Recent Articles

Multi-omics approach reveals gene co-alterations and survival benefit in ovarian cancer patients under platinum-based adjuvant therapy

November 2025

Ning Ding | Jiahui Chen | Xiaotian Zhao | Minyi Zhu | Qiuxiang Ou | Jiaohui Pang | Luxi Ruan | Ying Zhang | Wei Sun | Xiaoxiang Chen

The effect of sodium-glucose cotransporter 2 inhibition mediated by blood metabolites in lymphocytic leukemia

November 2025

Diguang Wen | Kai Lei | Xiang Ma | Jianchuan Deng

Bulk RNA sequencing combined with single-cell RNA sequencing analysis revealed the ferroptosis immune target of osteoarthritis synovial fibroblasts

November 2025

Qian Wu | Liang Zhou | Yuan Xue | Jiaqian Wang

Investigation of the temporal distribution of anti-VEGF drugs in the retina and the correlation with the distribution of FcR isoforms

November 2025

Jicai He | Yanping Jiang | Rongqin Yang | Ziwen Lu | Zhihuan Li | Zhigang Tu

Restored phagocytic ability of RPE patches derived from gene-corrected retinitis pigmentosa-hiPSCs on a biodegradable scaffold via clinical-grade protocol: Implications for autologous therapy

November 2025

Rodriguez-Jimenez Francisco Javier | Artero-Castro Ana | Studenovska Hana | Selles Francisca | Arteaga Claramunt Alba Maria | Brymova Anna | Jendelova Pavla | Motlik Jan | Petrovski Goran | Lytvynchuk Lyubomyr | Ardan Taras | Tichotová Lucie | Drutovič Saskia | Sharma Ruchi | Lukovic Dunja | Bharti Kapil | Erceg Slaven

A multi-omic integrative approach combining m6A-epitranscriptomic, transcriptomic, and splicing alternative events reveals potential candidates for colorectal cancer diagnosis

November 2025

Hatim Boughanem | Jesus Pilo | Alejandro Rego | Libia Ajendra Garcia-Flores | Teresa Dawid-de Vera | Francisco J. Tinahones | Gracia Maria Martin-Nuñez | Manuel Macias-González

Population-based screening of CYP17A1 Y329fs mutation carriers in the Han Chinese population

November 2025

Bing Han | Xiaoxi Zhang | Chang Liu | Hui Zhu | Wenjiao Zhu | Yue Xu | Fengxue Zhang | Kaiwen Zhang | Shuhua Xu | Jie Qiao

CMTM3 promotes adipocyte differentiation by regulating PPARγ in 3T3-L1 cells

November 2025

Yanni Zhao | Meiyu Piao | Yuankuan Li | Sung Ho Lee | Seung-Joo Nho | Yujian Jin | Chang-Yeol Yeo | Kwang Youl Lee

Role of angiogenesis-related lncRNAs in tumor microenvironment and prognosis of lung adenocarcinoma

November 2025

Lifeng Li | Yaqi Yang | Mengle Peng | Zhirui Fan | Xiaoran Duan | Ruyue Xue | Xuefeng Lv | Ming Cheng | Jie Zhao

In vivo adeno-associated virus-mediated LDLR/PCSK9 intervention for familial hypercholesterolemia

November 2025

Zeyu Han | Cheng Tan | Jianzhong Ai | Ye Zhu

A novel variant of TFAP2A in a familial case of branchio-oculo-facial syndrome: Insights from structural bioinformatics and molecular dynamics simulation

November 2025

Jingjing Zhao | Nuo Si | Ningbei Yin | Tao Song

Tryptophan attenuates acute hypoxic stress-induced intestinal injury through the modulation of intestinal barrier integrity and gut microbiota homeostasis

November 2025

Jianhua Zheng | Jingqing Chen | Wensheng Zhang | Yunpeng Wu | Tongtong Qin | Yunzhi Fa | Qianyan Dong | Rui Zhang | Yefeng Qiu

Evolutionary characteristics, biochemical structure, and function impact of MSTN gene

November 2025

Rui Zhang | Yunpeng Wu | Tianqi Sun | Zhengxing Lian | Jingqing Chen | Yefeng Qiu

The same genomic variants in the first three exons of KANSL1 can be either benign or causative of Koolen-de Vries syndrome: Definition of a validation procedure

November 2025

Federica Francesca L'Erario | Giuseppe Marangi | Anna Gloria Renzi | Marina Carapelle | Paolo Niccolò Doronzio | Domizia Pasquetti | Sabrina Maietta | Elena Sonnini | Annalisa Gazzellone | Marcella Zollino

Investigation of long-term epigenetic changes in the Nr3c1 gene by neonatal valproate exposure in juvenile rats

November 2025

Eun Hye Jang | Soon Ae Kim

circ-miR-524 accelerates the growth of liver cancer cells by inducing DNA damage repair through K-RAS

November 2025

Yanan Lu | Dongdong Lu

Welander distal myopathy-associated TIA1 mutation exacerbates P-body and stress granule dynamics concomitant with nucleolar stress under oxidative stress

November 2025

Beatriz Ramos Velasco | José Alcalde | José M. Izquierdo

iPSC-based merlin-deficient Schwann cell-like spheroids as an in vitro system for studying NF2 pathogenesis

November 2025

Núria Catasús | Gemma Casals-Sendra | Miguel Torres-Martin | Inma Rosas | Bernd Kuebler | Helena Mazuelas | Emilio Amilibia | Begoña Aran | Anna Veiga | Ángel Raya | Bernat Gel | Ignacio Blanco | Eduard Serra | Meritxell Carrió | Elisabeth Castellanos

Genetics, epidemiology and management of clubfoot and related disorders

November 2025

Muhammad Umar | Liping Tong | Hongting Jin | Tamas Terebessy | Di Chen

Clubfoot, medically termed congenital talipes equinovarus (CTEV), is a prevalent musculoskeletal birth defect, affecting approximately 0.3% of all live births. This serious congenital anomaly results...

Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment

November 2025

Luyao Wang | Ye Zhu | Chengying Huang | Qiuming Pan | Junxi Wang | Hongrui Li | Yudi Huang | Guozhong Yi | Zhiyong Li | Songtao Qi | Guanglong Huang | Shanqiang Qu

Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer...

Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation

November 2025

Caihan Duan | Junhao Wu | Zhe Wang | Xiaohua Hou | Chaoqun Han

Fucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable...

Unveiling the regulatory potential of the non-coding genome: Insights from the human genome project to precision medicine

November 2025

Paola Ruffo | Bryan J. Traynor | Francesca Luisa Conforti

The Human Genome Project marked a milestone in scientific exploration, unraveling the genetic blueprint of humanity. However, expectations of direct gene–disease associations gave way to realizing the...

The regulatory role and mechanism of energy metabolism and immune response in head and neck cancer

November 2025

Haofan Li | Qiu Peng | Linda Oyang | Wenjuan Yang | Shizhen Li | Yaqian Han | Mingjing Peng | Shiming Tan | Longzheng Xia | Jinguan Lin | Xuemeng Xu | Nayiyuan Wu | Yanyan Tang | Xia Luo | Xianjie Jiang | Qianjin Liao | Yujuan Zhou

Head and neck cancer, which includes cancers of the mouth, larynx, and pharynx, is one of the six most common cancers worldwide. Common risk factors include smoking, excessive alcohol consumption, betel...