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Open access

ISSN: 1570-1646
e-ISSN: 1875-6247

Exploration of atractylenolide III targeting MDM2/p53 axis in breast cancer cell progression based on network pharmacology, molecular docking and ubiquitination analysis

Atractylenolide III (AT III) is a promising drug used for cancer treatment. Herein, this study aimed to explore the anti-tumor mechanism of AT III in breast cancer (BC) associated with murine double...

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Advances in machine learning for optimizing pharmaceutical drug discovery

The integration of advanced machine learning methodologies has revolutionized the field of pharmaceutical drug discovery by addressing critical challenges in efficiency, scalability, and accuracy. This...

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Machine learning-based classification of viral membrane proteins

Viral membrane proteins (VMPs) are essential viral components located on the surface of enveloped viruses, playing a critical role during the viral infection of host cells. Based on their structural...

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SP1-mediated WTAP exacerbates the progression of colon adenocarcinoma by m6A methylation of KLK8

•KLK8 knockdown repressed COAD cell progression and promotes CD8+ T cell cytotoxicity.•KLK8 silencing blocks tumorigenesis of COAD in vivo.•WTAP knockdown inhibits COAD progression by regulating KLK8...

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Design, synthesis, and theoretical studies of sulfonylated purine derivatives as EGFR inhibitor

Four novel 6-amino-9-sulfonyl-purine derivatives were synthesized and characterized by 1H-NMR, 13C NMR, IR, and Mass spectral analyses. Further DNA binding studies were performed with the synthesized...

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An in-silico approach for structural and functional annotation of an uncharacterized protein of human papillomavirus (HPV)

Human papillomavirus (HPV) is the predominant viral infection, which causes various new cancer cases globally each year, encompassing cervical and various other cancer types. HPVs have developed throughout...

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Advances in bioinformatics techniques for ophthalmic diseases

As the population ages and lifestyles evolve, the prevalence of ophthalmic diseases such as diabetic retinopathy, age-related macular degeneration, and glaucoma continues to rise, imposing a significant...

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