2026
Stable isotope-labeled proteins are indispensable for NMR-based structural studies. E. coli is a cost-effective and high-yield expression host, but it often fails to support proper folding and post-translational...
Dimerization-induced conformational transitions of yeast iso-1 cytochrome c
August 2026
Cytochrome c is a multifunctional protein involved in electron transport and apoptosis. However, its conformational landscape is complex and heterogeneous, which has obscured the functional understanding—particularly...
NMR insights into the role of urea in cellulose dissolution: A stoichiometric study of cellobiose in NaOH/urea aqueous solution
August 2026
The mechanism underlying the enhanced dissolution of cellulose in NaOH/urea aqueous solutions has long been a subject of debate. In this study, high-resolution solution-state 1H and 13C DEPTq NMR spectroscopy...
New pulse sequence for improving cardiac black-blood and PSIR MRI quality in cases of arrhythmia
Available online 25 June 2026
Most conventional cardiac MRI scans, which rely on electrocardiogram (ECG)-triggered segmented acquisition for k-space data, are highly sensitive to arrhythmia—a vulnerability that can induce severe...
Applications and future development of solid-state nuclear magnetic resonance for investigating metal-organic frameworks
Available online 18 June 2026
Metal-organic frameworks (MOFs) are a class of porous materials that feature permanent porosity, high crystallinity, and diverse structures. The 2025 Nobel Prize in Chemistry was awarded to three pioneering...
Deciphering the hydrogen shuttle-mediated kinetic memory of Ge-related defects in UV-grade fused quartz via in situ EPR with 3D Imaging
Available online 18 June 2026
This study elucidates the photo-induced defect dynamics in standard UV-grade fused quartz (JGS2) by synergizing in situ electron paramagnetic resonance (EPR) spectroscopy with 3D volumetric imaging....
Real-time NMR analysis of glutamine metabolism for screening anti-cancer agents in living cells
Available online 12 June 2026
Metabolic reprogramming is a substantial obstacle for anticancer drug screening, as targeted therapeutics often lose efficiency due to the dynamic adaption of cancer cells. Glutamine metabolism in cancer...
Predictions and cross-center validation of IDH status and 1p/19q status in adult diffuse glioma with non-invasive magnetic resonance spectroscopy
Available online 1 June 2026
This study developed and validated a non-invasive multi-metabolite magnetic resonance spectroscopy framework for preoperative molecular subtyping of adult diffuse gliomas. Using a cross-center, cross-vendor...
Truncated enhanced constraint for low-rank plus sparse in cardiac dynamic MRI reconstruction
May 2026
Cardiac dynamic MRI has been widely used in cine and perfusion imaging, in which low-rank and sparse priors play an important role in reconstructing dynamic images with high temporal and spatial resolution...
Single-scan ultra-selective probing on targeted components from overlapped NMR spectra
May 2026
Benefitting from the non-invasive and quantitative detection property, liquid NMR spectroscopy shows broad applications in the identification, separation, and structural determination of chemical substances...
Structural anisotropy in celery stalks by microscopic MRI and polarized light microscopy
May 2026
Structural anisotropy of celery stalks was studied using T2 anisotropy in microscopic MRI (μMRI) and supplemented by quantitative polarized light microscopy (PLM) at optical resolutions. Parenchyma,...
Fragment-based discovery of TopBP1 inhibitors integrated with AI-driven molecular docking
May 2026
DNA topoisomerase IIβ-binding protein 1 (TopBP1) converges on multiple oncogenic pathways, e.g., Rb, p53, and PI3K/Akt, which are hallmarks of most cancer progression. However, the lack of structural...
A random fractional 13C labeling strategy for P. pastoris expressed eukaryotic membrane proteins for solid-state NMR studies
May 2026
Solid-state NMR (SSNMR) has emerged as an important technique for characterizing membrane protein structures. Using sparse 13C labeling of membrane proteins can significantly enhance spectral resolution....
OFC: Outside Front Cover
May 2026
Spin-echo measurements for capillary rheometry at low field
May 2026
A single spin-echo, acquired in the presence of a constant magnetic field gradient, has a phase proportional to the average velocity of the sample and an amplitude determined by the distribution of...
