A pretest on cuproptosis: Activating PPARγ inhibits cuproptosis following intracerebral hemorrhage
August 2025
Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and disability. Cuproptosis is a regulatory cell death modality dependent on intracellular copper ion concentration, the...
Share article
The role of subarachnoid hemorrhage in post-traumatic Seizures: Insights from a retrospective study on TBI and seizure patterns
August 2025
Traumatic brain injury (TBI) and post-traumatic seizures (PTS) have been interconnected since ancient times. Modern research emphasizes their impact on morbidity and mortality, with persistent seizures...
Share article
Identification of non-invasive biomarkers associated with glioma hemorrhage
August 2025
Gliomas are among the most prevalent primary intracranial malignancies, and their management remains complex due to high rates of morbidity and mortality. Hemorrhage within gliomas, although relatively...
Share article
Multi-modal Ultrafast Sonography Microscopy (MUSM) for super-resolution imaging of cerebral vascular dynamics in a mouse model of hypertension induced by Angiotensin-II and L-NAME
August 2025
Hypertension is a major cause of cerebral hemorrhage. Although they are widely used in preclinical studies on cerebral hemorrhage, traditional in vivo cerebrovascular imaging techniques, such as positron...
Share article
Non-coding RNAs in intracerebral hemorrhage: Roles, mechanisms, and therapeutic implications
August 2025
Intracerebral hemorrhage (ICH), which is a form of stroke triggered by the rupture of blood vessels within the brain tissue, is a leading cause of morbidity and mortality worldwide. Although significant...
Share article
Prophylactic barbiturate step-down infusion therapy has similar and favorable effects in elderly and non-elderly patients with severe traumatic brain injuries
August 2025
Objective: With the aging population, the number of elderly patients with severe traumatic brain injury (sTBI) inevitably increases. The high mortality rate for sTBI in the elderly necessitates effective...
Share article
Peak perihematomal edema expansion predicts poor outcome in patients with intracerebral hemorrhage
August 2025
Intracerebral hemorrhage (ICH) is a highly fatal and incapacitating form of stroke. Perihematomal edema (PHE) serves as a measurable radiological indicator in the progression of secondary injury and...
Share article
CORM-2 attenuates red blood cell-mediated inflammation by upregulating phagocytic capacity of cerebral microglial cells of the neonatal rat in vitro
Available online 8 August 2025
•Effectively inhibiting inflammatory response in peri-hematoma area may reduce ICH-mediated secondary ischemic brain injury.•We established microglia and RBCs co-culture in vitro, to investigate the...
Share article
Transformer-based weakly supervised intracerebral hemorrhage segmentation using image-level labels
Available online 29 July 2025
The segmentation of intracerebral hemorrhage (ICH) lesions in brain CT scans is of paramount importance for the diagnosis and treatment of stroke. Given the tremendous challenge of pixel-wise annotation...
Share article
Fatal complication unveiled: analyzing intracerebral hemorrhage risk after CAR-T therapy in hematologic malignancies
Available online 28 July 2025
Chimeric antigen receptor T (CAR-T) cell therapy has demonstrated significant efficacy in the treatment of hematologic malignancies, yet it can lead to severe complications. Intracranial hemorrhage...
Share article
The role of PGC-1α in brain injury: mechanisms and therapeutic potential
Available online 26 July 2025
Brain injury remains a significant contributor to mortality and long-term neurological disability worldwide, despite ongoing research efforts to develop effective therapies that can mitigate secondary...
Share article
Link between heart failure and stroke: a comprehensive review
Available online 25 July 2025
Heart failure and stroke are two major cardiovascular conditions that significantly contribute to morbidity and mortality worldwide.1 While the link between heart failure and ischemic stroke is well...
Share article
Perioperative management of brain hemorrhage: Advances in anesthetic strategies and translational medicine
Available online 16 July 2025
•Brain hemorrhage presents perioperative challenges, requiring optimized anesthetic strategies.•Anesthesia choice and agent selection significantly influence perioperative outcomes.•Advanced neuromonitoring...
