Dual-antibacterial nano-sheet synergizes resveratrol delivery for burn regeneration
2026
In the field of burn treatment, where infected wound sites face critical challenges such as inadequate antimicrobial efficacy and impaired tissue regeneration, developing multifunctional strategies...
Advanced nanomaterials for myocardial ischemia-reperfusion injury: Bridging precision imaging to targeted therapy
2026
Myocardial ischemia-reperfusion injury (MIRI) is a major cause of heart failure, driven by oxidative stress, inflammation, and rapid loss of cardiomyocytes. Traditional therapies for MIRI remain limited,...
Chiral noble-metal nanomaterials: Chiral origins and biomedical applications
2026
Chirality is a fundamental property in nature, and the rapid progress of nanoscience has enabled the design and fabrication of nanoscale materials with precisely controlled chiral architectures. These...
Smart DNA nanocages mitigate oxidative stress and guide bone immune microenvironment for osteoporotic jawbone regeneration
2026
Jawbone regeneration in osteoporotic patients remains a formidable challenge due to excessive reactive oxygen species (ROS), dysregulated bone immunity, and compromised osteogenic capacity. While nanomaterial-based...
Macrophage membrane-camouflaged nanoparticles as emerging therapeutics in metabolic dysfunction-associated steatotic liver disease
2026
Chronic liver disease (CLD) is a major global health burden, with metabolic dysfunction-associated steatotic liver disease (MASLD) as a primary contributor through its promotion of persistent inflammation,...
Transduction strategies in enzyme-free nanomaterial-based aptasensors for tetracycline antibiotics: A review
2026
Enzyme-free aptamer-based biosensors have gained increasing attention for tetracycline monitoring, yet existing studies remain highly fragmented across materials and sensing formats. This review presents...
A dynamic hydrogel platform enables localized delivery of microRNAs and osteogenic growth peptide for the treatment of osteosarcoma
2026
The clinical management of osteosarcoma remains a major therapeutic challenge, mainly owing to the high risk of tumor recurrence driven by residual cancer cells after surgical resection and the persistent...
Harnessing the foreign body response to fabricate tissue engineered vascular grafts in vivo: Progresses in biotube preparation and application
2026
There is a great demand for small-diameter vascular grafts in clinical practice, particularly for the treatment of cardiovascular disease and hemodialysis access. Compared with synthetic vascular grafts...
Integrating siRNA targeting PKM2 with photodynamic therapy to induce tumor energy collapse
2026
Tumor cells exhibit an exceptionally high demand for energy to sustain uncontrolled proliferation and predominantly rely on glycolysis, rendering them vulnerable to energy-targeting interventions. However,...
Advances in microfluidic devices and materials for atherosclerosis research
2026
In recent years, the application of microfluidic chips in atherosclerosis (AS) research has garnered significant attention. This technology, renowned for its precise control of fluid dynamics at the...
A photothermally catalytic nanocomposite dual-crosslinked hydrogel for all-in-one postoperative osteosarcoma bone repair
2026
Osteosarcoma is among the most aggressive primary bone malignancies in adolescents. Postoperative reconstruction presents a “dual challenge”: complete eradication of residual tumor tissue is required...
4D-printed auxetic biomaterials for adaptive and functional bone implants
2026
Mechanical compatibility, biological integration, and patient-specific adaptability are becoming key factors driving the development of bone implants. Additive manufacturing (AM) has emerged as a transformative...
Polymerized-carbon-coated metal nanoparticles: A multimodal platform for biomedical imaging and theranostic applications
2026
Polymerized-carbon-coated metal nanoparticles (C@NPs) are emerging as versatile nanomaterials with broad applicability in biomedical imaging and integrated diagnostic–therapeutic (theranostic) platforms....
Harnessing extracellular matrix hydrogel for synergistic neurorehabilitation in traumatic brain injury
2026
Traumatic brain injury (TBI) is characterized by neuronal loss, vascular disruption, and limited regenerative capacity, further exacerbated by the absence of a supportive extracellular matrix (ECM)...
Functional biomaterials meet osteosarcoma treatment
2026
Osteosarcoma (OS) is a highly aggressive primary bone malignancy with high incidences of pulmonary metastasis and mortality, predominantly affecting children and adolescents. Nanotechnology and nanomaterials...
Natural-sourced nanocomplex scavenging ROS and inhibiting inflammation by on-demand drug release for the treatment of rheumatoid arthritis
2026
Rheumatoid arthritis (RA) is a chronic autoimmune disease triggered by multiple factors, with a vicious cycle of “inflammation-oxidative stress-exacerbated inflammation”. The use of conventional RA...
Machine learning facilitating the design of antimicrobial, anticancer, and self-assembled peptide materials
2026
Peptides are composed of short-to medium-chain amino acid molecules that combine the bioactivity of proteins with the structural tunability of small molecules, enabling broad applications in antimicrobial,...
Gastrodin-encapsulated injectable hyaluronic acid hydrogel promotes volumetric muscle loss repair via myogenesis
2026
Volumetric muscle loss (VML) induces irreversible functional impairment, characterized by extensive loss of muscle mass and failure of endogenous regenerative mechanisms. Current tissue engineering...
Synergistic Effect of Topographical Cue and Local Drug Delivery: An Axially-Aligned AM80-Loaded Graft for Preventing Intimal Hyperplasia in Small-Diameter Vascular Grafts
Available online 24 June 2026
Small-diameter vascular grafts (SDVGs) continue to present significant clinical challenges due to their poor long-term patency, which primarily results from incomplete endothelialization and intimal...
Self-Driven Medical Robots: From Actuation Mechanisms to Biomedical Applications
Available online 11 June 2026
Robotics technology is undergoing rapid evolution, exerting a transformative impact across numerous fields. However, the majority of contemporary robotic systems require external energy to drive, which...
A Multifunctional Redox-Responsive Catecholamine-Based Nanoplatform for Atherosclerosis Therapy
Available online 6 June 2026
Cardiovascular disease remains the leading threat to human health, with both the number of cases and the incidence rate increasing annually. Atherosclerosis (AS) is the underlying cause of its pathogenesis....
Polyphenol–Metal Self-Catalyzed Conductive Hydrogel Enhances Implant–Tissue Integration for Bone Regeneration
Available online 29 April 2026
Artificial rigid scaffolds offer mechanical support and show potential for bone regeneration, yet their clinical application is often hindered by poor integration at the implant-bone interface and an...
Recent advances in polymer 4D printing: 3D printing techniques, smart material design, and healthcare applications
December 2025
Fourth-dimensional (4D) printing has progressed tremendously since its first conceptualization in 2013. 4D printing is an emerging branch of three-dimensional (3D) printing that allows printed parts...
EXPECT: A thermosensitive embedded bioprinting platform for guided spatial cell organization
December 2025
Complex tissue engineering requires precise spatial cell organization, but static or isotropic hydrogels hinder long-term pattern maintenance due to random cell migration. We developed EXtrusion Patterned...
Smart polymeric nanoparticles for targeted delivery and microenvironment-responsive therapy in pancreatic cancer
December 2025
Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal malignancies, characterized by aggressive biology, a dense fibrotic and immunosuppressive microenvironment, and profound resistance to...