Dual-port robot-assistant visualized minimally invasive aspiration (RAVMIA) for evacuation of irregular basal ganglia hemorrhage: A technical note
August 2026
The surgical management of intracerebral hemorrhage (ICH) remains controversial. While minimally invasive endoscopic techniques have shown promise, recent trials have not demonstrated positive outcomes...
Development and validation of an improved ICH score: Integrating clinical and radiographic parameters for enhanced prediction of 30-day mortality in spontaneous intracerebral hemorrhage
August 2026
•Adding pupil status and warfarin use improves ICH score mortality prediction.•The new score achieved an AUROC of 0.91, better than the original score of 0.87.•Enhanced accuracy benefits both nonoperative...
Machine learning-based radiomics model for predicting hematoma enlargement in spontaneous intracerebral hemorrhage: A multicenter study
August 2026
This study aimed to establish and validate three predictive models: a clinical model (CM), a radiomics model (RM), and a combined clinical–radiomics model (CRM) for forecasting hematoma progression...
Efficacy and safety of middle meningeal artery embolization in combination with burr hole craniostomy for chronic subdural hematomas: A single-center experience
August 2026
Chronic subdural hematoma (CSDH) is a prevalent neurosurgical condition. The mass effect of hematoma could lead to a series of neurological dysfunctions. Surgical intervention, such as burr hole craniostomy...
Reversible cerebral vasoconstriction syndrome: not just a “reversible” condition. Retrospective observational study and literature review
August 2026
This study aims to critically evaluate the evolving understanding of reversible cerebral vasoconstriction syndrome (RCVS) by examining its potential for long-term complications. While reversible cerebral...
Decoding the spatiotemporal pleiotropy of CCL2-CCR2 signaling to guide staged therapies in CNS injury
Available online 26 August 2026
Intracerebral hemorrhage (ICH) and other acute central nervous system (CNS) injuries share a devastating pathological hallmark: neuroinflammation. Within this complex immune network, the CCL2-CCR2 signaling...
Safety and efficacy of clazosentan monotherapy in aneurysmal subarachnoid hemorrhage with intracerebral hematoma: A real-world analysis
Available online 25 August 2026
Evidence for clazosentan in aneurysmal subarachnoid hemorrhage (aSAH) complicated by intracerebral hematoma (ICH) remains limited. We evaluated outcomes of clazosentan monotherapy in patients with ICH...
“ICH-CARE”: ICH-integrated care for accelerated response to intracerebral hemorrhage using a phased approach
Available online 17 August 2026
Intracerebral hemorrhage (ICH) is a deadly stroke subtype requiring ultra-early bundled interventions. The Mayo Clinic Comprehensive Stroke Center implemented a “ICH Phases” three-tiered communication...
Beyond recanalisation: The ATTRACTION trial shows a promising role for tirofiban after successful thrombectomy
Available online 25 July 2026
Despite successful thrombectomy, many patients with large-vessel occlusion stroke remain functionally dependent. The ATTRACTION trial evaluated low-dose tirofiban after successful endovascular reperfusion...
Microglia-neuron crosstalk in intracerebral hemorrhage: from neuroimmunomodulation to neurorepair
Available online 6 July 2026
Intracerebral hemorrhage (ICH) remains a devastating disease with high mortality and disability rates, yet effective therapeutic strategies are still limited. Emerging evidence has highlighted that...
The TLR4/MyD88 axis: Orchestrator of neuroinflammation from molecular initiation to systemic crosstalk
June 2026
Neuroinflammation is a convergent feature of neurodegenerative diseases, hemorrhagic and ischemic stroke, and spinal cord injury. Central to this process is the Toll-like receptor 4 (TLR4) and myeloid...
Digital twins for stroke prediction and management
June 2026
•Digital twins: dynamic computational replicas integrating multimodal patient data.•Patient-specific left atrial modelling stratifies AF-related embolic risk.•Imaging-informed cerebrovascular hemodynamics...
Association of pre-admission use of sartans and calcium channel antagonists with outcomes after spontaneous intracerebral hemorrhage: A retrospective cohort study
June 2026
Spontaneous intracerebral hemorrhage (ICH) is a severe stroke subtype associated with high morbidity and mortality. Preclinical studies suggest that angiotensin II-type 1 receptor blockers such as sartans...
Research progress of peripheral inflammation in spontaneous cerebral hemorrhage
June 2026
This review systematically summarizes the research progress on peripheral inflammation in spontaneous intracerebral hemorrhage (ICH), focusing on the interaction mechanisms of the “peripheral-central...
Minimally invasive puncture and drainage combined with urokinase in the treatment of spontaneous intracerebral hemorrhage in the basal ganglia (MIPDU): A multicenter randomized controlled trial protocol
June 2026
Spontaneous intracerebral hemorrhage (ICH) represents a severe subtype of stroke with a notably high incidence, particularly in China, where it constitutes 21%–48% of cerebrovascular events. This condition...
Sleep Disordered Breathing in Intracerebral Hemorrhage Survivors in Japan: a Meta-analysis and Systematic Review
April 2026
We evaluated the prevalence and correlates of sleep-disordered breathing (SDB) in intracerebral hemorrhage (ICH) survivors in Japan....
Inflammatory biomarkers in patients with intracranial aneurysms
April 2026
Intracranial aneurysm (IA) is a serious cerebrovascular disease. This study aimed to investigate the clinical characteristics and plasma biomarkers associated with IA....
Comparison of single-channel EEG decoding performance in imagined speech tasks
April 2026
Electroencephalography (EEG)-based imagined speech decoding technology offers a communication solution for patients with language impairments. However, existing research on English-language systems...
Prognostic value of TC/HDL-C ratios in ischemic stroke: a multicenter observational study
April 2026
This study aimed to determine the relationship between the total cholesterol to high-density lipoprotein cholesterol (TC/HDL-C) ratio and adverse outcomes in patients with first-ever ischemic stroke...
The role of blood lipid and triglyceride‑glucose index in intracranial aneurysms: A retrospective study
April 2026
The association between blood lipids and aneurysmal subarachnoid hemorrhage (aSAH) remains uncertain, with current research yielding conflicting results. Limited studies have explored the link between...
Perioperative management of brain hemorrhage: Advances in anesthetic strategies and translational medicine
April 2026
•Brain hemorrhage presents perioperative challenges, requiring optimized anesthetic strategies.•Anesthesia choice and agent selection significantly influence perioperative outcomes.•Advanced neuromonitoring...
Atorvastatin and glucocorticoid therapy for retroclival epidural hematoma: Case report and literature review
April 2026
Retroclival epidural hematomas (REDH) are particularly rare conditions. We report for the first time the effect of conservative treatment of this rare condition with atorvastatin and glucocorticoids...
Truncated Metabotropic glutamate receptor 1 worsens long-term neurological outcomes in a rat model of subarachnoid hemorrhage
Available online 28 April 2026
Truncation of mGluR1 occurs in cerebrospinal fluid (CSF) from aneurysmal subarachnoid hemorrhage (aSAH) patients, but the effect of truncated mGluR1 on brain injury is still unclear. This study aims...
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