Reframing cell death: Unveiling interactions and synergistic mechanisms in tumor immunity
February 2026
Cell death is a well-coordinated process that encompasses apoptosis as well as other mechanisms, including pyroptosis, autophagic cell death, ferroptosis and necroptosis. These modalities are hierarchically...
A research status and prospects of edible fungal-derived fibrinolytic enzymes: breakthroughs based on multi-omics and intelligent delivery technologies
February 2026
Thrombotic diseases represent a significant global health burden. Current clinical thrombolytic agents are plagued by limitations including short half-lives, high bleeding risks, and exorbitant costs....
Structure-based virtual screening and molecular dynamics simulation for the identification of novel potential inhibitors for the NDM-1 of Klebsiella Pneumoniae from the marine natural products
February 2026
The emergence of antibiotic-resistant bacteria, especially New Delhi Metallo-β-lactamase-1 (NDM-1) of Klebsiella pneumoniae, is a significant threat to serious public health. The aim of this study was...
Silencing of KLF9 alleviates palmitic acid-induced insulin resistance and inflammation in undifferentiated myoblasts by targeting GRB14, unveiling a pathogenic axis in Type 2 diabetic myopathy
February 2026
Skeletal muscle insulin resistance and inflammation are key drivers in the progression of skeletal muscle atrophy in Type 2 diabetes (T2D). This study aimed to identify novel molecular regulators underlying...
Etomidate alleviates PM2.5-induced cardiomyocyte injury by increasing the expression of HSCB based on transcriptome analysis
February 2026
Etomidate is a commonly used short-acting intravenous anesthetic and has become an important option for anesthesia induction in myocardial injury patients. However, the potential molecular mechanisms...
The mechanism of active components of Panax japonicus in mediating the HIF-VEGF signaling pathway to promote fracture healing: An investigation utilizing serum pharmacochemistry and network pharmacology approaches
February 2026
To establish a tibial fracture model in rats and preliminarily investigate the intervention mechanisms of Panax japonicus on the tibial fracture healing process based on the angiogenesis mechanisms...
Applications and challenges of tear proteomics in unveiling the molecular mechanisms and biomarkers of dry eye disease
February 2026
Dry Eye Disease (DED) stands as one of the most prevalent ocular surface disorders globally, with an increasing incidence that significantly impairs patients’ visual function and quality of life. Conventional...
METTL14 stabilizes KLF6 through m6A methylation modification, thereby exacerbating neuronal injury induced by ischemia-reperfusion
February 2026
Stroke is an acute cerebrovascular condition marked by high rates of disability and mortality. Kruppel-like factor 6 (KLF6), a pivotal transcription factor, is integral to cell proliferation and differentiation....
Identification of key fatty acid metabolism genes and lncRNAs in Tibial cortex transverse traction therapy for diabetic foot Ulcers
December 2025
To explore the potential molecular mechanisms of tibial cortex transverse traction (TTT) in diabetic foot ulcer (DFU) healing by identifying key fatty acid metabolism genes and long non-coding RNAs...
Proteome provides a full map on the physiology and mechanism of the gastrointestinal tract in humans and rodents
December 2025
GRHL3 promotes tumor growth and metastasis via the TGF-β signaling pathway in human epithelial ovarian cancer
December 2025
Grainyhead-like 3 (GRHL3) has been implicated in the biology of several epithelial malignancies, yet its function in epithelial ovarian cancer (EOC) remains insufficiently defined. Given the high mortality...
The progress and prospects of single-cell sequencing, multi-omics integration analysis, and immunotherapy targeting strategies in lung cancer research
December 2025
Lung cancer is a highly prevalent and lethal malignant tumor globally, imposing a heavy burden on public health. Traditional treatments such as surgery, chemotherapy, and radiotherapy have significant...
The expanding tool landscape of proteomics: From high-throughput quantification to intelligent data analysis
December 2025
Compounds isolated from Rhabdophyllum arnoldianum: promising new molecules for cancer treatment through their inhibitory properties on tyrosine kinases and dihydrofolate reductase, revealed by molecular docking
October 2025
Resistance to current anticancer therapies drives the demand for novel, multitarget agents with improved safety. We screened flavonoid-derived phytochemicals isolated from Rhabdophyllum arnoldianum...
Applications of artificial intelligence and large language models in cancer immunotherapy
October 2025
With the rapid advancement of artificial intelligence (AI) technologies, particularly the widespread adoption of large language models (LLMs), the field of cancer immunotherapy is experiencing unprecedented...
Proteomics and metabolomics analysis of Mongolian acupuncture therapy for type 2 diabetes mellitus with atherosclerosis
October 2025
Mongolian acupuncture therapy, a traditional modality involving stimulation of specific acupoints, has shown notable benefits in managing diabetes mellitus (DM) and its complications. However, its effects...
Advances in the combination of immunotherapy and radiotherapy for microsatellite-stable metastatic colorectal cancer
October 2025
Combining immunotherapy with radiotherapy has emerged as a novel and promising approach for treating microsatellite-stable metastatic colorectal cancer (MSS mCRC). This review offers an in-depth analysis...
A Multimodal artificial intelligence framework for mechanistic discovery and digital twin construction in cardiovascular medicine
October 2025
Multimodal artificial intelligence (AI) is reshaping contemporary cardiovascular medicine. Its contribution has moved far beyond early successes in image recognition, arrhythmia detection, and automated...
Immune biomarkers as key targets in managing tuberculosis: A systematic review
October 2025
Tuberculosis remains a major global health challenge and is one of the leading causes of mortality worldwide. In recent years, the resurgence of the disease has intensified research efforts aimed at...
Spatial omics: Deciphering heterogeneity in the tumor immune microenvironment and resistance to immunotherapy
October 2025
Drug resistance in tumor immunotherapy is a significant challenge, stemming from the high heterogeneity and intricate spatial architecture of the tumor immune microenvironment. Traditional omics technologies...
Emerging role of tumor associated macrophages in pan-tumor progression: Biological mechanisms to clinical application
October 2025
NSUN2/FOXM1 positive feedback pathway promotes the malignant development of non-small cell lung cancer
August 2025
•FOXM1 expression was upregulated in NSCLC tissues and cells.•FOXM1 silencing inhibited NSCLC cell proliferation, invasion, and M2 macrophage polarization and induced cell apoptosis and ferroptosis.•NSUN2...
Screening of immune-related secretory proteins linking primary Sjögren’s syndrome with pulmonary arterial hypertension based on comprehensive bioinformatics analysis and machine learning
August 2025
Pulmonary arterial hypertension (PAH) is a complication associated with primary Sjögren's syndrome (pSS). Nevertheless, the precise common mechanism linking pSS and PAH remains unclear. This study employs...