Nanoparticles in cancer therapy: Strategies to penetrate and modulate the tumor microenvironment – A review
August 2025
Despite advances in conventional cancer treatments such as surgery, chemotherapy, and radiation, these approaches still face significant challenges, including systemic toxicity, limited tumor specificity,...
Plant-derived exosome-like nanoparticles as promising biotherapeutic tools: recent advances and challenges
August 2025
Exosomes, naturally occurring extracellular vesicles with diameters of 30–150 nm, have been extensively characterized in mammalian systems. In contrast, plant-derived exosome-like nanoparticles (PELNs)...
Nanoparticle-based drug delivery systems for cancer therapy
2020
Nanoparticle-based drug delivery system (DDS) is considered promising for cancer treatment. Compared with traditional DDS, the nanoparticle-based DDS shows improved efficacy by: 1) increasing half-life...
A review on the applications of machine learning in biomaterials, biomechanics, and biomanufacturing for tissue engineering
August 2025
In recent years, machine learning, a powerful data analysis and modeling technique, is continuously revolutionizing the field of tissue engineering. Its ability to learn and extract information from...
Hydrogel wound dressings containing bioactive compounds originated from traditional Chinese herbs: A review
March 2024
Various factors can cause skin defects, resulting in the loss of physiological functions and even death due to severe concurrent infection. Dressings are often clinically used to fully cover the wounds...
Self-driven medical robots: From actuation mechanisms to biomedical applications
2026
Robotics technology is undergoing rapid evolution, exerting a transformative impact across numerous fields. However, the majority of contemporary robotic systems require external energy to drive, which...
Recent advances in polymer 4D printing: 3D printing techniques, smart material design, and healthcare applications
December 2025
Fourth-dimensional (4D) printing has progressed tremendously since its first conceptualization in 2013. 4D printing is an emerging branch of three-dimensional (3D) printing that allows printed parts...
Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects
August 2025
Shape memory polymers (SMPs) are a class of materials capable of undergoing deformation in response to external stimuli, and their unique shape-changing properties offer vast potential for applications...
4D-printed auxetic biomaterials for adaptive and functional bone implants
2026
Mechanical compatibility, biological integration, and patient-specific adaptability are becoming key factors driving the development of bone implants. Additive manufacturing (AM) has emerged as a transformative...
Recent progress of 3D printed vascularized tissues and organs
June 2024
Since the need for vascular networks to supply oxygen and nutrients while expelling metabolic waste, most cells can only survive within 200 μm of blood vessels; thus, the construction of well-developed...
Thera-regenerative hydrogel co-loaded with black phosphorus quantum dots and CD44-targeted nanoparticles for metastatic prostate cancer treatment
2026
Metastatic prostate cancer remains a major clinical challenge owing to limited tumour selectivity, systemic side effects, and the difficulty of achieving effective localised treatment at metastatic...
The cell-loaded alginate microspheres in cell culture and disease treatment
December 2025
Due to the properties of biocompatibility, affordability, and high-throughput production capabilities, alginate-based biomaterials have been extensively studied in the biomedical field, which can be...
Machine learning facilitating the design of antimicrobial, anticancer, and self-assembled peptide materials
2026
Peptides are composed of short-to medium-chain amino acid molecules that combine the bioactivity of proteins with the structural tunability of small molecules, enabling broad applications in antimicrobial,...
Advanced nanomaterials for myocardial ischemia-reperfusion injury: Bridging precision imaging to targeted therapy
2026
Myocardial ischemia-reperfusion injury (MIRI) is a major cause of heart failure, driven by oxidative stress, inflammation, and rapid loss of cardiomyocytes. Traditional therapies for MIRI remain limited,...
Chiral noble-metal nanomaterials: Chiral origins and biomedical applications
2026
Chirality is a fundamental property in nature, and the rapid progress of nanoscience has enabled the design and fabrication of nanoscale materials with precisely controlled chiral architectures. These...
Function and treatment strategies of β-hydroxybutyrate in aging
2023
Metabolic intermediates serve as precursors for bioactive molecule synthesis, the energy source for life activities, and signals for environmental adaptation. Ketone bodies are important metabolic intermediates...
Inhalable nanomedicine for lung cancer treatment
June 2024
Lung cancer has surpassed other types of cancer to become the primary cause of cancer-related deaths. Surgery stands as the foremost clinical treatment strategy available for tackling this condition,...
Anti-fouling coatings for blood-contacting devices
March 2024
Blood-contacting medical devices, such as vascular stents, intravascular catheters, and artificial heart valves, frequently encounter complications in clinical practice, including thrombosis, inflammatory...
Smart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer
December 2025
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies, characterized by aggressive biology, a dense fibrotic and immunosuppressive microenvironment, and profound resistance to...
A detailed protocol for cell force measurement by traction force microscopy
March 2024
Cellular traction forces (CTFs) are generated by adherent cells and involved in regulating migration, morphology, and homeostasis. Accurate measurement of CTFs is crucial for understanding fundamental...
Externally triggered drug delivery systems
September 2024
Externally triggered drug delivery systems empower patients or healthcare providers to utilize external stimuli to initiate drug release from implanted systems. This approach holds significant potential...
Recent advances in hyaluronic acid-based hydrogels for 3D bioprinting in tissue engineering applications
2023
3D bioprinting technology can rapidly process cell-loaded biomaterials to prepare personalized scaffolds for repairing defective tissues, tissue regeneration, and even printing tissues or organs. 3D...
Recent progress in surgical adhesives for biomedical applications
2022
The increasing demands for the management of hemostasis and tissue sealing drive the development of novel bioadhesives, which can overcome the disadvantages of conventional sutures such as additional...
Tailoring the elasticity of nerve implants for regulating peripheral nerve regeneration
2023
Numerous studies have conducted in-depth research on the biological and chemical properties of tissue-engineered neural graft (TENG) on peripheral nerve regeneration, while the physical properties of...
Polymerized-carbon-coated metal nanoparticles: A multimodal platform for biomedical imaging and theranostic applications
2026
Polymerized-carbon-coated metal nanoparticles (C@NPs) are emerging as versatile nanomaterials with broad applicability in biomedical imaging and integrated diagnostic–therapeutic (theranostic) platforms....
