Dual-antibacterial nano-sheet synergizes resveratrol delivery for burn regeneration
2026
In the field of burn treatment, where infected wound sites face critical challenges such as inadequate antimicrobial efficacy and impaired tissue regeneration, developing multifunctional strategies...
Advanced nanomaterials for myocardial ischemia-reperfusion injury: Bridging precision imaging to targeted therapy
2026
Myocardial ischemia-reperfusion injury (MIRI) is a major cause of heart failure, driven by oxidative stress, inflammation, and rapid loss of cardiomyocytes. Traditional therapies for MIRI remain limited,...
Chiral noble-metal nanomaterials: Chiral origins and biomedical applications
2026
Chirality is a fundamental property in nature, and the rapid progress of nanoscience has enabled the design and fabrication of nanoscale materials with precisely controlled chiral architectures. These...
Smart DNA nanocages mitigate oxidative stress and guide bone immune microenvironment for osteoporotic jawbone regeneration
2026
Jawbone regeneration in osteoporotic patients remains a formidable challenge due to excessive reactive oxygen species (ROS), dysregulated bone immunity, and compromised osteogenic capacity. While nanomaterial-based...
Macrophage membrane-camouflaged nanoparticles as emerging therapeutics in metabolic dysfunction-associated steatotic liver disease
2026
Chronic liver disease (CLD) is a major global health burden, with metabolic dysfunction-associated steatotic liver disease (MASLD) as a primary contributor through its promotion of persistent inflammation,...
Transduction strategies in enzyme-free nanomaterial-based aptasensors for tetracycline antibiotics: A review
2026
Enzyme-free aptamer-based biosensors have gained increasing attention for tetracycline monitoring, yet existing studies remain highly fragmented across materials and sensing formats. This review presents...
A dynamic hydrogel platform enables localized delivery of microRNAs and osteogenic growth peptide for the treatment of osteosarcoma
2026
The clinical management of osteosarcoma remains a major therapeutic challenge, mainly owing to the high risk of tumor recurrence driven by residual cancer cells after surgical resection and the persistent...
Integrating siRNA targeting PKM2 with photodynamic therapy to induce tumor energy collapse
2026
Tumor cells exhibit an exceptionally high demand for energy to sustain uncontrolled proliferation and predominantly rely on glycolysis, rendering them vulnerable to energy-targeting interventions. However,...
A Photothermally Catalytic Nanocomposite Dual-Crosslinked Hydrogel for All-in-One Postoperative Osteosarcoma Bone Repair
Available online 17 April 2026
Osteosarcoma is among the most aggressive primary bone malignancies in adolescents. Postoperative reconstruction presents a “dual challenge”: complete eradication of residual tumor tissue is required...
Advances in Microfluidic Devices and Materials for Atherosclerosis Research
Available online 11 April 2026
In recent years, the application of microfluidic chips in atherosclerosis (AS) research has garnered significant attention. This technology, renowned for its precise control of fluid dynamics at the...
Harnessing the Foreign Body Response to Fabricate Tissue Engineered Vascular Grafts In Vivo: Progresses in Biotube Preparation and Application
Available online 14 March 2026
There is a great demand for small-diameter vascular grafts in clinical practice, particularly for the treatment of cardiovascular disease and hemodialysis access. Compared with synthetic vascular grafts...
Recent advances in polymer 4D printing: 3D printing techniques, smart material design, and healthcare applications
December 2025
Fourth-dimensional (4D) printing has progressed tremendously since its first conceptualization in 2013. 4D printing is an emerging branch of three-dimensional (3D) printing that allows printed parts...
EXPECT: A thermosensitive embedded bioprinting platform for guided spatial cell organization
December 2025
Complex tissue engineering requires precise spatial cell organization, but static or isotropic hydrogels hinder long-term pattern maintenance due to random cell migration. We developed EXtrusion Patterned...
Smart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer
December 2025
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies, characterized by aggressive biology, a dense fibrotic and immunosuppressive microenvironment, and profound resistance to...
Nanofiber membrane-foam composite sheet with dual pH-responsive functions of drug release and color change
December 2025
Chronic wound repair remains challenging in skin regenerative medicine due to complex pathology and dynamic microenvironments. Traditional single-functional dressings fail to integrate exudate management,...
Smart nanomaterial-crosslinked hydrogels for biomedical applications
December 2025
Hydrogels have advanced significantly in biomedical applications, yet their inherent hydrophilic matrices often hinder the efficient encapsulation and controlled release of hydrophobic drugs. Nanomaterial-crosslinked...
The cell-loaded alginate microspheres in cell culture and disease treatment
December 2025
Due to the properties of biocompatibility, affordability, and high-throughput production capabilities, alginate-based biomaterials have been extensively studied in the biomedical field, which can be...
Programmable nucleic acid origami nanostructures for immunotherapy
December 2025
Immunotherapy has emerged as a pivotal strategy for restoring immune balance in diseased tissues, harnessing the immune system to eliminate malignant cells and suppress aberrant inflammatory responses...
Self-adhesive and conductive hydrogel based on MIL-53 (Fe)-anchored graphene oxide for bioelectronics and wound healing
December 2025
The integration of bioelectronics with biological tissues remains challenging due to mechanical and interfacial mismatches. In addition, existing bioelectronic hydrogels typically exhibit monofunctional...
Advanced oxygen therapeutics for treatments of acute hemorrhagic shock and organ preservation
August 2025
Oxygen (O2) is vital in respiratory process that maintains biological balance in mammals. O2 therapeutics treat ischemic tissues by facilitating O2 transport and alleviating cellular hypoxia. The development...
Revolutionizing high altitude cerebral edema management: nanotechnology-enabled diagnostics and targeted drug delivery
August 2025
Due to the increasing commercial activities and adventure travels, millions of people visit high-altitude regions every year. A rapid increase in altitude results in high-altitude cerebral edema (HACE),...
A review on the applications of machine learning in biomaterials, biomechanics, and biomanufacturing for tissue engineering
August 2025
In recent years, machine learning, a powerful data analysis and modeling technique, is continuously revolutionizing the field of tissue engineering. Its ability to learn and extract information from...
Recent advances in shape memory polymers for biomedical applications: Bridging macro- and micro-scale effects
August 2025
Shape memory polymers (SMPs) are a class of materials capable of undergoing deformation in response to external stimuli, and their unique shape-changing properties offer vast potential for applications...
Two-dimensional materials for anti-inflammatory applications
August 2025
Due to unique physicochemical properties including high surface-to-volume ratio, abundant active sites, and tunable surface functionalities, two-dimensional (2D) materials have emerged as an intriguing...
Engineered gold nanoparticle-based miRNA precision regulation for tumor diagnosis and synergistic therapy
August 2025
Cancer remains a major global health challenge, with traditional therapies such as chemotherapy, radiotherapy, and surgery often limited by side effects, drug resistance, and incomplete tumor eradication....