Biofabrication of natural Au/bacterial cellulose hydrogel for bone tissue regeneration via in-situ fermentation
2023
Bacterial cellulose (BC) possesses the desirable properties of biocompatibility, high porosity, high surface area and noticeable mechanical strength as a scaffold in bone tissue engineering. However,...
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Natural biopolyester microspheres with diverse structures and surface topologies as micro-devices for biomedical applications
2023
Based on their excellent biocompatibility and adjustable biodegradability, the two natural polyesters polylactic acid (PLA) and polyhydroxyalkanoates (PHAs) have been widely used in medical engineering...
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Antibacterial silk sericin/poly (vinyl alcohol) hydrogel with antifungal property for potential infected large burn wound healing: Systemic evaluation
2023
Hydrogel-based burn wound dressings with excellent antibacterial, antifungal, and mechanical properties are ideal biomaterials to promote infected large burn wound healing. In this study, the hydrogel...
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3D-printed bioactive scaffolds for bone regeneration bearing carbon dots for bioimaging purposes
2022
Additive manufacturing, also known as 3D-printing, has been successfully employed to create novel bioactive scaffolds incorporating carbon dots for bioimaging purposes. Fused filament fabrication technique...
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Twisted fiber batteries for wearable electronic devices
2022
Wearable electronic devices are important in recording signals related to human activities. Because the performance of wearable electronic devices depends heavily on power sources, batteries, especially...
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Signaling pathways implicated in enhanced stem/progenitor cell differentiation on electroactive scaffolds
2022
Cells are naturally surrounded by an electroactive extracellular matrix in vivo, which is composed of a diverse array of charged molecules such as glycosaminoglycans and proteoglycans, together with...
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Designing a novel CaO–MgO–SiO2-based multiphase bioceramic with adjustable ion dissolution behavior for enhancing osteogenesis
2022
Many bioactive inorganic ions such as calcium (Ca), magnesium (Mg) and silicon (Si) have been confirmed to take part in bone regeneration through promoting the secretion of osteogenesis-related growth...
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Recent advances in orthopedic polyetheretherketone biomaterials: Material fabrication and biofunction establishment
2022
Polyetheretherketone (PEEK) is a kind of nontoxic high-performance thermoplastic widely used for medical applications. Compared with other special engineering plastics, PEEK has many excellent properties,...
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Recent progress in surgical adhesives for biomedical applications
2022
The increasing demands for the management of hemostasis and tissue sealing drive the development of novel bioadhesives, which can overcome the disadvantages of conventional sutures such as additional...
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Multi-scale adaptions of dynamic bio-interfaces
2022
Biodevices including wearable sensors, medical implants or protheses (e.g., tissue engineering scaffolds and neural electrodes), have attracted extensive attentions over the past several decades due...
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A photo-crosslinked proteinogenic hydrogel enabling self-recruitment of endogenous TGF-β1 for cartilage regeneration
2022
Cartilage regeneration is crucial to the functional reconstruction of damaged or degenerated joints, involving a variety of biological factors. Transforming growth factor-beta 1 (TGF-β1) play an important...
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DNA nanostructures for stimuli-responsive drug delivery
2022
DNA molecules have shown potential for drug delivery owing to their predictability and programmability. Due to the continuous development of DNA nanotechnology and the unique properties of DNA nanomaterials,...
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Recent progress on coatings of biomedical magnesium alloy
2022
Magnesium (Mg) alloy has received thorough attention in the biomedical field due to its excellent mechanical properties, good biocompatibility, and biodegradability. However, Mg alloy usually shows...
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Biodegradable Zn–Sr alloys with enhanced mechanical and biocompatibility for biomedical applications
2022
Zinc (Zn) is a new generation of biodegradable metal as temporary biomedical implants with a promising degradation rate. However, its clinical applications have been limited because of the insufficient...
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Anti-microbial/oxidative/inflammatory nanogels accelerate chronic wound healing
2022
The most common cause of delayed healing in chronic wounds is microbial pathogenesis, in which localized colonization can cause severe inflammation, systemic infection, and even sepsis in some cases....
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High strength HA-PEG/NAGA-Gelma double network hydrogel for annulus fibrosus rupture repair
2022
The low back pain (LBP) caused by intervertebral disc (IVD) herniation and degeneration bring huge physical and economic burden to individuals and families. Since current clinical treatment methods...
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A three-layered hydrogel patch with hierarchy releasing of PLGA nanoparticle drugs decrease neointimal hyperplasia
2022
Hydrogel is a nature scaffold that can degraded in animal body and can be used as a drug delivery system, we hypothesized that patch made of three layers of hydrogel with different PLGA nanoparticle...
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MR imaging guided iron-based nanoenzyme for synergistic Ferroptosis−Starvation therapy in triple negative breast cancer
2022
Triple negative breast cancer (TNBC), as the most aggressive BC, accounts for the leading cause of worldwide women death. Owing to the deficiency of related hormone receptors, the efficacy of hormone...
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The increased ratio of Mg2+/Ca2+ from degrading magnesium alloys directs macrophage fate for functionalized growth of endothelial cells
2022
Biomedical magnesium (Mg) alloys have been widely studied as important structural materials and biodegradable materials in cardiovascular stents system. However, excessively rapid degradation and delayed...
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3D-bioprinted vascular scaffold with tunable mechanical properties for simulating and promoting neo-vascularization
2022
Alternative artificial vessels with tissue-matching mechanical and biological performance have been continuously taking great attention in bioengineering. However, it is challenging to take into account...
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Extraction and isolation of Isoflavonoids from stem bark of Bauhinia purpurea (L): Its biological antipsychotic and analgesic activities
2022
The present research work reports the solvent extraction and isolation of Isoflavonoids from Bauhinia purpurea stem bark and their antipsychotic with analgesic activities were studied. Flavonoids are...
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N-doping of the TiO2/C nanostructure derived from metal-organic frameworks with high drug loading for efficient sonodynamic & chemotherapy
2022
Therapeutic agents can be effectively used for clinically treating cancer rely on critically enhancing their efficacy in the tumor microenvironment under hypoxic conditions. Sonodynamic therapy is a...
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Light controlled biomaterials for regulating cell migration and differentiation
2022
Cell microenvironments in human body are always complex, dynamic, and asymmetric. Light-controlled materials can mimic different physical and chemical environments non-invasively, in site, and dynamically,...
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Charge-reversal nanomedicines as a smart bullet for deep tumor penetration
2022
Complex composition and abnormal growth state of cells and tissues in the solid tumor microenvironment often lead to high density and stiffness different from normal tissues, thus forming a solid physical...
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Localized delivery of FTY-720 from 3D printed cell-laden gelatin/silk fibroin composite scaffolds for enhanced vascularized bone regeneration
2022
Three-dimensional (3D) printing can construct products with accurate complex architecture. Engineered bone tissues that can promote vascularization and regulate directed differentiation of bone marrow-derived...
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