Evaluation of the efficacy, safety and economy of different amphotericin B formulations in invasive fungal disease: A retrospective cohort study
Available online 11 September 2025
Fungal infections have emerged as an increasingly serious public health challenge globally. Four Formulations of amphotericin B are widely used in antifungal therapy. Despite the same active ingredient,...
Molecular aspects of metformin’s anti-aging properties for muscle function and longevity in Drosophila melanogaster
Available online 11 September 2025
Muscle aging, characterized by the progressive loss of muscle mass and function, presents a significant clinical challenge, contributing to sarcopenia and age-related frailty. Recent research highlights...
Advances and challenges in personalized diagnosis and therapies for the management of recurrent glioblastoma
Available online 11 September 2025
Recurrent glioblastoma (rGBM) remains one of the most formidable challenges in neuro-oncology due to its aggressive evolution, treatment resistance, and profound intratumoral heterogeneity. Despite...
A bibliometric analysis of mechanisms and linkage studies on neurological disorders and statins over the past 20 years
Available online 11 September 2025
Neurological disorders are one of the major contributors to the burden of disease, affecting the quality of life of the global population.Statins, known for their cholesterol-lowering properties, have...
Quality evaluation of the guidelines for vericiguat treatment of heart failure with reduced ejection fraction
June 2025
Heart failure (HF) bears a heavy disease burden, and vericiguat is the only guanylate cyclase stimulator proved to improve its prognosis. However, its clinical use needs a further improvement....
Biologic therapy for immune-mediated inflammatory diseases during pregnancy and lactation: Efficacy, safety, and challenges
June 2025
Immune-mediated inflammatory diseases (IMIDs) commonly affect women of reproductive age, and concerns regarding the impact of therapeutic drugs on pregnancy outcomes, fetal development, and infant health...
Exploring the mechanism of Simiao Yong’an decoction in treating diabetic foot based on metabolomics
June 2025
In recent years, diabetic foot has become a significant cause of disability and mortality among individuals with diabetes. With the progression of time and technology, both modern medicine and traditional...
Evidence-based pharmacological investigation of the clinical practice and rational use of metformin in prediabetes mellitus
June 2025
Prediabetes is a condition where blood glucose levels have deviated from the normal range but have not yet reached the diagnostic criteria for diabetes. It represents a transitional phase between health...
Current status of the potentially inappropriate medications and omissions of medicines among older adults in Hubei Province
June 2025
Potentially inappropriate medications (PIMs) and omissions of medicines among older adults are increasingly popular with the aging population in China....
A retrospective study on the impact of glucocorticoids on the efficacy of posaconazole in the prevention/treatment of invasive fungal infections in patients with hematological malignancies
March 2025
Posaconazole (PCZ) has been used to prevent and treat invasive fungal infections in immunocompromised patients with hematological malignancies. There is a significant correlation between plasma drug...
Effects of lianggu decoction combined with clomiphene on insulin resistance, ovarian hemodynamics, and pregnancy outcomes in infertile patients with obese polycystic ovary syndrome
March 2025
To investigate the effects of Lianggu Decoction combined with clomiphene on insulin resistance, ovarian hemodynamics, and pregnancy outcomes in infertile patients with obese polycystic ovary syndrome...
Study on administration timing and combination therapy of NSAIDs for preventing post-ERCP pancreatitis
March 2025
To determine the optimal timing, dosage, and efficacy of combination NSAID therapy in preventing post-ERCP pancreatitis....
A comprehensive evaluation of ALK inhibitors in the first-line treatment of patients with ALK-positive non-small cell lung cancer
March 2025
There are currently six ALK inhibitors available for the first-line treatment of patients diagnosed with ALK-positive advanced non-small cell lung cancer (NSCLC). However, clinicians face challenges...
Establishment and evaluation of a risk prediction model for venlafaxine plasma concentration exceeding alert levels
March 2025
To investigate the factors influencing venlafaxine blood concentration exceeding the alert threshold in patients with depression and to develop a risk prediction model for elevated venlafaxine concentrations,...
Application status of traditional computational methods and machine learning in cancer drug repositioning
December 2024
The escalating global burden of cancer has spurred extensive research and development efforts aimed at discovering effective anti-cancer agents. However, the prohibitively high costs associated with...
Effects of lianggu decoction combined with Gonal-F on IVF outcomes, embryo quality, and pregnancy in infertility patients undergoing IVF-ET
December 2024
To investigate the effects of Lianggu decoction combined with Gonal-F on the outcomes of in vitro fertilization and embryo transfer (IVF-ET) outcomes in infertility patients, including embryo quality...
Effects of donepezil on emotion, cognitive function, and inflammatory factors in patients with Hashimoto's thyroiditis
December 2024
To investigate the impact of donepezil on emotional responses, cognitive function, and inflammatory factors in patients with Hashimoto's thyroiditis (HT)....
Mechanistic investigation of Kuntai capsule in endometriosis treatment: A network pharmacology, molecular docking, and molecular dynamics simulation approach
December 2024
To explore the mechanism of action of Kuntai capsule in the treatment of endometriosis (EMT)....
Simultaneous determination of concentration of sulfamethoxazole and trimethoprim in human plasma by dual-quaternary HPLC and its clinical application
December 2024
Sulfamethoxazole compound, a combination of sulfamethoxazole and trimethoprim, is commonly prescribed to organ transplant recipients for infections caused by Nocardia, Burkholderia cepacia, and Pneumocystis...
Therapeutic drug monitoring for promotion of rational medication in the elderly: Overview, challenges and opportunities
November 2024
In the context of rapid development of clinical pharmacy in China, therapeutic drug monitoring (TDM) has become a vital tool for rational medication and is widely concerned. TDM combines the knowledge...
Precision individualized medication strategies and challenges for cardiovascular diseases
November 2024
With the ongoing societal development and changes in lifestyle, the incidence of cardiovascular diseases continues to rise. Although the most effective means of preventing atherosclerotic cardiovascular...
Unlocking precision medicine: Innovative strategies for druggable target identification and therapeutic enhancement
November 2024
Precision medication emphasizes tailored treatment approaches based on individual patient characteristics, yet the limitations in current drug target identification hinder therapeutic advancements....
Surgical pharmacy for catalyzing pharmacy service throughout surgical continuum
November 2024
The greater the complementarity between pharmacists’ knowledge and doctors’ knowledge, the more significant the role pharmacists can play in clinical practice. Physicians extensively use drugs for disease...
Current status and prospects of nucleic acid mass spectrometry in clinical pharmacogenomics
November 2024
Pharmacogenomics is an essential means to achieve personalized medicine. Multi-gene and multi-loci panel testing is an inevitable trend in its development, comprehensively analyzing the impact of genes...
Integrating pharmacy practice into precision emergency medicine: A pathway to enhanced patient care
November 2024
Precision emergency medicine (EM) represents a transformative approach to healthcare, integrating advanced technologies and human-centric data to tailor treatments to individual patient needs. This...