Hypoxia-mediated CRIP2 activation via NICD1 translocation regulates glycolysis and cell death
March 2026
Optimized Yamanaka factors combined with TERT gene therapy for enhanced anti-aging effects
March 2026
Intense light mitigates hypoxia-induced right ventricular remodeling and dysfunction through reducing inflammation associated with PF4+ resident macrophages
March 2026
Hypoxia-induced right ventricular (RV) remodeling and dysfunction present a significant health risk to populations experiencing prolonged hypoxic conditions. Intense light, a noninvasive and easily...
Deficiency of TMEM16F in hair cells prevents diabetes-related and noise-induced hearing loss
March 2026
Mechanotransduction and musculoskeletal regeneration: Molecular mechanisms and interdisciplinary applications
March 2026
Distraction osteogenesis, or the Illizarov technique, induces bone regeneration using distractive mechanical forces. Nevertheless, Wolff's law holds that bone adapts to reverse compressive mechanical...
Non-clinical safety considerations on genome editing using the CRISPR/Cas system
March 2026
Recent advances in gene editing using the CRISPR/Cas system have revolutionized genome editing, opening new horizons for human cellular and gene therapy products. Genome editing technologies are rapidly...
Defective biological networks associated with pseudogene-derived lncRNAs in cancer drug resistance: Promising prospects for their clinical targets in cancer therapy
March 2026
Cancer is a major cause of mortality globally, characterized by its multifactorial nature and intricate treatment procedures. The main treatment options include targeted drug therapies and chemotherapy....
RNA modifications in intestinal macrophages: Implications for gut immunity and inflammation
March 2026
Intestinal macrophages are critical regulators of mucosal immunity, playing essential roles in microbial surveillance, barrier maintenance, and tissue repair. As highly responsive immune cells, they...
The advancements in organoids: Potential and challenges in researching the esophagus and esophageal squamous cell carcinoma
March 2026
Esophageal squamous cell carcinoma (ESCC) ranks among the top six deadliest malignancies globally, characterized by an alarmingly low five-year survival rate. This aggressive cancer is especially prevalent...
