Mitochondrial DNA (mtDNA) mutations and variations have been reported in various human diseases, including cancer. mtDNA metabolism and dynamics are regulated with a unique set of mechanisms that are largely different from those of nuclear DNA. Due to the lack of in-depth understanding of mtDNA biology, and a well-established methodology to investigate mtDNA, there is much misinformation and disinformation on the topic of mtDNA and cancer. For this special issue, we welcome contributions from researchers working in this area in the form of original research articles or review papers.
- mtDNA replication, mtDNA copy number in cancer
- mtDNA dynamics in cancer
- mtDNA mutation and cancer, chicken or egg
- Mitochondrial haplogroups, epidemiology and mechanistic investigation
- Quality control of mtDNA and cancer
- Manipulation of mtDNA; new approach, new hope?
- Target mtDNA as a cancer treatment strategy
Submissions open: 15 July 2022
Submissions close: 31 December 2023
Expected time to first decision: 4 weeks after submission
Please read the Guide for Authors before submitting. All submissions should be made via the online editorial system and will be subject to peer review. If the manuscript is accepted, the article will be published open access with no fee payable by the author.
Professor Yidong Bai
- University of Texas Health San Antonio, USA. Email: BaiY@uthscsa.edu