KeAi Talks: Mitochondrial Communications serial webinar 5

26 May 2022, 09:00 - 11:00

Time: Thursday 26 May, 9:00 - 10:30 (Beijing time)


9:00 – 10:00  Mitochondrial calcium and redox communications 
György Hajnóczky, MD, PhD

10:00 – 10:30  Dysregulation of Ca2+ homeostasis and human diseases 
Tie-Shan Tang (唐铁山), PhD  


Professor Quan Chen, PhD

Editor-in-Chief of the journal Mitochondrial Communications

Dean of the College of Life Sciences, Nankai University, China

Professor Xingguo Liu, PhD

Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, China


Ms. Huan Guo,

Meeting ID: 859 5828 3959

Password: 0000

Zoom link:

Mitochondrial calcium and redox communications Introduction

Calcium transport and redox reactions (reduction and oxidation), the source of various reactive oxygen species (ROS), are tightly controlled in the cells. Transient elevations of ionised calcium and ROS concentration are central to physiological signalling, whereas their prolonged and excessive increases cause cell injury and death. Calcium and ROS act synergistically on specific targets and control the generation and elimination of each other. They directly interact with and alter conformation and function of a range of proteins, as well as lipid membranes. In recent decades, mitochondria have emerged as central hubs in these signalling systems, and as regulators of both calcium and ROS homeostasis. This talk will focus on the mechanisms and functions of mitochondrial calcium and redox communications, with a focus on local signalling at the contacts of mitochondria with other organelles.

György Hajnóczky, MD, PhD

György Hajnóczky, MD, PhD Raphael Rubin Professor, Director of the MitoCare Center for Mitochondrial Imaging Research and Diagnostics, Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, USA

Education and career

MD and PhD, Semmelweis University, Budapest - 1987

National Academy of Sciences, Hungary - 1995

Founding Director of the MitoCareCenter for Mitochondrial Imaging Research and Diagnostics - Jan 2014 to present

Research and clinical interests

Intracellular calcium signalling; inositol trisphosphate-linked hormones; organisation of calcium mobilisation from endoplasmic/sarcoplasmic reticulum; mitochondrial calcium signalling; calcium-dependent control over life and death of cells; fluorometric, fluorescence microscope imaging and electrophysiological approaches.

Signaling, calcium, ER, mitochondria, metabolism, apoptosis, imaging

Tie-Shan Tang (唐铁山), PhD

Professor, Beijing Institute of Stem Cell and Regenerative Medicine, Institute of Zoology, Chinese Academy of Sciences (CAS), China

Professor Tie-Shan Tang received his PhD degree from the Institute of Developmental Biology, Chinese Academy of Sciences, in 1998, before completing his postdoctoral training at UT Southwestern Medical Center in the US. He set up his group at the Institute of Zoology, Chinese Academy of Sciences, in 2009. His studies focus on dysregulations of Ca2+ signalling, mitochondrial function and DNA repair pathways in neurological diseases. Prof. Tang has published over 60 scientific papers in peer-reviewed journals such as Cell, Mol Cell, Nucleic Acids Res, Proc Natl Acad Sci USA, PLoS Biol, and J Cell Biol. He has received a series of honours, including Chief Scientist of the National Key Research and Development Program of China, National Program of Leading Scientific and Technological Talents, Chief Scientist of the Innovation Team of the Ministry of Science and Technology, and Excellent Tutor of the Chinese Academy of Sciences

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