Rewiring ER-associated degradation for selective elimination of transmembrane proteins
December 2026
Artificial intelligence in osteosarcoma imaging: current applications, challenges, and translational pathways
Available online 21 October 2026
Osteosarcoma is the most common primary malignant bone tumor in children and adolescents. Imaging is essential for its diagnosis, staging, treatment planning, response assessment, and follow-up, but...
Interpreting the evidence and clinical implementation of anti-Aβ therapies in Alzheimer’s disease
Available online 20 October 2026
The approval of anti-amyloid-β (Aβ) monoclonal antibodies has marked an important transition in Alzheimer’s disease (AD) therapeutics from symptomatic treatment toward disease modification. However,...
The NAT10/ac4C axis in liver disease: an epitranscriptomic rheostat from steatosis to hepatocellular carcinoma
Available online 16 October 2026
N4-acetylcytidine (ac4C), once considered mainly as a modified nucleoside in tRNA and rRNA, has emerged as an mRNA modification that can modulate transcript stability and translation. Its best-characterized...
Methods and advances in infectious disease burden estimation
Available online 15 October 2026
Accurate estimation of infectious disease burden is essential for evidence-based public health decision-making, including resource allocation, priority setting, and evaluation of interventions. The...
CSE deficiency promotes osteoporotic bone loss through THBS1-associated extracellular matrix dysregulation and metabolic dysfunction
Available online 13 October 2026
Cystathionine-γ-lyase (CSE)/hydrogen sulfide (H2S) plays a critical role in skeletal homeostasis, but its precise pathophysiological function in osteoporosis remains unclear. This study aimed to clarify...
Fascia fibroblast: a target to heal severe skin wounds without scar
Available online 12 October 2026
Toward a global cradle brain health initiative
September 2026
LRP8: the cellular entry receptor for yellow fever virus
September 2026
The evolving landscape of mRNA-LNP medicine: advances, challenges, and future perspectives
September 2026
Messenger RNA lipid nanoparticle (mRNA-LNP) technology has developed from a successful pandemic vaccine platform into a versatile therapeutic approach applicable to infectious diseases, oncology, autoimmune...
Food preservative intake and cancer risk: a commentary on evidence from a large prospective cohort study
September 2026
Engineered microbe-based micro/nanorobots for interventional therapy of luminal cancers
September 2026
Luminal cancers, including gastrointestinal, genitourinary, and peritoneal cavity-associated malignancies, are, in principle, amenable to local intervention, yet durable therapeutic control remains...
From passive loading to network formation: click clotting inspires the next generation of bone repair materials
September 2026
Global mortality and DALY burden across major disease categories, 1990–2021: trends, SDI-related distribution, and drivers of DALY changes
September 2026
Global disease burden is being reshaped by epidemiological and demographic transitions. We assessed global trends, the sociodemographic index (SDI)-related distribution of mortality and disability-adjusted...
Axial length-stratified cataract phenotypes revealed by automated lens density quantification from IOL Master 700
September 2026
To evaluate automated lens average density from IOL Master 700 as a quantitative supplementary measure for cataract assessment, and whether cataract phenotypes and risk profiles differ by axial length...
Deep brain stimulation: from mechanism to application
September 2026
Deep brain stimulation (DBS) has emerged as a transformative neuromodulation therapy for a variety of neurological and psychiatric disorders, including Parkinson’s disease, epilepsy, and obsessive-compulsive...
Revisiting selenium in osteoarthritis: from nutritional deficiency to targeted therapeutic opportunities
September 2026
PLD4 mutations and SLE: insights from genetic and functional studies to clinical precision treatment
June 2026
Circadian rhythms in cardiovascular disease: a new perspective on inter-organ crosstalk
June 2026
Cardiovascular diseases (CVDs) constitute a global health crisis, responsible for approximately 31% of all-cause mortality, and increasingly manifest as multisystem disorders involving cardio-cerebral,...