Temperature dependence of two or more water species in delignified wood and lignocellulosic, tracked by LFNMR relaxometry
February 2026
Distributions of nuclear magnetic resonance (NMR) relaxation times provide detailed information about the water in wood. This study documents the water dynamics analysis of T2 and T1 distributions for...
Protamine-1 encoded recombinant adeno-associated virus for enhanced brain magnetic resonance imaging
February 2026
Magnetic resonance imaging (MRI) is a powerful tool for diagnosing and monitoring brain diseases, but its low sensitivity can hinder early detection. To address this challenge, we utilized chemical...
Fast acquisition of high resolution liquid NMR spectroscopy
February 2026
Nuclear magnetic resonance (NMR) spectroscopy is a powerful tool for analyzing molecular structure and composition. However, traditional NMR experiments suffer from long acquisition times, especially...
SNMR with short pulses: Optimizing the kernel calculation by considering the influence of pulse shape and phase
February 2026
In the past few years, efforts have been made to extend the sensitivity of surface nuclear magnetic resonance (SNMR) to short relaxation times, typical for strongly bound water, which, for example,...
Self-supervised pre-training based hybrid network for deep gray matter nuclei segmentation
February 2026
The accurate segmentation of deep gray matter nuclei is critical for neuropathological research, disease diagnosis and treatment. Existing methods employ the supervised learning training approach, which...
Exploring the effect of ethanol-water structuring on the transport properties of ethanol in porous silicas
February 2026
The transport properties of liquid mixtures confined within porous media can change significantly from those observed for bulk mixtures due to changes in the liquid structuring within the pore space....
Characterization of the interaction between human cytochrome c and transfer RNAphe
February 2026
Cytochrome c (cyt c) is released from mitochondria into the cytosol upon apoptotic stimulation, ultimately triggering programmed cell death. Recent studies have revealed that transfer RNA (tRNA) interacts...
Lighting up β-cell function: Noninvasive MRI of glucose-stimulated Zn2+ secretion
Available online 30 January 2026
NMR spectral simplification with imidazolium ionic liquid-coated silica nanoparticles
Available online 8 January 2026
NMR spectral simplification is a powerful strategy for facilitating the analysis and structural characterization of complex mixtures. In this work, we present a nanoparticle-assisted protocol that employs...
Production of isotope-labeled nanobody KN035 in Pichia pastoris yields native-like conformation and PD-L1 binding activity comparable to KN035 expressed in mammalian cells
Available online 7 January 2026
Stable isotope-labeled proteins are indispensable for NMR-based structural studies. E. coli is a cost-effective and high-yield expression host, but it often fails to support proper folding and post-translational...
Impact of mutual and environmental dipole-dipole interactions on the relaxation of MQ NMR coherences in two-spin system in course of their excitation and reconversion
Available online 7 January 2026
The relaxation of multiple-quantum (MQ) NMR coherences on the excitation and reconversion periods of MQ NMR experiment was investigated for the spin-pairs coupled by dipole-dipole interaction. The 1H...
Heptanuclear iron complex as a potential contrast agent for MRI
Available online 30 December 2025
A heptanuclear complex of the composition [Fe(II)(CN)6{Fe(III)](L)}6](SCN)2, where L = dianion N,N-bis(1-hydroxy-2-benzylidene)-1,7-diamino-4-azageptane has been studied as a potential contrast agent...
NMR methods for investigating functionally relevant biomolecular dynamics
November 2025
The dynamics of biomolecules span across a wide range of timescales, reflecting the complexity of free energy landscapes of biomolecules. Among these, the microsecond-to-millisecond (μs–ms) timescale...
Validity of the Gaussian phase distribution approximation for analysis of isotropic diffusion encoding applied to restricted diffusion in a cylinder
November 2025
The Gaussian phase distribution approximation enables analysis of restricted diffusion encoded by general gradient waveforms but fails to account for the diffraction-like features that may occur for...
Revisiting classical diffusion magnetic resonance methods as a means to measure time-dependent diffusion
November 2025
The field of diffusion microstructural magnetic resonance (MR) aims to probe time-dependent diffusion, i.e., an ensemble-averaged mean-squared displacement ⟨r2(t)⟩ that is not linear in time. This time-dependence...
Rapid and quantitative 1D 13C NMR analysis of polypropylene tacticity with relaxation agent and proton polarization transfer
November 2025
Polypropylene (PP) accounts for approximately 28.0% of the global polyolefin market, valued at $243.4 billion in 2022. Known for its lightweight, chemical resistance, cost-effectiveness, high strength...
NMR-guided rational exploration of co-factors in boosting the Pfu DNA polymerase
November 2025
With rapid developments of emerging technologies like synthetic biology, the demand for DNA polymerases with superior activities including higher thermostability and processivity has increased significantly....
Transmembrane association of DDR1 and DDR2 mediated by Leucine zipper motifs
November 2025
Discoidin domain receptors (DDRs) are single-pass transmembrane proteins belonging to receptor tyrosine kinases (RTKs) family, which are activated by collagen ligands with unusual slow, sustained kinetics,...
Characterization of kerogen nanopores using 2D NMR relaxation and MD simulations
November 2025
The characterization of kerogen nanopores is crucial for predicting the geostorage capacity and recoverability of natural gas in unconventional gas shale reservoirs. Towards this end, a powerful technique...
OFC: Outside Front Cover
November 2025
Chemical exchange saturation transfer NMR: An analytical tool and its applications
Available online 26 November 2025
NMR spectroscopy has proven to be a powerful tool for elucidating structural information and studying dynamic processes. Among NMR techniques, chemical exchange saturation transfer (CEST) is particularly...
Fast three-dimensional NMR spectroscopy reconstruction based on Hankel matrix with two-directional sliding windows
Available online 4 November 2025
Nuclear magnetic resonance (NMR) spectroscopy has grown into a formidable tool in biomedical analysis and quantification. However, the lengthy acquisition for high-dimensional NMR spectroscopy hinders...
A random fractional 13C labeling strategy for P. pastoris expressed eukaryotic membrane proteins for solid-state NMR studies
Available online 3 November 2025
Solid-state NMR (SSNMR) has emerged as an important technique for characterizing membrane protein structures. Using sparse 13C labeling of membrane proteins can significantly enhance spectral resolution....
Fragment-based discovery of TopBP1 inhibitors integrated with AI-driven molecular docking
Available online 30 October 2025
DNA topoisomerase IIβ-binding protein 1 (TopBP1) converges on multiple oncogenic pathways, e.g., Rb, p53, and PI3K/Akt, which are hallmarks of most cancer progression. However, the lack of structural...