Dual-antibacterial nano-sheet synergizes resveratrol delivery for burn regeneration
2026
In the field of burn treatment, where infected wound sites face critical challenges such as inadequate antimicrobial efficacy and impaired tissue regeneration, developing multifunctional strategies...
Advanced nanomaterials for myocardial ischemia-reperfusion injury: Bridging precision imaging to targeted therapy
2026
Myocardial ischemia-reperfusion injury (MIRI) is a major cause of heart failure, driven by oxidative stress, inflammation, and rapid loss of cardiomyocytes. Traditional therapies for MIRI remain limited,...
Chiral noble-metal nanomaterials: Chiral origins and biomedical applications
2026
Chirality is a fundamental property in nature, and the rapid progress of nanoscience has enabled the design and fabrication of nanoscale materials with precisely controlled chiral architectures. These...
Smart DNA nanocages mitigate oxidative stress and guide bone immune microenvironment for osteoporotic jawbone regeneration
2026
Jawbone regeneration in osteoporotic patients remains a formidable challenge due to excessive reactive oxygen species (ROS), dysregulated bone immunity, and compromised osteogenic capacity. While nanomaterial-based...
Macrophage membrane-camouflaged nanoparticles as emerging therapeutics in metabolic dysfunction-associated steatotic liver disease
2026
Chronic liver disease (CLD) is a major global health burden, with metabolic dysfunction-associated steatotic liver disease (MASLD) as a primary contributor through its promotion of persistent inflammation,...
Transduction strategies in enzyme-free nanomaterial-based aptasensors for tetracycline antibiotics: A review
2026
Enzyme-free aptamer-based biosensors have gained increasing attention for tetracycline monitoring, yet existing studies remain highly fragmented across materials and sensing formats. This review presents...
A dynamic hydrogel platform enables localized delivery of microRNAs and osteogenic growth peptide for the treatment of osteosarcoma
2026
The clinical management of osteosarcoma remains a major therapeutic challenge, mainly owing to the high risk of tumor recurrence driven by residual cancer cells after surgical resection and the persistent...
Integrating siRNA targeting PKM2 with photodynamic therapy to induce tumor energy collapse
2026
Tumor cells exhibit an exceptionally high demand for energy to sustain uncontrolled proliferation and predominantly rely on glycolysis, rendering them vulnerable to energy-targeting interventions. However,...
Natural-Sourced Nanocomplex Scavenging ROS and Inhibiting Inflammation by On-demand Drug Release for the Treatment of Rheumatoid Arthritis
Available online 23 May 2026
Rheumatoid arthritis (RA) is a chronic autoimmune disease triggered by multiple factors, with a vicious cycle of “inflammation-oxidative stress-exacerbated inflammation”. The use of conventional RA...
Functional Biomaterials Meet Osteosarcoma Treatment
Available online 20 May 2026
Osteosarcoma (OS) is a highly aggressive primary bone malignancy with high incidences of pulmonary metastasis and mortality, predominantly affecting children and adolescents. Nanotechnology and nanomaterials...
Harnessing extracellular matrix hydrogel for synergistic neurorehabilitation in traumatic brain injury
Available online 17 May 2026
Traumatic brain injury (TBI) is characterized by neuronal loss, vascular disruption, and limited regenerative capacity, further exacerbated by the absence of a supportive extracellular matrix (ECM)...
Polymerized-carbon-coated metal nanoparticles: A multimodal platform for biomedical imaging and theranostic applications
Available online 14 May 2026
Polymerized-carbon-coated metal nanoparticles (C@NPs) are emerging as versatile nanomaterials with broad applicability in biomedical imaging and integrated diagnostic–therapeutic (theranostic) platforms....
4D-Printed Auxetic Biomaterials for Adaptive and Functional Bone Implants
Available online 9 May 2026
Mechanical compatibility, biological integration, and patient-specific adaptability are becoming key factors driving the development of bone implants. Additive manufacturing (AM) has emerged as a transformative...
Polyphenol–Metal Self-Catalyzed Conductive Hydrogel Enhances Implant–Tissue Integration for Bone Regeneration
Available online 29 April 2026
Artificial rigid scaffolds offer mechanical support and show potential for bone regeneration, yet their clinical application is often hindered by poor integration at the implant-bone interface and an...
A Photothermally Catalytic Nanocomposite Dual-Crosslinked Hydrogel for All-in-One Postoperative Osteosarcoma Bone Repair
Available online 17 April 2026
Osteosarcoma is among the most aggressive primary bone malignancies in adolescents. Postoperative reconstruction presents a “dual challenge”: complete eradication of residual tumor tissue is required...
Advances in Microfluidic Devices and Materials for Atherosclerosis Research
Available online 11 April 2026
In recent years, the application of microfluidic chips in atherosclerosis (AS) research has garnered significant attention. This technology, renowned for its precise control of fluid dynamics at the...
Harnessing the Foreign Body Response to Fabricate Tissue Engineered Vascular Grafts In Vivo: Progresses in Biotube Preparation and Application
Available online 14 March 2026
There is a great demand for small-diameter vascular grafts in clinical practice, particularly for the treatment of cardiovascular disease and hemodialysis access. Compared with synthetic vascular grafts...
Recent advances in polymer 4D printing: 3D printing techniques, smart material design, and healthcare applications
December 2025
Fourth-dimensional (4D) printing has progressed tremendously since its first conceptualization in 2013. 4D printing is an emerging branch of three-dimensional (3D) printing that allows printed parts...
EXPECT: A thermosensitive embedded bioprinting platform for guided spatial cell organization
December 2025
Complex tissue engineering requires precise spatial cell organization, but static or isotropic hydrogels hinder long-term pattern maintenance due to random cell migration. We developed EXtrusion Patterned...
Smart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer
December 2025
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies, characterized by aggressive biology, a dense fibrotic and immunosuppressive microenvironment, and profound resistance to...
Nanofiber membrane-foam composite sheet with dual pH-responsive functions of drug release and color change
December 2025
Chronic wound repair remains challenging in skin regenerative medicine due to complex pathology and dynamic microenvironments. Traditional single-functional dressings fail to integrate exudate management,...
Smart nanomaterial-crosslinked hydrogels for biomedical applications
December 2025
Hydrogels have advanced significantly in biomedical applications, yet their inherent hydrophilic matrices often hinder the efficient encapsulation and controlled release of hydrophobic drugs. Nanomaterial-crosslinked...
The cell-loaded alginate microspheres in cell culture and disease treatment
December 2025
Due to the properties of biocompatibility, affordability, and high-throughput production capabilities, alginate-based biomaterials have been extensively studied in the biomedical field, which can be...
Programmable nucleic acid origami nanostructures for immunotherapy
December 2025
Immunotherapy has emerged as a pivotal strategy for restoring immune balance in diseased tissues, harnessing the immune system to eliminate malignant cells and suppress aberrant inflammatory responses...
Self-adhesive and conductive hydrogel based on MIL-53 (Fe)-anchored graphene oxide for bioelectronics and wound healing
December 2025
The integration of bioelectronics with biological tissues remains challenging due to mechanical and interfacial mismatches. In addition, existing bioelectronic hydrogels typically exhibit monofunctional...