Share article
Advancing deep learning for automated stroke detection: a review
Available online 13 July 2025
Stroke remains a leading cause of death and disability worldwide, necessitating improved diagnostic tools for early detection and classification. Machine learning (ML) techniques have shown promise...
Share article
Grading of acute spontaneous cerebral hemorrhage combined with gut dysfunction assessment as a novel and improved prognostic score
Available online 13 July 2025
•The GD-ICH model demonstrated greater accuracy and predictive value than conventional models.•Gut dysfunction is as a reliable prognostic factor in ICH.•Gut dysfunction >7.5 days predicts poor prognosis,...
Share article
The impact of body-mass-index on functional outcomes and bleeding volumes in patients suffering spontaneous intracerebral haemorrhage
Available online 7 July 2025
The association between obesity and clinical as well as radiological outcomes in patients suffering spontaneous intracerebral haemorrhage (ICH) remains unclear. The obesity paradox suggests a protective...
Share article
Ultra-early hematoma growth predicts gastrointestinal bleeding after spontaneous intracerebral hemorrhage
Available online 3 July 2025
Ultra-early hematoma growth (uHG) has been shown to predict hematoma expansion (HE) and poor outcomes in intracerebral hemorrhage (ICH) patients. Gastrointestinal bleeding, a severe ICH complication,...
Share article
Stromal vascular fraction cell therapy: A promising therapeutic method for intracerebral hemorrhage
June 2025
Intracerebral hemorrhage (ICH) is one of the most devastating and life-threatening forms of stroke, characterized by bleeding within the brain parenchyma. The condition is associated with a high mortality...
Share article
Advancing brain injury treatment and neuroprotection with ligustilide: Mechanisms and therapeutic potential
June 2025
Brain injury is one of the leading causes of death and disability worldwide, attributable to diverse etiologies such as trauma, hypoxia, stroke, infection, or neurodegenerative diseases. Due to the...
Share article
Premorbid long-term statin use can reduce the risk of hemorrhagic transformation after ischemic stroke
June 2025
Hemorrhagic transformation (HT) of cerebral infarction is considered as one of the most serious complications. Increasing evidence show that statin use might reduce the neuroinflammation and even improve...
Share article
Coexistence of ruptured basilar artery perforator aneurysm undetected on initial angiogram and unruptured anterior cerebral artery saccular aneurysm: Case report and literature review
June 2025
Ruptured basilar artery perforator aneurysm (BAPA) is a rare cause of subarachnoid hemorrhage (SAH) and is difficult to diagnose....
Share article
The Progressive Frontier of Aneurysmal subarachnoid Hemorrhage: Diagnosis and treatment Advances
June 2025
Aneurysmal subarachnoid hemorrhage affects 6 to 9 out of every 100,000 people annually, with a mortality rate of 35%. Many people suffer from long-term disabilities, often associated with cognitive...
Share article
Effectiveness of 3D printing technology-assisted neuroendoscopic surgery for hypertensive intracerebral hemorrhage in primary hospitals
June 2025
We aimed to investigate the clinical effectiveness of integrating 3D-printing technology with neuroendoscopy for treating hypertensive intracerebral hemorrhage (HICH)....
Share article
Simultaneous bilateral basal ganglia hemorrhage: case report and literature review
Available online 16 June 2025
To present a rare case of symmetric hemorrhages in the bilateral basal ganglia with unique imaging findings and discuss potential pathophysiological mechanisms....
Share article
Integrated network pharmacology reveals the mechanisms of punicalagin in cardiovascular and cerebrovascular diseases treatment
Available online 10 June 2025
Cardiovascular and cerebrovascular diseases, including coronary artery disease (CAD), myocardial infarction (MI), carotid atherosclerosis (CAS), and cerebral ischemic stroke (CIS), continue to impose...
Share article
Production and hosting by Elsevier on behalf of KeAi Communications Co. Ltd