Distinct association of HRAS and KRAS with Mn2+ ion illustrated by paramagnetic NMR
February 2025
Rat sarcoma virus oncogene (RAS) proteins are of crucial oncogenic proteins and are involved in several essential intracellular processes. The RAS protein has an intrinsic metal binding site for Mg2+,...
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Operando EPR imaging of lithium dendrites on the graphite in extreme-fast-charging full cells
February 2025
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In-cell dehydration of sodium manganese hexacyanoferrate cathode revealed by solid-state NMR
February 2025
The hard-to-remove lattice water has been regarded as a significant obstacle impeding the practical use of Prussian blue analogue cathodes for sodium-ion batteries. This work monitored the electrochemical...
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Advances in solid-state NMR methods for studying RNA structures and dynamics
February 2025
Ribonucleic acid (RNA) structures and dynamics play a crucial role in elucidating RNA functions and facilitating the design of drugs targeting RNA and RNA-protein complexes. However, obtaining RNA structures...
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OFC: Outside Front Cover
February 2025
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Rigid and stable nitroxide spin label for high-resolution distance measurements on proteins by DEER experiments
Available online 28 February 2025
The distance distributions between two site-specifically anchored spin labels in a protein, measured by pulsed electron-electron double resonance (PELDOR or DEER), provide rich sources of structural...
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19F NMR study of proteins with parallel incorporation of multiple fluorinated aromatic amino acids
Available online 22 February 2025
Although the parallel incorporation of fluorinated aromatic amino acids (FAAAs) into proteins has been explored since 2010, the corresponding 19F NMR investigation has been lacking to date. To assess...
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A magnetically compatible, arbitrary positioning system for accurate spatial mapping of magnetic fields for shimming studies in MRI
Available online 17 February 2025
After the fabrication of magnetic resonance superconducting magnets, the magnetic field inhomogeneity needs to be accurately measured for subsequent shimming. However, conventional measurement methods...
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Cryoporometry for short T2 samples: A T1 filter method. Application to battery electrodes characterization
Available online 11 February 2025
The pore size distribution is often an important parameter for transport processes in porous media. Cryoporometry experiments can provide such data in the meso and macropore size up to 1 μm providing...
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The rise of NMR-integrated fragment-based drug discovery in China
Available online 29 January 2025
Nuclear magnetic resonance (NMR) spectroscopy is an indispensable tool to probe weak protein-ligand interactions, which are key to the hit identification and hit-to-lead evolution in fragment-based...
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Dynamic nuclear polarization and chemically induced hyperpolarization: Progress, mechanisms, and opportunities
Available online 29 January 2025
Nuclear magnetic resonance (NMR) spectroscopy is a powerful and broadly used spectroscopic technique for characterizing molecular structures and dynamics. Yet the power of NMR is restricted by its inherently...
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Adaptive k-space learning and high-dimensional subsets embedding for parallel MRI reconstruction
Available online 29 December 2024
Magnetic resonance imaging (MRI) inherently requires considerable time for data acquisition, but obtaining multi-contrast MRI data further prolongs this process, thereby increasing susceptibility to...
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Femtotesla atomic magnetometer for zero- and ultralow-field nuclear magnetic resonance
Available online 10 December 2024
Zero- and ultralow-field nuclear magnetic resonance (ZULF NMR) has experienced rapid development and provides an excellent tool for diverse research fields ranging from materials science and quantum...
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Fast T1 mapping MRI in preclinical and clinical settings using subspace-constrained joint-domain reconstructions
November 2024
This work aims to develop fast T1 mapping methods for preclinical and clinical scanners based on subspace-constrained reconstructions. Two sequences are explored for rapid T1 characterizations: 1) Interleaved...
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Unexpected temperature dependence of 1H paramagnetic shift in MAS NMR of nickelocene
November 2024
This work revisits the temperature dependence of 1H paramagnetic shift in nickelocene as a potential nuclear magnetic resonance (NMR) thermometer under fast magic angle spinning (MAS) rate. Surprisingly,...
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Diffusion tractography of kidney by high angular resolution diffusion imaging
November 2024
Diffusion magnetic resonance imaging (MRI) has been utilized to probe the renal microstructures but investigating the three-dimensional (3D) tubular network still presents significant challenges due...
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Enantiodifferentiation of chiral diols and diphenols via recognition-enabled chromatographic 19F NMR
November 2024
A novel and efficient method for distinguishing between chiral diols and diphenols has been established through the use of 19F NMR spectroscopy. Central to this system's efficacy is a chiral amine,...
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Unveiling structural and dynamical features of chromatin using NMR spectroscopy
November 2024
Eukaryotic deoxyribonucleic acid (DNA) is wrapped around histone octamers (HOs) to form nucleosome core particles (NCPs), which in turn interact with linker DNA and linker histones to assemble chromatin...
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Progress in magnetic resonance imaging of the glymphatic system
November 2024
The glymphatic system (GS) is a newly discovered brain anatomy. Its discovery improves our understanding of brain fluid flow and waste removal paths and provides an anatomical basis for the flow of...
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Solid-state NMR of vulcanized natural rubber/butadiene rubber blends: Local organization and cross-linking heterogeneities
November 2024
Elastomer blends, among which natural rubber (NR) and butadiene rubber (BR), are involved in many components of the automotive/tire industry. A comprehensive understanding of their mechanical behavior...
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Solid-state NMR studies of proteins in condensed phases
August 2024
Some proteins perform their biological functions by changing their material states through liquid-liquid phase separation. Upon phase separation, the protein condenses into a concentrated liquid phase...
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Transient NOE driven signal enhancement of INADEQUATE solid-state NMR spectroscopy for the structural analysis of rubbers
August 2024
INADEQUATE (Incredible Natural Abundance DoublE QUAntum Transfer Experiment) is one of the most important techniques in revealing the carbon skeleton of organic solids in solid-state NMR spectroscopy....
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Analysis of the electron transfer pathway in small laccase by EPR and UV–vis spectroscopy coupled with redox titration
August 2024
Bacterial small laccases (SLAC) are promising industrial biocatalysts due to their ability to oxidize a broad range of substrates with exceptional thermostability and tolerance for alkaline pH. Electron...
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