Plant-derived exosome-like nanoparticles as promising biotherapeutic tools: recent advances and challenges
August 2025
Exosomes, naturally occurring extracellular vesicles with diameters of 30–150 nm, have been extensively characterized in mammalian systems. In contrast, plant-derived exosome-like nanoparticles (PELNs)...
Nanoparticles in cancer therapy: Strategies to penetrate and modulate the tumor microenvironment – A review
August 2025
Despite advances in conventional cancer treatments such as surgery, chemotherapy, and radiation, these approaches still face significant challenges, including systemic toxicity, limited tumor specificity,...
Biomimetic 3D printing of photocrosslinkable biodegradable elastomers-modified hybrid scaffolds as instructive platforms for bone tissue regeneration
March 2025
3D printing is regarded as an ideal method for large-scale bone defect repair. A rapid curing rate and strong mechanical properties throughout the product's shelf life are key development goals in 3D-printed...
Soft bioelectronics for the diagnosis and treatment of heart diseases
March 2025
Soft bioelectronics is a type of innovative technology that creates electronic devices of organic or inorganic materials on flexible/ductile substrate, holding tremendous promise for the diagnosis and...
The cardiac electrophysiology-inspired patches for repairing myocardial infarction: A review
March 2025
Myocardial infarction has been a serious threat to human health due to its high morbidity and mortality all over the world. The major problem is the loss of limited regenerative cardiomyocytes and occurrence...
Advancements in graphene-based composites: A review of the emerging applications in healthcare
March 2025
Graphene and related materials are emerging revolutionary materials due to fascinating stimuli-responsive physiochemical properties having widespread applications in developing advanced nano-systems...
Nanoparticles, a promising treatment for gastric cancer
March 2025
Globally, gastric cancer (GC), as a fatal malignant tumor, remains a significant health challenge. Thus, it is imperative to explore novel treatment strategies. Despite the fact that the survival rate...
Bright antimicrobial surfaces based on Schottky interfaces: From light illumination to bacterial charging
March 2025
The growing threat of resistant bacterial infections is a global concern. Therefore, it is crucial to discover new antimicrobial agents or alternative mechanisms to address this issue. This article...
A polymeric dexamethasone prodrug attenuates focal segmental glomerulosclerosis (FSGS) in an Adriamycin-induced mouse model with minimal glucocorticoid side effects
March 2025
Focal segmental glomerulosclerosis (FSGS) is chronic renal injury characterized by proteinuria and podocyte injury with glomerulus scarring and tubulointerstitial fibrosis. Glucocorticoids (GCs) are...
Light-responsible ECM-mimetic scaffolds for neural differentiation. Intracellular versus extracellular photothermal stimulation
March 2025
The development of approaches and materials that combine several types of stimulatory effects on nerve tissue growth is a promising task for biotechnology. The aim of this work was a comparative study...
Ultrasound-activated mechanochemical reactions for controllable biomedical applications
December 2024
Intramolecular bonds in small organic molecules, macromolecules, and organic-inorganic hybrids are broken or formed by ultrasound-activated mechanical force that can be applied with spatial and temporal...
Programming-via-spinning: Electrospun shape memory polymer fibers with simultaneous fabrication and programming
December 2024
Porous shape memory polymer (SMP) scaffolds are promising ‘smart’ materials for potential use in a wide range of biomedical applications. Electrospinning provides an approach to produce fibrous SMP...
Progress of smart material in the repair of intervertebral disc degeneration
December 2024
Intervertebral disc degeneration (IVDD) is a prevalent condition leading to back and leg pain as well as chronic disability. It refers to the degeneration of intervertebral disc structure, including...
Bioactive MXene hydrogel promotes structural and functional regeneration of skeletal muscle through improving autophagy and muscle innervation
December 2024
Complete skeletal muscle regeneration after traumatic injuries remains a challenge due to impaired regenerative capability and dysregulated microenvironments. Autophagy plays a crucial role in the muscle...
Nanobody-as versatile tool emerging in autoimmune diseases
December 2024
Nanobody (Nb) is derived from the variable domain of heavy-chain antibody (HCAb), naturally displaying notable properties like nano-scale size, exceptional stability, high specificity, low immunogenicity,...
Current situation and challenges of polyhydroxyalkanoates-derived nanocarriers for cancer therapy
December 2024
The sustained-release system for chemotherapeutic drugs or photosensitizer based on drug-loaded biopolyester nanocarriers can effectively reduce the overall dosage and frequency of administration, thereby...
Bioactive matters based on natural product for cardiovascular diseases
December 2024
Natural products are valuable sources of bioactive compounds for drug development. It is useful to explore natural products to treat cardiovascular disease. This review provides an overview of the natural...
Smart materials in medicine 5th anniversary
September 2024
Advances in smart biomaterials that modulate the bone microenvironment to promote bone defect repair in diabetes mellitus
September 2024
Diabetes mellitus (DM) is a chronic metabolic disorder that can affect the balance of bone metabolism and bone microenvironment, leading to impaired fracture healing. There are several underlying mechanisms...
Pulmonary delivery of bioadhesive nanoparticles for ALI improvement and ARDS prevention with a single-dose administration
September 2024
Acute respiratory distress syndrome (ARDS), a severe form of acute lung injury (ALI), is the major cause of intensive care unit death worldwide. ALI/ARDS is a common condition characterized by a storm...
Mitochondrial targeted prodrug nanoparticles for chemo-photodynamic combinational tumour therapy
September 2024
Prodrug nanoparticles have been explored as an effective means for drug delivery because of controlled drug release in a stimulus-responsive manner. Organellar-targeted drug delivery could enhance the...
Advances of surface modification to alleviate oxidative stress-induced valve degeneration
September 2024
Valvular heart disease (VHD) is a significant public health threat, with heart valve replacement surgery being the standard treatment for severe cases. Despite of advancements in artificial heart valves,...
Externally triggered drug delivery systems
September 2024
Externally triggered drug delivery systems empower patients or healthcare providers to utilize external stimuli to initiate drug release from implanted systems. This approach holds significant potential...
Magnesium-based bioceramic-enhanced composites fabricated via friction stir processing
September 2024
Improving the degradation performance and enhancing the biocompatibility are the main challenges of Mg-based biodegradable implants. In this study, a nano-hydroxyapatite-enhanced (nHA) Mg matrix composite...
The state-of-the-art therapeutic paradigms against sepsis
September 2024
Sepsis frequently leads to life-threatening organ failure due to an in appropriate response by the body to bacterial, viral, and fungal infections. In recent years, there has been an increasing interest...